• These include ischemic conditions caused by a restricted blood supply to the muscle such as angina, and myocardial infarction. (wikipedia.org)
  • We show that PDE4D gene inactivation in mice results in a progressive cardiomyopathy, accelerated heart failure after myocardial infarction, and cardiac arrhythmias. (nih.gov)
  • The simulation of the time course of development of heart failure after an acute myocardial infarction requires large, open-access datasets. (biomed-data.eu)
  • In this report, we present large echocardiographic datasets of cardiac function in rats after myocardial infarction at two different time points (2 and 13 weeks). (biomed-data.eu)
  • The occurrence of myocardial infarction (MI) in men is expected earlier and with higher severity compared to age-matched women [ 1 ]. (biomedcentral.com)
  • In chronic heart failure following myocardial infarction, dramatic reduction of the microdomain-specific β 2 -AR/cAMP signals and β 2 -AR dependent PLM phosphorylation was accompanied by a pronounced loss of local PDE3 and an increase in PDE2 effects. (dundee.ac.uk)
  • We have used computational models to investigate fundamental mechanisms that underlie calcium-dependent arrhythmias, the same class of arrhythmias that follow myocardial infarction, heart failure and diverse genetic arrhythmic diseases. (gmu.edu)
  • Is essential for left ventricular remodeling responses to myocardial infarction. (icr.ac.uk)
  • Develop fast computational toolkits to reproduce the heart structure and function, including ionic dynamics and activation (electrophysiology), contraction and pump blood (mechanics) and scar growth and remodelling (biochemistry), and search key mechanisms in myocardial infarction (MI), aiming to aid clinical management and drug development for MI. (ox.ac.uk)
  • Cardiac muscle cells also called cardiomyocytes are the contractile myocytes of the cardiac muscle. (wikipedia.org)
  • The primary focus of my lab is to study how ion channels regulate the function (both electrical and mechanical) of cardiac myocytes under both normal conditions and disease states. (queensu.ca)
  • NAADP influences excitation-contraction coupling by releasing calcium from lysosomes in atrial myocytes. (ox.ac.uk)
  • In atrial myocytes, the sarcoplasmic reticulum (SR) has an essential role in regulating the force of contraction as a consequence of its involvement in excitation-contraction coupling (ECC). (ox.ac.uk)
  • This characteristic would provide an opportunity to both protect (rescue) the cardiac myocytes during (after) cardiac insults. (mmu.ac.uk)
  • Characterizing excitation-contraction coupling in isolated cardiac myocytes has been essential to our understanding of heart function. (insidescientific.com)
  • Being so fully immersed in working with isolated cardiac myocytes, he reached the conclusion that the field needed a more standardized instrument, and in 2015 he set up Cytocypher, that developed the high throughput system for calcium/contractility measurements that is the subject of this webinar. (insidescientific.com)
  • The normal heart beats in a regular, coordinated way because electrical impulses generated and spread by myocytes with unique electrical properties trigger a sequence of organized myocardial contractions. (msdmanuals.com)
  • Myocardial electrophysiology and reactive oxygen species My research focuses on the physiological and pathophysiological processes that regulate cardiac function. (queensu.ca)
  • The aim of this study is to calibrate and evaluate human ventricular electro-mechanical models for investigations on the effect of the electro-mechanical coupling and pharmacological action on human ventricular electrophysiology, calcium dynamics, and active contraction. (ox.ac.uk)
  • The most recent models of human ventricular electrophysiology, excitation-contraction coupling, and active contraction were integrated, and the coupled models were calibrated using human experimental data. (ox.ac.uk)
  • Simulations were then conducted using the coupled models to quantify the effects of electro-mechanical coupling and drug exposure on electrophysiology and force generation in virtual human ventricular cardiomyocytes and tissue. (ox.ac.uk)
  • Simulation results correctly predicted the inotropic response of different multichannel action reference compounds and demonstrated that electro-mechanical coupling improves the robustness of repolarisation under drug exposure compared to electrophysiology-only models. (ox.ac.uk)
  • Though Mr Fourre has initially a background in cardiac electrophysiology (particularly in the technique of patch-clamping), his interests have broadened since his arrival at Imperial College London. (imperial.ac.uk)
  • In patients, PDE inhibitors have been linked to heart failure and cardiac arrhythmias, although the mechanisms are not understood. (nih.gov)
  • PDE4D3 levels in the RyR2 complex were reduced in failing human hearts, contributing to PKA-hyperphosphorylated, "leaky" RyR2 channels that promote cardiac dysfunction and arrhythmias. (nih.gov)
  • Cardiac arrhythmias and dysfunction associated with PDE4 inhibition or deficiency were suppressed in mice harboring RyR2 that cannot be PKA phosphorylated. (nih.gov)
  • Dysfunction of critical calcium signaling proteins in heart is associated with lethal inherited cardiac arrhythmias. (gmu.edu)
  • Even very common arrhythmias (one episode of sudden cardiac death in a month) are rare when normalized to the events occurring within a single cell over the period of a typical long experiment (e.g. one hour). (gmu.edu)
  • We start with the most elementary event of cardiac calcium release, the calcium spark, and construct stochastic models that explain mechanisms of calcium release termination, calcium homeostasis and the sarcoplasmic reticulum calcium leak, and the generation of arrhythmias from defects in calcium signaling. (gmu.edu)
  • Interplay between cardiac function and structure in modulating deadly arrhythmias in the human heart, computer modelling and simulation towards a reduction and replacement of animals in research and safer drugs in human, and advanced mathematical modelling for cardiac tissue and magnetic resonance imaging. (ox.ac.uk)
  • The development of novel non-invasive imaging modalities (Electrocardiographic Imaging, ECGI) for the diagnosis and guided therapy of cardiac arrhythmias. (ox.ac.uk)
  • During development, as blood pressure and performance increase, the cardiomyocytes become more packed with structures involved in excitation-contraction (e-c) coupling (SR and myofilaments) and the generation of ATP (mitochondria) to fuel the contraction. (nih.gov)
  • Within the myocardium, there are several sheets of cardiac muscle cells or cardiomyocytes. (wikipedia.org)
  • Specialised modified cardiomyocytes known as pacemaker cells, set the rhythm of the heart contractions. (wikipedia.org)
  • Contraction with the coronary heart is really a elaborate course of action established by conduction associated with an actions potential thru intercalated discs into the contractile cardiomyocytes induced by pacemaker cells which moves among sarcomeres triggering the calcium routes from the T tubules. (casasantalucia.it)
  • From myocyte isolation to data acquisition, analysis, and post-analysis plotting, Dr. Michiel Helmes and Dr. Diederik Kuster demonstrate best practices and new techniques in high-content, higher throughput investigations of excitation-contraction coupling in isolated cardiomyocytes. (insidescientific.com)
  • During this 60 minute live webinar, Michiel Helmes and Diederik Kuster deliver a comprehensive how-to demonstration of higher throughput excitation-contraction coupling investigations with isolated cardiomyocytes. (insidescientific.com)
  • Also known as myocardiocytes, cardiomyocytes are cells that make up the heart muscle/cardiac muscle. (microscopemaster.com)
  • It serves as the mechanical linkage between the cardiac cells (cardiomyocytes) through the specialized intercalated disks. (microscopemaster.com)
  • We utilized the cellular model to study effects of the electromechanical coupling between cardiomyocytes in a 1D heterogeneous muscle strand formed of 90% of normal (N) cardiomyocytes and 10% of sub-critical (SC) cardiomyocytes with decreased Na + -K + pump activity. (icgbio.ru)
  • Single SC‑cardiomyocytes did not demonstrate spontaneous activity during isometric contractions at a reference length. (icgbio.ru)
  • The results obtained in the model suggest that ectopic activity may emerge in a sub-critical myocardial region, e.g. comprising cardiomyocytes with moderately depressed N+-K+ pump, due to its mechanical interactions in the myocardial tissue. (icgbio.ru)
  • Moreover, such ectopic zone may expand by capturing normal regions in myocardium via the electro-mechanical coupling between cardiomyocytes. (icgbio.ru)
  • In selected patients affected by HF and severe dysfunction of left ventricle ejection fraction (LVEF), with left bundle brunch block, the cardiac resynchronization therapy with a defibrillator (CRT) is the treatment of choice to improve symptoms, NYHA class, and quality of life. (hindawi.com)
  • Chronic diclofenac exposure increases mitochondrial oxidative stress, inflammatory mediators, and cardiac dysfunction. (nih.gov)
  • however, the septic shock in the early onset of sepsis, which induced by cytokine storm and cardiac dysfunction, is also an important cause of death for septic patients, especially for the young patients with toxic shock syndrome or meningococcemia ( 2 ). (frontiersin.org)
  • The endotoxin-induced myocardial dysfunction probably depends on the toll-like receptor (TLR) 4-induced cytokines release as a delay in onset of myocardial depression after endotoxin administration ( 10 ). (frontiersin.org)
  • Other TLR-related genes (TLR2, 3, and 9) were demonstrated to be involved in sepsis-induced cardiac dysfunction from recent studies. (frontiersin.org)
  • Although myocardial remodeling initially helps to maintain cardiac output, it eventually becomes maladaptive and contributes to further myocardial dysfunction. (smashessays.com)
  • Conditions such as cardiomyopathies or heart failure are associated with structural alterations of the cardiac tissue as well as generation of pathways with altered conduction characteristics. (medscape.com)
  • CRT effects are related to alterations in genes and microRNAs (miRs) expression, which regulate cardiac processes involved in cardiac apoptosis, cardiac fibrosis, cardiac hypertrophy and angiogenesis, and membrane channel ionic currents. (hindawi.com)
  • Dr. Kuster's research has focused on understanding molecular changes that underlie cardiac muscle function, hypertrophy and hypertrophic cardiomyopathy. (insidescientific.com)
  • A pathological cardiac hypertrophy model, junctate-1 transgenic mice and control mice, were analyzed using label-free quantitative phosphoproteomics to identify differentially phosphorylated proteins and sites. (molcells.org)
  • Cardiac hypertrophy can be characterized as the response of the heart to various hemodynamic stresses. (molcells.org)
  • Although cardiac hypertrophy is initiated by various receptors at cell membranes sensing biomechanical signals and hormones, it is generally mediated by cellular signaling cascades. (molcells.org)
  • In cardiac hypertrophy, phosphorylation-dependent functional modulation of proteins, especially sarcoplasmic reticulum (SR) and sarcomere proteins, has been demonstrated. (molcells.org)
  • Cardiac muscle tissue or myocardium forms the bulk of the heart. (wikipedia.org)
  • We present in addition measurements showing the degree of cardiac injury assessed by the area and weight of the scar tissue.These data represent the progressive nature of cardiac remodelling and could be used to build computational models to predict the development of heart function deterioration based on the extent of myocardial injury and the devel-opment of LV remodelling. (biomed-data.eu)
  • FFPE tissue slides were scanned and analyzed digitally, while myocardial proteins were quantified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) using isobaric labeling. (biomedcentral.com)
  • By enhancing blood supply to the damaged heart tissue, these therapeutic genes can potentially improve cardiac function and reduce symptoms such as shortness of breath and fatigue. (aliyuncs.com)
  • Cardiac muscle tissue has a unique quality which is the chance to contact and loosen up without worried arousal (myogenic). (casasantalucia.it)
  • An inward influx on the extracellular calcium ions via the ion routes (calcium mineral) in the T tubules offers depolarization of your cardiac muscles tissue for an extended time. (casasantalucia.it)
  • The human calibrated and evaluated modelling and simulation framework constructed in this study opens new avenues for future investigations into the complex interplay between the electrical and mechanical cardiac substrates, its modulation by pharmacological action, and its translation to tissue and organ models of cardiac patho-physiology. (ox.ac.uk)
  • These varying tissue properties are associ- ated with certain strain patterns that may allow to establish a diagnosis by means of non-invasive imaging without the necessity of harmful myocardial biopsies or con- trast agent application. (kit.edu)
  • Total nucleic acids were retrospectively extracted from lar mechanisms related to the switch from the acute to the flash-frozen cardiac tissues by using NucliSens easyMAG persistent CV-B infection in human cardiac tissue are still instrument protocols (bioMérieux, Marcy l'Etoile, France) unknown, but they could be related to terminal deletions according to the manufacturer's instructions. (cdc.gov)
  • In the context of cardiac inflammation, this involves work at the levels of genetics, transcriptional (co-)regulation, cellular signalling pathways, intercellular communications and tissue structure or function. (imperial.ac.uk)
  • Excitation spread along the tissue via electro-diffusional cell coupling followed by cell contractions and force development in the fiber. (icgbio.ru)
  • We aimed to investigate the early, sex-specific functional and proteomic changes following myocardial ischemia in an unbiased approach. (biomedcentral.com)
  • REPERFUSION of the myocardium after sustained ischemia induces myocardial cell necrosis and apoptosis, resulting in increased infarct size despite the restoration of coronary blood flow. (silverchair.com)
  • Cell-based functional screening against 18 selected phosphorylation sites identified three phosphorylation sites (Ser-98, Ser-179 of Ldb3, and Ser-1146 of palladin) displaying near-complete inhibition of cardiac hypertrophic growth of NRVMs. (molcells.org)
  • Unidirectional conduction: delay, excitation or inhibition. (uninsubria.eu)
  • Designed as an adaptive, regenerative reaction, innate immunity may nevertheless become overactivated and thus contribute to the development of HF by altering the pacemaker rhythm, contraction, and electromechanical coupling, presumably by impairing the calcium homeostasis. (highwire.org)
  • TITLE: Computational Studies of Cardiac Excitation-Contraction Coupling: From Molecule to Arrhythmia SPEAKER: Dr. Saleet Jafri Department of Molecular Neuroscience, Krasnow Institute for Advanced Study DATE: Monday, September 16, 2013 TIME: 4:00 p.m. (gmu.edu)
  • It is well-known that Ca 2+ overload may cause cardiac arrhythmia. (icgbio.ru)
  • Cardiac muscle (also called heart muscle or myocardium) is one of three types of vertebrate muscle tissues, with the other two being skeletal muscle and smooth muscle. (wikipedia.org)
  • The cardiac muscle (myocardium) forms a thick middle layer between the outer layer of the heart wall (the pericardium) and the inner layer (the endocardium), with blood supplied via the coronary circulation. (wikipedia.org)
  • In patients under optimal medical therapy with moderate to severe HF and cardiac dyssynchrony, cardiac resynchronization therapy (CRT) with a defibrillator improves contractile function and reverse ventricular remodeling, ameliorating symptoms, quality of life (QoL), and clinical outcomes [ 7 , 8 ]. (hindawi.com)
  • The CRT-induced "reverse molecular remodeling" in responders patients is related to an increase in the expression of genes involved in the regulation of excitation-contraction coupling and a reversal in the isoforms switching of the contractile genes [ 9 ] ultimately leading to remodeling effects and improving of myocardial performance. (hindawi.com)
  • Abstract: We have reported that, in canine hearts, cardiac cooling to 29C enhanced left ventricular contractility but changed neither the contractile efficiency of cross-bridge (CB) cycling nor the excitation-contraction coupling energy. (cellml.org)
  • The sarcomere the contractile device of your myocardial cells consist of myosin, troponin, tropomysin and actin filaments. (casasantalucia.it)
  • Intercalated discs store surrounding cardiac fabric with each other, anchor contractile protein and contain the space stations which permit pass on of measures possible amongst body cells leading to contraction of nearby materials just about simultaneous. (casasantalucia.it)
  • Contraction will involve a healthy connections among calcium supplement ions, cell method of travel systems of calcium supplements, contractile protein as well as significant power phosphates. (casasantalucia.it)
  • The operation of contraction is not going to come to pass for a bottom reaction to connections involving calcium mineral ions and contractile protein but ATP represents a serious purpose in presenting power which critical for the procedure of contraction and rest. (casasantalucia.it)
  • As the chief cell type of the heart, cardiac cells are primarily involved in the contractile function of the heart that enables the pumping of blood around the body. (microscopemaster.com)
  • Contractile proteins - (acting and myosin) involved in the contraction of myofilament. (microscopemaster.com)
  • Another approach involves delivering genes that regulate myocardial contractility, aiming to improve the heart's pumping ability. (aliyuncs.com)
  • Multiple factors contribute to impaired contractility, including changes in cellular and subcellular processes, neurohormonal factors, and myocardial remodeling. (smashessays.com)
  • Additionally, changes in intracellular calcium regulation can disrupt the normal excitation-contraction coupling process, further compromising contractility. (smashessays.com)
  • Electrical stimulation in the form of a cardiac action potential triggers the release of calcium from the cell's internal calcium store, the sarcoplasmic reticulum. (wikipedia.org)
  • The sarcoplasmic reticulum on the cardiac muscular cell phone stores and produces calcium supplement ions for contraction. (casasantalucia.it)
  • From the coronary heart lean muscle, excitation contraction coupling depends upon the calcium mineral-stimulated calcium launch sensation where calcium supplements causes launch of more calcium supplements coming from the lean muscle sarcoplasmic reticulum. (casasantalucia.it)
  • Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. (icr.ac.uk)
  • Previous hypothesis-driven experiments have highlighted the role of sex hormones on distinct inflammatory responses, mitochondrial proteins, extracellular remodeling and estrogen-mediated cardioprotective signaling pathways related to post-ischemic recovery, which were associated with better cardiac functional outcomes in females. (biomedcentral.com)
  • For example, adenoviral vectors can be used to introduce genes encoding calcium-handling proteins involved in excitation-contraction coupling, which is essential for proper contraction and relaxation of cardiac muscle cells. (aliyuncs.com)
  • In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. (icr.ac.uk)
  • Several studies have been conducted on rodents to gain morphological, functional and molecular insights into sex-related differences in response to myocardial ischemic insults. (biomedcentral.com)
  • In both cardiac surgical and cardiological settings, clinical interventions used to reperfuse the ischemic heart are associated with myocardial damage that is likely to influence long-term functional recovery. (mmu.ac.uk)
  • Mr Fourre's main interest is the heterocellularity of the heart, which contributes to cardiac function, plasticity and disease in various ways. (imperial.ac.uk)
  • In addition, it contributes to the excitation and contraction coupling through the transverse tubules (invaginations of the sarcolemma into the cytoplasm of cardiac cells). (microscopemaster.com)
  • Contraction and relaxing on the cardiac muscle mass is proven from the sliding filament type of contraction (below) in which myosin filaments slide together actin filaments to extend or shorten the cardiac fibres. (casasantalucia.it)
  • The actin filament is dragged because of the myosin top of your head toward the core of the sarcomere causing contraction with the cardiac lean muscle. (casasantalucia.it)
  • Afterwards, he switched to the department of Physiology as a postdoc to focus on the function of cardiac myosin binding protein C (cMyBP-C). Combining biochemistry, mass-spectrometry and muscle mechanics, he identified a novel phosphorylation site on cMyBP-C, which was phosphorylated by GSK3β, and which increased the kinetics of contraction. (insidescientific.com)
  • Cardiac muscle contracts in a similar manner to skeletal muscle, although with some important differences. (wikipedia.org)
  • May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. (icr.ac.uk)
  • 2. Delineate between the 3 types of muscle (skeletal, cardiac, and smooth)? (fsu.edu)
  • Mechanisms determining variability in the response of the human heart to anti-arrhythmic therapy in acute myocardial ischaemia, hypertrophic cardiomyopathy and atrial fibrillation. (ox.ac.uk)
  • The current review will explore a hypothesis of the involvement of the calcium-regulating hormones such as parathyroid hormone and parathyroid hormone-related protein in counteracting the detrimental impact of the excess of DAMPs and therefore improving the functional cardiac characteristics especially in the acute phase of the disease. (highwire.org)
  • A large mammal MI model was established demonstrating the typical ST-T segment electrocardiographic changes with VAs observed on MI induction along with the rise and fall of serum troponin levels and an established infarct on cardiac extraction. (manchester.ac.uk)
  • Myocardial infarct size was assessed by triphenyltetrazolium staining. (silverchair.com)
  • Especially, the modelling of the ionic mechanisms underlying excitation-contraction coupling, genetic disorders in ion channels, and drug response in human. (ox.ac.uk)
  • Suleiman, M. S. , Singh, R. J. R. and Stewart, Claire E. (2007) Apoptosis and the cardiac action of insulin-like growth factor I. Pharmacology & Therapeutics, 114 (3). (mmu.ac.uk)
  • The major drawback of the former approach is that the excised heart might not accurately represent in vivo cardiac function, while the disadvantage of the latter method is that echocardiographic functional parameters are largely dependent on loading conditions (changes in preload or afterload). (biomedcentral.com)
  • Functional states of the sodium channel (closed, open, and inactivated) and their structure help to understand the cardiac regulation processes. (bvsalud.org)
  • There are areas in the cardiac muscle with anatomical and functional differentiation that present automatism, thus subjecting the rest of the fibers to their own rhythm. (bvsalud.org)
  • The resulting calibrated human electro-mechanical models yielded active tension, action potential, and calcium transient metric that are in agreement with experiments for endocardial, epicardial, and mid-myocardial human samples. (ox.ac.uk)
  • Within the myocyte, the excitation-contraction (EC) coupling process facilitates the rise and fall of Ca2+ with resultant cardiac contraction and relaxation and relies on key structures such as the ryanodine receptor (RyR) and thus, ultrastructural alterations can affect Ca2+ handling. (manchester.ac.uk)
  • The cardiac muscles neural materials match the contraction and relaxation in the cardiac muscle tissues to get an effective moving of bloodstream in your system. (casasantalucia.it)
  • These structures allow the depolarizing current to flow through the cardiac muscle cells from one to another and thus contribute to the contraction and relaxation of the cells. (microscopemaster.com)
  • It is composed of individual cardiac muscle cells joined by intercalated discs, and encased by collagen fibers and other substances that form the extracellular matrix. (wikipedia.org)
  • Their genome is flanked on the myocardial biopsies (n = 5) were performed at the time of 5 end by a noncoding region (NCR), which is crucial for hospitalization to assess the potential causes of IDCM ( 8 ). (cdc.gov)
  • The phosphodiesterase 4D3 (PDE4D3) was found in the cardiac ryanodine receptor (RyR2)/calcium-release-channel complex (required for excitation-contraction [EC] coupling in heart muscle). (nih.gov)
  • To illustrate this potential, consider the hypothetical case study of John, a 45-year-old patient suffering from chronic heart failure due to impaired cardiac function. (aliyuncs.com)
  • In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. (icr.ac.uk)
  • Cardiac hypertrophic signaling cascades resulting in heart failure diseases are mediated by protein phosphorylation. (molcells.org)
  • LOCATION: Lecture Room (Room 229) Krasnow Institute Building George Mason University, Fairfax, VA ABSTRACT: Calcium dynamics in the cardiac myocyte links the electrical excitation of the heart to contraction in a process known as excitation-contraction coupling. (gmu.edu)
  • In parallel, the e-c coupling relies increasingly on calcium fluxes through the SR, while metabolism relies increasingly on fatty acid oxidation. (nih.gov)
  • it may be encountered in a number of cardiac conditions associated with high rates of conduction, including atrial fibrillation , Wolff-Parkinson-White Syndrome , ventricular tachycardia, SVT, and accelerated idioventricular rhythm. (medscape.com)
  • Isometric, isotonic and isovelocation contraction. (uninsubria.eu)
  • Cyclic adenosine monophosphate (cAMP) regulates cardiac excitation-contraction coupling by acting in microdomains associated with sarcolemmal ion channels. (dundee.ac.uk)
  • After his PhD studying titin mechanics in cardiac muscle with Dr. Granzier, he has kept various academic appointments, at Boston University, the University of Oxford, and now the VU University Medical center in Amsterdam, The Netherlands. (insidescientific.com)
  • Cardiac mechanics. (uninsubria.eu)
  • There are plenty of mitochondria over the cardiac cells to functionality the required vigor. (casasantalucia.it)
  • Suppression of inflammation and fibrosis using soluble epoxide hydrolase inhibitors enhances cardiac stem cell-based therapy. (nih.gov)
  • paper writing service Cardiac materials are prolonged, cylindrical tissues. (casasantalucia.it)
  • We discuss work by ourselves and others in these areas and also consider recent work describing the cellular signaling associated with the IGF-I receptor (IGF-IR) in the heart and its potential role in regulating excitation-contraction coupling. (mmu.ac.uk)
  • The mechanisms of cellular excitability and propagation of electrical signals in the cardiac muscle are very important functionally and pathologically. (bvsalud.org)
  • For example, electrical alternans related to the T wave (ie, T wave alternans) has shown its potential value in cardiac risk stratification and prediction of sudden cardiac death. (medscape.com)
  • This heterogeneity manifests as T-wave alternans, which is increasingly being utilized for risk stratification of sudden cardiac death (see the discussion in the Workup section under Other tests ). (medscape.com)
  • Watch to understand how cardiac slices and the IonOptix Cardiac Slice System can be used to complement and improve upon traditional cardiac investigations. (insidescientific.com)