• To assess the causal relation between acute mental stress and myocardial ischemia, we evaluated cardiac function in selected patients during a series of mental tasks (arithmetic, the Stroop color--word task, simulated public speaking, and reading) and compared the responses with those induced by exercise. (nih.gov)
  • Ischemia induced by mental stress was symptomatically "silent" in 19 of the 23 patients with wall-motion abnormalities (83 percent) and occurred at lower heart rates than exercise-induced ischemia (P less than 0.05). (nih.gov)
  • Personally relevant mental stress may be an important precipitant of myocardial ischemia--often silent--in patients with coronary artery disease. (nih.gov)
  • Further examination of the pathophysiologic mechanisms responsible for myocardial ischemia induced by mental stress could have important implications for the treatment of transient myocardial ischemia. (nih.gov)
  • May increase myocardial ischemia. (wikipedia.org)
  • at higher dosages, may exacerbate myocardial ischemia by increasing heart rate. (medscape.com)
  • As asymptomatic myocardial ischemia (MI) is frequent in diabetes, we hypothesized that DPN may be associated with MI in patients with type 2 diabetes mellitus and no history of cardiovascular events. (springer.com)
  • All subjects underwent Technetium-99 m sestamibi single-photon emission computed tomographic imaging for the estimation of myocardial ischemia, expressed as Summed Stress Score (SSS). (springer.com)
  • Diabetes is a pivotal cause of asymptomatic myocardial ischemia (MI) even in the absence of coronary artery disease [ 3 ]. (springer.com)
  • At higher dosages, it may cause an increased heart rate, exacerbating myocardial ischemia. (medscape.com)
  • These animal models may be used as whole animal models, where measurements like pressure, heart rate and electrocardiogram are used as biomarkers of ischemia and MI. (datasci.com)
  • The study was a multicentre placebo-controlled trial in which 1012 acute STEMI patients with no history of heart failure were randomised to either eplerenone (25/50 mg per day) or placebo, initiated within 24 hours of the onset of symptoms and in addition to standard therapy. (medindia.net)
  • We assessed the incremental prognostic value of heart rate reserve (HRR) over stress myocardial perfusion single-photon emission computed tomography (MPS) findings in patients with suspected coronary artery disease (CAD). (unina.it)
  • A myocardial perfusion scan uses a tiny amount of a radioactive substance, called a radioactive tracer. (onteenstoday.com)
  • 5. In the absence of coronary stenosis and myocardial hypertrophy, coronary blood flow increases proportionally as diastolic perfusion time decreases during stress tests. (onteenstoday.com)
  • How does heart rate influence coronary artery perfusion? (onteenstoday.com)
  • Myocardial perfusion scans help us diagnose: Coronary artery disease. (onteenstoday.com)
  • How would heart rate influence coronary artery perfusion and myocardial oxygen delivery? (onteenstoday.com)
  • As the heart rate increases, the myocardial oxygen requirement increases, yet there is a concomitant decrease in diastolic filling period, which consequently decreases the available time for perfusion. (onteenstoday.com)
  • There is increasing concern about radiation exposure from myocardial perfusion SPECT (MPS). (snmjournals.org)
  • The imaging data of patients with normal myocardial perfusion and 30 patients with mid-sized to large perfusion defects who had undergone stress 99m Tc-tetrofosmin MPS were postprocessed. (snmjournals.org)
  • 6 min) is feasible using a hybrid CZT SPECT/CT camera without compromising image quality or significantly altering quantification of myocardial perfusion or LV function. (snmjournals.org)
  • SPECT with 99m Tc-labeled radiotracers has been widely used for the detection of abnormalities of myocardial perfusion and left ventricular (LV) function ( 1 - 9 ). (snmjournals.org)
  • DSI and the Harvard Bioscience family have solutions for cardiomyocyte isolation, isolated heart perfusion, telemetry that measures pressure, heart rate and electrocardiograms in freely moving subjects, as well as hardwired solutions capable of combining telemetry with other systems used in tissue research. (datasci.com)
  • For mouse to small rabbit hearts, Hugo Sachs perfusion systems are designed for simple and constant flow perfusion for cardiomyocyte isolation from small rodent hearts. (datasci.com)
  • Hugo Sachs' IH series of isolated heart perfusion systems is the gold standard for cardiac physiology measurements in both retrograde heart perfusion and working ejecting heart perfusion modes. (datasci.com)
  • LVEF does not only vary according to LV contractility, but also according to heart rate, pre-load and after-load. (escardio.org)
  • There is a need for an accurate and reproducible echo parameter to identify early myocardial contractility abnormalities that cannot be detected with traditional methods in order to optimise the timing of surgery in this type of patient. (escardio.org)
  • Strain and strain-rate have come up quite recently as quantitative variables that can accurately estimate regional myocardial contractility. (escardio.org)
  • Beta-blockers slow an individual's heart rate, decrease myocardial contractility, and lower blood pressure, thus lessening the heart's overall workload and decreasing its demand for oxygen. (cms.gov)
  • Myocardial oxygen demand is governed by three principal factors: heart rate, contractility, and wall tension. (onteenstoday.com)
  • Thus spectral analysis of heart rate variability indicates that in patients after MI there is an alteration of neural control mechanisms as indicated by the presence of signs of sympathetic activation and by the attenuation of the nocturnal increase in vagal tone. (nih.gov)
  • Aims Heart rate variability (HRV) is a measure of cardiac autonomic control and is therefore subject to regulation by the renin-angiotensin system. (birmingham.ac.uk)
  • We aim to assess the effect of TH on heart rate variability (HRV) in infants with HIE. (nature.com)
  • The role of autonomic function in the assessment of HIE, and the evidence that heart rate variability (HRV) is a measure of autonomic function, suggests that HRV may offer useful diagnostic or prognostic information in infants with HIE. (nature.com)
  • The main advantage of strain and strain-rate analysis compared to myocardial velocity measurements is the ability to differentiate active contraction from passive motion, resulting from the global heart translation, or from the pulling by surrounding myocardium. (escardio.org)
  • Dual voltage/calcium optical mapping of post-MI Langendorff perfused hearts (using RH-237 and Rhod2) demonstrated that the border zone was significantly more prone to alternans than the surrounding myocardium at longer cycle lengths, predisposing to spatially heterogeneous alternans. (frontiersin.org)
  • Strain rate imaging after dynamic stress provides objective evidence of persistent regional myocardial dysfunction in ischaemic myocardium: regional stunning identified? (bmj.com)
  • Approximately one-quarter of all myocardial infarctions are "silent", that is without chest pain or other symptoms. (medicalxpress.com)
  • In the US, about 1.0 million myocardial infarctions occur annually. (msdmanuals.com)
  • Out of 632 age- and gender-matched autopsies in Missouri, 136 myocardial infarctions: more than 100 times the rate of our #1 killer. (nutritionfacts.org)
  • Pacemakers are generally implanted to alleviate symptoms of decreased cardiac output related to rate or arrhythmia. (cms.gov)
  • Why it's done You may need a nuclear stress test if you have signs or symptoms of heart disease such as chest pain or shortness of breath. (onteenstoday.com)
  • If, during treatment, heart rate decreases below 50 beats per minute (bpm) at rest or the patient experiences symptoms related to bradycardia such as dizziness, fatigue or hypotension, the dose must be titrated downward including the lowest dose of 2.5 mg twice daily. (medicines.org.uk)
  • Treatment must be discontinued if heart rate remains below 50 bpm or symptoms of bradycardia persist despite dose reduction. (medicines.org.uk)
  • After two weeks of treatment, the dose can be increased to 7.5 mg twice daily if resting heart rate is persistently above 60 bpm or decreased to 2.5 mg twice daily if resting heart rate is persistently below 50 bpm or in case of symptoms related to bradycardia such as dizziness, fatigue or hypotension. (medicines.org.uk)
  • If during treatment, heart rate decreases persistently below 50 beats per minute (bpm) at rest or the patient experiences symptoms related to bradycardia, the dose must be titrated downward to the next lower dose in patients receiving 7.5 mg twice daily or 5 mg twice daily. (medicines.org.uk)
  • However, the investigators found that this primary endpoint difference was largely driven by changes in levels of BNP/NT-proBNP, with lower overall levels in the treatment group (BNP and NT-pro-BNP levels in blood increase when heart failure symptoms worsen). (medindia.net)
  • This causes abnormal symptoms to linger in the heart even after the infection. (vejthani.com)
  • The symptoms of heart arrhythmia tend to occur in numerous Long COVID patients. (vejthani.com)
  • A severe myocardial contusion may lead to signs and symptoms of a heart attack. (medlineplus.gov)
  • There is a net decrease in myocardial wall tension, and O2 consumption when using amrinone. (wikipedia.org)
  • In addition, a significant decrease in the activities of myocardial injury markers i.e., creatine phosphokinase-MB (CK-MB isoenzyme) and lactate dehydrogenase (LDH) was also observed in the heart of ISP control group as compared to sham control. (scialert.net)
  • Cardiac dysfunction was observed as a decrease in mean arterial pressure (MAP), heart rate (HR), left ventricular rate of peak positive and negative pressure change {(+) and (-) LV dP/dt} and elevated left ventricular end diastolic pressure (LVEDP) following ISP administration. (scialert.net)
  • Speckle-tracking-derived strain and strain-rate may detect those patients with a post-operative LVEF decrease greater than 10% (9). (escardio.org)
  • In animal studies, dobutamine produces less increase in heart rate and less decrease in peripheral vascular resistance for a given inotropic effect than does isoproterenol. (drugs.com)
  • The main goal (or purpose) of this EBP proposal is to decrease the readmission rate of Hocking Valley Community Hospital (HVCH) to less than 4%, with an intended goal of 2% or less and increasing patient satisfaction by initiating comprehensive discharge planning. (bartleby.com)
  • does it decrease hospital readmission rates? (bartleby.com)
  • [3] Treating people who have strep throat with antibiotics can decrease the risk of rheumatic heart disease. (wikipedia.org)
  • Researchers studying MI are interested in a number of aspects surrounding the event, including risk factors, prevention, treatment (before, during and after MI), and pain management during an event to decrease the workload of the heart. (datasci.com)
  • A high index of suspicion for MI should be maintained, especially when evaluating women, patients with diabetes, older patients, patients with dementia, patients with a history of heart failure, cocaine users, patients with hypercholesterolemia, and patients with a positive family history for early coronary disease (see Etiology ). (medscape.com)
  • The peak temperature of all case-patients and controls was recorded within the first 24 hours of admission as well as heart rate and blood pressure at that point. (cdc.gov)
  • The heart rates at peak temperatures for patients with dengue fever were compared with rates for controls at all temperatures. (cdc.gov)
  • It is a drug that may improve the prognosis in patients with congestive heart failure. (wikipedia.org)
  • Amrinone also has beneficial effects during diastole in the left ventricle, including relaxation, compliance and filling in patients with congestive heart failure. (wikipedia.org)
  • Early studies in patients with heart failure showed that amrinone produced short-term hemodynamic improvement, but had limited long-term clinical benefit. (wikipedia.org)
  • This paper focuses on the assessment of the growth of a double product (DP) during the 6MWT and its diagnostic value in the assessment of patients with heart failure. (hindawi.com)
  • The patients were divided into two groups: one with diagnosed heart failure and a control group. (hindawi.com)
  • The patients with diagnosed heart failure, compared to the control group, were characterized by a shorter walking distance and greater DP increase at equal walking intervals. (hindawi.com)
  • It can be used, for example, in the qualification of patients with heart failure for ICD implantation or for amiodarone therapy [ 15 ]. (hindawi.com)
  • The beneficial prognostic role of the 6MWT was demonstrated in patients with heart failure and low left ventricular ejection fraction [ 16 - 18 ]. (hindawi.com)
  • Similar relationships have been demonstrated for patients with heart failure and preserved left ventricular diastolic function [ 19 ]. (hindawi.com)
  • In patients with stable coronary heart disease, a relationship was observed between the distance in the corridor walk test and the risk of cardiovascular events [ 20 ]. (hindawi.com)
  • Strain and strain-rate are new parameters that provide crucial information able to unmask latent myocardial dysfunction in patients with severe MR. This promising diagnostic tool can help the cardiologist choose the timing of surgery in asymptomatic patients with chronic severe MR. Once contractile dysfunction is detected, surgery should be promptly performed to avoid the development of irreversible and significant LV dysfunction. (escardio.org)
  • TDI-derived strain-rate analysis may detect subclinical LV dysfunction in patients with severe asymptomatic MR (8). (escardio.org)
  • Trimetazidine (TMZ) is effective at improving clinical outcomes in chronic heart failure and stable coronary artery disease patients. (hindawi.com)
  • We have many specialty clinics and programs for patients with particular heart and vascular conditions, giving you the care and support you need. (uwhealth.org)
  • The prognosis value of apelin-12 in predicting short-term (during hospitalisation) and long-term (2.5 years) major adverse cardiovascular events, respectively, was analysed among patients with estimated glomerular filtration rate exceeding and below 90 mL/min×1.73m 2 . (bmj.com)
  • Ivabradine is indicated in chronic heart failure NYHA II to IV class with systolic dysfunction, in patients in sinus rhythm and whose heart rate is ≥ 75 bpm, in combination with standard therapy including beta-blocker therapy or when beta-blocker therapy is contraindicated or not tolerated. (medicines.org.uk)
  • After three to four weeks of treatment, if the patient is still symptomatic, if the initial dose is well tolerated and if resting heart rate remains above 60 bpm, the dose may be increased to the next higher dose in patients receiving 2.5 mg twice daily or 5 mg twice daily. (medicines.org.uk)
  • As background to their report, the authors note that eplerenone has been shown to reduce mortality in patients with heart failure, particularly in those following recent MI. (medindia.net)
  • No significant reduction found in composite time to either death from cardiovascular causes, surviving a cardiac arrest, or hospitalization to manage heart failure in heart patients with Aldactone. (medindia.net)
  • When Dr. Ornish published his Lifestyle Heart Trial years later, proving with quantitative angiography that coronary artery disease could indeed be reversed in the majority of patients without drugs or surgery-just a plant-based diet and other healthy lifestyle changes, I assumed that it was going to be a game-changer. (nutritionfacts.org)
  • COVID-19 has a major impact on patients with heart disease. (vejthani.com)
  • Chez les patients hypertendus, le taux de mortalité était plus élevé uniquement chez les patients admis pour un infarctus du myocarde avec sus-décalage du segment ST. Après ajustement des résultats en fonction des variables de référence, l'hypertension s'est révélé être un facteur prédictif indépendant de l'insuffisance cardiaque (OR = 1,31) et de l'accident vasculaire cérébral (OR = 2,47). (who.int)
  • diovascular disease, including stroke, RACE-2, which was a 9-month prospec- Systemic hypertension was defined in coronary artery disease (CAD), heart tive, multicentre study of 7847 consecu- the current registry as: either history of failure and peripheral vascular dis- tive patients with ACS from 6 adjacent hypertension diagnosed and treated ease [1-3]. (who.int)
  • To evaluate whether miR-21 could be a biomarker, we prospectively collected the sera of patients with congenital heart disease- (CHD) related PAH. (bvsalud.org)
  • Among 76 CHD-induced PAH patients, 19 who were hospitalized for heart failure represented with a significantly lower expression of circulating miR-21. (bvsalud.org)
  • OBJECTIVES: Right ventricular (RV) failure is a leading cause of death in patients with congenital heart disease. (bvsalud.org)
  • Congestive heart failure (CHF) is characterized by a reduction in ventricular performance and abnormalities in peripheral circulation and organs. (wikipedia.org)
  • Evidence supports exercise training in people with heart failure as a means of reversing cardiac and skeletal muscle abnormalities, and improving functional status, quality of life and clinical outcomes. (racgp.org.au)
  • Animal and human experiments indicate that metoprolol slows the sinus rate and decreases AV nodal conduction. (nih.gov)
  • Indoor and outdoor air pollution together cause about one fifth of the global mortality from stroke and ischaemic heart disease, and more than one third of deaths from chronic obstructive pulmonary disease. (who.int)
  • The most common symptom of an MI is chest pain, resulting from deprivation of oxygen to the heart. (proprofs.com)
  • By blocking catecholamine-induced increases in heart rate, in velocity and extent of myocardial contraction, and in blood pressure, metoprolol reduces the oxygen requirements of the heart at any given level of effort, thus making it useful in the long-term management of angina pectoris. (nih.gov)
  • At the same time, by increasing the oxygen demand, increases in heart rate also shorten diastolic duration and thus the time interval of the cardiac cycle, in which almost all of the coronary blood flow occurs. (onteenstoday.com)
  • Congestive heart failure (CHF) is a condition in which the heart fails to work adequately as a pump that can deliver oxygen rich blood to the body. (medindia.net)
  • Irreversible damage occurs within 30 minutes of oxygen deprivation, so fast response in MI recognition and treatment is necessary to not only prevent further damage to the heart, but to prevent death. (datasci.com)
  • The plant Tribulus terrestris Linn, a deciduous tree of the Zygophyllaceae family, is an important herb from Indian and Chinese traditional medicine literature for the treatment of various diseases especially ischemic heart diseases (Warrier, 1994). (scialert.net)
  • Through this mechanism, TMZ is thought to correct disturbances in myocardial cellular homeostasis that result from acute ischemic damage and to protect against cardiomyocyte injury [ 14 , 15 ]. (hindawi.com)
  • Infarcted hearts undergo considerable remodeling, providing a substrate for arrhythmia via multiple mechanisms. (frontiersin.org)
  • this group also had a significantly lower left ventricular ejection fraction and glomerular filtration rate than those who did not experience cardiovascular death. (medscape.com)
  • Clinical pharmacology studies have demonstrated the beta-blocking activity of metoprolol, as shown by (1) reduction in heart rate and cardiac output at rest and upon exercise, (2) reduction of systolic blood pressure upon exercise, (3) inhibition of isoproterenol-induced tachycardia, and (4) reduction of reflex orthostatic tachycardia. (nih.gov)
  • African Medical Journal describing its use of service claims data to patient investigation and treatment, as well as providing a framework determine standardised mortality rates, across hospital systems, for against which clinical outcomes can be measured. (who.int)
  • Research and clinical trials offer hope to many who live with heart conditions. (uwhealth.org)
  • Additionally, clinical, echocardiographic and right heart catheterization information was collected. (bvsalud.org)
  • Significant beta-blocking effect (as measured by reduction of exercise heart rate) occurs within one hour after oral administration, and its duration is dose related. (nih.gov)
  • Of deaths due to outdoor air pollution 80% are attributed to heart disease and stroke and 20% to respiratory illnesses and cancers. (who.int)
  • For household pollution, acute respiratory diseases in children and chronic obstructive pulmonary disease are the most serious consequences, followed by heart disease and stroke. (who.int)
  • In the case of dobutamine, this increase is usually not accompanied by marked increases in heart rate (although tachycardia is occasionally observed), and the cardiac stroke volume is usually increased. (drugs.com)
  • In contrast, isoproterenol increases the cardiac index primarily by increasing the heart rate while stroke volume changes little or declines. (drugs.com)
  • Healthy eating can help lower your risk of heart disease, high blood pressure, stroke, diabetes and some cancers. (who.int)
  • But there was no significant difference in any other components of the primary endpoint - though the investigators point out that cardiovascular event rates in this study were too small to show statistically significant change. (medindia.net)
  • Cardiogenic shock severely impairs the pumping function of the heart muscle, causing diminished blood flow to the organs of the body. (proprofs.com)
  • Ivabradine is indicated for the symptomatic treatment of chronic stable angina pectoris in coronary artery disease adults with normal sinus rhythm and heart rate ≥ 70 bpm. (medicines.org.uk)
  • The possible underlying mechanism of the cardioprotective effect of T. terrestris could be due to restoration of endogenous myocardial antioxidant status or free radical scavenging activity along with correction of the altered hemodynamic parameters and preservation of histoarchitectural and ultrastructural alterations. (scialert.net)
  • Prostaglandin E 1 is used for the treatment of ductal-dependent, cyanotic congenital heart disease caused by decreased pulmonary blood flow. (medscape.com)
  • Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the β-receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. (drugs.com)
  • People with a mild myocardial contusion will recover completely most of the time. (medlineplus.gov)
  • In 2019, the age-adjusted death rate from heart disease among adults aged 45-64 years was 121.1 per 100,000 and was higher in rural counties (160.0) than urban counties (114.5). (cdc.gov)
  • Among men, the age-adjusted death rate from heart disease was 221.4 in rural counties and 165.1 in urban counties. (cdc.gov)
  • Among women, the age-adjusted death rate from heart disease was 99.5 in rural counties and 66.8 in urban counties. (cdc.gov)
  • 60 years, preexisting substantial heart or lung disease or concurrent medication affecting heart rate, e.g., β-blockers, β-agonists, calcium channel blockers, or xanthine derivatives. (cdc.gov)
  • Comparison of observed and joinpoint-modeled age-adjusted heart disease death rates, Maine, 1999-2017. (cdc.gov)
  • A sedentary lifestyle and poor cardiorespiratory fitness are independent risk factors for coronary atherosclerotic heart disease [ 8 ]. (hindawi.com)
  • Our team diagnoses, monitors and manages all types of heart disease. (uwhealth.org)
  • Heart disease can be present at birth or develop later in life. (uwhealth.org)
  • This might happen when you have heart damage or heart disease. (onteenstoday.com)
  • Cardiovascular disease ( CVD ) is any disease involving the heart or blood vessels . (wikipedia.org)
  • [3] Rheumatic heart disease may follow untreated strep throat . (wikipedia.org)
  • This is a picture of me, right around the time that my grandma was diagnosed with end-stage heart disease and sent home to die. (nutritionfacts.org)
  • This landmark article from the 50s started out with a shocking statement: "In the African population of Uganda, coronary heart disease is almost non-existent. (nutritionfacts.org)
  • whereas here, heart disease is an epidemic. (nutritionfacts.org)
  • Even the heart muscles and tissues of people without heart disease could be affected. (vejthani.com)
  • Boccalandro F, Shreyder K. Traumatic heart disease. (medlineplus.gov)
  • Strain-rate expresses the velocity of myocardial deformation (1). (escardio.org)