Myeloid leukemia chronic biological markers. Medical search. Frequent questions

However, the predictive value of cellular senescence-related signature in clinical outcome and treatment response in acute myeloid leukemia (AML) remains unexplored. (bvsalud.org)
We review current research and patented technologies that focus on nanomaterials as promising tools in detection and treatment of chronic and acute leukemia. (eurekaselect.com)
Herrmann F, Komischke B, Odenwald E, Ludwig W. Use of monoclonal antibodies as a diagnostic tool in human leukemia, I: Acute myeloid leukemia and acute phase of chronic myeloid leukemia. (bdbiosciences.com)
The patient was treated with corticosteroids for acute graft versus host disease following bone marrow transplantation for chronic myeloid leukemia. (medscape.com)
Acute myeloid leukemia (AML) is a heterogeneous group of aggressive hematological malignancies commonly associated with treatment resistance, high risk of relapse, and mitochondrial dysregulation. (nature.com)
These compounds exhibited synergy with several anti-leukemia agents in AML, acute lymphoblastic leukemia (ALL), or chronic myelogenous leukemia (CML). (nature.com)
Resveratrol-induced apoptosis is enhanced in acute lymphoblastic leukemia cells by modulation of the mitochondrial permeability transition pore. (nature.com)
Leukemia stem cells (LSCs) in acute myeloid leukemia (AML) played important roles in development of leukemia, chemotherapeutic drug resistance, and disease relapse and progression. (researchsquare.com)
Acute myeloid leukemia (AML) is generally regarded as a stem cell disease, and it originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity [ 1 , 2 ]. (researchsquare.com)
Here we provide an overview of the most prominent CSC markers, focusing on solid cancers (lung, stomach, liver, breast, and colorectal cancers) and hematological cancers (acute and chronic myeloid leukemia). (atlasantibodies.com)
CSCs were first identified in hematological cancer such as acute myeloid leukemia in the late '90s when scientists isolated a subpopulation of leukemia cells that expressed the surface marker CD34 but not CD38. (atlasantibodies.com)
Acute (AML) and chronic (CML) myeloid leukemia are cancers of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production. (atlasantibodies.com)
DNA (cytosine-5)-methyltransferase 3A (DNMT3A)-mutated acute myeloid leukemia (AML) has a poor prognosis, but the exact mechanism is still unclear. (frontiersin.org)
Acute myeloid leukemia (AML) is a common, heterogeneous, and aggressive hematopoietic malignancy, characterized by apparent genetic abnormalities ( 1 ). (frontiersin.org)
reported that miRNAs including miR-15a miR-15b miR-16-1 miR-223 miR-342 and miR-107 are upregulated whereas miR-181b can be downregulated in acute promyelocytic leukemia (18). (techblessing.com)
These data are discussed in terms of three exposure periods - acute, intermediate, and chronic. (cdc.gov)
The Working Group was not aware of any good rodent models that simulate the occurrence of acute myeloid leukemia in humans. (who.int)
High BAALC expression levels at acute myeloid leukemia diagnosis have been linked to adverse outcomes. (oncotarget.com)
Recent data indicate that high BAALC expression levels may also be used as marker for residual disease following acute myeloid leukemia treatment. (oncotarget.com)
Allogeneic hematopoietic stem cell transplantation (HSCT) offers a curative treatment for acute myeloid leukemia patients. (oncotarget.com)
We performed absolute quantification of BAALC copy numbers in peripheral blood prior (median 7 days) to HSCT in complete remission (CR) or CR with incomplete peripheral recovery in 82 acute myeloid leukemia patients using digital droplet PCR (ddPCR) technology. (oncotarget.com)
Evaluation of pre-HSCT BAALC / ABL1 copy numbers in peripheral blood by ddPCR represents a feasible and rapid way to identify acute myeloid leukemia patients at high risk of early relapse after HSCT. (oncotarget.com)
In the future, prospective studies should evaluate whether acute myeloid leukemia patients with high pre-HSCT BAALC / ABL1 copy numbers benefit from additional treatment before or early intervention after HSCT. (oncotarget.com)
The identification of cytogenetic, molecular, and clinical factors impacting on outcome at acute myeloid leukemia (AML) diagnosis improved risk stratification [ 1 , 2 ]. (oncotarget.com)
Luckily, we discovered a novel gene having same N-terminal motif in post synaptic lipid rafts that is brain specific, but highly expressed in acute leukemia- -BAALC (brain and acute leukemia, cytoplasmic) [1]. (symbiosisonlinepublishing.com)
Clinical data underlined that BAALC is a suitable marker to prognosis outcome of a sub-group acute myeloid leukemia [3]. (symbiosisonlinepublishing.com)
From the article: 'In a real-world setting of new and emerging targeted therapies, a study found that patients with acute myeloid leukemia (AML) had unmet needs that hindered their ability to receive genomic testing and treatment options, especially for older patients with AML. (cdc.gov)
Some persons with clonal hematopoiesis are at increased risk for the development of myeloid cancers such as acute myeloid leukemia or myelodysplastic syndromes, a risk that increases as the hematopoietic clone expands in size.16 Stopping this expansion may delay or avert leukemic progression, and therapeutic approaches to this end are being developed and tested. (cdc.gov)
Pharmacotypes across the genomic landscape of pediatric acute lymphoblastic leukemia and impact on treatment response. (cdc.gov)
Association of Inherited Genetic Factors With Drug-Induced Hepatic Damage Among Children With Acute Lymphoblastic Leukemia. (cdc.gov)
CLL), acute myeloid leukaemia, chronic myeloid leukaemia and CLL while controlling for potential confounders. (cdc.gov)

Reports record over 40,000 new cases of patients afflicted with myeloid and lymphocytic leukemia annually worldwide. (eurekaselect.com)
In chronic lymphocytic leukemia the balance between the pro-apoptotic and anti-apoptotic members of the bcl-2 family is involved in the pathogenesis, chemorefractoriness and clinical outcome. (haematologica.org)
Bax/bcl-2 was 1.50 or over in 263 patients (52%) with chronic lymphocytic leukemia. (haematologica.org)
In conclusion, we defined the prognostic power of bax/bcl-2 ratio, as determined by a flow cytometric approach, and highlighted a correlation with chemoresistance and outcome in chronic lymphocytic leukemia. (haematologica.org)
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by the accumulation of CD5CD23 B-cell lymphocytes. (haematologica.org)
The BD ® AbSeq Assay enables expression analysis of CD11c and CD5 markers in chronic lymphocytic leukemia (CLL) samples. (bdbiosciences.com)
Clinical Prognostic Biomarkers in Chronic Lymphocytic Leukemia and Diffuse Large B-Cell Lymphoma. (razavihospital.ir)
discovered that Diosmetin 65% of B cell chronic lymphocytic leukemia individuals possess deletions of chromosome 13q14 a locus which includes miR-15a and miR-16-1 which as a result present downregulated manifestation (17). (techblessing.com)
Chronic lymphocytic leukemia (CLL) is a mature B cell neoplasm with a predilection for older individuals. (biomedcentral.com)
Chronic lymphocytic leukemia (CLL) is a mature B cell neoplasm characterized by monoclonal proliferation and accumulation of B lymphocytes in the blood, bone marrow, and lymphoid tissues [ 1 ]. (biomedcentral.com)
in humans they appear to occur 60-year-old man who had chronic lymphocytic leukemia predominantly in patients who have chronic granulomatous and in whom cerebral aspergillosis later developed and disease (CGD), a rare disorder of phagocytes in which the was confi rmed by biopsy. (cdc.gov)
Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features. (cdc.gov)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)

Molecular genetic biomarkers in myeloid malignancies. (razavihospital.ir)
Lately practical and prognostic research have verified that miRNAs takes on an active part in hematologic malignancies plus some miRNAs have already been suggested as prognostic markers and restorative focuses on in leukemia treatment. (techblessing.com)
The NCI group has published a recent update of one of their studies, with an additional 10 years of follow-up, and it continues to suggest a possible link between formaldehyde exposure and mortality due to lymphohematopoietic malignancies, particularly myeloid leukemia (Beane Freeman, Blair et al. (who.int)
As such, in the current review, we summarize the generation and biological functions of circRNAs and exosomes, analyze the mechanism of exosomal circRNAs in a wide variety of malignant tumors including solid cancers and hematological malignancies, and highlight their promising potential not only as diagnostic molecular markers but also as therapeutic targets. (biomedcentral.com)

Management and prognosis of disease requires the accurate determination of specific biomarkers indicative of normal or disease-related biological processes or responses to therapy. (mdpi.com)
As such, identifying additional prognostic markers of CLL treatment response, including CLL relapse, may have implications for prognosis, and potentially, treatment selection. (biomedcentral.com)
Thus, it is vital to develop new markers for evaluating patient prognosis. (biomedcentral.com)
Ploidy and MYCN amplification have been used as genetic markers for risk stratification and therapeutic decision making, and, more recently, gene expression profiling and genome-wide DNA copy number analysis have come into the picture as sensitive and specific tools for assessing prognosis. (biomedcentral.com)

We investigated bax/bcl-2 ratio by flow cytometry in 502 patients and identified a cut off of 1.50 to correlate bax/bcl-2 ratio with well-established clinical and biological prognosticators. (haematologica.org)
The clinical heterogeneity of neuroblastoma mirrors the biological and genetic heterogeneity of these tumors. (biomedcentral.com)
Clinical trial design, and eventually clinical practice, needs to focus on using biological phenotype rather than symptoms or number of prior chemotherapeutic regimens as the basis for selecting the proper treatment for a patient. (cancernetwork.com)
Analyzing samples from 805 children with newly diagnosed ALL from three consecutive clinical trials, we determined the ex vivo sensitivity of primary leukemia cells to 18 therapeutic agents across 23 molecular subtypes defined by leukemia genomics. (cdc.gov)

For lung cancers, CSC markers include CD44 and CD133 (PROM1), but also CD117 (KIT), CD90 (or THY1), CD166, EpCAM for non-small-cell lung carcinoma (NSCLC), and PODXL-1, PTCH, and CD87 for small-cell lung carcinoma (SCLC) 25 . (atlasantibodies.com)
in particular, patients with rare diseases like spinal muscular atrophy and certain cancers such as chronic myelogenous leukemia may now be prescribed personalized medicine treatments that simply didn't exist a couple of decades ago. (cdc.gov)

On the other hand, in brain tumors, such as glioma and glioblastoma, CSCs have instead been identified using cell surface markers, including SSEA-1 20 , EGFR 21 , and CD44 22 . (atlasantibodies.com)
In the next tables, we have selected our CSC markers for solid (Table 1) and hematological (Table 2) tumors. (atlasantibodies.com)
We reviewed 71 tumors fulfilling criteria for AFX and PDS to further stratify their biological potential. (netlify.app)
Anticipated technological breakthroughs will create numerous opportunities for determining genetic predisposition, detecting specific tumors, and monitoring biological response to cancer therapy. (aarkstore.com)
The biological role and underlying mechanism of action of zinc-finger protein 326 (ZNF326) in malignant tumors, including breast cancer, are still not clear. (cancerindex.org)

In such systems, biological markers and genetic materials such as siRNA and peptides tagged with nanoparticles (dendrimers, aptamers, and metal nanoparticles) form the fundamental elements that work at the molecular level and confer a high degree of specificity for recognition and capture, and in a therapeutic context, cytotoxicity for eradication of cancerous cells. (eurekaselect.com)
Leukocyte Typing II: Human Myeloid and Hematopoietic Cells. (bdbiosciences.com)
The pharmacological NFkappaB inhibitors BAY117082 and MG132 induce cell arrest and apoptosis in leukemia cells through ROS-mitochondria pathway activation. (nature.com)
Therefore, our results suggest that CD45 dim CD34 + CD38 - CD133 + cells in AML might have the potential of leukemia stem cells. (researchsquare.com)
Using multiple microchannels functionalized with different antibodies in a parallel fluidic connection, we first demonstrate the capacity for simultaneous detection of multiple surface markers in small EVs (sEVs) from NSCLC cells. (izon.com)
The present in vitro study adds new information concerning the biochemical composition of CSE-related EVs, useful to predict their biological effects on target cells. (izon.com)
The BD ® AbSeq Assay facilitates identification of specific changes in the myeloid cells of high-fat diet (HFD) mice. (bdbiosciences.com)
t-SNE visualization of differences in expression of Adgre1 (encodes F4/80) gene expression and CD11c protein expression (identified via AbSeq) in different cell clusters of myeloid cells from the adipose tissue of HFD mouse. (bdbiosciences.com)
demonstrated that 14 miRNAs are upregulated (miR-128a miR-142-3p Vamp5 miR-142-5p miR-150 miR-181a miR-181b miR-181c miR-193a miR-196b miR-30e-5p miR-34b miR-365 miR-582 and miR-708) and 5 downregulated (miR-100 miR-125b miR-151-5p miR-99a and allow-7e) in severe lymphoblastic leukemia cells weighed against normal Compact disc34+ cells (20). (techblessing.com)
G and H) Representative immunoblots show increased pSTAT5 and total STAT5 (G), and pERK (H) protein expression levels in NS/JMML CD33+ myeloid cells. (eprf.ca)
I) and expression levels in CD33+ myeloid cells. (eprf.ca)
J) Annexin V and (K) Ki-67 staining of CD33+ myeloid cells show apoptosis and proliferation, respectively. (eprf.ca)
However, we know less about the biological effects of IL-21 and its signaling mechanisms in leukemia cells and monocytes. (intechopen.com)
In this chapter, we will focus on IL-21's biological effects and signaling pathways as well as discuss the potential implications and applications of IL-21 in leukemia cells. (intechopen.com)
The aim of this study is to evaluate the prognostic impact of myeloid-derived suppressor cells (MDSCs) in multiple myeloma (MM) in the context of autologous stem cell transplantation (ASCT). (biomedcentral.com)
Large numbers of myeloid-derived suppressor cells (MDSCs), a mixture of monocytic and granulocytic cells, accumulate during many pathologic conditions, including cancer, infectious diseases, trauma, and sepsis. (biomedcentral.com)
Several possible mechanisms were considered for the induction of human leukemia, such as clastogenic damage to circulatory stem cells. (who.int)
Whilst LiCl exposure did not significantly alter the proportion of cells expressing markers for stem cells/undifferentiated cells (Oct4, SSEA4), neurons (Neurofilament M), astrocytes (GFAP) or cell cycle phase, the drug caused a 1.4-fold increase in total cell number. (plos.org)

Also called molecular marker and signature molecule. (wikipedia.org)
Numerous efforts in oncological scientific research have revealed many causative facets of leukemia, explaining mechanistic aspects of disease progression at the molecular scale. (eurekaselect.com)

Since these tissues are all intimately connected through both the circulatory and the immune system, a disease affecting one system will often affect the other as well, making myeloproliferation (leukemias) and lymphoproliferation (lymphomas) closely related and often overlapping conditions. (atlasantibodies.com)

MDSCs are characterized by myeloid origin, immature state, and most importantly by their potent ability to suppress different aspects of immune responses, especially T cell proliferation and cytokine production [ 7 ]. (biomedcentral.com)

Examples of hematologic cancer include leukemia, lymphoma, and multiple myeloma. (atlasantibodies.com)

Schubauer-Berigan conducted5 a meta-analysis using information from occupational and environmental studies to estimate the excess relative risk (ERR) of leukaemia, excluding the chronic lymphocytic subtype (CLL). (cdc.gov)

Bernstein ID, Self S. Joint report of the Myeloid Section of the Second International Workshop on Human Leukocyte Differentiation Antigens. (bdbiosciences.com)
Goyert SM, Ferrero E. Biochemical analysis of myeloid antigens and cDNA expression of gp55 (CD14). (bdbiosciences.com)
Furthermore, it was developed using the basic platform of the CD34 + CD38 - markers, but applying more advanced antigens such as CD45 dim and CD133. (researchsquare.com)

Today, the pilot platform includes up to 500 antibodies and well-conceived bioinformatics has been developed for selection of the orthogonal markers generating the optimal signature for maximum specificity and sensitivity for a particular diagnosis. (lu.se)

Nonmolecular fungal markers in serum or other biological samples represent a noninvasive diagnostic tool, which can help in therapeutic decisions. (medscape.com)
The research of Prof. Carl Borrebaeck has over the years been focussed on biological therapeutic concepts for cancer treatments as well as advanced diagnostics based on multiplexed biomarker discovery. (lu.se)

assessed by immunohistochemistry or flow cytometry, by using a handful of phenotypic markers. (lu.se)

The selected biomarkers are defined with antibodies directed against cancer associated markers released by the tumor (the secretome) or immuno regulatory proteins, as part of a systematic response. (lu.se)
As such, given the increasing incidence of CLL, the growing global aging population, and the age-related nature of CLL, examining the underlying determinants and biological processes of CLL may aid in the development of biomarkers for risk stratification, survival, and potentially, response to treatment. (biomedcentral.com)

DBC1 functions as a coactivator for AR-V7 and is required for the expression of AR-V7 target genes including CDH2, a mesenchymal marker linked to CRPC progression. (cancerindex.org)

Some background Anti-PD-1 is a type of biological therapy that has significantly improved treatment results for patients with certain types of cancer. (medivizor.com)
Earlier, more targeted treatment and also new drugs-the biological disease-modifying antirheumatic drugs (bDMARDs)-have contributed to this and have definitely changed the lives of many patients. (bmj.com)
The BAALC knockout mouse seems do not survive, our future study will employ knock-in or transgenic animal models, and utilize other platforms to decipher the mechanism of BAALC in introduction and maintenance of stemness in oncology (hematology), uncover the regulation rules of expression of BAALC and expression pattern of its diverse isoforms in leukemia patients, explore the environmental risk factors to develop preventive medicine for leukemia. (symbiosisonlinepublishing.com)

The DNMT3A mutation can cause significant changes in epigenetic modifications and is one of the essential regulatory factors for the occurrence and development of leukemia ( 4 ). (frontiersin.org)

Therefore, on the basis of the data available at this time, it was not possible to identify a mechanism for the induction of myeloid leukemia in humans. (who.int)

The method detects the difference in the streaming current generated by EV binding to the surface of a functionalized microcapillary, thereby estimating the expression level of a marker. (izon.com)
Expression of key cell surface markers identified by the BD ® AbSeq Assay in both healthy and CLL samples. (bdbiosciences.com)
Emerging evidence suggest that BAALC expression stops differentiation of myeloid [2]. (symbiosisonlinepublishing.com)

The analysis of sEVs from a patient prior and post ALK-TKI crizotinib treatment reveals significant increases in the expressions of some markers (EGFR and PD-L1). (izon.com)
While these studies demonstrate the risk stratification and prognostic value of epigenetic markers in CLL, the identification of epigenetic features associated with treatment response remains understudied. (biomedcentral.com)

This review presents a complex summary of GVHD pathogenesis with focus on references considering basic biological processes such as DNA damage response and cellular senescence. (hindawi.com)
This review summarizes the updated GVHD pathogenesis linking GVHD with biological processes such as DNA damage response (DDR) and cellular senescence (Figure 1 ). (hindawi.com)
Biological processes underlying GVHD pathogenesis are shown at the bottom of the scheme. (hindawi.com)
SHP-2 is usually a member of the tyrosine phosphatase family and regulates several biological processes, particularly embryogenesis and hematopoietic cell development (Tartaglia and Gelb, 2008). (eprf.ca)

The National Cancer Institute (NCI), in particular, defines biomarker as a: "A biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. (wikipedia.org)
Unfortunately, at 54 years of age, she developed a secondary cancer of therapy-related (t-) chronic myelomonocytic leukemia (t-CMML). (frontiersin.org)
Fanconi anemia, breast/ovarian cancer, leukemia) ( 5 - 7 ). (frontiersin.org)
Since the current gold standard for approval of drugs in castration-resistant prostate cancer is based on overall survival, prospective evaluation of these types of markers as a surrogate for survival is clearly needed, particularly with the plethora of new agents. (cancernetwork.com)

The electrokinetic signals show detection of these markers on sEVs, highlighting distinct interpatient differences, e.g., increased EGFR levels in sEVs from a patient with EGFR mutation as compared to an ALK-fusion one. (izon.com)

CD14++ monocytes, CD14+/CD16+ subset and soluble CD14 as biological markers of inflammatory systemic diseases and monitoring immunosuppressive therapy. (bdbiosciences.com)

The past two decades have witnessed an unprecedented and impressive improvement in the therapy of many rheumatic diseases, more specifically chronic inflammatory conditions such as rheumatoid arthritis (RA) and spondyloarthritis (SpA). (bmj.com)

Genome-wide association study identifies a PSMD3 variant associated with neutropenia in interferon-based therapy for chronic hepatitis C. Iio E, et al . (nih.gov)

Flow cytometry analysis showed that this differentiating lines expressed the pan-hematopoietic marker CD45 at least until Day 28 (Physique S2B). (eprf.ca)

Leukemia sensitivity to these two agents was highly associated with MRD although with distinct patterns and only in B cell ALL. (cdc.gov)

Cigarette smoke (CS) represents one of the most relevant environmental risk factors for several chronic pathologies. (izon.com)
Increased risk for leukemia has consistently been observed in studies of professional workers and in two of three of the most relevant studies of industrial workers. (who.int)
The biological aging is the most risk factor for human diseases. (symbiosisonlinepublishing.com)

Allogeneic hematopoietic stem cell transplantation is curative but it requires a histocompatible donor and is associated with significant morbidity and mortality, so it is reserved for severe cases of PNH with aplastic anemia or transformation to leukemia. (medscape.com)

Assembly of collagen fibrils and other multimeric structures_Homosapiens_R-HSA-2022090 in pathway analysis and progesterone_CTD_00006624 in DSigDB analysis were the most significant and SLC2A1, hsa-miR-188-3p, hsa-miR-378a-3p and hsa-miR-150-5p were selected as survival markers. (cancerindex.org)

Hemoglobin adducts as a marker of exposure to chemical substances, especially PRTR class I designated chemical substances. (who.int)

Anatomy27

Organisms8

Diseases57

Chemicals and Drugs73

Analytical, Diagnostic and Therapeutic Techniques and Equipment56

Psychiatry and Psychology1

Phenomena and Processes43

Disciplines and Occupations2

Information Science4

Health Care24

Geographicals1

Acute31

Lymphocytic leukemia13

Malignancies4

Prognosis4

Clinical4

Cancers2

Tumors5

Cells18

Molecular2

Lymphomas1

Immature1

Multiple myeloma1

Leukaemia1

Antigens3

Diagnosis1

Therapeutic2

Phenotypic Markers1

Biomarkers2

Progression1

Patients3

Occurrence1

Mechanism1

Expression3

Treatment2

Processes4

Cancer4

EGFR1

Systemic1

Inflammatory1

Identifies1

CD451

Distinct1

Risk3

Mortality1

Survival1

Exposure1