• acute
  • Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer. (wikipedia.org)
  • Overexpression of HOXB6, along with the addition of MEIS1 protein, has been implicated in the development of acute myeloid leukemia (AML). (wikipedia.org)
  • Acute myeloid leukemia is a cancer of the blood cells, specifically the leukocytes. (wikipedia.org)
  • Acute myeloid leukemia Chronic myelogenous leukemia Hematopoietic stem cell Kawamoto H, Minato N (2004). (wikipedia.org)
  • The long-term objective of this project is to define the mechanisms by which the aged BM vascular niche leads to the functional decline in aged HSCs, as well as to define the mechanisms by which dysregulation in the aged BM vascular niche leads to the initiation and progression of age-associated acute myeloid leukemia (AML). (jasonbutlerlab.com)
  • Changes in adaptive immune cells after chemotherapy in adult acute myeloid leukemia (AML) may have implications for the success of immunotherapy. (biomedcentral.com)
  • Results: Injection of the T-cell acute lymphoblastic leukemia derived tel-jak2a significantly perturbed lymphopoiesis with a lesser effect on myelopoiesis in zebrafish embryos. (haematologica.org)
  • The FLT3 gene is one of the most frequently mutated genes in acute myeloid leukemia (AML). (wikipedia.org)
  • CD11b
  • In this study, we characterized rabbit BM after the arrest of B lymphopoiesis and found a dramatic increase in fat, increased CD11b + myeloid cells, and upregulated expression of the inflammatory molecules, IL-1β and S100A9, by the myeloid cells. (jimmunol.org)
  • vitro
  • In vitro models of the T-lymphopoiesis system have revealed that the emigration of mature T-cells occurs as a result of immunorepulsion away from a chemokinetic agent generated from within the thymic organ via a G-protein coupled receptor. (wikipedia.org)
  • cells
  • Lymphopoiesis is now usually used interchangeably with the term "lymphocytopoiesis" - the making of lymphocytes - but other sources may distinguish between the two, stating that "lymphopoiesis" additionally refers to creating lymphatic tissue, while "lymphocytopoiesis" refers only to the creation of cells in that tissue. (wikipedia.org)
  • Similarly, myelogenous usually refers to nonlymphocytic white blood cells, and erythroid can often be used to distinguish "erythrocyte-related" from that sense of myeloid and from lymphoid. (wikipedia.org)
  • Exposure of aged HSC s to thrombin‐cleaved OPN attenuates aging of old HSC s, resulting in increased engraftment, decreased HSC frequency, increased stem cell polarity and a restored balance of lymphoid and myeloid cells in peripheral blood. (embopress.org)
  • Through the conversion of ATP to cAMP by the enzyme adenylate cyclase, the production of TNF-α, a signaling cytokine important for inducing inflammation, is inhibited in liver myeloid cells. (wikipedia.org)
  • CD135 is important for lymphocyte (B cell and T cell) development, but not for the development of other blood cells (myeloid development). (wikipedia.org)
  • Humans
  • In the case of mammals such as humans, lymphopoiesis begins with limited passive provision by the mother of lymphocytes and substantial immunoglobulin G that cross the placenta and enter the fetus to provide some protection against pathogens, and also leukocytes that come from breast milk and enter circulation via the digestive tract. (wikipedia.org)
  • molecules
  • Blocking arginase and inducible NO synthase did not restore B lymphopoiesis, indicating that inhibition is not mediated by these molecules. (jimmunol.org)
  • Wnt molecules are produced in the BM, and we here ask whether canonical Wnt signaling has a role in regulating human BM B lymphopoiesis. (biomedsearch.com)
  • innate
  • Thus, among leukocytes, the term myeloid is associated with the innate immune system, in contrast to lymphoid, which is associated with the adaptive immune system. (wikipedia.org)
  • common
  • The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. (nih.gov)
  • contrast
  • In contrast, injection of the atypical chronic myelogenous leukemia derived tel-jak2a resulted in significant perturbation of the myeloid compartment. (haematologica.org)
  • decline
  • We suggest that inflammaging contributes to a decline of B lymphopoiesis in aged individuals, and furthermore, that MDSCs and IL-1 provide therapeutic targets for restoration of B lymphopoiesis in aged and obese individuals. (jimmunol.org)
  • immune
  • In addition, trypanosomes are able to weaken the immune system by inducing B cell apoptosis (cell death) and the degradation of B cell lymphopoiesis. (wikipedia.org)
  • expression
  • Furthermore, different B progenitor maturation stages showed differential expression of Wnt receptors and co-receptors, beta-catenin, plakoglobin, LEF-1 and TCF-4 mRNAs, suggesting canonical Wnt signaling as a regulator of early B lymphopoiesis. (biomedsearch.com)
  • human
  • CONCLUSION: These results indicate that canonical Wnt signaling is involved in human BM B lymphopoiesis where it acts as a negative regulator of cell proliferation in a direct or stroma dependent manner. (biomedsearch.com)