• chronic
  • Though leprosy is not common, the discoveries have significant ramifications for chronic infectious disorders and for host-pathogen interactions in other more prevalent mycobacterial diseases such as tuberculosis, said Edison Liu, M.D., Executive Director of GIS, one of the research institutes sponsored by Singapore's Agency for Science, Technology and Research (A*STAR). (redorbit.com)
  • susceptibility
  • In the first genome-wide association study (GWAS) of leprosy and the largest GWAS on an infectious disease, scientists at the Genome Institute of Singapore (GIS) and 26 institutes in China identified seven genes that increase an individual's susceptibility to leprosy. (redorbit.com)
  • This is a very impressive study, which uncovers entirely new genes that control susceptibility to leprosy and perhaps also other related diseases. (redorbit.com)
  • The discovery of the seven susceptibility genes not only improves scientists' understanding about genetic susceptibility to the disease, but also may stimulate additional biological and clinical research to reveal the mechanism of leprosy development. (redorbit.com)
  • patients
  • The discovery of these genes, reported in the 16 Dec. 2009 New England Journal of Medicine, highlights the important role of the innate immune response in the development of leprosy, said the scientists, who analyzed over 10,000 samples from leprosy patients and healthy controls in China. (redorbit.com)
  • skin
  • Pulmonary infections of M. fortuitum are uncommon, but Mycobacterium fortuitum can cause local skin disease, osteomyelitis (inflammation of the bone), joint infections and infections of the eye after trauma. (wikipedia.org)
  • Tuberculoid leprosy is characterized by the presence of few, hypopigmented skin lesions involving differing degrees of anesthesia. (ajtmh.org)