HLA-A3 (A3) is a human leukocyte antigen serotype within HLA-A serotype group. (wikipedia.org)
Haplotypes1
The relative increase in CII-reactivity in RA patients as compared with healthy control individuals, and the association of a higher response with RA-associated HLA haplotypes, suggest the existence of a potentially pathogenic cellular reactivity against CII in RA. (biomedcentral.com)
Patients3
A3 serotype is a secondary risk factor for myasthenia gravis and lower CD8+ levels in hemochromatosis patients. (wikipedia.org)
After recalculating the response to CII taking this hyporesponsiveness into account the CII response was higher in RA patients, and was associated with human leucocyte antigen (HLA)-DRB1*0401 and HLA-DQA1*0301-DQB1*0302 (HLA-DQ8). (biomedcentral.com)
To study cellular immune reactivity to CII in patients with RA and in healthy control individuals and to correlate this reactivity to HLA class II genotypes and to the presence of antibodies to CII in serum. (biomedcentral.com)
Class1
One strong indicator for antigenic involvement in RA is the fact that certain major histocompatibility complex (MHC) class II genotypes [human leucocyte antigen (HLA)-DR4 and HLA-DR1] predispose for the development of the disease [ 1 ]. (biomedcentral.com)
Response2
HLA-A3 selects HIV evolution for a mutation Gag KK9 epitope and results in a rapid decline in the CD8 T-cell response. (wikipedia.org)
This type of evolved response may not be specific for HLA-A3 and since HIV is capable of adapting quickly in situ to selective factors. (wikipedia.org)
8] This patient had DQA1 0102, 0103 and DQB1 0602, 0601 that were considered as type 1 diabetes-protective HLA alleles. (medscape.com)
Autoimmune1
An intergenic single-nucleotide polymorphism (SNP), rs9275596, located between the HLA-DQB1 and HLA-DQA2 genes, is in significant association with various autoimmune diseases according to genome-wide association studies (GWASs). (bvsalud.org)
Homozygous2
Three out of 7 FDR with CD were HLA DQB102 homozygous. (bvsalud.org)
The odds of being CD is 5 times, 95% confidence interval (0.99, 26.23), greater for HLA DQ B102 homozygous in FDR. (bvsalud.org)
Antibody1
The serotype is determined by the antibody recognition of α3 subset of HLA-A α-chains. (wikipedia.org)
Risk3
A3 serotype is a secondary risk factor for myasthenia gravis and lower CD8+ levels in hemochromatosis patients. (wikipedia.org)
Risk factor genotypes with rare alleles included were associated with the MS common cohort (p (bvsalud.org)
DESIGN: Umbilical cord serum samples from 764 children born from 1994 to 2004 with HLA-DQB1 conferred risk for T1D participating in the Type 1 Diabetes Prediction and Prevention Study were analyzed for 25(OH)D using an enzyme immunoassay. (bvsalud.org)
Type1
This type of evolved response may not be specific for HLA-A3 and since HIV is capable of adapting quickly in situ to selective factors. (wikipedia.org)
Rare1
Results: The rs9275596 rare alleles were identified as a disease susceptibility factor in association with the MS main group and in affected females (p (bvsalud.org)
Association2
13] Association between PAS III and myasthenia gravis has been reported with both generalized myasthenia[14] and seronegative ocular myasthenia. (medscape.com)
The aim of the study was to verify the data on rs9275596 association in multiple sclerosis in a case/control study of the Latvian population and to evaluate eventual functional significance of allele substitutions. (bvsalud.org)