Maternal AgePoint MutationMutation, MissenseMutationPregnancyPaternal AgeDown SyndromeFrameshift MutationBirth OrderPregnancy, High-RiskGerm-Line MutationInfant, NewbornAmniocentesisParityPregnancy OutcomePedigreeGestational AgeBirth WeightMutation RatePrenatal DiagnosisTrisomyPregnancy Trimester, FirstPregnancy ComplicationsCongenital AbnormalitiesExonsNondisjunction, GeneticBase SequenceHeterozygoteAmino Acid SubstitutionAbortion, SpontaneousRisk FactorsAneuploidyPolymerase Chain ReactionDNA Mutational AnalysisChromosome DisordersBirth CertificatesMolecular Sequence DataAllelesCrown-Rump LengthNuchal Translucency MeasurementPolymorphism, Single-Stranded ConformationalGenotypeGenetic TestingMutagenesis, Site-DirectedCesarean SectionPregnancy Trimester, SecondFetal DeathInfant, Low Birth WeightUltrasonography, PrenatalAmino Acid SequenceCodon, NonsenseHomozygoteInfant MortalityMutagenesisChorionic Gonadotropin, beta Subunit, HumanPregnancy, MultipleSequence Analysis, DNAMothersPremature BirthHernia, UmbilicalPregnancy-Associated Plasma Protein-ACohort StudiesGastroschisisGenes, RecessivePreimplantation DiagnosisChromosome AberrationsSequence DeletionPrenatal CareCase-Control StudiesGenes, DominantProtein Structure, TertiaryFertilization in VitroStillbirthDNA PrimersLive BirthEscherichia coliSuppression, GeneticFetal DiseasesReproductive Techniques, AssistedPerinatal MortalityPhenotypeBirth IntervalsModels, MolecularInfant, Small for Gestational AgeChromosome MappingCodonAbortion, EugenicChromosomes, Human, Pair 21KaryotypingCell LineBinding SitesPregnancy in AdolescenceSequence Homology, Amino AcidDNA-Binding ProteinsPolar BodiesRetrospective StudiesGenetic Complementation TestChromosomes, Human, Pair 18Chorionic Villi SamplingDelivery, Obstetric