Animal Use AlternativesDisease Models, AnimalModels, AnimalPoint MutationMutation, MissenseMutationFrameshift MutationGerm-Line MutationPedigreeMutation RateBase SequenceExonsMolecular Sequence DataAllelesHeterozygoteAmino Acid SubstitutionPolymerase Chain ReactionDNA Mutational AnalysisAmino Acid SequenceGenotypePhenotypePolymorphism, Single-Stranded ConformationalMutagenesisMutagenesis, Site-DirectedSequence Analysis, DNAMice, Inbred C57BLModels, GeneticChromosome MappingCodon, NonsenseHomozygoteCell LineMice, TransgenicGenes, RecessiveDNA PrimersGenetic Predisposition to DiseaseGenetic LinkageSequence DeletionGene DeletionGenes, DominantGenetic TestingProtein Structure, TertiaryDNA-Binding ProteinsEscherichia coliSuppression, GeneticMice, KnockoutGenetic Diseases, InbornHuntington DiseaseModels, MolecularTranscription FactorsProtein BindingCodonSignal TransductionEthylnitrosoureaCells, CulturedBinding SitesMembrane ProteinsModels, BiologicalSequence Homology, Amino AcidNeurodegenerative DiseasesGenetic Complementation TestRNA, MessengerNuclear ProteinsFounder EffectGenes, p53TransfectionSyndromeMice, Mutant StrainsCloning, MolecularPolymorphism, Single NucleotideSequence AlignmentDNAMutant ProteinsParkinson DiseaseGenetic VariationGene Expression RegulationReverse Transcriptase Polymerase Chain ReactionSaccharomyces cerevisiaeConsanguinityBacterial ProteinsAnimals, Genetically ModifiedEpistasis, GeneticPlasmidsRecombinant ProteinsNerve Tissue ProteinsGenetic MarkersGene ExpressionDrosophila melanogasterNeuronsBrainGenes, LethalComputer Simulation