KeratinsPoint MutationMutation, MissenseMutationKeratins, Type IIKeratins, Hair-SpecificKeratins, Type IKeratin-8Frameshift MutationIntermediate FilamentsKeratin-14Germ-Line MutationKeratin-10PedigreeEpidermolysis Bullosa SimplexHyperkeratosis, EpidermolyticKeratin-1Base SequenceKeratin-5Molecular Sequence DataMutation RateEpidermisExonsHeterozygoteKeratin-18Amino Acid SequenceAmino Acid SubstitutionPolymerase Chain ReactionDNA Mutational AnalysisAllelesKeratinocytesPolymorphism, Single-Stranded ConformationalMutagenesis, Site-DirectedHomozygoteHairKeratoderma, PalmoplantarIntermediate Filament ProteinsSkinCodon, NonsenseMutagenesisGenotypeKeratin-16PhenotypeSequence Analysis, DNAGenes, RecessiveCell LineGenes, DominantKeratin-17Sequence DeletionProtein Structure, TertiaryDNA PrimersKeratin-2Chromosome MappingHair DiseasesSequence Homology, Amino AcidDNAEscherichia coliCloning, MolecularGenetic TestingEpitheliumCodonBinding SitesGene DeletionSuppression, GeneticDNA-Binding ProteinsRNA, MessengerKeratin-13Hair FollicleModels, MolecularTranscription FactorsProtein BindingTransfectionHoof and ClawDesmosomesCells, CulturedMice, TransgenicKeratin-15Genetic LinkageFeathersKeratin-6Genetic Complementation TestPromoter Regions, GeneticMembrane ProteinsSequence AlignmentMutant ProteinsTranscription, GeneticFounder EffectGenes, p53ImmunohistochemistrySyndromePlasmidsGene Expression RegulationGenetic Predisposition to DiseasePachyonychia CongenitaGenesModels, GeneticSaccharomyces cerevisiaeVimentinFluorescent Antibody TechniqueNuclear Proteins