MitochondrialDrosophilaGeneHypothesisDistinctTaxonomicHumanResistantGenesVirusesFunctionalProteinEmbryonicResistanceCellsMechanismsDetectionSpeciesHumansCharacteristicsResearch GroupRoleDevelopmentalLeadsStudyMethodsModelsDevelopmentModelCell populationExpressionTimesSmallKingdomLifeSitesGrowthIndividualsTopicsEssentialAreaCurrentHealthScienceDisease
Mitochondrial3
- We have identified a number of genes through nutrient-sensitized genome-wide screen using yeast mutants that are likely involved in the function or formation of the mitochondrial respiratory chain. (tamu.edu)
- Researchers in GEE have been investigating the mechanism responsible for this apparent paradox - mitochondrial inactivation - and have discovered that this mechanism is extremely widespread in the animal kingdom. (ucl.ac.uk)
- Recently, GEE's Prof John Allen, along with Wilson de Paula (Queen Mary University of London) and colleagues have investigated this phenomenon further and discovered that this system of mitochondrial inactivation is widespread across the animal kingdom. (ucl.ac.uk)
Drosophila3
- The fruit fly Drosophila melanogaster made the jump from nature to laboratory animal in 1901. (wikipedia.org)
- He was one of the first in the field to realize the potential of mapping the chromosomes of Drosophila melanogaster and all known mutants. (wikipedia.org)
- This is because Drosophila genes controlling fundamental cellular functions, such as cell growth and death, are quite identical to those found in human cells. (ataxia.org)
Gene6
- He received a B.A. in Integrative Biology from the University of California at Berkeley (1998), and worked as a technician for 2 years in Sarah Hake's plant genetics group at the USDA/ARS Plant Gene Expression Center. (yale.edu)
- She uses genetic approaches to identify novel disease genes for dominantly inherited polycystic kidney and liver diseases: a phenotypic spectrum from autosomal dominant polycystic kidney disease (ADPKD) to isolated polycystic liver disease (PCLD), and both in vitro and animal models to further disease gene mechanism investigation. (yale.edu)
- This focuses on the expression of the human tdp1 mutant gene in brain tissue of flies lacking the endogenous Gkt protein. (ataxia.org)
- The best-aligned sequences were annotated with gene ontology groups. (frontiersin.org)
- 2011). The student will induce TW formation in wild-type A. thaliana and mutants known to lack functional MS channel gene families (e.g., mid-1 complementing activity, MscS-Like, and AtPiezo), plants grown in advance of arrival of the REU student following Wyatt et al. (wustl.edu)
- pendent of those associated with cretory ducts, columnar epithelia the KRAS gene is more frequent- other key mechanistic characteris- lining the gastrointestinal tract and ly mutated in human cancer, which tics of IARC Group 1 carcinogens. (who.int)
Hypothesis1
- He holds several other pseudoscientific and fringe -science views including the spiteful mutant hypothesis [1] [2] and belief in paranormal such as spiritual mediumship . (rationalwiki.org)
Distinct2
- is the term applied to laboratory techniques using cell-cultures (tissue culture), as distinct from those using human subjects or live animals for testing possible harmful products. (emfacts.com)
- Muscle tissue houses 5-10 distinct populations of cells that communicate with each other and with their environment. (wustl.edu)
Taxonomic2
- Species is the most fundamental taxonomic category used in all biological classification. (cdc.gov)
- This view cannot be supported from taxonomic standpoint microbiology encompasses the study of groups of organisms in all three divisions of biology it may be argued that it covers greater biological diversity than the other two divisions. (gurujistudy.com)
Human8
- His current work is focused on two broad goals: (1) mapping variants and genes that confer risk to human disease, with ongoing projects focused on coronary artery disease and cardiometabolic traits in unique and underrepresented populations, and (2) developing methods for the detection and interpretation of human genome variation, with an emphasis on structural variation and other difficult-to-detect forms, and on comprehensive trait association in human disease studies. (yale.edu)
- 95% homogeneous populations of human astrocytes within 30 days of differentiation from cortical neural progenitor cells (NPCs). (nature.com)
- The cellular pathology of astroglia in the context of human AD remains enigmatic, mainly because of severe limitations of animal models, which, although reproducing some pathological features of the disease, do not mimic its progression in full. (nature.com)
- Neuronal loss and cognitive deficits, which are the hallmarks of AD in humans, are limited in animal models 15 and there is an increasing body of evidence showing that significant differences exist between rodent and human astrocytes. (nature.com)
- The new findings suggest that it may be possible to solve the global problem of plastic pollution by introducing human-engineered improvements to an enzyme that is already adept at consuming plastics (such as the mutant PETase) - and further work with this enzyme (and its mutant cousins) could make them even more efficient plastic eaters, the study authors reported. (livescience.com)
- We evaluated interaction between mutant human disrupted-in-schizophrenia 1 (mhDISC1) and maternal immune activation implicated in schizophrenia and mood disorders. (researchgate.net)
- The human eye, Darwin argued, could have evolved from a simple light-catching patch of tissue of the kind that animals such as flatworms grow today. (dialogue21.com)
- Infection with viruses of animal origin pose a significant threat to human populations. (bvsalud.org)
Resistant3
- Antibiotic resistance typically induces a fitness cost that shapes the fate of antibiotic-resistant bacterial populations. (elifesciences.org)
- Such strategies implicitly presume that resistance leads to reduced bacterial fitness in an antibiotic-free environment, and therefore these resistant populations should be rapidly outcompeted by antibiotic-sensitive variants. (elifesciences.org)
- If the cancer stem cell model is correct and if such cells retain the hallmarks of some tissue stem cells in being rare and entering the cell cycle infrequently, they could constitute a population that is intrinsically resistant to current therapies designed to kill cycling cells. (aacrjournals.org)
Genes2
- We propose that the evolution of the neural crest is linked not only to the recruitment of ancestral regulatory genes but also to the emergence of signaling peptides that control the increasingly complex lineage diversification of this plastic cell population. (biomedcentral.com)
- This means that mitochondria genes evolve much faster than nuclear ones---around 10 to 30 times faster in animals and up to a hundred thousand times faster in some fungi. (discovermagazine.com)
Viruses2
- Host parasite interaction: Recognition and entry processes of different pathogens like bacteria, viruses into animal and plant host cells, alteration of host cell behavior by pathogens, virus-induced cell transformation, pathogen-induced diseases in animals and plants, cell-cell fusion in both normal and abnormal cells. (pathfinderacademy.in)
- As the SFV RBD is structurally different from known retroviral RBDs, our data provide fundamental knowledge on the structural basis for the inhibition of viruses by nAbs. (bvsalud.org)
Functional1
- We defined the regions targeted by the nAbs using mutant SU proteins modified at the glycosylation sites, RBD functional subregions, and genotype-specific sequences that present properties of B-cell epitopes. (bvsalud.org)
Protein1
- We previously showed that the toxicity is both linked to a loss and a gain of function of the mutant protein but the neuronal role of the TG6 is still not known. (ataxia.org)
Embryonic1
- The neural crest is a transient population of embryonic cells that originate at the boundary between neural plate and dorsal ectoderm. (biomedcentral.com)
Resistance1
- Two main groups of factors contribute to the development of drug resistance. (nature.com)
Cells3
- Resting on this archetypal chordate body plan, unique populations of cells, the neural crest and the ectodermal placodes, evolved in craniates (referred to here as 'vertebrates' for simplicity). (biomedcentral.com)
- In this context it means the production of cells by non-sexual means - not just the duplication of animals/plants. (emfacts.com)
- Usually mutant cells are targeted for apoptosis (programmed cell death) but not always. (emfacts.com)
Mechanisms2
- The group aims to understand the mechanisms of morphogenesis and cell differentiation within an embryo. (royalsociety.org)
- Also, more atten- tion should be devoted to sensitive groups, toxicological mechanisms and interactions as most workplace exposures are mixtures. (cdc.gov)
Detection1
- His group has developed bioinformatics tools for variant detection, variant interpretation, sequence alignment, data processing, and data integration. (yale.edu)
Species4
- More than 50 ICTV study groups were tic of the viral biosystem as a whole and are not present in given the task of demarcating the 1,550 viral species that its constituent parts. (cdc.gov)
- As a result, field research on a large group of mosquitoes previously considered intractable became possible by collecting eggs from soil samples and identifying them to the species level. (nationalacademies.org)
- Mitochondria are only inherited through the maternal line - every mitochondria in your body came from your mother, and this is true for most animal species. (ucl.ac.uk)
- Brazil has a very large number of native plant species that are considered medicinal, but many do not have any scientific assessment of their medicinal potential, which is essential to be used safely by the population 9 . (bvsalud.org)
Humans1
- These or the occurrence of multinucleated dance between humans and experi- agents were examined with regard to cel s by light microscopy, and through mental animals. (who.int)
Characteristics2
- The three existing groups of the phylum Chordata, namely urochordates (ascidians), cephalochordates (amphioxus), and craniates (including vertebrates and agnates), share many characteristics. (biomedcentral.com)
- Understanding phenotypic bleeding characteristics, well-being status, treatment, and higher risk groups for bleeding among pre-adolescent children with VWD will aid physicians in efforts to educate families about bleeding symptoms. (cdc.gov)
Research Group3
- Diabetes Control and Complications Trial Research Group: the impact of intensive therapy of diabetes on the development and progression of lengthy-time period complications in insulin-dependent diabetes mellitus, N Engl J Med 329:977вЂ"986, 1993 [url=https://calasiao.gov.ph/wp-content/practice/order-cheap-prometrium-no-rx/] symptoms bone cancer discount prometrium[/url]. (ehd.org)
- She joined Imperial College in 2011, and now leads a research group of 7 full-time researchers. (royalsociety.org)
- She established an independent research group at King's College London in 1995 and has authored over 70 peer-reviewed publications. (royalsociety.org)
Role2
- Environmental cues found throughout neural crest migratory routes play a fundamental role not only in instructing the precursor's differentiation into particular phenotypes, but also in controlling their proliferation and survival [ 7 ]. (biomedcentral.com)
- Serendipity often plays a significant role in fundamental scientific research, and our discovery here is no exception," John McGeehan, a professor of structural biology at the University of Portsmouth in the U.K., said in a statement . (livescience.com)
Developmental1
- The meeting brought together multidisciplinary research groups in this exciting 'young' area of developmental biology for the first time, enabling formation of a network and sparking new collaborations. (royalsociety.org)
Leads1
- The late biology professor Lynn Margulis famously stated: "Never, however, did that one mutation make a wing, a fruit, a woody stem, or a claw appear…No evidence in the vast literature of heredity changes shows unambiguous evidence that random mutation itself, even with geographical isolation of populations, leads to speciation. (ubc.ca)
Study1
- While the newcomer mutant enzyme works somewhat more quickly than PETase does, its more important feature lies in its ability to consume another type of plastic: polyethylene furandicarboxylate (PEF), "literally drilling holes through the PEF sample," study co-author Gregg Beckham, a senior engineer at the National Renewable Energy Laboratory (NREL), said in a statement issued by NREL. (livescience.com)
Methods1
- The observation of the locomotor and exploratory behaviors of rodents in an open field is one of the most fundamental methods used in the field of behavioral pharmacology. (researchgate.net)
Models2
- Nevertheless, most of our knowledge of AD derives from studies that utilise cell- and animal-based models of the clinically rare, early-onset, dominantly inherited familial AD (FAD). (nature.com)
- The student will also design and test a system to scale up the biotransport experiments to larger animal models. (wustl.edu)
Development2
- These are extremely important issues not only in clinical practice but also fundamental in drug development ( Garattini, 2007 ). (nature.com)
- Dr Nowlan's group are working on a range of topics relating to foetal movements and skeletal development, funded by grants from the European Research Council and the Arthritis Research UK and Leverhulme Trust charities. (royalsociety.org)
Model1
- To uncover TG6 function, we generated a knockout animal model that shows early mild signs of motor and coordination impairment. (ataxia.org)
Cell population1
- This cell population is considered a vertebrate innovation and, accordingly, chordate ancestors lacked neural crest counterparts. (biomedcentral.com)
Expression1
- Animals received manual bladder expression twice daily and were inspected for weight loss, dehydration, and distress, with appropriate veterinary care when needed. (oxjournal.org)
Times2
- We have identified a sporulation mutant that dies during stressful times because instead of forming a spore it continues to divide without growing until there is essentially no cell left. (tamu.edu)
- Statistics show that those with major depression are 20 times more likely to kill themselves than are individuals in the general population. (talyarkoni.org)
Small2
- Drosophila's lateral posterior neurons (LPNs) belong to a small group of circadian clock neurons that is so far not characterized in detail. (sdbonline.org)
- Typically the nucleus contains only small groups of chromosome fragments. (emfacts.com)
Kingdom1
- Bacteria, algae, and fungi have in the past been considered to be part of the Plant Kingdom while protozoa have been included in the Animal Kingdom. (gurujistudy.com)
Life2
- In a new paper, Nick Lane, a biochemist at University College London, argues that some of the most fundamental aspects of eukaryotic life are driven by the need to keep these two genomes dancing in time. (discovermagazine.com)
- We found it almost everywhere we looked across the kingdoms of life - in living animals, and those extinct for millions of years. (uncommondescent.com)
Sites1
- Histopathology: Dose sites from one animal of each breed of minipig focus of 0. (ehd.org)
Growth2
- By assessing growth recovery after animal bite treatment (mimicked by cutting the leaves with scissors), we found that C. virgata could rapidly regenerate leaves after being damaged, suggesting high regeneration potential against grazing. (frontiersin.org)
- Thus, ZPG (or zero population growth) is being popularly promoted, so that most everyone (even Believers) is now trying to have fewer and fewer offspring. (gorge.net)
Individuals1
- The primary purpose of this chapter is to provide public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective on the toxicology of used mineral- based crankcase oil. (cdc.gov)
Topics1
- Even, I occur a fundamental first habit in future topics of everything flow and new tubes. (private-art.com)
Essential1
- This sensory information tells an animal essential details about its surroundings, such because the temperature or if a predator is nearby. (ehd.org)
Area1
- The nociceptive intensity was determined by the timing at which the animal remained rubbing the injected area. (bvsalud.org)
Current1
- Kindling will increase the sensitivity of rats to opposed population utilizing the current method [url=https://calasiao.gov.ph/wp-content/practice/buy-prednisolone-online-no-rx/] allergy forecast ynn cheap prednisolone 40mg with amex[/url]. (ehd.org)
Health2
Science1
- Mindy Weisberger is a Live Science editor for the channels Animals and Planet Earth. (livescience.com)
Disease1
- Dr Gosling says the multi-disciplinary team aims to understand how there could have been historical benefits of genetic variants that now cause disease, which will provide insight into the prevalence of metabolic disease in Pacific populations. (otago.ac.nz)