• biopsy
  • Muscle weakness is a prominent feature in DMD and BMDand common MR and biopsy findings include fatty infiltration and inflammation of muscular tissue. (lumc.nl)
  • progressive
  • Duchenne muscular dystrophy is characterized by progressive muscle weakness, ambulation loss and premature death 3 . (scielo.br)
  • This leads to progressive loss of muscular tissue resulting in weakness and ultimately failure of skeletal, respiratory and heart musculature. (lumc.nl)
  • The signs and symptoms consistent with muscular dystrophy are: Progressive muscular wasting Poor balance Scoliosis (curvature of the spine and the back) Progressive inability to walk Waddling gait Calf deformation Limited range of movement Respiratory difficulty Cardiomyopathy Muscle spasms Gowers' sign These conditions are generally inherited, and the different muscular dystrophies follow various inheritance patterns. (wikipedia.org)
  • Centers
  • This work was supported by grants from the National Institutes of Health (NIH), a Paul D. Wellstone Muscular Dystrophy Cooperative Research Centers grant, and a Robert A. Welch Foundation grant. (eurekalert.org)
  • cases
  • Lane R.J.M., Roses A.D., Robinow M. Segregation analysis in sibs born subsequent to first affected boys in families of isolated cases of Duchenne muscular dystrophy: implications for carrier risk assessment . (springer.com)
  • drug
  • The muscular dystrophy community is particularly well organized and has lobbied the agency for years to approve the drug, including getting members of Congress to write letters to the agency. (sfgate.com)
  • tissue
  • Fatty infiltration and edema/inflammation of muscular tissue are clearly visible using MRI and will be assessed quantitatively. (lumc.nl)
  • The experiments utilizing laminin-111 as a source of therapy for Duchenne muscular dystrophy suggest that it has protective qualities in addition to its association with muscle tissue. (wikipedia.org)