• The 501 incident cases of exertional rhabdomyolysis in 2020 represented an unadjusted annual incidence rate of 37.8 cases per 100,000 p-yrs among active component service members, the lowest of the 5-year surveillance period of 2016-2020. (health.mil)
  • Exertional rhabdomyolysis is a serious illness associated with physically demanding activities, particularly in hot weather. (health.mil)
  • Among active component service members in 2020, there were 501 incident cases of exertional rhabdomyolysis, for an unadjusted incidence rate of 37.8 cases per 100,000 person-years (p-yrs). (health.mil)
  • During 2016-2020, crude rates of exertional rhabdomyolysis reached a peak of 42.9 per 100,000 p-yrs in 2018 after which the rate decreased to a low of 37.8 per 100,000 p-yrs in 2020. (health.mil)
  • Most cases of exertional rhabdomyolysis were diagnosed at installations that support basic combat/ recruit training or major ground combat units of the Army or the Marine Corps. (health.mil)
  • Medical care providers should consider exertional rhabdomyolysis in the differential diagnosis when service members (particularly recruits) present with muscular pain or swelling, limited range of motion, or the excretion of darkened urine after strenuous physical activity, especially in hot, humid weather. (health.mil)
  • 1,2 In exertional rhabdomyolysis, damage to skeletal muscle is generally caused by high-intensity, protracted, or repetitive physical activity, usually after engaging in unaccustomed strenuous exercise (especially with eccentric and/or muscle-lengthening contractions). (health.mil)
  • 1-3,6 A diagnosis of exertional rhabdomyolysis should be made when there are severe muscle symptoms (e.g., pain, stiffness, and/or weakness) and laboratory results indicating myonecrosis (usually defined as a serum creatine kinase level 5 or more times the upper limit of normal) in the context of recent exercise. (health.mil)
  • During 2015-2019, crude rates of exertional rhabdomyolysis fluctuated between a low of 35.2 per 100,000 p-yrs in 2015 and a high of 42.4 per 100,000 p-yrs in 2018, after which the rate decreased to 38.9 per 100,000 p-yrs in 2019. (health.mil)
  • Compared to service members in other race/ethnicity groups, non-Hispanic blacks had the highest overall rate of exertional rhabdomyolysis in every year except 2018. (health.mil)
  • During the 5-year period, the annual numbers and rates of incident exertional rhabdomyolysis cases peaked in 2018 and then dropped in 2019. (health.mil)
  • Exertional rhabdomyolysis continued to occur most frequently from late spring through early fall at installations that support basic combat/recruit training or major Army or Marine Corps combat units. (health.mil)
  • Prompt recognition and treatment of exertional rhabdomyolysis usually prevent severe complications. (health.mil)
  • However, some service members who experience exertional rhabdomyolysis may be at risk for recurrences, which may limit their military effectiveness and potentially predispose them to serious injury. (health.mil)
  • These can progress into sporadic episodes of tying up or exertional rhabdomyolysis. (poulingrain.com)
  • Sporadic exertional rhabdomyolysis occurs most commonly in horses that are exercised in excess of their level of conditioning. (poulingrain.com)
  • Increased exercise on random hot, humid days may also elicit sporadic exertional rhabdomyolysis in susceptible horses because of high body temperatures, loss of fluid and electrolytes in sweat, and depletion of muscle energy stores. (poulingrain.com)
  • In some instances, horses seem more prone to exertional rhabdomyolysis following respiratory infections. (poulingrain.com)
  • A well-designed gradual exercise program and a nutritionally balanced diet with appropriate caloric intake and adequate vitamins and minerals are the core elements of treating sporadic exertional rhabdomyolysis. (poulingrain.com)
  • Atypical presentations include a severe Duchenne-like course, exercise-induced stiffness and myalgia before the onset of weakness, and early and clinically significant contractures (especially of the ankles, elbow, and neck) similar to those of Emery-Dreifuss muscular dystrophy. (medscape.com)
  • The participant in Sarepta's trial, which is testing a micro-dystrophin gene therapy candidate for Duchenne muscular dystrophy, was hospitalized for observation and determined to be asymptomatic. (centerwatch.com)
  • The ultrastructural images demonstrate the presence of finely fibrillary (~8.5nm thickness) material within the nucleus characteristic of Oculopharyngeal Muscular Dystrophy (OPMD) due to trinucleotide repeat expansion (poly-alanine) in the PABPN1 gene. (arkanalabs.com)
  • Correlation between PABPN1 genotype and disease severity in oculopharyngeal muscular dystrophy. (arkanalabs.com)
  • Yamashita S. Recent Progress in Oculopharyngeal Muscular Dystrophy. (arkanalabs.com)
  • Muscular dystrophy is a group of inherited disorders that cause muscle weakness and loss of muscle tissue, which get worse over time. (adam.com)
  • High CPK levels, meaning over 120 mcg/L, could be a sign of a heart attack, stroke, inflammation of the heart, myopathy (muscle disease), lung tissue disease, muscular dystrophy, or serious muscle breakdown called rhabdomyolysis, one of the more serious side effects of statin drugs . (healthy-heart-guide.com)
  • Neuromuscular disorders encompass a number of different disease processes, including myasthenia gravis (MG), Lambert-Eaton myasthenic syndrome (LEMS), Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), and hypokalemic periodic paralysis. (medscape.com)
  • CK is assayed as a marker of rhabdomyolysis (severe muscle breakdown), muscular dystrophy and monitoring statin therapy. (nwlpathology.nhs.uk)
  • To determine muscular dystrophy. (mfine.co)
  • However, it may also appear as chronic myopathy with severe weakness and, rarely, even as massive rhabdomyolysis with acute kidney injury (AKI). (degruyter.com)
  • The clinical picture of drug-induced myopathies may range from asymptomatic or mild myalgias, with or without muscle weakness, which are likely underreported, to chronic myopathy with severe weakness and rarely, even to massive rhabdomyolysis with acute kidney injury (AKI) [ 1 ]. (degruyter.com)
  • Muscle-related symptoms range from statin-associated muscle symptoms (SAMS), myalgias, myopathy, and in rare cases rhabdomyolysis - a severe form of myopathy with serum enzyme elevations greater than 40 times the upper threshold. (cardiometabolichealth.org)
  • Although febuxostat-assocated rhabdomyolysis was reported in some patients with CKD, the association between CKD and febuxostat-associated myopathy remains uncertain. (tmu.edu.tw)
  • The outcome was febuxostat-associated myopathy defined as elevated creatine kinase levels during febuxostat use that were not attributed to other muscular injuries. (tmu.edu.tw)
  • Rhabdomyolysis (shortened as rhabdo) is a condition in which damaged skeletal muscle breaks down rapidly. (wikipedia.org)
  • Rhabdomyolysis is characterized by the breakdown of skeletal muscle cells and the subsequent release of intracellular muscle contents into the circulation. (health.mil)
  • Recurrent metabolic crises with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration (MECRCN) is an autosomal recessive disorder characterized by episodic metabolic degeneration affecting skeletal muscle, cardiac muscle, and the nervous system. (nih.gov)
  • All have important functions, but it is the skeletal muscle that is affected by rhabdomyolysis. (belmarrahealth.com)
  • More severe rhabdomyolysis is characterized by muscle pain, tenderness, weakness and swelling of the affected muscles. (wikipedia.org)
  • In a systematic review by Stahl et al 3 with the main goal of finding a definition of rhabdomyolysis, the authors concluded that the most consensual definition is a clinical syndrome of acute muscle weakness, myalgia and swelling combined with a CK cut-off value of >1000 IU/L or >5x the upper limit of normal (ULN). (pediatriconcall.com)
  • The characteristic triad of rhabdomyolysis includes weakness, myalgias, and red to brown urine (due to myoglobinuria) accompanied by an elevated serum concentration of creatine kinase. (health.mil)
  • Fortunately rhabdomyolysis is very rare - somewhere between one in 10,000 and one in 100,000 patients per year - but it is useful to be aware that it may present with severe muscular weakness without pain on occasions. (pulsetoday.co.uk)
  • Recurrent rhabdomyolysis may result from intrinsic muscle enzyme deficiencies, which are usually inherited and often appear during childhood. (wikipedia.org)
  • 6,7 Patients with metabolic myopathies may present with indolent myopathic features, exercise intolerance or recurrent rhabdomyolysis. (pediatriconcall.com)
  • Myoglobinuria and renal symptoms, and broad-spectrum an- myositis or rhabdomyolysis among failure associated with infl uenza. (cdc.gov)
  • Several risk factors for adverse muscular symptoms have been identified, including hypothyroidism, preexisting muscle disease, renal impairment, as well as East Asian heritage. (cardiometabolichealth.org)
  • 4 Patients with severe injuries that develop rhabdomyolysis-induced renal failure have a mortality of approximately 20% but is higher if multiple organ dysfunction is present. (wfsahq.org)
  • There are several possible causes for the occurrence of rhabdomyolysis, such as trauma, rigorous physical exercise, side effects of drugs such as statins, substances of abuse like ethanol and cocaine and infections like viral myositis. (pediatriconcall.com)
  • That's high serum protein due to muscular cell death and breakdown (too much protein floating around in our bodies) = kidney failure. (simplholistic.org)
  • Moreover, the rapid rise of new therapeutics with the potential to cause SKM injury, such as immunotherapies and targeted therapies, as well as new treatments (such as gene therapy) specifically targeting muscular or neuromuscular diseases, demands an improved clinical strategy to identify myocyte injury and enable appropriate and timely clinical intervention. (degruyter.com)
  • Rhabdomyolysis is a condition when there is a severe muscle breakdown with the release into the circulation of muscle breakdown toxins which can cause kidney damage," Kaldas said. (kxlf.com)
  • In addition, life-threatening acute metabolic crises can occur, including rhabdomyolysis with elevated creatine phosphokinase and liver transaminases, hypoglycemia, prolonged QTc on EKG, ventricular arrhythmias, and/or cardiomyopathy. (nih.gov)
  • Affected individuals usually present in childhood with acute encephalomyopathic features, including rhabdomyolysis, hypotonia, and neurologic regression, although most patients have delayed psychomotor development before the acute onset. (nih.gov)
  • Radiographs showed bilateral Infl uenza-associated rhabdomyolysis DOI: 10.3201/eid1603.091818 pulmonary infi ltrates, and he was hy- with myoglobinuria have been shown poxemic. (cdc.gov)
  • Rhabdomyolysis is the breakdown of muscle tissue that leads to the release of muscle fiber contents into the blood. (adam.com)
  • These early warning signs can progress to heat stroke, rhabdomyolysis (the breakdown of muscular tissue), or even a heart attack . (articleify.com)
  • Rhabdomyolysis is reported about 26,000 times a year in the United States. (wikipedia.org)
  • A trip to the emergency room revealed that Slusher had developed rhabdomyolysis - a potentially fatal condition impacting 26,000 Americans each year. (kxlf.com)
  • Rhabdomyolysis patients often show symptoms within 24-72 hours. (kxlf.com)
  • 1 Rhabdomyolysis occurs in up to 85% of patients with traumatic injuries. (wfsahq.org)
  • 3 About a third of all patients with rhabdomyolysis will develop AKI and it is suggested that 5-25% of all AKI results from rhabdomyolysis. (wfsahq.org)
  • Muscular toxicity may be seen in telbivudine-treated patients so regular monitoring is advised. (medscape.com)
  • It is a significant problem for those injured in earthquakes, and relief efforts for such disasters often include medical teams equipped to treat survivors with rhabdomyolysis. (wikipedia.org)
  • Medline DOI: 10.1097/ formed, and drug therapy was of rhabdomyolysis was reported in a INF.0b013e3181c03cf2 broadened to include voriconazole, 28-year-old patient ( 5 ). (cdc.gov)
  • The sponsor says that neither it nor the trial's principal investigator reported an adverse event involving a participant who experienced rhabdomyolysis. (centerwatch.com)