• A MIBI scan or sestamibi scan is now a common method of cardiac imaging. (wikipedia.org)
  • Stress Testing In stress testing, the heart is monitored by electrocardiography (ECG) and often imaging studies during an induced episode of increased cardiac demand so that ischemic areas potentially at risk. (msdmanuals.com)
  • We investigated the role of technetium-99m (99mTc) sestamibi cardiac imaging and dobutamine echocardiography in detecting myocardial viability early after acute myocardial infarction. (cnr.it)
  • Careful evaluation of the patient's history and physical examination (including signs of congestion, such as jugular venous distention [JVD]) can provide important information about the underlying cardiac abnormality in heart failure. (medscape.com)
  • 1 The American College of Cardiology/American Heart Association (ACC/AHA) 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery 3 stratify cardiac risk of non-cardiac surgery, according to procedure - vascular surgery is associated with the highest cardiac risk. (cadth.ca)
  • As with nuclear imaging for other cardiac indications, the relative distribution of the radionuclide allows for visualization of blood flow through the heart and gives information regarding the functional capacity of the heart. (cadth.ca)
  • Technetium (99mTc) sestamibi is a lipophilic cation which, when injected intravenously into a patient, distributes in the myocardium proportionally to the myocardial blood flow. (wikipedia.org)
  • More recently, breast radiologists administer lower doses of 99mTc sestamibi (approximately 150-300 MBq or 4-8 mCi) for Molecular Breast Imaging (MBI) scans which results in a high sensitivity (91%) and high specificity (93%) for breast cancer detection. (wikipedia.org)
  • Nineteen patients (mean age 52 ± 10 years) underwent coronary angiography, low-dose dobutamine echocardiography and rest 99mTc sestamibi imaging within 10 days of myocardial infarction. (cnr.it)
  • Systolic wall thickening after coronary artery occlusion and subsequent reperfusion in normal and ischemic zones. (medscape.com)
  • Preoperative non-invasive testing aims to provide information primarily about coronary artery disease (myocardial ischemia or reduced blood supply to the heart muscle), left ventricular (LV) dysfunction, and heart valve abnormalities in selected patients. (cadth.ca)
  • Single photon emission computed tomography (SPECT) imaging of the heart is performed using a gamma camera to detect the gamma rays emitted by the technetium-99m as it decays. (wikipedia.org)
  • Single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) with technetium-99m ( 99m Tc)-labelled radiotracers. (cadth.ca)
  • Attenuation is more likely with technetium-99m ( 99m Tc) than with radioactive thallium 201 (Tl-201). (msdmanuals.com)
  • 7 Viable myocardial cells take up the radionuclide tracer (either thallium isotope [ 201 TI] or isotope 99m Tc-labelled radiotracer) in proportion to blood flow. (cadth.ca)
  • 1 The basic principle of radionuclide MPI is to administer a radiopharmaceutical intravenously and image blood flow to the heart muscle (myocardial perfusion), both at rest and under stress. (cadth.ca)
  • However, sestamibi imaging is useful to identify patients with dysfunctional segments without contractile reserve which may benefit by revascularization. (cnr.it)
  • For intravenous injection after radiolabelling with sodium (Tc-99m) pertechnetate solution and is indicated for: - adjunct for diagnosis of ischaemic heart disease. (studylib.net)
  • The vial is reconstituted with a maximum of 11 GBq of oxidant-free sodium (Tc-99m) pertechnetate solution for injection in 1 - 5 ml. (studylib.net)
  • In cases of severe heart failure, however, prolonged, rigid sodium restriction, coupled with intensive diuretic therapy and the inability to excrete water, may lead to dilutional hyponatremia, which occurs because of a substantial expansion of extracellular and intravascular fluid volume and a normal or increased level of total body sodium. (medscape.com)
  • This will promote rapid hepatobiliary clearance of technetium Tc-99m sestamibi resulting in less liver activity in the image. (studylib.net)
  • The suggested dose range for intravenous administration to a patient of average weight (70 kg) is: Diagnosis of ischaemic heart disease Two injections are required (at stress and at rest) in order to differentiate between transient and persistent perfusion defects. (studylib.net)
  • The ESC indicates that pulmonary function testing is generally not helpful in the diagnosis of heart failure. (medscape.com)
  • These factors may be related to the patient (including unique aspects of the patient's heart), the nuclear medicine equipment, or the actions of the technologist. (snmjournals.org)
  • [ 3 ] However, other studies and/or tests may be necessary to identify structural abnormalities or conditions that can lead to or exacerbate heart failure. (medscape.com)
  • Longer delays are required for resting images and for stress with vasodilators alone because of the risk of higher subdiaphragmatic Tc-99m activity. (studylib.net)
  • To limit gut activity adjacent to the heart, patients should have nothing by mouth or have only a light meal, depending on the institution's preference. (snmjournals.org)
  • Serum electrolyte values are generally within reference ranges in patients with mild to moderate heart failure before treatment. (medscape.com)
  • The heart to background ratio will increase with time but the ideal imaging time, reflecting the best compromise between heart count rate and contrast, is approximately 15 - 60 min. (studylib.net)
  • This article will review the preimaging, technical, patient-related, and heart-related artifacts and pitfalls that may compromise the performance and interpretation of MPI studies. (snmjournals.org)
  • This study was designed to assess the relationship between tetrofosmin uptake after nitrate administration and metabolic activity as assessed by positron emission tomography (PET) in patients with ischemic LV dysfunction. (cnr.it)
  • Thirty-six patients with chronic myocardial infarction and LV dysfunction (ejection fraction, 35% ± 6%) underwent resting technetium 99m tetrofosmin single photon emission computed tomography (SPECT) imaging under control conditions (baseline) and after sublingual administration of 10 mg isosorbide dinitrate. (cnr.it)
  • The drug is a coordination complex consisting of the radioisotope technetium-99m bound to six (sesta=6) methoxyisobutylisonitrile (MIBI) ligands. (wikipedia.org)
  • Lack of technetium-99m methoxyisobutylisonitrile ((99m) Tc-MIBI) uptake is consistently reported to predict poor response to subsequent chemotherapy in a variety of human malignant tumours. (cnr.it)
  • Since (99m) Tc-MIBI accumulates within mitochondria, which also play a central role in apoptosis through the integration of death signals by Bcl-2 family members, we tested whether early (99m) Tc-MIBI uptake is affected by alterations of the apoptotic pathway. (cnr.it)
  • Forty-two breast cancer patients were intravenously injected with 740 MBq of (99m) Tc-MIBI and planar images were obtained 10 min post injection with the patients in the prone lateral position. (cnr.it)
  • Ten carcinomas failed to accumulate (99m) Tc-MIBI and could not be visualised on scintigraphic images despite being larger than 1. (cnr.it)
  • Thirty-two of the 42 breast carcinomas showed focal uptake of (99m) Tc-MIBI (MIBI positive), and 10 min tumour-to-background ratios (T/B) varied between 1. (cnr.it)
  • Attenuation is more likely with technetium-99m ( 99m Tc) than with radioactive thallium 201 (Tl-201). (msdmanuals.com)
  • In general, nuclear medicine studies involve the use of a radioactive source, usually technetium ( 99m Tc), which has a short half life (six hours). (bmj.com)
  • GTN can also be used alone or in combination with other agents to decrease the number of ischaemic episodes in patients with proven CAD or ischaemic cardiomyopathy with a high degree of effectiveness. (bmj.com)
  • Technetium (99mTc) sestamibi is a lipophilic cation which, when injected intravenously into a patient, distributes in the myocardium proportionally to the myocardial blood flow. (wikipedia.org)
  • Technetium-99m (Tc-99) Myocardial. (msdmanuals.com)
  • Myocardial infarction (MI) (ie, heart attack) is the irreversible necrosis of heart muscle secondary to prolonged ischemia. (medscape.com)
  • In patients with ischemic left ventricular (LV) dysfunction, myocardial perfusion imaging after nitrate administration may improve the identification of dysfunctional but viable myocardium. (cnr.it)
  • Sestamibi is taken up by tissues with large numbers of mitochondria and negative plasma membrane potentials. (wikipedia.org)
  • Marked ischemic ST-segment elevations in inferior limb leads (II, III, aVF) and laterally (V 6 ) suggestive of acute inferolateral MI, and prominent ST-segment depressions with upright T waves in V 1 -V 4 are consistent with associated acute posterior MI. (basicmedicalkey.com)
  • More recently, breast radiologists administer lower doses of 99mTc sestamibi (approximately 150-300 MBq or 4-8 mCi) for Molecular Breast Imaging (MBI) scans which results in a high sensitivity (91%) and high specificity (93%) for breast cancer detection. (wikipedia.org)
  • For example, 99m Tc-methylene diposphonate (MDP) binds to bone while 99m Tc-iminodiacetic acid (IDA) is taken up and excreted by the hepatocytes, and labelled macroaggregates of human serum albumin ( 99m Tc-MAA) are trapped in the terminal pulmonary arterioles due to their relatively large size. (bmj.com)
  • The resulting two sets of images are compared with each other to distinguish ischemic from infarcted areas of the myocardium. (wikipedia.org)