Muscle dermatomyositis. Medical search. Frequent questions

Polymyositis is a similar inflammatory condition that also involves muscle weakness, swelling, tenderness, and tissue damage but no skin rash. (medlineplus.gov)
2016 American College of Rheumatology/European League against rheumatism criteria for minimal, moderate, and major clinical response in adult dermatomyositis and polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. (medlineplus.gov)
Dermatomyositis and polymyositis are autoimmune diseases that can both cause muscle weakness. (livestrong.com)
Recently, an analysis of 195 patients with polymyositis and dermatomyositis looked to determine predictors of response to rituximab, and found that antisynthetase and anti-Mi2 autoantibodies, as well as lower disease damage and juvenile-onset disease, were predictors of clinical improvement with rituximab. (medscape.com)
Polymyositis (PM) begins with muscle weakness in the muscles closest to the trunk of the body and then expands from there. (healthline.com)
Polymyositis affects the same muscle groups dermatomyositis does. (upmc.com)
Necrotizing myopathy is a more newly defined form of myositis with muscle weakness similar to that of dermatomyositis and polymyositis. (upmc.com)
It shows different features on a muscle biopsy than dermatomyositis and polymyositis do. (upmc.com)
Polymyositis and dermatomyositis are rare inflammatory diseases. (adam.com)
Dermatomyositis and polymyositis are related topics. (limamemorial.org)
I knew there was dermatomyositis and polymyositis. (medscape.com)
Immune-mediated inflammatory myopathies include polymyositis, dermatomyositis, myositis resulting from a rheumatic disease or overlap syndrome, inclusion body myositis (IBM), and immune-mediated necrotizing myopathy. (mhmedical.com)
Polymyositis and dermatomyositis are systemic disorders of unknown cause whose principal manifestation is muscle weakness. (mhmedical.com)
Intravenous immunoglobulins for steroid-refractory esophageal involvement related to polymyositis and dermatomyositis: a series of 73 patients. (qxmd.com)
To assess the long-term outcome of esophageal complications in the group of patients receiving intravenous immunoglobulins (IVIG) for the treatment of severe steroid-refractory esophageal involvement related to polymyositis/dermatomyositis (PM/DM). (qxmd.com)
Autoimmune myositis causes inflammation and weakness in the muscles (polymyositis) or in the skin and muscles (dermatomyositis). (msdmanuals.com)
Dermatomyositis usually causes skin changes that do not occur in polymyositis, which helps doctors differentiate the two disorders. (msdmanuals.com)

In addition, some patients with dermatomyositis need treatment for other systemic manifestations or complications. (medscape.com)

LONDON - For patients with juvenile dermatomyositis , a rare autoimmune disease that affects children, anti-tumor necrosis factor (TNF) agents appear to be an exciting new treatment option, results from a large observational cohort study suggest. (medscape.com)
More than 500 children with juvenile dermatomyositis are being treated at the Institute of Child Health, despite the fact that the disease occurs annually in only two or three children per million, she reported. (medscape.com)
Dr Campanilho-Marques and her colleagues analyzed data from the Juvenile Dermatomyositis Cohort and Biomarker Study and Repository for children who met the Bohan-Peter diagnostic criteria for dermatomyositis ( N Engl J Med . (medscape.com)
Juvenile dermatomyositis can be a very debilitating disease, with high morbidity and mortality rates if not properly treated," Dr Campanilho-Marques explained. (medscape.com)
That's a helpful point about this study because the data here are more striking: there is clearly benefit from anti-TNF treatment in this treatment-refractory group of juvenile dermatomyositis patients for both muscle and skin," she told Medscape Medical News . (medscape.com)
Sixty percent of children with juvenile dermatomyositis have a myositis-specific antibody (MSA). (wikipedia.org)
Dermatomyositis demonstrates a bimodal incidence, with the adult form most commonly seen in individuals aged 45-60, and the juvenile form found in children aged 10-15 years. (medpagetoday.com)
Bethany was diagnosed with Juvenile dermatomyositis when she was four after an MRI scan showed that, without treatment, she might have difficulty swallowing and breathing later in life. (make-a-wish.org.uk)
when the onset is in childhood it is known as Juvenile dermatomyositis (JDM). (bca.org)
Two children with skin rash and muscle weakness: juvenile dermatomyositis]. (bvsalud.org)

Available at: https://www.ninds.nih.gov/Disorders/All-Disorders/Dermatomyositis-Information-Page. (epnet.com)
Muscular dystrophy is a group of inherited disorders that cause muscle weakness and loss of muscle tissue, which get worse over time. (adam.com)
Neuromuscular disorders involve the muscles and the nerves that control them. (adam.com)
Disorders of the skeletal muscle. (limamemorial.org)
She specializes in neuromuscular disorders and is considered an expert in skeletal muscle channelopathies. (utsouthwestern.edu)
Dermatomyositis is one of a group of relatively uncommon diseases known as inflammatory myopathies, or inflammatory disorders of the muscles. (healthofchildren.com)
These disorders are characterized by progressive muscle weakness, and all but IBM demonstrate an inflammatory infiltrate in muscle tissue. (mhmedical.com)
This category includes systemic lupus erythematosus (SLE or lupus), dermatomyositis and scleroderma, disorders in which the body's immune defenses mistakenly attack healthy areas of the body, including the skin. (drugs.com)
There are more than 150 disorders that affect muscles, bones, and joints. (muysalud.com)
These disorders result in muscle inflammation (myositis), disabling muscle weakness, and occasionally tenderness. (msdmanuals.com)
Necrotizing immune-mediated myopathies are disorders that kill muscle cells (myocytes) and do not damage tissue other than the muscles. (msdmanuals.com)

Muscle biopsy hallmarks include perifascicular atrophy, loss of intramuscular capillaries, perivascular and perimysial inflammation and the overexpression of IFN-inducible genes. (nih.gov)
A muscle biopsy is not usually performed to confirm the diagnosis of JDM, as it is for adult myositis. (medscape.com)
[ 88 ] MRI also helps in localizing an area for a potential muscle biopsy. (medscape.com)
Emerging data has suggested that muscle biopsy findings may be useful in predicting the clinical course and prognosis of JDM based on extensive active myopathic and arteriopathic changes. (medscape.com)
If muscle biopsy is performed, a moderately weak muscle should be selected with specimens frozen for cryostat sections to perform histologic and enzyme histochemical stains and immunocytochemistry for major histocompatibility complex (MHC) antigens, immunophenotyping of T cells, and detection of cytokines and complement. (medscape.com)
We conducted a double-blind, placebo-controlled study of 15 patients (age, 18 to 55 years) with biopsy-proved, treatment-resistant dermatomyositis. (nih.gov)
Elevated creatine kinase, myositis-specific antibodies, diagnostic muscle biopsy. (mhmedical.com)
Muscle histopathologic findings from a biopsy of the quadriceps showed features of an inflammatory myopathy (interstitial edema, perivascular lymphocytic cuffing, and degenerating fibers) consistent with the features of early dermatomyositis. (cdc.gov)
Biopsy samples of muscle also look different under the microscope. (msdmanuals.com)
Muscle biopsy indicative of active idiopathic inflammatory myopathy (IIM) in the past 3 months e. (who.int)

Inclusion body myositis is a separate disorder that can cause muscle weakness and wasting away of muscle, most commonly in the legs, hands, and feet. (msdmanuals.com)

Inflammatory diseases of muscle and other myopathies. (medlineplus.gov)
The clinical picture of drug-induced myopathies may range from asymptomatic or mild myalgias, with or without muscle weakness, which are likely underreported, to chronic myopathy with severe weakness and rarely, even to massive rhabdomyolysis with acute kidney injury (AKI) [ 1 ]. (degruyter.com)

23andMe's Rare Disease Research Study will start with a handful of rare diseases, recruiting individuals to participate in innovative genetic research around - systemic sclerosis (a study we first started in 2021), ANCA-associated vasculitis, pemphigus vulgaris, and dermatomyositis. (familytree.com)

Lambert-Eaton myasthenic syndrome is a rare autoimmune condition that causes miscommunication between your nerves and muscles. (healthline.com)
Dermatomyositis is a rare autoimmune systemic disease of the connective tissue that is characterized by inflammatory and debilitating degenerative changes in the muscles and in the skin. (glutenfreeworks.com)

Skeletal muscle tissue (SKM) may be damaged due to mechanical, metabolic, and exertional causes. (degruyter.com)
Its use is supported by a series of randomized and controlled trials assessing diseases that affect the peripheral nerve, neuromuscular junction, and skeletal muscle. (nursingcenter.com)
It is found mainly in the heart, brain, and skeletal muscle. (ucsfhealth.org)
In this paper, we discuss the current available information about the role that different phenotypes of macrophages plays after injury and during the remodelling phase in different tissue types, with particular attention to the skeletal muscle. (hindawi.com)

Dermatomyositis is a disease that involves muscle inflammation and a skin rash. (medlineplus.gov)
If a tumor is causing the condition, the muscle weakness and rash may get better when the tumor is removed. (medlineplus.gov)
Patients with dermatomyositis may also have a rash that appears on the eyelids and over the bony prominences of the hands. (livestrong.com)
Its symptoms are generally a skin rash and worsening muscle weakness over time. (wikipedia.org)
The main symptoms include several kinds of skin rash along with muscle weakness in both upper arms or thighs. (wikipedia.org)
Dermatomyositis is a clinically distinct myopathy characterized by rash and a complement-mediated microangiopathy that results in the destruction of muscle fibers. (nih.gov)
Clinical response was gauged by assessing muscle strength, neuromuscular symptoms, and changes in the rash. (nih.gov)
A 51-year-old woman visited her primary care doctor complaining of a rash, pruritus, myalgias, and muscle weakness that made normally easy tasks like standing from a seated position difficult. (medpagetoday.com)
A heliotrope rash, a violaceous edematous periorbital erythema that may be slightly scaly, is considered pathognomonic for dermatomyositis. (medpagetoday.com)
When we look at the painting with much higher detail, it is clear the father character has a skin rash that is consistent with the disease of dermatomyositis," Ashrafian tells Lorenzi. (smithsonianmag.com)
Dermatomyositis (dur-muh-toe-mi-uh-SY-tis) is an inflammatory muscle disease that weakens muscles and produces a distinctive skin rash. (akronchildrens.org)
Dermatomyositis is distinguished from other diseases in this category by the fact that it causes a characteristic skin rash as well as affecting the strength and functioning of the muscles. (healthofchildren.com)
Dermatomyositis is an inflammatory disease marked by muscle weakness and a distinctive skin rash. (familytree.com)
Active dermatomyositis (DM) skin rash d. (who.int)

Autoimmune disease overlap - Dermatomyositis can occur in conjunction with systemic lupus erythematosus (SLE), mixed-connective tissue disease, Sjögren syndrome, scleroderma, and rheumatoid arthritis. (medpagetoday.com)
Dermatomyositis is an autoimmune disease affecting skin and muscle, and 15%-20% of patients eventually develop cancer. (dermatologyfoundation.org)

Dermatomyositis may develop as a paraneoplastic syndrome associated with several forms of malignancy. (wikipedia.org)
Malignancy in association with dermatomyositis is more prevalent after age 60. (wikipedia.org)
There is an increased risk of malignancy, especially in dermatomyositis. (mhmedical.com)
Indeed, up to one patient in four with dermatomyositis has an occult malignancy. (mhmedical.com)

Conclusion: In DM, anti-NXP-2 autoantibodies are associated with subcutaneous edema, calcinosis, and a muscle phenotype characterized by myalgia, proximal and distal weakness, and dysphagia. (johnshopkins.edu)
lipodystrophy and, as in the example here, calcinosis - hard calcium lumps under the skin or muscle. (bca.org)

Myasthenia gravis is a condition that causes muscle weakness that worsens after activity and improves with rest. (healthline.com)
Clinical Review of Muscle-Specific Tyrosine Kinase-Antibody Positive Myasthenia Gravis. (utsouthwestern.edu)
argenx BVBA is conducting a long-term, single-arm, open-label, multicenter phase 3 follow-on trial of the ARGX-113-1704 study to evaluate the safety and tolerability of ARGX-113 in patients who have myasthenia gravis with generalized muscle weakness. (rarediseases.org)

Dermatomyositis is an idiopathic inflammatory myopathy with characteristic cutaneous findings that occur in children and adults (see the image below). (medscape.com)

Diagnosis is typically based on some combination of symptoms, blood tests, electromyography, and muscle biopsies. (wikipedia.org)

Dermatomyositis is an inflammatory myopathy characterized by symmetrical proximal muscle weakness and skin changes. (nih.gov)

Contact your provider if you have muscle weakness or other symptoms of this condition. (medlineplus.gov)
The team assessed muscle symptoms with the Childhood Myositis Assessment Scale (CMAS) and the Manual Muscle Testing (MMT8). (medscape.com)
Primary symptoms may include muscle pain and soreness, fatigue, trouble swallowing, and difficulty breathing. (healthline.com)
Their mean muscle-strength scores increased from 74.5 to 84.7, and their neuromuscular symptoms improved. (nih.gov)
Myositis can cause problems in muscle groups and other symptoms throughout the body. (upmc.com)
The symptoms of autoimmune myositis are similar for people of all ages, but the muscle inflammation often appears to develop more abruptly in children than in adults. (msdmanuals.com)

Dermatomyositis is a multisystem autoimmune connective tissue disease that is most often characterized by a symmetric proximal extensor inflammatory myopathy, a characteristic violaceous cutaneous eruption, and pathogenic circulating autoantibodies. (medpagetoday.com)
Dermatomyositis, a type of inflammatory myopathy, can occur at any age, but is most common in children age 5-15 and adults age 40-60. (akronchildrens.org)

Eighty percent of adults with adult-onset dermatomyositis have a myositis-specific antibody (MSA). (wikipedia.org)

The field has moved away from the idea that anti-TNF therapy could be helpful in dermatomyositis, because in adult forms of the disease, study results have been extremely mixed, said Lisa Rider MD, deputy chief, Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, Maryland. (medscape.com)
Rehabilitative exercise is also recommended for both adult and pediatric patients in order to maintain muscle strength, even during the course of active muscle disease. (medscape.com)

Similar to the other forms of myositis, JM is characterized by muscle weakness and skin rashes. (healthline.com)
It also causes the same skin rashes that patients with dermatomyositis have. (upmc.com)

Clinical features of dermatomyositis can be categorized into cutaneous and systemic manifestations. (medpagetoday.com)
Variants - Dermatomyositis sine myositis is the amyopathic form where dermatomyositis is clinically limited to cutaneous involvement. (medpagetoday.com)

Objective: Dermatomyositis (DM) patients typically present with proximal weakness and autoantibodies that are associated with distinct clinical phenotypes. (johnshopkins.edu)
Although their clinical presentations (aside from the presence of certain skin findings in dermatomyositis, some of which are pathognomonic) and treatments are similar, the two diseases are pathologically distinct. (mhmedical.com)
Clinical features included hepatitis, edema, and a dermatomyositis-like syndrome. (cdc.gov)
Clinical features, including hepatitis, edema, and a dermatomyositis-like syndrome, were similar to those mentioned in the original descriptions of disseminated enteroviral infections in children with X-linked agammaglobulinemia (XLA) ( 4 , 5 ). (cdc.gov)

Dermatomyositis (DM) is the easiest form of myositis to diagnose due to the purple-red rashes in the shape of the heliotrope flower . (healthline.com)

STIR findings must be interpreted cautiously, however, because patients with muscle dystrophies may have inflammation as well. (medscape.com)
If you're thinking dermatomyositis specifically because there's muscle weakness and skin findings, then you have to think about age-appropriate cancer screening. (medscape.com)

When the total CPK level is very high, it most often means there has been injury or stress to muscle tissue, the heart, or the brain. (ucsfhealth.org)
Muscle tissue injury is most likely. (ucsfhealth.org)
The immune system becomes overactive and attacks the body's muscle tissue. (upmc.com)
Blood tests to look for elevated creatine kinase levels, signaling inflammation in the muscle tissue in people with myositis. (upmc.com)
SSc is a systemic connective tissue disease characterized by vasomotor instability, fibrosis, and immunologic disturbances, as well as by atrophy of the skin, subcutaneous tissue, muscles, and internal organs. (medscape.com)
Dermatomyositis is a rare connective-tissue disease that weakens the immune system, muscles and skin. (blogspot.com)
Reverse transcription PCR of the muscle tissue indicated enterovirus RNA. (cdc.gov)
Doctors check muscle enzymes in the blood and may test electrical activity of muscles, do magnetic resonance imaging on muscles, and examine a piece of muscle tissue. (msdmanuals.com)
Also, the muscle tissue has a different appearance under the microscope. (msdmanuals.com)

Fortunately, most patients with this form of muscle disease recover completely. (livestrong.com)
Inpatient care is needed for patients with fulminant dermatomyositis with muscle and/or internal organ involvement. (medscape.com)
Several general measures are helpful in the care of patients with dermatomyositis. (medscape.com)
In patients with muscle weakness, especially children, a program of physical therapy is useful to help prevent the contractures that can complicate the disease when patients do not fully move their joints. (medscape.com)
Disease is often detectable on muscle MRI, and many of these patients go on to develop muscle weakness as the disease progresses. (medpagetoday.com)
Simvastatin 80 mg daily dosage is restricted to patients who have been taking simvastatin 80 mg daily chronically (e.g., for 12 months or more) without evidence of muscle toxicity. (nih.gov)
Muscle weakness, thoracic myopathy, and aspiration pneumonia were independent predictive factors of IVIG-treated esophageal complications in PM/DM patients. (qxmd.com)

Here are 10 of the most common and clinically interesting muscle diseases. (muysalud.com)

Inflammatory muscle diseases. (medlineplus.gov)
However, steroids also have powerful anti-inflammatory effects, and are therefore used in some autoimmune diseases that affect muscles. (livestrong.com)
Selcen D. Muscle diseases. (limamemorial.org)
The most common muscle diseases are actually quite rare among the general population (except for lower back pain). (muysalud.com)
Unfortunately, there are certain common muscle diseases that make the process difficult. (muysalud.com)
What are the most common muscle diseases? (muysalud.com)
These include diseases caused by an intrinsic disorder of the muscle. (muysalud.com)
As you can see, muscle diseases aren't only common, they're also notable for their diversity. (muysalud.com)

Dermatomyositis (DM) is a long-term inflammatory disorder which affects the skin and the muscles. (wikipedia.org)
Dermatomyositis affects muscles mainly in the arms, legs, and trunk, as well as those that help you swallow. (upmc.com)
Aspiration pneumonia from food or liquid going into the lungs if it affects the swallowing muscles. (upmc.com)
If the paralysis affects the muscles that cause breathing, it is quickly life-threatening. (adam.com)

Eleven months after she began taking obinutuzumab, the patient sought treatment for 4 weeks of fatigue, myalgias, muscle tenderness, and leg edema without fever. (cdc.gov)

Therapy for dermatomyositis involves both general measures and specific measures to control the muscle disease and the skin disease. (medscape.com)
The condition is called dermatomyositis when it involves the skin. (adam.com)

[ 72 , 73 ] In addition to its positive effects on refractory muscle and skin disease, IVIG has been reported to be beneficial for other systemic manifestations, including severe esophageal dysfunction. (medscape.com)
Gastrointestinal - Dysphagia can be seen due to esophageal muscle involvement. (medpagetoday.com)

Bed rest is often valuable for those with severe inflammation of the muscles. (medscape.com)
Myositis is a chronic, progressive inflammation of the muscles. (healthline.com)
The definition of myositis is inflammation of the muscles. (upmc.com)

We found that there was a striking reduction in all outcome measures in terms of skin and muscle involvement and that anti-TNF agents seem to be well tolerated in children," said Raquel Campanilho-Marques, MD, from the Lisbon Academic Medical Center in Portugal. (medscape.com)
In addition, they administered the Physician Global Assessment (PGA), measured levels of muscle enzymes, and assessed skin involvement with a modified disease activity score. (medscape.com)
Muscle and skin involvement significantly improved," Dr Campanilho-Marques reported, "as did measures of global disease activity. (medscape.com)
Though this disease often causes pain in the muscles, the actually site of involvement is the joints. (livestrong.com)
Generally, methotrexate, mycophenolate mofetil, or azathioprine are used first line as glucocorticoid-sparing agents for muscle involvement. (medscape.com)

Complications may include calcium deposits in muscles or skin. (wikipedia.org)
There are further complications possible with dermatomyositis. (wikipedia.org)
These complications include difficulty swallowing due to the muscles in the esophagus being affected which can result in malnutrition and can cause the breathing of food or liquids, into the lungs. (wikipedia.org)
Dermatomyositis is a serious disease that can result in life-threatening complications such as cancer, heart disease, lung disease, and pneumonia. (akronchildrens.org)

Muscle damage may cause muscle pain and muscle weakness may cause difficulty lifting the arms above the shoulders, climbing stairs, or arising from a sitting position. (msdmanuals.com)

These muscle injuries occur when the muscle is stretched or damaged beyond normal for a limited time. (muysalud.com)
Muscle disease may occur concurrently, may precede the skin disease, or may follow the skin disease by weeks to years. (medscape.com)

Levels of muscle enzymes such as aspartate aminotransferase, lactate dehydrogenase, creatine kinase, and aldolase may be elevated early in the disease course. (medscape.com)

Over time, the muscles get weak. (upmc.com)

High-dose intravenous immune globulin is a safe and effective treatment for refractory dermatomyositis. (nih.gov)

Experts think it may be due to a viral infection of the muscles or a problem with the body's immune system. (medlineplus.gov)

Factors that may affect test results include cardiac catheterization , intramuscular injections, trauma to muscles, recent surgery, and heavy exercise. (ucsfhealth.org)

The muscle weakness with these conditions is commonly felt in the upper arms, shoulders, neck, hips and thighs according to Mayo Clinic . (livestrong.com)
It can more commonly affect muscles in the hands, impacting grip strength and weakening the arms and legs. (upmc.com)

Viral protein 1 gene obtained from RNA extracted from muscle was sequenced, and we identified the virus as echovirus 6. (cdc.gov)

It may present as asymptomatic or mild myalgias, with or without muscle weakness, which are likely underreported. (degruyter.com)

In the world, about 1.710 million people have at least one disorder of the muscles , bones, joints, or all of these elements at the same time. (muysalud.com)

Persons with dermatomyositis often present with skin disease as one of the initial manifestations, and it may be the sole manifestation at onset in perhaps as many as 40% of individuals with this condition. (medscape.com)

Magnetic resonance imaging (MRI) with T2-weighted fat suppression and short tau inversion recovery (STIR) is useful in the diagnostic workup because it reveals edema, a marker of muscle inflammation. (medscape.com)

The loss of muscle function after these types of events can be severe. (adam.com)

An Unusual Presentation of Dermatomyositis With Muscle Hypertrophy. (utsouthwestern.edu)
Malignancies may be evident at the time of presentation with the muscle disease but may not be detected until months afterward in some cases. (mhmedical.com)

People with DM experience progressively worsening muscle weakness in the proximal muscles (for example, the shoulders and thighs). (wikipedia.org)

Anatomy13

Diseases15

Chemicals and Drugs10

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes3

Information Science1

Polymyositis17

Need treatment for1

Juvenile10

Disorders11

Biopsy10

Inclusion-body myo1

Myopathies2

20211

Rare autoimmune2

Skeletal4

Rash14

Autoimmune disease2

Malignancy4

Calcinosis2

Myasthenia3

Idiopathic1

Diagnosis1

Proximal muscle weakness1

Symptoms6

Inflammatory myopathy2

Antibody1

Adult2

Skin rashes2

Cutaneous2

Clinical4

Form of myositis1

Findings2

Tissue9

Patients7

Clinically1

Diseases8

Affects4

Fatigue1

Involves2

Esophageal2

Inflammation of the muscles3

Involvement5

Complications4

Difficulty1

Occur2

Creatine kinase1

Weak1

Refractory1

Body's1

Include1

Commonly2

Viral1

Myalgias1

Joints1

Onset1

Diagnostic1

Severe1

Presentation2

Worsening muscle weakness1