Murine cells secreting interleukin helper th2 cells. Medical search. Frequent questions

They aid the activity of other immune cells by releasing cytokines. (wikipedia.org)
Th cells contain and release cytokines to aid other immune cells. (wikipedia.org)
Cytokines are small protein mediators that alter the behavior of target cells that express receptors for those cytokines. (wikipedia.org)
Th1 and Th2 responses are crucial in understanding the role of cytokines in the immune response to infectious agents [ 4 , 5 ]. (hindawi.com)
The aim of our research was to determine how immunotherapy changes the proportion of lymphocyte subsets in dog peripheral blood and the levels of cytokines secreted by these cells during therapy. (mdpi.com)
Natural-killer (NK) cells are specialized lymphocytes that have cytotoxic properties in addition to their ability to produce cytokines that assist in the orchestration of adaptive immunity. (medscape.com)
During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)
T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. (cdc.gov)
However, more recent studies have revealed the potential collaboration of other helper T cells and their cytokines in this process. (cdc.gov)
The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33) in asthma. (cdc.gov)
MS is an inflammatory-mediated demyelinating disease that has been associated with production of interferon (IFN)-γ and interleukin (IL)-17, two cytokines that are produced by Th1 and Th17 cells, respectively 12 . (nature.com)
Furthermore, allergic rhinitis mice exhibited overproduction of epithelial-derived cytokines (thymic stromal lymphopoietin, interleukin-25, interleukin-33), C-C motif chemokine ligand 26 (CCL26), and mucin 5 AC (MUC5AC). (balkanmedicaljournal.org)
The histological feature of AR is typical type 2 inflammation is induced mainly by the type 2 cytokines interleukin (IL)-4, IL-15, and IL-13. (balkanmedicaljournal.org)
5 In addition to these Th2 cell-secreted molecules, damaged airway epithelial cells participate in the sensitization process via the secretion of cytokines, including thymic stromal lymphopoietin (TSLP), IL-25, and IL-33, to trigger Th2 immune responses. (balkanmedicaljournal.org)
Using mice lacking the DNA hydroxymethylase TET2, we showed the requirement for TET2 in optimal production of hallmark cytokines by ILC3s and interleukin-17A (IL-17A) by inflammatory ILC2s. (stanford.edu)
The interleukin-1 (IL-1) family is a growing group of cytokines, consisting of at least 11 members, and the balance between pro- and anti-inflammatory cytokines is crucial in the pathogenesis of many human diseases ( 3 ). (frontiersin.org)
IL-33 induces T cells to produce IL-4, IL-5, and IL-13, and potently induces pro-inflammatory cytokines and chemokines through a Th2-dependent pathway, and also promotes Th1-type responses ( 5 ). (frontiersin.org)
Deletion of IL-33/ST2 function enhances cytotoxicity of NK cells and increases levels of TNF-α, IFN-γ, and IL-17, and systemic pro-inflammatory cytokines, leading to attenuated tumor growth ( 8 ). (frontiersin.org)
To verify this hypothesis, we examined the frequency of Th1, Th2 and Th17 cell populations as well as the concentrations of cytokines involved in Th17 cell differentiation and migration in BM from RA and OA patients. (biomedcentral.com)
Compared to WT mice, IL-10 −/− mice had exacerbated CIA development, which was associated with increased production of T helper 17 cell (Th17)/Th1 proinflammatory cytokines and CII-specific immunoglobulin G2a antibody after CII immunization. (biomedcentral.com)
Many of the immunosuppressive characteristics of IL-10 can be traced to their effects on macrophages and DCs by preventing the production of the T helper 1 cell (Th1)-associated cytokines IL-2 and interferon γ (IFN-γ). (biomedcentral.com)
CD4 and CD8 T lymphocytes play an import role in the inflammatory response, as these cells may manage the profile of cytokines produced against an infectious agent 4 . (bvsalud.org)
Progression of periodontal lesions is caused by dysregulation of molecules (cytokines) released by specific cell populations 5 . (bvsalud.org)
They can be distinguished based on the profile of cytokines produced: Th1 cells produce characteristic cytokines such as IL-2, IFN-γ, TNF-β, IL-12, while active Th2 cells secrete IL-4, IL-5, IL-6, IL-10 and IL-136. (bvsalud.org)

They are considered essential in B cell antibody class switching, breaking cross-tolerance in dendritic cells, in the activation and growth of cytotoxic T cells, and in maximizing bactericidal activity of phagocytes such as macrophages and neutrophils. (wikipedia.org)
Professional antigen-presenting cells are primarily dendritic cells, macrophages and B cells, although dendritic cells are the only cell group that expresses MHC Class II constitutively (at all times). (wikipedia.org)
However, it is not clear how gut macrophages, relative to recruited blood monocytes and other myeloid cells, contribute to the intestinal inflammatory milieu, nor how macrophages and their monocyte precursors mediate recruitment of other immune cells to the inflamed intestine. (frontiersin.org)
In addition, mRNA expression profiles in human and murine colon samples, and in macrophages and monocytes from healthy and inflamed murine colons, were analysed by quantitative PCR (qPCR) and mRNA microarray. (frontiersin.org)
Finally, our data reveal that, independent of inflammation, murine colon macrophages act as a major source of Ccl7 and Ccl8 chemokines that trigger further recruitment of their pro-inflammatory monocyte precursors. (frontiersin.org)
It has recently been shown that murine intestinal macrophages are continually repopulated from circulating blood monocytes, identified by expression of the cell surface markers Ly6C, CCR2, and CD62L ( 6 ). (frontiersin.org)
IgG2a also engages in high affinity interactions with Fc receptors on immune cells which can result in antibody-dependent cell-mediated cytotoxicity (ADCC) as well as antibody-dependent cellular phagocytosis (ADCP) by phagocytosing cells like macrophages 3-8 . (researchsquare.com)
Our objective in the present study was to determine the signaling pathway of interleukin 10 (IL-10) for modulating IL-17 expression in macrophages and the importance of this mediation in collagen-induced arthritis (CIA). (biomedcentral.com)
Interleukin 10 (IL-10) is an important immunoregulatory cytokine produced by many cell populations, including macrophages, dendritic cells (DCs), T-cell subsets (Th2, Tc2 and Tr1) and B cells [ 3 ]. (biomedcentral.com)
Several immune cell types play a role in the pathogenesis of RA, such as fibroblasts, T lymphocytes, B lymphocytes and macrophages [ 13 ]. (biomedcentral.com)
SARS-CoV-2 infects alveolar endothelial cells (see, ACE2 below) and/or macrophages. (mthfrsupport.com)
The infiltration of multiple types of tumor-promoting immune cells, including myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), regulatory T cells (Tregs) and other immune cells, mediates immune evasion and tumor progression [ 9 ]. (biomedcentral.com)

Th1 cells that produce IL-2, IFN- γ , TNF- α, and TNF- β evoke cell-mediated immunity and phagocyte-dependent inflammation while Th2 cells that produce IL-5, IL-4, IL-6, IL-10, and IL-13 induce a strong antibody response that comprises the IgE class and eosinophil accumulation, but it inhibits several functions of phagocytic cells [ 7 ]. (hindawi.com)
We show that the monocyte:macrophage balance is disrupted in colon inflammation to favour recruitment of CD14 + HLA-DR Int cells in humans, and Ly6C Hi monocytes in mice. (frontiersin.org)
In contrast, murine colon monocytes are pro-inflammatory but infrequent in the steady state, increasing during inflammation ( 2 , 8 - 10 ). (frontiersin.org)
Previous studies have shown the accumulation of human CD14 Hi or CD14 + HLA-DR Int cells in the GI tract lamina propria (LP) during inflammation ( 2 , 6 , 11 - 14 ). (frontiersin.org)
Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)
In contrast, regulatory T cells (Tregs) play a cardinal role in protecting against autoimmune diseases, inflammation and tissue damage 13 through secretion of IL-10 (ref. 14 ) and other mechanisms. (nature.com)
They can be subdivided based on such as age of onset, presence of allergy (skin prick test or systemic allergen specific immunoglobulin E (IgE)), with or without nasal polyps and/or T helper (Th) cell 2 prominent inflammation. (encyclopedia.pub)
Skin inflammation during contact hypersensitivity is mediated by early recruitment of CD8 + T cytotoxic 1 cells inducing keratinocyte apoptosis. (medecinesciences.org)
Dual role of dendritic cells in the induction and down-regulation of antigen-specific cutaneous inflammation. (medecinesciences.org)
Innate CD4 + CD25 + regulatory T cells are required for oral tolerance and inhibition of CD8 + T cells mediating skin inflammation. (medecinesciences.org)
A comparative study between T regulatory type 1 and CD4 + CD25 + T cells in the control of inflammation. (medecinesciences.org)
in contrast, are implicated as effector cells in helminthic infections, releasing their many cytoplasmic granules, containing toxic molecules, in response to antigenic stimuli.8 Moreover, they notably contribute to allergic inflammation at airway mucosal sites.9 Recent studies have also demonstrated that eosinophils are able to function as antigen-presenting cells (APCs). (dnametabolism.com)
Pulmonary exposure to NQ dose-dependently aggravated antigen-related airway inflammation, as characterised by infiltration of eosinophils and lymphocytes around the airways and an increase in goblet cells in the bronchial epithelium. (ersjournals.com)
Eosinophils are a prominent feature in the pulmonary inflammation that is associated with allergic airway diseases, suggesting that inhibition of interleukin-5 is a viable treatment. (biomedcentral.com)
The present review addresses the data that relate interleukin-5 to pulmonary inflammation and function in animal models, and the use of neutralizing anti-interleukin-5 monoclonal antibodies for the treatment of asthma in humans. (biomedcentral.com)
Therefore, exclusively inhibiting the actions of interleukin-5 can suppress at least one of the alleged causes of asthma, namely tissue damage due to eosinophil accumulation during pulmonary inflammation. (biomedcentral.com)
In the course of RA, the BM microenvironment can promote the development of Th17 cell responses and overproduction of IL-17AF that may lead to increased inflammation and tissue destruction in RA BM. (biomedcentral.com)
A Deficiency in the Cytokine TNFSF14/LIGHT Limits Inflammation and Remodeling in Murine Eosinophilic Esophagitis. (ucsd.edu)

however, follicular dendritic cells may acquire MHC Class II proteins via exosomes that become attached to them). (wikipedia.org)
Other cellular components of the innate immune system include mononuclear phagocytes, dendritic cells, and NK cells. (medscape.com)
Dendritic cells-based therapeutic approach may be a potential strategy for SARS-CoV-2 infection. (medsci.org)
Basis of treatment based dendritic cells to combat coronavirus infections is summarized. (medsci.org)
Human CD4 + T lymphocytes with remarkable regulatory functions on dendritic cells and nickel-specific Th1 immune responses. (medecinesciences.org)
However, although it is dendritic cells of the immune system have been implicated in clear that the first months of life represent a crucial time win- mediating the increased translocation level. (sagepub.com)
17. Kawamura, K. Virus-stimulated plasmacytoid dendritic cells induce CD4+ cytotoxic regulatory T cells / K. Kawamura [et al. (niidi.ru)
Because the cytokine profile of Th cells is often regulated by dendritic cells (DC), we studied the modulatory effects of GA on the T cell regulatory function of human DC. (aai.org)
Dendritic cells (DC) 3 make up a family of highly specialized cells that upon activation by pathogens or their products mature into professional APC. (aai.org)

Epithelial cell adhesion molecules (EpCAM) are highly expressed in many carcinomas and regulate the epithelial-mesenchymal transition, which is required for tumor metastasis. (bvsalud.org)
The upper portion of the female reproductive tract consists of the fallopian tubes, uterus body, and endocervix, which has columnar epithelial cells and is distincted from ectocervix which is part of the lower tract characterized by squamous epithelial cells [ 4 , 6 ]. (hindawi.com)
In this issue of JCI Insight, Glisinski and colleagues report that the inflammatory cytokine IL-13 markedly altered self-renewal and differentiation of type 2 alveolar epithelial cells (AEC2s), resulting in ectopic expression of bronchial cell-associated markers and a hyperplastic phenotype. (jci.org)
It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. (cancerindex.org)
Interleukin-13-stimulated human nasal mucosa epithelial cells were used for in vitro studies. (balkanmedicaljournal.org)
In human nasal mucosa epithelial cells, interleukin-13 enhanced SOX11 expression in a time-dependent manner, and signal transducer and activator of transcription 6 (STAT6) was involved in the interleukin-13-mediated expression of SOX11 by regulating transcription. (balkanmedicaljournal.org)
Knockdown of SOX11 reduced epithelial-derived cytokine expression and MUC5AC levels in interleukin-13-treated human nasal mucosa epithelial cells. (balkanmedicaljournal.org)
Although the aetiology of these disorders remains unknown, in this review we analyse the pathogenic mechanisms by cell of interest (fibroblast, fibrocyte, myofibroblast, endothelial and alveolar epithelial cells and immune competent cells). (ersjournals.com)
He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)
Isoforms of Wilms' tumor suppressor gene (WT1) have distinct effects on mammary epithelial cells. (famri.org)

Both innate and adaptive immune responses - ranging from leukocyte mobilization, trafficking, and chemotaxis to cytokine release and T cell differentiation -are mediated in a time of day-dependent manner. (jci.org)
IL-23-dependent, IL-17A-producing CD4+ T cells (Th-17 cells) have been identified as a unique subset of Th cells that develops along a pathway that is distinct from the Th1- and Th2- cell differentiation pathways. (thermofisher.com)
Reactivation of the gammaherpesviruses Epstein-Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV) and murine gammaherpesvirus 68 (MHV68) from latently infected B cells has been linked to plasma cell differentiation. (prelekara.sk)
We have previously shown that the MHV68 M2 protein is important for virus reactivation from B cells and, when expressed alone in primary murine B cells, can drive B cell differentiation towards a pre-plasma cell phenotype. (prelekara.sk)
Together, these studies argue in favor of a model wherein M2 activation of the NFAT pathway initiates events leading to increased levels of IRF4 - a key player in plasma cell differentiation - which in turn triggers IL-10 expression. (prelekara.sk)
In the context of previous findings, the data presented here provides insights into how M2 facilitates plasma cell differentiation and subsequent virus reactivation. (prelekara.sk)
We show that NAD + regulates CD4 + T-cell differentiation through tryptophan hydroxylase-1 ( Tph1 ), independently of well-established transcription factors. (nature.com)
Our findings unravel a new pathway orchestrating CD4 + T-cell differentiation and demonstrate that NAD + may serve as a powerful therapeutic agent for the treatment of autoimmune and other diseases. (nature.com)
Although differentiation of naïve CD4 + T cells has been considered to be an irreversible process, accumulating evidence suggests that T cells are much more flexible than initially believed with the ability to interchange between helper phenotypes 15 . (nature.com)
SRY-box transcription factor 11 (SOX11) is a member of the SOX C protein family and is implicated in multiple biological processes, such as neurogenesis, cell differentiation, and embryonic development. (balkanmedicaljournal.org)
Differentiation into Th1 depends on the presence of IFN-γ and IL-12, which bind to receptors on the surface of CD4 T cells 5 . (bvsalud.org)
This binding initiates a cascade of events that culminates in differentiation into Th1 cells, by increasing the transcription factor T-bet 12 . (bvsalud.org)
Th2 cells have a differentiation process which is dependent on IL-4, which causes the activation of the transcription factor STAT 6 . (bvsalud.org)
GATA-3 acts as a master regulator of Th2 differentiation 12-13 . (bvsalud.org)

If the antigen expresses appropriate molecular patterns (sometimes known as signal 0), it can induce maturation of the dendritic cell which results in enhanced expression of costimulatory molecules needed to activate T cells (see signal 2) and MHC Class II. (wikipedia.org)
Schistosomes are known to downregulate host immune responses and to induce a modified Th2 response [ 13 ]. (hindawi.com)
IFN-α (interferon-alpha) is known to stimulate NK (natural killer ) cells, induce MHC (major histocompatibility complex) class I response, augments the ability of Th1 (T-helper cells) and increase antibody recognition -- all mechanisms that stimulate the immune response in the bladder [2,3]. (blogspot.com)
Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse IL-17A receptor. (thermofisher.com)
In addition, it was recently shown that Th17 cells that were generated with transforming growth factor (TGF)-β and IL-6 were not pathogenic and did not induce EAE without exposure to IL-23 (ref. 23 ). (nature.com)
Previous studies have indicated that organic chemicals extracted from DEP result in induction of apoptosis 11 , increase oxidative stress 12 , and induce the production of inflammatory cells 13 - 15 through the release of pro-inflammatory molecules in vitro 15 , 16 . (ersjournals.com)
DC exposed to GA induce effector IL-4-secreting Th2 cells and enhanced levels of the anti-inflammatory cytokine IL-10. (aai.org)
RT can directly induce cancer cell death through various mechanisms, such as apoptosis, necrosis, and autophagy. (nature.com)

The hallmark effector molecules of Th1 and Th2 cells, e.g. (thermofisher.com)
Each distinct CD4 + T-cell subset has a specific function and can mainly be distinguished by its cytokine profile, the expression pattern of cell surface molecules, and the activation of specific transcription factors 8 . (nature.com)
Through gene knockout studies he has shown that these molecules act as a type of molecular "Teflon" to make cells more mobile and invasive and also facilitate chemotaxis. (ubc.ca)
The eosinophils express major histocompatibility complex (MHC) class I and class II, and the costimulatory molecules CD28, CD40, CD80 and CD86, suggesting that these cells can directly communicate with T cells to regulate immune responses. (dnametabolism.com)
The current authors have recently shown that PQ induces recruitment of inflammatory cells, such as eosinophils and neutrophils, into the lung with the lung expression of pro-inflammatory molecules such as interleukin (IL)-5 and eotaxin in vivo 24 . (ersjournals.com)
In this review, we discuss the changes in irradiated cancer cells and immune cells in the TME under different RT regimens and describe existing and potential molecules that could be targeted to improve the therapeutic effects of RT. (nature.com)

In addition, we are investigating the role of innate immune cells such as natural killer (NK) cells in innate and adaptive immune responses to these viruses. (dukecancerinstitute.org)
Both T helper 1 (Th1) and T helper 2 (Th2) responses are induced in response to the infection [ 3 ]. (hindawi.com)
Helminth infections are typically linked with Th2-dependent responses leading to IgE production and eosinophilia. (hindawi.com)
For schistosomiasis, Th2 responses with the production of IgE antibodies against a restricted range of adult worm antigens are associated with protection against reinfection after chemotherapy. (hindawi.com)
Individuals in whom Th2 responses against egg antigens predominate show less severe egg-associated morbidity than those where Th1 responses predominate. (hindawi.com)
Consequently, Th2-mediated responses are thought to be selectively advantageous to the human host in S. mansoni infection and perhaps other helminth infections [ 13 ]. (hindawi.com)
Interleukin-17A (IL-17A) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. (thermofisher.com)
1 The clinical manifestations of AR are caused by a series of inhalant allergen-induced type 2 helper T (Th2) cell responses, including excessive allergen-specific immunoglobulin E (IgE) release, mast cell activation, eosinophil infiltration, and goblet cell hyperplasia. (balkanmedicaljournal.org)
The goal of this study was to explore a RIG-I agonist (SDI-nanogel) and a TLR7/8 agonist (Imidazoquinoline (IMDQ)‐PEG‐Chol) as adjuvants, when co-administered with a licensed quadrivalent inactivated influenza vaccine (QIV), and to determine the role of these adjuvants in directing helper T (Th) cell responses for their role in the immunoglobulin (Ig) class switching. (researchsquare.com)
Administration of QIV with the two adjuvants, individually or combined, resulted in enhanced HA-specific serum ELISA IgG titers, serum hemagglutination inhibition (HAI) titers and splenic T cell responses as examined by IFN-γ and IL-4 enzyme-linked immunosorbent spot (ELISPOT) assays, 4-weeks post-prime and post-boost vaccination in BALB/c mice. (researchsquare.com)
While QIV+SDI-nanogel largely induced antigen-specific IgG1 responses, QIV+IMDQ-PEG-Chol predominantly induced IgG2a antibody isotypes post-prime vaccination, suggesting efficient induction of Th2 (IL-4) and Th1 (IFN-γ) responses, respectively. (researchsquare.com)
Vaccine-induced antibody and T cell responses correlated with protection against lethal influenza virus infection. (researchsquare.com)
Protective anti-influenza immunity often correlates with antibody responses to influenza surface glycoproteins, particularly hemagglutinin (HA), the main antigenic determinant on the surface of both influenza virus and infected cells. (researchsquare.com)
Dubois B, Chapat L, Goubier A, Kaiserlian D. CD4 + CD25 + T cells as key regulators of immune responses. (medecinesciences.org)
CD4 + T cells regulate CD8 + T cell-mediated cutaneous immune responses by restricting effector T cell development through a Fas ligand-dependent mechanism. (medecinesciences.org)
CD8 + T cells produce IL-2, which is required for CD4 + CD25 + T cell regulation of effector CD8 + T cell development for contact hypersensitivity responses. (medecinesciences.org)
Mounting evidence has shown several deficiencies of adaptive immunity in neonates and infants for both cell- and antibody-mediated responses. (dnametabolism.com)
Although it has become clear that GA induces protective degenerate Th2/IL-10 responses, its precise mode of action remains elusive. (aai.org)
IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. (tamu.edu)
Heterologous immunization with defined RNA and subunit vaccines enhances T cell responses that protect against Leishmania donovani. (ac.ir)
Therefore, murine airway CD8 + T cell-responses to aspiration of Aspergillus conidia may be mediated in part by the ability of conidia to germinate in the host lung tissue. (cdc.gov)

To date, several CD4 + Th cell subsets have been described. (nature.com)
New insights into the complex cellular contributions and interactions will be provided, comparing the role of cell subsets in the pathogenesis of IPF and systemic sclerosis. (ersjournals.com)
We identified differentially methylated regions (DMRs) and differentially hydroxymethylated regions (DHMRs) between ILC and NK cell subsets and correlated them with transcriptional signatures. (stanford.edu)
In the T cell areas of lymphoid organs, mature effector DC not only present pathogen-derived peptides to T cells, but also adapt the class of immune response to the type of invading pathogen by driving the development of protective effector Th cell subsets. (aai.org)

This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. (cancerindex.org)
Remarkably, Clec4a4+ eosinophils were instructed by the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor that imprints many gut immune cells. (stanford.edu)
Interleukin-5 is produced by a number of cell types, and is responsible for the maturation and release of eosinophils in the bone marrow. (biomedcentral.com)
In humans, interleukin-5 is a very selective cytokine as a result of the restricted expression of the interleukin-5 receptor on eosinophils and basophils. (biomedcentral.com)
Further trials designed to measure eosinophil accumulation and lung function in asthmatic persons are currently underway, and will help to define the role of interleukin-5 and eosinophils in general in this disease. (biomedcentral.com)
In patients with papular or nodular lesions, perivascular mixed cellular infiltrates (eosinophils and other cell types) are present. (medscape.com)

Clinically, EBV-associated malignancies such as Hodgkin's lymphoma offer a unique model to explore antigen-defined immunotherapy approaches because EBV-derived tumor antigens are specific for tumor cells only. (dukecancerinstitute.org)
Role of interleukin-10 in specific immunotherapy. (medecinesciences.org)
Immunotherapy mainly includes immune checkpoint inhibitors (ICIs), such as inhibitors of PD-1 (programmed cell death 1)/programmed cell death ligand 1 (PD-L1). (nature.com)
One study reported an increased survival benefit with simultaneous RT compared with sequential administration, 8 while another study found no significant difference between the two strategies, 9 possibly because simultaneous RT plus immunotherapy and the administration of an ICI before RT may kill cancer cells as well a substantial number of immune cells, leading to poor systemic response and toxic side effects. (nature.com)
This has led to the need for new immunotherapy-based approaches, including adoptive cell transfer (ACT), therapeutic vaccines, and novel immune checkpoint inhibitors. (biomedcentral.com)
The use of cell therapies, drivers of immune response, and trends in immunotherapy were the focus of the Immunotherapy Bridge (November 30th-December 1st, 2022), organized by the Fondazione Melanoma Onlus, Naples, Italy, in collaboration with the Society for Immunotherapy of Cancer. (biomedcentral.com)
This has resulted in the development of additional immunotherapy-based approaches, including adoptive cell transfer (ACT), therapeutic vaccines, and inhibitors of other immune checkpoints. (biomedcentral.com)
The use of cell therapies, drivers of immune response, and trends in immunotherapy were the focus of the Immunotherapy Bridge (November 30th-December 1st, 2022). (biomedcentral.com)
However, chimeric antigen receptor T (CAR-T) cell immunotherapy and immune checkpoint blockade (ICB), which have produced unprecedented clinical benefits in a variety of different cancers, produce promising results in only some highly selected patients with PDAC. (biomedcentral.com)

According to previous studies, recombinant interleukin (IL)-10 protein and genetically modified bacteria secreting IL-10 ameliorate dextran sulfate sodium (DSS)-induced colitis in mice. (bvsalud.org)
Animal models with recombinant IL-2-secreting strains of BCG have shown an enhanced antitumor cytotoxicity and local immune response when compared with BCG alone [14-16]. (blogspot.com)

Furthermore, EpCAM overexpression induces tumor cells to develop a stem cell-like phenotype and promotes tumor progression. (bvsalud.org)
Moreover, these receptors are functional, as treatment of FRT tissue cells with ligands for TLR and NOD induces production of proinflammatory CXCL8 [ 13 ], and those receptors actively participate in immune response to pathogens, as Neisseria gonorrhea and HIV-1 [ 14 ]. (hindawi.com)
This signal together with the T Cell Receptor (TCR) induces the expression of GATA-3. (bvsalud.org)

In addition, expression of M2 in primary murine B cells leads to secretion of high levels of IL-10 along with enhanced proliferation and survival. (prelekara.sk)
Vaccines face multiple issues, such as the low activity of neutralizing antibodies after immunization, or the aggravation of pathological reactions from the imbalance of Th1/Th2 cytokine secretion after formalin inactivated hRSV is administered. (fortunejournals.com)

T cells require antigens to be processed into short fragments which form linear epitopes on MHC Class II (in the case of helper T cells because they express CD4) or MHC class I (in the case of cytotoxic T cells which express CD8). (wikipedia.org)
During an immune response, professional antigen-presenting cells (APCs) endocytose antigens (typically bacteria or viruses), which undergo processing, then travel from the infection site to the lymph nodes. (wikipedia.org)
In phase 2, as the parasites mature and reproduce with the production of eggs, the Th1 response is reduced and a strong Th2 response develops, induced mostly by egg antigens. (hindawi.com)
Type II, or "cytotoxic" hypersensitivity, results from the binding of IgG or IgM antibodies to cell membranes or fixed tissue antigens, causing activation of the complement system. (mcgill.ca)
The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)
Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)
In addition, tumor-associated antigens (TAAs) produced by irradiated tumor cells can be captured by antigen-presenting cells (APCs) in the TME and presented to T cells. (nature.com)
One is the ability to administer large numbers of highly selected cells with high avidity for tumor antigens that can recognize shared and patient-specific mutated (neo) antigens. (biomedcentral.com)

Airway IFN-γ + CD8 + T-cells were decreased and lung germination was eliminated in mice that aspirated A. fumigatus conidia that were formaldehyde-fixed or heat-inactivated. (cdc.gov)
Furthermore, A. fumigatus particles exhibited greater persistence in the lungs of recipient mice when compared to non-viable A. fumigatus or A. versicolor , and this correlated with increased maintenance of airway memory-phenotype CD8 + T cells. (cdc.gov)

In recent years, it was shown that T helper 17 (Th17) cells are involved in the pathogenesis of IBD, which makes them an attractive therapeutic target. (mdpi.com)
Th17 cell may have a role in severe asthma and chronic obstructive pulmonary disease (COPD). (cdc.gov)
More recently, the role of Th1 and Th17 CD4 + cells in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), the most commonly used experimental model for human MS, has been challenged, and it has been demonstrated that the transcription factor T-bet (also known as Tbx21 ) is critical for controlling Th1/Th17-mediated autoimmunity 12 . (nature.com)
It has been shown that Th17 cells can also co-express Foxp3 or T-bet 18 , 19 , which are the master regulators of Tregs and Th1 cells, respectively. (nature.com)
Thus, these reports suggest the existence of broad plasticity of Th1 and Th17 cells. (nature.com)
Interleukin-17 is predominantly expressed by a specific subset of human T-helper cells-Th17 cells. (biomedcentral.com)
In the present study we hypothesized that the RA BM microenvironment supports the development of Th17 cells and Th17 cell response. (biomedcentral.com)
In addition to Th1 and Th2 cells, Th17, Treg and T Fh cells have also been described 7 , Treg cells are associated with reduction of clinical scores of disease in soft and hard tissues 8 . (bvsalud.org)
Usually, protective and destructive roles are assigned to the Th1 and Th17 3,9-11 cells, while Th2 and Treg cells are more involved in processes that reduce the destruction of the periodontium 10 . (bvsalud.org)

Overexpressed EZH2 resulted in downregulation of SULF1 in chondrosarcoma cell lines, which in turn activated cMET pathway. (bvsalud.org)
Here, employing an inducible B cell expression system, we have determined that M2 activates the NFAT pathway in a Src kinase-dependent manner - leading to induction of the plasma cell-associated transcription factor, Interferon Regulatory Factor-4 (IRF4). (prelekara.sk)
In primary murine B cells, addition of cyclosporine (CsA) resulted in a significant decrease in M2-induced IL-10 levels as well as IRF4 expression, emphasizing the importance of the NFAT pathway in M2- mediated induction of IL-10. (prelekara.sk)
Murine Gammaherpesvirus M2 Protein Induction of IRF4 via the NFAT Pathway Leads to IL-10 Expression in B Cells. (prelekara.sk)
In studies on mouse mammary carcinoma, the IL-33/ST2 pathway promotes BC progression and metastasis through increased intratumoral accumulation of immunosuppressive cells and by diminishing innate anti-tumor immunity ( 11 ). (frontiersin.org)

The mice were intravenously injected with B16F10 and CT26 cells pre-incubated with or without Salmonella, and the survival of tumor-bearing mice in the Salmonella group increased, indicating an antimetastatic effect. (bvsalud.org)
4. UsherwoodEJ, StewartJP, RobertsonK, AllenDJ, NashAA (1996) Absence of splenic latency in murine gammaherpesvirus 68-infected B cell-deficient mice. (prelekara.sk)
An in vivo murine allergic rhinitis model was established using ovalbumin treatment in female mice. (balkanmedicaljournal.org)
The introduction of β-cell autoantigens via the gut through Lactococcus lactis ( L. lactis ) has been demonstrated to be a promising approach for diabetes reversal in NOD mice. (silverchair.com)
Here we show that a combination therapy of low-dose anti-CD3 with a clinical-grade self-containing L. lactis , appropriate for human application, secreting human proinsulin and interleukin-10, cured 66% of mice with new-onset diabetes, which is comparable to therapy results with plasmid-driven L. lactis . (silverchair.com)
Given that IL-10 is a Th2 cytokine and downregulates IFN-α production [[56, 57]], early expression in Irf5−/− mice may indirectly contribute to reduction of the type I IFN signature. (reninsignaling.com)
To this extent, we also provide evidence that T-cell polarization is altered in Irf5−/− mice and that IRF5 has a critical role in T-cell activation. (reninsignaling.com)
We observed a significant increase in IFN-γ-producing CD8 + T cells in bronchoalveolar lavage fluid (BALF) of immunocompetent mice that repeatedly aspirated A. fumigatus conidia in contrast to mice challenged with A. versicolor , a species that is not typically associated with invasive, disseminated disease. (cdc.gov)

Interleukin (IL)-2 is a cytokine that enhances the production of cytotoxic lymphocytes capable of lysing tumor cells while leaving benign cells unharmed -- IL-2 activated lymphocytes are known as "lymphocyte-activated killer" or LAK cells [8,9]. (blogspot.com)
The tumor of case 2 predominantly showed the features of papillary ependymoma, and some tumor cells were swollen and contained similar eosinophilic granules. (dehydrogenase-signal.com)
Immune cells engage in extensive and dynamic crosstalk with stromal components in the tumor tissue in addition to tumor cells, which subsequently impacts tumor suppression or promotion to a large extent. (biomedcentral.com)

We explored whether LPL affects (a) lipoprotein transport across bovine aortic endothelial cells or (b) lipoprotein binding to subendothelial cell matrix (retention). (jci.org)
However, PDAC is characterized by an abundant tumor stroma that includes a heterogeneous mixture of immune cells, fibroblasts, endothelial cells, neurons and some molecular events. (biomedcentral.com)

Innate immunity includes barriers such as the epithelium, mucus, pH, complement system, and cells of the immune system. (hindawi.com)
Eliciting long-lived memory T cell response is an ultimate goal of vaccination to provide long-term immunity against cancer. (dukecancerinstitute.org)
Accumulating evidence has shown that the immunosuppressive CD4+CD25+Foxp3+ regulatory T cells (T Reg ) play a critical role in the suppression of anti-tumor immunity. (dukecancerinstitute.org)
Innate immunity resides in the skin, mucous membranes, polymorphonuclear (PMN) cells, complement system, and a select group of cells that possess cytotoxic capabilities. (medscape.com)
Spatial distribution of LTi-like cells in intestinal mucosa regulates type 3 innate immunity. (stanford.edu)
Murine breast carcinoma models suggest disruption of ST2 signaling may enhance the anti-tumor immune response, suggesting IL-33 impedes anti-tumor immunity. (frontiersin.org)
revealing a strong granulomatous response and a low susceptibility to disseminated infections.3 T-cell-mediated immunity is a critical component of protective immunity against infection with C. neoformans. (dnametabolism.com)
3. Sakaguchi, S. Immunologic tolerance maintained by CD25+CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance / S. Sakaguchi, N. Sakaguchi, J. Shimizu // Immunol. (niidi.ru)
10. Gurk, P. Pathogen-specific regulatory T cells provoke a shift in the Th1/Th2 paradigm in immunity to infectious diseases / P. Gurk, K. Mills // Trends in Immunol. (niidi.ru)
15. Rouse, B. Regulatory T cells and immunity to pathogens /B. Rouse, S. Suvas // Expert. (niidi.ru)
12. Scott P. Development and regulation of cell-mediated immunity in experimental leishmaniasis. (ac.ir)
Some tumor cell-inherent resistance mechanisms, such as the tumor mutational burden and aberrant expression of oncogenic pathways, restrain antitumor immunity [ 10 ]. (biomedcentral.com)

Myeloid cell populations isolated from colonic inflammatory bowel disease (IBD) or murine dextran sulphate sodium (DSS) induced colitis were assessed using flow cytometry and compared to healthy controls. (frontiersin.org)
T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production : interferon gamma-producing (Tc1) effector CD8 + T cells and interleukin (Il) 4/Il-10-producing (Th2) negative regulatory CD4 + T cells. (medecinesciences.org)

A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma. (tamu.edu)

type IV-B results from the direct killing of target cells by cytotoxic T lymphocytes (CTL). (mcgill.ca)
There is also a need for rational combinations beyond interleukin (IL)-2 and programmed death (PD)-1/ cytotoxic T-lymphocyte-associated antigen (CTLA)-4 immune checkpoint blockade and to combat exhaustion and restore costimulatory functions, e.g., with gene-engineered or pharmacologic agent-treated TILs. (biomedcentral.com)
The immunosuppressive TME of PDAC is characterized by T cell exhaustion resulting in the loss of cytotoxic effector functions. (biomedcentral.com)

However, little is known about how T Reg suppress T cell activation in vivo. (dukecancerinstitute.org)
Furthermore, the absence of M2 in vivo leads to a defect in the appearance of MHV68 infected plasma cells in the spleen at the peak of MHV68 latency. (prelekara.sk)
This review discusses the anti-inflammatory properties of cannabinoid compounds at molecular, cellular and whole animal levels, first by examining the evidence for anti-inflammatory effects of cannabinoids obtained using in vivo animal models of clinical neuroinflammatory conditions, specifically rodent models of multiple sclerosis, and second by describing the endogenous cannabinoid (endocannabinoid) system components in immune cells. (420magazine.com)
These cells can be activated ex vivo to exhibit a potent antitumor effector function. (biomedcentral.com)
The study and/or manipulation of administered cells can potentially result in identification of the exact cell subpopulations and effector functions required for cancer regression in vivo. (biomedcentral.com)

In addition, we identify that murine blood monocytes receive systemic signals enabling increased release of IL-1β prior to egress from the blood into the colon. (frontiersin.org)
Further, once within the colon and relative to other myeloid cells, monocytes represent the dominant local source of both IL-1β and TNF. (frontiersin.org)
Results from murine studies ( 2 ) combined with the observation of radiolabelled blood monocytes in the inflamed intestinal mucosa of IBD patients ( 15 ), indicate that increased LP inflammatory mononuclear cells are a result of monocyte recruitment, rather than expansion of a tissue resident macrophage population. (frontiersin.org)
Additionally, IL-2 augments the immune system through a variety of interactions with NK cells, monocytes and Th1 cells [9,10]. (blogspot.com)

We investigated the homing-related chemokine expression levels of MSCs treated with a prostate cancer cell line (PC-3) -conditioned medium. (cancerindex.org)

Stimulation of cells by anti-receptor autoantibodies (such as the anti-TSH receptor antibodies of Graves' disease) has been designated as type V hypersensitivity by some authors. (mcgill.ca)
Antibodies (immunoglobulin (Ig) A, IgD, IgE, IgG, IgM) are secreted by B-cells that are activated to plasma cells after antigen presentation in regional lymph nodes or secondary lymphoid organs ( Figure 1 ) [ 9 ] . (encyclopedia.pub)
Monoclonal antibodies (mAbs) come from a single B-cell parent clone and recognize specifically a single epitope per antigen [ 10 ] . (encyclopedia.pub)
Antibodies are crucial to make leukocytes (such as T killer cells) to detect and destroy pathogens and infected host cells. (encyclopedia.pub)
Clinical trials with humanized antibodies against interleukin-5 have begun. (biomedcentral.com)

A review of studies published in Pharmacology OnLine Newsletter found effectiveness on murine cytomegalovirus infection, avian influenza (H9N2), Schistosoma Mansoni Infection, PPR virus, Broad bean mosaic virus, HIV, Hepatitis C Virus, Zucchini Yellow Mosaic Virus, and Papaya Ring Spot Virus [iv] . (herbalpharmacist.com)

In a matrigel invasion assay, interferon-gamma, a specific inhibitor of eotaxin-related homing, significantly reduced the transmigration of PC-3 cells, under co-cultured condition with MSCs, in a dose-dependent manner (P (cancerindex.org)
Interferon-γ is a potent multifunctional cytokine which is secreted primarily by activated NK cells and T cells. (biolegend.com)

In general, mature naive T cells are stimulated by professional antigen presenting cells to acquire an effector module. (wikipedia.org)
Class II MHC proteins are generally only found on the surface of professional antigen-presenting cells (APCs). (wikipedia.org)
IFN-γ can upregulate MHC class I and II antigen expression by antigen-presenting cells. (biolegend.com)

11. Weiner, H. Induction and mechanism of action of TGF- β-secreting regulatory cells / H. Weiner // Immunol. (niidi.ru)

Following docking of SARS-CoV-2 onto ACE2 receptors (mostly in lungs and GI), and virus-cell membrane fusion via TMPRSS2 and FURIN , a cascade of enzymatic steps and subsequent immune system mobilization occurs. (mthfrsupport.com)

Cryptolepine-induced cell death of Leishmania donovani promastigotes is augmented by inhibition of autophagy. (ac.ir)

Soluble interleukin 23 receptor gene therapy with adeno-associated vectors for the treatment of multiple sclerosis. (benthamscience.com)

The first technique described in 1975 was based on creating a hybridoma by combining an activated B-cell from an immunized animal spleen and immortalized myeloma cell, resulting in a stable hybrid cell line producing monoclonal antibody [ 11 ] . (encyclopedia.pub)

The T helper cells (Th cells), also known as CD4+ cells or CD4-positive cells, are a type of T cell that play an important role in the adaptive immune system. (wikipedia.org)
CD4+ T cells are generally treated as having a pre-defined role as helper T cells within the immune system. (wikipedia.org)
The adaptive immune system consists of 2 types of lymphocytes: T cells (70-75% of the adaptive immune force) and B cells (10-20% of the adaptive immune force). (medscape.com)
NK cells are specialized effectors of the innate immune system that destroy their targets by antibody-dependent cell-mediated cytotoxicity, have prominent antitumor effects, and are potent killers of virally infected cells. (medscape.com)
Dendritic cell as sentinel of the immune system plays an irreplaceable role. (medsci.org)
8. Chen, W. CD4+CD25+ T regulatory cells and TGF-beta in mucosal immune system: the good and the bad / W. Chen,S. Perruche, J. Li // urr. (niidi.ru)
We have also selected relevant genes that are associated with protection of cell wall permeability and may assist with modulation of your immune system. (mthfrsupport.com)
This can be either stimulates or suppresses the immune system and may help the body fight abnormal cell production, infection, or other diseases. (herbalpharmacist.com)
The prevention and elimination of cancer cells are dependent on the host's immune system. (biomedcentral.com)

However, some immune cells are immunosuppressive or transform into immunosuppressive phenotypes under specific conditions, leading to the development of radioresistance. (nature.com)
CD4 T cells may assume different phenotypes under different stimulations, changing to Th1 and Th2 cells. (bvsalud.org)

These recent thymic emigrants exhibit a defect in their acquisition of the Th1 function, whereas transitional B cells are less functionally effective than mature naive B cells. (dnametabolism.com)

CD4+ cells are mature Th cells that express the surface protein CD4. (wikipedia.org)
Mature Th cells express the surface protein CD4 and are referred to as CD4+ T cells. (wikipedia.org)
Combined exposure to NQ and antigen enhanced the local expression of interleukin (IL)-4, IL-5, eotaxin, macrophage chemoattractant protein-1 and keratinocyte chemoattractant, compared with exposure to antigen or NQ alone. (ersjournals.com)
Long-term activation of protein kinase c causes chronic Na/H antiporter stimulation in cultured proximal tubule cells. (jci.org)
To examine the role of protein kinase C as a chronic regulator of proximal tubule Na/H antiporter activity, the effect of phorbol 12-myristate 13-acetate (PMA) on the Na/H antiporter was studied in cultured proximal tubule cells. (jci.org)
Bae KM, Wang H, Jiang G, Chen MG, Lu L, Xiao L. Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner. (famri.org)

1993), expressed primarily by immune cells. (420magazine.com)

Different immunoglobulin G (IgG) subclasses produced by class-switched B cells help in opsonization and virus neutralization and hence, facilitate viral clearance from the host. (researchsquare.com)

Hawrylowicz CM, O'Garra A. Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma. (medecinesciences.org)

Type I hypersensitivity reactions result from IgE-dependent degranulation of mast cells or basophils. (mcgill.ca)

Moreover, Th1 IFN-γ-producing cells have been shown to have the capacity to produce the immunosuppressive cytokine IL-10, initially considered a Th2 cytokine 20 . (nature.com)

The first mAbs used in therapeutic purposes were of murine origin, which generated unwanted immunogenic reactions and human anti-mouse antibody formation [ 12 ] . (encyclopedia.pub)
Given the current data in human SLE and murine models of lupus [[35, 36, 39]], it would be expected that factors capable of regulating the Th1/Th2 balance would potentially alter lupus development. (reninsignaling.com)
Clinical activity of TIL therapy has also been reported in other cancer types, including human papillomavirus-associated cancers, cholangiocarcinoma, non-small-cell lung cancer (NSCLC), and triple-negative breast cancer (TNBC). (biomedcentral.com)
Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. (famri.org)

Recent studies demonstrated that high serum levels of soluble ST2 (sST2) are a worse prognostic factor in hepatocellular carcinoma ( 9 ), and that serum IL-33 is a diagnostic and prognostic marker in non-small cell lung cancer, independent of the therapeutic intervention ( 10 ). (frontiersin.org)
The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
Therefore, exploration of the interactions between the stroma and immune cells may offer new therapeutic opportunities for PDAC. (biomedcentral.com)

Maturation of RTE in SLO results in the generation of mature naive T cells (naïve meaning they have never been exposed to the antigen that they are programmed to respond to), but naive T cells now lack or have downregulated (reduced) expression of the RTE-related surface markers, such as CD31, PTK7, Complement Receptor 1 and 2 (CR1, CR2) and the production of interleukin 8 (IL-8). (wikipedia.org)
In this study, we aimed to investigate whether the expression of the murine IL-19 gene carried by Salmonella choleraesuis (S. choleraesuis) could ameliorate murine IBD. (bvsalud.org)
Furthermore, we show that expression of IRF4 alone in a B cell line up-regulates IL-10 expression in culture supernatants, revealing a novel role for IRF4 in B cell induced IL-10. (prelekara.sk)
reported that transgenic expression of IL-33 may activate CD8(+) T cells and NK cells, and inhibit tumor growth and metastasis in B16 melanoma and Lewis lung carcinoma metastatic models ( 12 ). (frontiersin.org)
to the Th2-type response), and decreased MHC class II expression on APCs [13, 15, 18-20]. (dnametabolism.com)
19. Carpentier, A. Increased expression of regulatory Tr1 cells in recurrent hepatitis C after liver transplantation / A. Carpentier [et al. (niidi.ru)
Aim: To evaluate the involvement of Th2 cells in different periods of the active phase of experimental periodontal disease and expression of the R1 subunit of the receptor for IFN-γ during the early and advanced progression of the disease. (bvsalud.org)
Results: Light microscopy analysis revealed a decreased expression of GATA-3-positive cells when bone loss progressed. (bvsalud.org)
IFN-γ R1 was detected at an early stage during the active phase of disease, but the expression of positive cells remained unaltered during the remaining period of the study. (bvsalud.org)

Th9 cells were first identified as a Th2 subpopulation have many important roles. (cdc.gov)

For example, when an antigen-presenting cell displays a peptide antigen on MHC class II proteins, a CD4+ cell will aid those cells through a combination of cell to cell interactions (e.g. (wikipedia.org)
In this epithelium, as well as in the more fragile single cell layer epithelium of endocervix, the cells are held together by proteins that form desmosomes, tight junctions, and adherens junctions, which decrease its permeability [ 19 ]. (hindawi.com)
There he worked with Dr. Max D. Cooper (Howard Hughes Medical Institute, National Academy of Sciences) and his research focused on cell surface proteins expressed by preB cells that regulate B cell maturation and homing. (ubc.ca)
In addition, he identified a number of novel hematopoietic stem cell surface proteins and began analyzing their function. (ubc.ca)
His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
In this regard, his lab has identified a novel family of hematopoietic cell surface proteins, called the CD34 family, and shown that these are essential for a number of developmentally important processes. (ubc.ca)

This study aimed to clarify the role of mesenchymal stem cells (MSCs) as a component of the cancer microenvironment. (cancerindex.org)
CD4 + T helper (Th) cells play a central role in regulating the adaptive immune response associated with pathogen invasion. (nature.com)
MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. (tamu.edu)
Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development. (tamu.edu)
Conclusions: These results indicate that the Th2 response may have a protective role during the pathogenesis of experimental periodontal disease, and that the IFN-γ R1 subunit may not be associated with periodontal disease progression. (bvsalud.org)

Transferred T cells that persist in the blood and form memory have a phenotype consistent with a less differentiated state (CD27/CD28/IL-7 receptor-α) [ 3 ]. (biomedcentral.com)

He is a member of the Stem Cell Network Centre of Excellence (past member of the Stem Cell Policy Committee and Research Management Committee and current Sub-chair of the Training and Education Committee), and a member of the AllerGen Network Centre of Excellence (Research Management Committee and Co-Chair of the Biomarkers Program). (ubc.ca)

Cell-to-cell interactions set off a cascade of events that may result in T- or B-cell activation and, ultimately, host defense. (medscape.com)

2. Annacker, O. On the ontogeny and phisiology of regulatory T cells / O. Annacker, R. Pimenta-Araujo, O. Burlen- Defra noux // Immunol. (niidi.ru)
14. Mauri, C. The 'short' history of regulatory B cells /C. Mauri, M. Ehrenstein // Trends Immunol. (niidi.ru)

In the chronic phase of infection, forming phase 3, the Th2 response is moderated and granulomas, which form around newly deposited eggs, become smaller than they were earlier during the infection [ 3 ]. (hindawi.com)
The cover image shows expansion of a subset of AEC2s that express the bronchial lineage marker SCGB1A1 (red) in murine-derived organoids in response to IL-13 treatment. (jci.org)
DC exposed to GA have an impaired capacity to secrete the major Th1 polarizing factor IL-12p70 in response to LPS and CD40 ligand triggering. (aai.org)
We show that loss of Irf5 significantly alters cyto-kine production in response to pristane, ultimately skewing the cytokine (and autoantibody) profile toward a Th2-like response, and inhibits the type I IFN signature that is critical for disease pathogenesis in this model of lupus. (reninsignaling.com)
Impaired immune effector cell infiltration and inactivation of the immune response contribute to the poor prognosis of PDAC patients. (biomedcentral.com)

Genetic variation in regulatory elements expressed by CD4+ cells determines susceptibility to a broad class of autoimmune diseases. (wikipedia.org)
3. Regulatory T Cell Biology. (dukecancerinstitute.org)
A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis. (benthamscience.com)
Effector and regulatory T cells in allergic contact dermatitis. (medecinesciences.org)
Paust S, Cantor H. Regulatory T cells and autoimmune disease. (medecinesciences.org)
Sakaguchi S. Naturally arising Foxp3-expressing CD25 + CD4 + regulatory T cells in immunological tolerance to self and non-self. (medecinesciences.org)
Nakamura K, Kitani A, Strober W. Cell contact-dependent immunosuppression by CD4 + CD25 + regulatory T cells is mediated by cell surface-bound transforming growth factor beta. (medecinesciences.org)
6. Ralainirina, N. Control of NK cell functions by CD4+CD25+regulatory T cells / N. Ralainirina, A. Poli, T. Michel // J. Leukoc. (niidi.ru)
9. Cassis, L. Natural versus adaptive regulatory T cells /L. Cassis, S. Aiello, M. Noris // Contrib. (niidi.ru)
13. Lu, L. Generation and regulation of CD8+ regulatory T cells / L. Lu, H. Cantor // Cell. (niidi.ru)
18. Zu, Y. Roles of CD8+CD28- T regulatory cells in acute infectious mononucleosis in children / Y. Zu [et al. (niidi.ru)

12. Trinchieri, G. Interleukin-10 production by effector T cells: Th1 cells show self control / G. Trinchieri // J. Exp. (niidi.ru)
The effect of IL-15 stimulation on IL-17 production by BM mononuclear cells was examined in vitro. (biomedcentral.com)
Finally, abundant in RA BM, IL-15 increased IL-17 production by cultured BM mononuclear cells. (biomedcentral.com)

A non-biased chromatin immunoprecipitation sequence, cDNA microarray analysis, and validation of chondrosarcoma cell lines identified sulfatase 1 (SULF1) as the top EZH2-targeted gene to regulate chondrosarcoma progression. (bvsalud.org)
IFN gamma and IL-4, have each been found to negatively regulate the generation of these Th-17 cells. (thermofisher.com)
Mesenchymal stem cells up-regulate the invasive potential of prostate cancer cells via the eotaxin-3/CCR3 axis. (cancerindex.org)
Consistent with the latter observation, we show that IRF4 can regulate the IL-10 promoter in B cells. (prelekara.sk)
Major histocompatibility complex class I-restricted CD8 + T cells and class II-restricted CD4 + T cells, respectively, mediate and regulate contact sensitivity to dinitrofluorobenzene. (medecinesciences.org)

Anatomy42

Organisms25

Diseases12

Chemicals and Drugs97

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Psychiatry and Psychology1

Phenomena and Processes58

Disciplines and Occupations1

Information Science3

Health Care1

Cytokines24

Macrophages12

Inflammation19

Dendritic cells9

Epithelial10

Differentiation14

Induce8

Molecules6

Responses21

Subsets4

Eosinophils6

Immunotherapy9

Recombinant2

Induces3

Secretion2

Antigens8

Airway2

Th179

Pathway5

Mice8

Tumor cells3

Endothelial Cells2

Immunity12

Populations2

Effector cells1

Cytotoxic3

Vivo5

Monocytes4

Chemokine1

Antibodies5

Cytomegalovirus1

Interferon2

Antigen-prese3

Induction1

Receptors1

Inhibition1

Receptor gene1

Monoclonal1

Immune system9

Phenotypes2

Thymic1

Protein6

Primarily1

Immunoglobulin1

Asthma1

Hypersensitivity1

Cytokine IL-101

Human4

Therapeutic3

Expression9

Subpopulation1

Proteins6

Role5

Phenotype1

Biomarkers1

Host defense1

Immunol2

Response5

Regulatory11

Production3

Regulate5