• P450scc
  • The rapid actions of ACTH include stimulation of cholesterol delivery to the mitochondria where the P450scc enzyme is located. (wikipedia.org)
  • The first step of steroidogenesis is dependent on the transfer of electrons from NADPH to a P450 type enzyme (P450scc) via an electron-transfer chain that includes two additional proteins. (wikipedia.org)
  • liver
  • Now little-used due to high incidences of elevated liver enzymes and hepatotoxicity and the availability of safer agents. (wikipedia.org)
  • More effective than the first-generation NSAAs due to increased efficacy and potency and shows no risk of elevated liver enzymes or hepatotoxicity. (wikipedia.org)
  • Cytochrome P450 3A4 (abbreviated CYP3A4) (EC 1.14.13.97), is an important enzyme in the body, mainly found in the liver and in the intestine. (wikipedia.org)
  • In particular, much higher concentration of such enzymes are found in the kidneys and in the liver, making such organs the primary site for alcohol catabolism. (wikipedia.org)
  • In human embryos and fetuses, ethanol is not metabolized via this mechanism as ADH enzymes are not yet expressed to any significant quantity in human fetal liver (the induction of ADH only starts after birth, and requires years to reach adult levels). (wikipedia.org)
  • potency
  • One of the cyclic nucleotide derivatives tested, 8-parachlorophenylthio cAMP, exhibited dramatically higher potency (ED 50 for kinase activation and enzyme induction ≅ 2-3 µM) than N 6 ,O 2 '-dibutyryl cAMP (ED 50 ≅ 100 µM). (aspetjournals.org)
  • gene
  • Therefore, these enzymes will be inserted by gene cloning and then N-glycan structures will be analyzed. (postech.ac.kr)
  • The gene coding for this enzyme is located on chromosome 4, locus 4q21-q23. (wikipedia.org)
  • Resistance to cephalosporins and aztreonam may arise through induction of a plasmid-based extended spectrum beta-lactamase (ESBL) or plasmid-based ampC-type enzyme Serratia marcescens has an ampC gene which can be induced by exposure to antibiotics such as cephalosporins. (wikipedia.org)
  • His lab was the first to clone the cDNAs and the gene coding for adrenodoxin reductase - the first enzyme in the electron transfer chain of the mitochondrial P450 system. (wikipedia.org)
  • repression
  • As a result, we knew that N-glycans from S2 cells were simple core structures and expression and repression of some enzymes that participated in N-glycosylation should be needed. (postech.ac.kr)
  • protein
  • The results demonstrate that enzyme induction is tightly coupled to protein kinase activation and is consistent with the possibility that these two processes are causally related. (aspetjournals.org)
  • Upon ligand binding, the receptor undergoes conformation changes that stimulate the enzyme adenylyl cyclase, which leads to an increase in intracellular cAMP and subsequent activation of protein kinase A. ACTH influences steroid hormone secretion by both rapid short-term mechanisms that take place within minutes and slower long-term actions. (wikipedia.org)
  • Induction of protein sumoylation by cellular stresses, J. Biol. (wikipedia.org)
  • The substrate-binding site of the enzyme was determined to be at the base of a long funnel that extends 25 Å from the surface into the interior of the protein. (wikipedia.org)
  • mediates
  • In this study, we have shown that NGF mediates the specific induction of the key enzymes in catecholamine biosynthesis, tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine-N-methyltransferase (PNMT). (jneurosci.org)
  • pharmacological
  • We have compared NGF-mediated TH and AChE induction and have provided pharmacological evidence that TH induction involves a post-transcriptional, polyadenylation-dependent event (blockable by 9-beta-arabinofuranosyladenine but not by alpha- amanitin), whereas AChE induction requires transcription (blockable by alpha-amanitin). (jneurosci.org)
  • Inducers
  • These preliminary data using a few prototypical inducers show that Fa2N-4 cells can be a reliable surrogate for primary human hepatocytes, and, when used in conjunction with the Invader technology, could provide a reliable assay for assessment of induction of drug-metabolizing enzymes and transporters. (aspetjournals.org)
  • The mean activities of microsomal CYP1A2, CYP2B6, and CYP3A4/5 from modafinil-treated hepatocytes were higher (up to 2-fold) than those in the solvent-treated controls but were less than those produced by reference inducers of these enzymes. (aspetjournals.org)
  • Pharmacology
  • Many drug molecules are enzyme inhibitors, so their discovery and improvement is an active area of research in biochemistry and pharmacology. (wikipedia.org)
  • mitochondrial
  • During his Ph.D. thesis research, Israel isolated the mitochondrial enzymes that catalyze the first step in the synthesis of steroid hormones in all steroidogenic tissues, including the adrenal cortex, and the reproductive organs. (wikipedia.org)
  • produces
  • As compared to NGF, cAMP produces a different pattern of enzyme induction (in addition to TH, DBH, PNMT, and AChE, dopa decarboxylase (DDC) is also induced), it acts rapidly (a 12-hr exposure produces the full effect), and it acts only at the transcriptional level (its effects are blocked by alpha-amanitin). (jneurosci.org)
  • MNNG also produces multiple lesions which may be handled by cells in different ways. (springer.com)
  • different
  • Intensification chemotherapy is identical to consolidation chemotherapy but a different drug than the induction chemotherapy is used. (wikipedia.org)
  • The importance of the motifs he identified was confirmed by re-engineering of coenzyme specificities of different enzymes. (wikipedia.org)
  • drug
  • Drug-metabolizing enzymes, including cytochromes P450 (P450s), and transporters are involved in the clearance of drugs. (aspetjournals.org)
  • Induction of drug-metabolizing enzymes and drug transporters by drugs and other chemicals is an adaptive response of mammals and other organisms to increase the removal of potentially toxic endobiotics and xenobiotics. (aspetjournals.org)
  • Induction chemotherapy is the first line treatment of cancer with a chemotherapeutic drug. (wikipedia.org)
  • Based upon the accumulated evidence, a medical review from late 2014 argued that accumbal ΔFosB expression can be used as an addiction biomarker and that the degree of accumbal ΔFosB induction by a drug is a metric for how addictive it is relative to others. (wikipedia.org)
  • family
  • LAAOs that have been purified from the venoms of various snake species have proven to be the best suitors for examining this novel family of enzymes. (wikipedia.org)
  • This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with oxygen as acceptor. (wikipedia.org)
  • increase
  • The time course of TH induction is such that NGF must be continuously present for at least the first 36 hr (during which time TH levels remain unchanged), and then the entire increase takes place during the subsequent 12 hr. (jneurosci.org)
  • complex
  • 2004 Nov 19;16(4):549-61 Bernier-Villamor, V. , Sampson, D.A. , Matunis, M.J. & Lima, C.D. Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1. (wikipedia.org)
  • central nervou
  • Similar to enzalutamide and apalutamide, but with increased efficacy as an AR antagonist, little or no central nervous system distribution, and no induction of seizures in animals. (wikipedia.org)
  • example
  • One example of the enzyme in action occurs with the conversion L-alanine into pyruvic acid (2-oxopropanoic acid), as shown in Figure 1. (wikipedia.org)
  • often
  • It is often resistant to a wide array of antibiotics but is usually sensitive to co-trimoxazole Acinetobacter are becoming more common and may be resistant to carbapenems such as imipenem and meropenem Burkholderia cepacia is an important organism in people with cystic fibrosis and is often resistant to multiple antibiotics Methicillin-resistant Staphylococcus aureus is an increasing cause of VAP. (wikipedia.org)
  • shown
  • Following hydrolysis of the intermediate, the enzyme successfully affords the 2-oxo acid, as shown in Scheme 1. (wikipedia.org)
  • variety
  • The dose-response relationships for a variety of these derivatives revealed a highly significant correlation between kinase activation and enzyme induction. (aspetjournals.org)
  • Although LAAOs are present in a variety of eukaryotic and prokaryotic organisms, snake venom is a particularly rich source of the enzyme and the LAAOs are proposed to supply toxic effects upon envenomation. (wikipedia.org)
  • site
  • The production of multiple mutations but not of single-site mutations is blocked in rec A and uvr E strains. (springer.com)
  • The binding of an inhibitor can stop a substrate from entering the enzyme's active site and/or hinder the enzyme from catalyzing its reaction. (wikipedia.org)
  • Multiple weak bonds between the inhibitor and the active site combine to produce strong and specific binding. (wikipedia.org)
  • Analysis of the phylogeny of this enzyme in eukaryotes showed that the NADP binding site sequence is strictly conserved. (wikipedia.org)