• While doctors are still unsure of the exact cause of multiple myeloma, they do know it involves changes in the genes that are in charge of plasma cell growth and division. (healthline.com)
  • Classic studies of twins, adoptees, half siblings, and families 1 - 4 have led to a widely accepted notion that multiple sclerosis (MS) is a complex trait in which susceptibility is determined by the interplay of genes and environmental factors. (bmj.com)
  • CRISPR is a technique so revolutionary it has allowed the most highly skilled researchers at Harvard Medical School to edit 60 genes at one time in pigs, clearing out genetic impediments to organ transplant & paving that way for pigs to grown organs that can be readily transplanted into human beings without causing rejection. (constantcontact.com)
  • Subsequent genomic sequence analysis of multiple genes including elongation factor 3, a component of fungi protein synthesis not found in protozoa, further supported this notion. (medscape.com)
  • The accurate information about burden of multiple myeloma (MM) at national and provincial level remains unknown in China. (nih.gov)
  • It was estimated that there were 16,500 new cases and 10,300 deaths of multiple myeloma in China in 2016. (nih.gov)
  • Multiple myeloma. (nih.gov)
  • What is multiple myeloma? (healthline.com)
  • Multiple myeloma is a rare type of cancer that affects the bone marrow and alters your blood's plasma cells. (healthline.com)
  • Multiple myeloma leads to an accumulation of cancer cells in your bone marrow. (healthline.com)
  • Knowing the most common signs and symptoms of multiple myeloma may help you detect it before it becomes advanced. (healthline.com)
  • Dendritic cells in bone marrow can also contribute to multiple myeloma. (healthline.com)
  • Signs and symptoms of multiple myeloma aren't always easy to detect. (healthline.com)
  • You may not experience early symptoms of multiple myeloma. (healthline.com)
  • Doctors diagnose multiple myeloma when there is evidence of a plasma cell tumor or a minimum of 10 percent of plasma cells in the bone marrow. (healthline.com)
  • One of the first tools for diagnosing multiple myeloma is performing lab tests, such as blood and urine tests. (healthline.com)
  • Once your doctor has confirmed a diagnosis of multiple myeloma, the next step is to see how far it has spread in the body. (healthline.com)
  • Multiple myeloma is categorized into three different stages and each stage can determine a person's survival rate and treatment options. (healthline.com)
  • Immunocompromised status, failure to culture the bacterium in 30 days or to apply appropriate three drug treatment, and age were significant factors in mortality. (bmj.com)
  • The infant such as income or demographic factors in- mortality rate has decreased from 10.5 per cluding education and occupation. (who.int)
  • Road Traffic Accident represents a significant risk for morbidity and mortality in Ethiopia, of which head injury and multiple sites injury increase injury severity. (who.int)
  • Date of diagnosis was determined and data were collated on key demographic factors, clinical, radiological and treatment details. (bmj.com)
  • Almost all image quality losses occur the first time an image is compressed as JPEG. (stackexchange.com)
  • While there is some understanding of the type of defects that occur in these materials upon radiation exposure, Ahmed said it has been arduous to model how radiation, along with other factors, such as the temperature of the reactor and the microstructure of the material, together contribute to the formation defects and their growth. (timesofnation.com)
  • Research on predicting which individuals will experience MDD recurrence needs to start with the initial clinical episode of major depression, before multiple episodes occur, since recurrences and corresponding treatments confound comparisons. (medpagetoday.com)
  • Multiple mental illnesses can occur at the same time and at random. (fda.gov)
  • You can clearly get reinfections that occur before that [120-day] time interval. (abc.net.au)
  • An online survey assessed children's lifestyle factors including diet, physical activity, screen time, sleep difficulties, and having ADHD diagnosis. (edu.au)
  • Main outcome measure Diagnosis of multiple sclerosis. (bmj.com)
  • Contributing Factors: Key contributing factors identified in this investigation include: 1. (cdc.gov)
  • Today's software can help maintenance workers monitor scheduled and unscheduled breakdowns as well as the average time of repair. (forbes.com)
  • ABSTRACT A case-control study evaluated the relationship between hypertension and socioeconomic and lifestyle factors in Al-Ain city. (who.int)
  • Within each call type, managers tracked three metrics: total volume of calls, average handle time (AHT) for calls directed to internal staff, and a separate "external" AHT metric for calls addressed by vendors. (mckinsey.com)
  • This may be due to inherited conditions that increase the risk of HPV infections or other genetic risk factors. (medicalnewstoday.com)
  • Only three published case-control studies have assessed risk factors for human infections. (cdc.gov)
  • Indoor air pollution (for example from cooking and heating with biomass fuels, or coal) is a major factor associated with acute respiratory infections in both rural and urban areas of developing countries. (who.int)
  • Objectives To determine if risk of multiple sclerosis (MS) is associated with month of birth in countries in the northern hemisphere and if factors related to month of birth interact with genetic risk. (bmj.com)
  • Populations 17 874 Canadian patients and 11 502 British patients with multiple sclerosis. (bmj.com)
  • Multiple sclerosis ( MS ) is a disease that causes demyelination (disruption of the myelin that insulates and protects nerve cells) of spinal nerve and brain cells. (medicinenet.com)
  • women have about two to three times the risk for multiple sclerosis than men. (medicinenet.com)
  • What does multiple sclerosis (MS) look like (pictures)? (medicinenet.com)
  • Multiple sclerosis is a disease that involves an immune-mediated process that results in an abnormal response in the body's immune system that damages central nervous system (CNS) tissues in which the immune system attacks myelin, the substance that surrounds and insulates nerve fibers causing demyelination that leads to nerve damage. (medicinenet.com)
  • Because the exact antigen or target of the immune-mediated attack is not known, many experts prefer to label multiple sclerosis as 'immune-mediated instead of an autoimmune disease. (medicinenet.com)
  • Multiple sclerosis is a disease that causes demyelination of the brain and spinal cord nerve cells. (medicinenet.com)
  • Can children and teenagers develop multiple sclerosis (pediatric MS)? (medicinenet.com)
  • Children and teens with multiple sclerosis are treated with the same therapies as adults, but they are considered "off label" for treating children, (not an FDA approved the use of the drug, but it is/may be effective for some people with the condition). (medicinenet.com)
  • For problems with multiple simultaneous requests, a specified cost (arc-length) and capacity. (lu.se)
  • Whether you're interested in saving money on your monthly mortgage payments, or considering a cash-out refinance, Credible's free online tool will let you compare rates from multiple mortgage lenders. (foxbusiness.com)
  • If you decide to refinance your mortgage, be sure to shop around and compare rates from multiple mortgage lenders. (foxbusiness.com)
  • Credible's free online tool will let you compare rates from multiple mortgage lenders. (foxbusiness.com)
  • Be sure to shop around and compare rates with multiple mortgage lenders. (foxbusiness.com)
  • No compression Attached is the graph which gives plot of % CPU utilization versus time elapsed for each of the compression algorithms. (mail-archive.com)
  • For each type of feature extraction multiple machine learning algorithms are tested and compared. (lu.se)
  • algorithms for multiple unicast, multicast and multiple multicast problems. (lu.se)
  • These interventions are typically time-consuming and do not allow for agile responses to immediate changes in demand patterns. (mckinsey.com)
  • HPV is the most common viral infection affecting the reproductive tract, and in over 90% of cases, the HPV infection will clear by itself over time. (medicalnewstoday.com)
  • Health authorities typically define a reinfection as a case 90 days or more after a previous COVID infection, to exclude people who simply shed the virus for a long period of time. (abc.net.au)
  • Credible can help you compare multiple lenders at once in just a few minutes. (foxbusiness.com)
  • If you're ready to take advantage of current mortgage refinance rates that are below average historical lows, you can use Credible to check rates from multiple lenders . (foxbusiness.com)
  • Preliminary multiple regression showed only sleep quality was significantly different between children with and without ADHD. (edu.au)
  • At the same time, these risk exposures significantly increased the odds of both externalising and internalising diagnoses, over and above the influence of maternal depression. (cambridge.org)
  • Moreover, organic matter (in both particulate and dissolved forms) may be a major factor that controls the composition and structure of microbial communities in marine waters ( Dang and Lovell, 2016 ). (frontiersin.org)
  • WASHINGTON, October 9, 2013 - Calling for greater urgency to end extreme poverty, World Bank Group President Jim Yong Kim today announced that the World Bank has set an interim target to reduce global poverty to 9 percent in 2020, which, if achieved, would mark the first time the rate has fallen into the single digits. (worldbank.org)
  • Term Structure Dynamics, Macro-Finance Factors and Model Uncertainty ," Essex Finance Centre Working Papers 18195, University of Essex, Essex Business School. (repec.org)
  • Term Structure Dynamics, Macro-Finance Factors and Model Uncertainty ," SIRE Discussion Papers 2015-71, Scottish Institute for Research in Economics (SIRE). (repec.org)
  • Term Structure Dynamics, Macro-Finance Factors and Model Uncertainty ," MPRA Paper 63844, University Library of Munich, Germany. (repec.org)
  • Can Tai Chi training impact fractal stride time dynamics, an index of gait health, in older adults? (crossref.org)
  • This study aimed to describe the clinical, microbiological, molecular epidemiology and treatment of multidrug resistant tuberculosis (MDRTB) cases in the UK and to determine factors associated with survival. (bmj.com)
  • 1, 2 Clinical drug resistance is becoming of increasing importance worldwide and is attributed to factors including patient non-adherence to treatment, inappropriate treatment regimens, drug malabsorption, and a poor health infrastructure needed for the effective delivery of treatment. (bmj.com)
  • The most difficult clinical cases are caused by multiple drug resistant tuberculosis (MDRTB) defined as resistance to at least isoniazid and rifampicin. (bmj.com)
  • Presently, the clinical course of recurrent and nonrecurrent MDD subsets cannot be predicted at the time of an individual's initial depressive episode with any statistical accuracy or clinical confidence. (medpagetoday.com)
  • Thus, the clinician should take into consideration the clinical presentation and give due attention to the identified contributing factors in its management. (who.int)
  • CDC's lung injury response efforts have been multifaceted and in addition to being committed to identifying, defining the risk factors or causes of EVALI, CDC is detecting and tracking cases of EVALI in the U. S. Through information collected and committed to communicating actionable recommendations, to state, local and clinical audiences. (cdc.gov)
  • In general, mothers with depression experience more environmental and family risk factors, and lead riskier lifestyles, than mothers who are not depressed. (cambridge.org)
  • To test whether the exposure of a child to risk factors associated with mental health adds to the prediction of child psychopathology beyond exposure to maternal depression. (cambridge.org)
  • Maternal depression increased diagnoses of externalising and internalising disorders, but a substantial portion of these associations was explained by increased risk factor exposure (41% for externalising and 37% for internalising disorders). (cambridge.org)
  • Being able to distinguish between recurrent and nonrecurrent depression subtypes around the time of the onset would allow both acute-phase therapies and prevention strategies to become more focused and personalized. (medpagetoday.com)
  • Distinguishing individuals who will have no or very few MDD recurrences from those who will have multiple episodes over their lifetimes "forces a reevaluation of almost everything presently believed about depression, from etiology through acute phase treatments and recurrence prevention, to questioning the utility of extant research on predicting and preventing recurrences," the authors wrote. (medpagetoday.com)
  • Children of clinically depressed mothers were exposed to more risk factors associated with maternal mental health. (cambridge.org)
  • Baseline comparisons between people who never have any additional episodes and those who eventually experience multiple episodes could provide clinically useful information about biologic, endophenotypic, genetic, psychological, social, and other contributing factors of recurrences. (medpagetoday.com)
  • The World Bank Group has defined ending extreme poverty as reaching 3 percent poverty globally, due to constant fluctuations of populations above and below the line because of conflict, disasters, loss of employment, and other factors. (worldbank.org)
  • Hence, providing health education on the timing of antenatal care is important. (hindawi.com)
  • Air pollution is a major environment-related health threat to children and a risk factor for both acute and chronic respiratory disease as well as other diseases. (who.int)
  • In 2001, the in the UAE population of the relationship gross domestic product (GDP) per capita between health and socioeconomic factors were estimated as US$ 22 800. (who.int)
  • Supports from multiple levels including both human and environment, and managers and employees, are important for a successful participatory occupational health/health promotion program. (cdc.gov)
  • to date, approximately 300 staff from across the agency have been engaged in response efforts, including multiple staff who have been deployed to assist health departments in investigating these lung injuries. (cdc.gov)
  • The existing detection methods for this disease have numerous shortcomings, including low sensitivity, time consuming procedures, and high contamination vulnerability. (medscimonit.com)
  • Multiple modern methods of statistical feature extraction and machine learning are applied to classification of encoding and retrieval of episodic memories using electroencephalogram (EEG) recordings. (lu.se)
  • Raw data, different time-frequency methods, and multiclass common spatial patterns are used for statistical feature extraction. (lu.se)
  • Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. (wikipedia.org)
  • The results of canonical correspondence analyses (CCA) indicated that salinity, total phosphate (TP), total nitrogen (TN), temperature, and pH were the most important factors shaping microbial community structure. (frontiersin.org)
  • one of the most important and comprehensive is overall equipment effectiveness (OEE), which is a measure of how well a facility fulfills its output potential during the time it's scheduled to run. (forbes.com)
  • Time onsite is also an important cost factor. (thumbtack.com)
  • An important distinguishing factor about this questionnaire evaluation is that respondents clearly understood its purpose. (cdc.gov)
  • Management support, financial resources, and release time for participation were identified as the three most important factors. (cdc.gov)
  • Factors relating to sexual history may increase the risk of cervical cancer, as these may increase the risk of HPV exposure. (medicalnewstoday.com)
  • Here we demonstrate for the first time that exposure to field-realistic concentrations of neonicotinoid pesticides during development can severely affect queens of western honey bees ( Apis mellifera ). (nature.com)
  • Changing economic conditions, central bank policy decisions, investor sentiment and other factors influence the movement of mortgage refinance rates. (foxbusiness.com)
  • There are multiple factors why every investor wants to invest in real estate. (indiatimes.com)
  • Risks include being sexually active at a young age, having multiple sexual partners, and having one sexual partner with a high risk of passing on HPV. (medicalnewstoday.com)
  • Most people who are sexually active get infected with genital HPV at some time. (mayoclinic.org)
  • The proposed method allows us to estimate plausible real-time term premia, whose countercyclicality weakened during the financial crisis. (repec.org)
  • In a pseudo-real-time setting, we show that the DFM outperforms univariate benchmarks, as well as other commonly used nowcasting models, such as MIDAS and bridge regressions. (repec.org)
  • Nowcasting: The real-time informational content of macroeconomic data ," Journal of Monetary Economics , Elsevier, vol. 55(4), pages 665-676, May. (repec.org)
  • Nowcasting GDP and inflation: the real-time informational content of macroeconomic data releases ," Finance and Economics Discussion Series 2005-42, Board of Governors of the Federal Reserve System (U.S. (repec.org)
  • Nowcasting GDP and Inflation: The Real-Time Informational Content of Macroeconomic Data Releases ," Money Macro and Finance (MMF) Research Group Conference 2006 164, Money Macro and Finance Research Group. (repec.org)
  • Nowcasting GDP and Inflation: The Real Time Informational Content of Macroeconomic Data Releases ," CEPR Discussion Papers 5178, C.E.P.R. Discussion Papers. (repec.org)
  • Quotes displayed in real-time or delayed by at least 15 minutes. (foxbusiness.com)
  • If the package is less than a mile away, you can view the location of the driver in real-time. (talkradionews.com)
  • To overcome shortcomings for detecting animal chlamydiosis, a multiplex quantitative polymerase chain reaction (PCR) assay was established for simultaneously detecting and differentiating 3 Chlamydia species ( C. pecorum , C. abortus , and C. psittaci ) by real time PCR based on TaqMan-MGB technology. (medscimonit.com)
  • Automated AI-driven forecasting promotes these benefits by consuming real-time data and continuously identifying new patterns. (mckinsey.com)
  • Per the authors, although current concepts and research practices evolve from "complex and largely unproven assumptions," there is promise for future investigations, through improved definitions and operational guidelines, to decipher which factors will predict that those experiencing their first depressive episode will progress to multiple recurrences. (medpagetoday.com)
  • This interaction of multiple causes makes it increasingly difficult to find solutions to the migration problem - and that currently applies to almost every country from which new arrivals are coming to Germany in this refugee crisis. (mpg.de)
  • Factors that can affect your wedding photographer prices include the photographer's reputation and experience. (thumbtack.com)
  • Anxiety disorders happen when extreme anxiety affects your daily activities, such as going to work or school or spending time with friends and family. (fda.gov)
  • As O'Brien reviewed the risk-assessment formulas-a series of calculations that runs into the billions-he found himself unable to account for several factors, the terrorist-intent notion principal among them. (schneier.com)
  • Collectively, these results showed that environmental factors influenced the structure and function of water microbial communities, while salinity was the principal environmental factor instead of temperature, TP, TN, and pH in shrimp cultural enclosure ecosystems. (frontiersin.org)
  • Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. (wikipedia.org)
  • We allow the model dimension and parameters to change over time, accounting for model uncertainty and sudden structural changes. (repec.org)
  • Other risk factors, cial change, and UAE, along with other such as obesity, dyslipidaemia, diabetes and Gulf Arab states, have experienced a rapid smoking, are also higher among hyperten- transition in its socioeconomic status. (who.int)
  • Now it's time for the next step, and the big question: How will the situation change when paramedics are given the proper training? (cdc.gov)
  • This protein circulates in the bloodstream in an inactive form, bound to another molecule called von Willebrand factor, until an injury that damages blood vessels occurs. (wikipedia.org)
  • Some factors are external, like work or school schedules. (cdc.gov)
  • If you do not wish for your participation to be recorded, please exit at this time. (cdc.gov)
  • People with high levels of factor VIII are at increased risk for deep vein thrombosis and pulmonary embolism. (wikipedia.org)
  • For example, people who do shift work or work multiple jobs tend to have trouble getting enough good quality sleep. (cdc.gov)
  • A Quasi-Maximum Likelihood Approach for Large, Approximate Dynamic Factor Models ," The Review of Economics and Statistics , MIT Press, vol. 94(4), pages 1014-1024, November. (repec.org)
  • A quasi maximum likelihood approach for large approximate dynamic factor models ," Working Paper Series 674, European Central Bank. (repec.org)
  • A Quasi Maximum Likelihood Approach for Large, Approximate Dynamic Factor Models ," Post-Print hal-00638440, HAL. (repec.org)
  • A Quasi Maximum Likelihood Approach for Large, Approximate Dynamic Factor Models ," PSE-Ecole d'économie de Paris (Postprint) hal-00638440, HAL. (repec.org)
  • A Quasi Maximum Likelihood Approach for Large Approximate Dynamic Factor Models ," CEPR Discussion Papers 5724, C.E.P.R. Discussion Papers. (repec.org)
  • A Quasi Maximum Likelihood Approach for Large Approximate Dynamic Factor Models ," Working Papers ECARES 2008_034, ULB -- Universite Libre de Bruxelles. (repec.org)
  • The more practical approach to two-factor authentication is to combine something you know, a PIN or password, with something you have. (redhat.com)
  • This is a random password that is valid for a short period of time (usually 30 or 60 seconds). (redhat.com)
  • They can also last for a short or long period of time. (fda.gov)
  • Everyone has this sort of trouble from time to time but when it happens on most nights, for an extended period of time, it can really have a negative impact on your quality of life. (cdc.gov)
  • Structural equation modeling (SEM) tested how lifestyle factors play mechanism roles one another in the impact of ADHD to seek theoretical and intervention insights. (edu.au)
  • Significant triple mediation effects suggested diet, physical activity, and screen time mediated the ADHD impact on sleep quality. (edu.au)
  • You should be aware that many factors can impact the delivery time of your parcel. (talkradionews.com)
  • A substantial proportion of the global burden of disease is associated with environmental risk factors, and over 40% of this burden falls on children under five years of age. (who.int)
  • Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). (wikipedia.org)
  • This protein undergoes multiple cleavage events. (wikipedia.org)
  • Factor VIII protein consists of six domains: A1-A2-B-A3-C1-C2, and is homologous to factor V. The A domains are homologous to the A domains of the copper-binding protein ceruloplasmin. (wikipedia.org)
  • The factor VIII protein has a half-life of 12 hours in the blood stream when stabilized by the von Willebrand factor. (wikipedia.org)
  • No longer protected by vWF, activated FVIII is proteolytically inactivated in the process (most prominently by activated protein C and factor IXa) and quickly cleared from the blood stream. (wikipedia.org)
  • the incidence of these inhibitors is dependent of various factors, including the factor VIII product itself. (wikipedia.org)
  • We conducted a case-control study to investigate risk factors for acquiring autochthonous alveolar echinococcosis in Germany. (cdc.gov)
  • Accordingly, the multiple of TCF is influenced by factors that relate to current revenue and future revenue potential. (steelintheair.com)
  • Thirdly, it can appreciate over time, thus creating a potential for capital gains. (indiatimes.com)
  • Other designations for variables in the formula are almost befuddling, O'Brien says, such as the "attractiveness factor," which seeks to establish how terrorists might prefer one sort of target over another, and the "chatter factor," which tries to gauge the intent of potential terror plotters based on communication intercepts. (schneier.com)
  • Moreover, the contribution of spatial distribution to the microbial community assembly was investigated via aggregated boosted tree (ABT) analyses, and the results indicated spatial isolation was not a major factor affecting the phylogenetic diversity and phylotypes of water microbial communities. (frontiersin.org)
  • The server, knowing the PIN, seed, and time (or count) can generate the code it expects and will attempt to match this expected value to the data as entered by the user. (redhat.com)
  • If a distinction could be made between recurrent and nonrecurrent subtypes around the time of the first onset, both acute-phase therapies and prevention strategies could become more focused and personalized based on the individual's susceptibility profile and heightened proneness to recurrence. (medpagetoday.com)
  • Elevated levels of lead in soil and dust often happen at the same time. (cdc.gov)
  • In spite of having multiple different designs, almost all classifier combinations involving the retrieval data fail to reach significant classification levels. (lu.se)
  • The effects of environmental factors on water microbial communities have been extensively studied, but little is known about the effects in shrimp cultural enclosure ecosystems. (frontiersin.org)
  • We analyzed 16S rRNA gene amplicons to determine the principal environmental factors that shape the structure and function of microbial communities in shrimp cultural enclosure ecosystems from Guangdong and Hainan provinces, in China. (frontiersin.org)
  • 1 This may implicate environmental factor(s) such as shared timing of gestation or birth, or both. (bmj.com)
  • Multiple regression and SEM were planned to identify significant correlates and mediators of ADHD in explaining lifestyle differences. (edu.au)
  • I've seen significant amounts of wasted time and duplicated efforts," says Smith. (cdc.gov)
  • Most of the time, several factors compound or reinforce each other. (mpg.de)
  • The taxonomic classification of the Pneumocystis genus was debated for some time. (medscape.com)
  • Dr. Wheaton] There are multiple things that can contribute to sleep problems. (cdc.gov)