Tumor Suppressor Protein p53Tumor Suppressor ProteinsGenes, Tumor SuppressorMutationVon Hippel-Lindau Tumor Suppressor ProteinPoint MutationMolecular Sequence DataTumor Suppressor Protein p14ARFMutation, MissenseRetinoblastoma ProteinBase SequenceCell Line, TumorProto-Oncogene Proteins c-mdm2Amino Acid SequenceGenes, p53DNA-Binding ProteinsCell LineNuclear ProteinsDNA Mutational AnalysisProtein BindingTranscription FactorsGene Expression Regulation, NeoplasticApoptosisTransfectionPolymerase Chain ReactionNeurofibromin 2Adenomatous Polyposis Coli ProteinPhenotypeMutagenesisGenes, SuppressorCell CycleNeoplasmsProto-Oncogene ProteinsCyclin-Dependent Kinase Inhibitor p16Promoter Regions, GeneticUbiquitin-Protein LigasesTumor Cells, CulturedDNA PrimersSignal TransductionPTEN PhosphohydrolaseCell Cycle ProteinsCell Transformation, NeoplasticMutagenesis, Site-DirectedCyclin-Dependent Kinase Inhibitor p21Protein Structure, TertiaryTranscription, GeneticCarrier ProteinsAmino Acid SubstitutionCell ProliferationPhosphorylationAllelesNeoplasm ProteinsRNA, MessengerRepressor ProteinsExonsCell DivisionProteinsLigasesDNA DamageBinding SitesSuppression, GeneticCyclinsBlotting, WesternTranscriptional ActivationSequence Analysis, DNAFrameshift MutationE2F Transcription FactorsDNADown-RegulationTumor Markers, BiologicalGene DeletionSequence Homology, Amino AcidSequence DeletionGerm-Line MutationGene SilencingProtein-Serine-Threonine KinasesLoss of HeterozygosityRecombinant Fusion ProteinsGenotypeReverse Transcriptase Polymerase Chain ReactionHeLa CellsFibroblastsGene Expression RegulationCells, CulturedPlasmidsDNA MethylationE2F1 Transcription FactorCloning, MolecularModels, MolecularSuppressor of Cytokine Signaling ProteinsRNA InterferenceMembrane ProteinsDNA, NeoplasmTrans-ActivatorsKidney NeoplasmsCell NucleusTranscription Factor DP1RNA, Small InterferingOncogene Proteins, ViralWT1 Proteins