Multicentre study patient dropouts. Medical search. Frequent questions

Methods and analysis This is a multicentre, randomised, double-blind, placebo-controlled clinical trial. (bmj.com)
This article will introduce an important research development to provide an evidence-based approach to current treatment methods and practices for young patients. (lww.com)
Methods The INTENSE study is a multicentre, open-label, randomised, pragmatic, phase-IV clinical trial to demonstrate the non-inferiority of a 7-day vs 14-day course for the treatment of uncomplicated enterococcal bacteraemia and incorporating the early switching to oral antibiotics when feasible. (bmj.com)
METHODS: Prospective interventional feasibility study without control group. (lu.se)
METHODS: This was a cross-sectional study at the Instituto do Cancer do Estado de São Paulo, at the Faculdade de Medicina da Universidade de São Paulo with the approval of the local research ethics committee. (bvsalud.org)
METHODS: A multicentre cohort study was conducted in 20 Latin American transplant centres, including 994 listed patients for LT with HCC from 2012 to 2018. (bvsalud.org)
Methods: We developed a Markov model to assess the costs and benefits of sodium oxybate plus antidepressants and stimulants or current standard treatment based on their effects on the quality of life of patients. (omicsonline.org)
Evaluation of a virtual coaching system eHealth intervention: A mixed methods observational cohort study in the Netherlands. (rrd.nl)
Methods The CCQ, St George's Respiratory Questionnaire (SGRQ), Chronic Respiratory Questionnaire (CRQ) and COPD Assessment Test (CAT) were measured in 261 patients with COPD before and after outpatient PR. (bmj.com)
METHODS:In this single-blinded, multicentre, superiority randomised controlled trial, patients were assigned 1:1 to 10 weeks of groups-based PTR (60 min, three times weekly) or conventional PR (90 min, two times weekly). (puppyreading.com)
Methods A randomised controlled multicentre trial (RCT) including 1193 participants was conducted. (bmj.com)
The study highlights where threats to internal and external validity are likely to arise in any future studies of similar structured physical activity interventions for colorectal cancer patients using similar methods being conducted in similar contexts. (biomedcentral.com)
Traditional Treatment methods used by psychiatric patients seeking treatment from The University Psychiatric Unit, National Hospital Sri Lanka. (who.int)

Supervised pulmonary tele-rehabilitation versus pulmonary rehabilitation in severe COPD: a randomised multicentre trial. (puppyreading.com)

Predicting cutaneous malignant melanoma patients' survival using deep learning: a retrospective cohort study. (cdc.gov)
Very narrow cohort of patients based on inclusion/exclusion criteria. (thebottomline.org.uk)
However, this is a study with very limited external validity due to a narrow cohort in a single centre. (thebottomline.org.uk)
This large Spanish retrospective cohort study found that a new prescription (not issued in the previous year) of tramadol was significantly associated with a higher risk of all-cause mortality (hazard ratio 2.31), cardiovascular events (hazard ratio 1.15), and fractures (hazard ratio 1.5) compared with a matched cohort who were prescribed codeine. (bmj.com)
Alongside the RCT, a prospective cohort study will be conducted among cancer survivors' partners ( n = 267). (biomedcentral.com)
Participants in the RCT and cohort study will be asked to complete questionnaires at baseline, and after six and 12 months, assessing work- and health-related outcomes. (biomedcentral.com)
For the cohort study, logistic or linear regression modelling will be applied assessing work- and health-related outcomes (primary outcome: working hours) of cancer survivors' partners, and what factors predict these outcomes. (biomedcentral.com)

Deep learning-based model detects atrial septal defects from electrocardiography: a cross-sectional multicenter hospital-based study. (cdc.gov)
In a cross-sectional, multicentre study in Ajman Emirate, 250 patients with hypertension were randomly selected from outpatient clinics. (who.int)
A cross-sectional US study of 37 348 patients who received one or more of 44 new oral targeted cancer drugs found that the proportion of patients receiving drugs without documented overall survival benefit increased from 13% in 2011 to 59% in 2018, and accounted for 52% of the $3.5bn estimated cumulative spending on new oral targeted cancer drugs by the end of 2018. (bmj.com)
Two of the three adolescent studies were cross-sectional (Dempsey 2012, Lam 2007). (bvsalud.org)
All but three adult studies used a cross-sectional, descriptive, or case control design, and thus were not amenable to GRADE analysis. (bvsalud.org)
Stage I wa a hospital based study conducted in the Kurunegala district and comprised of a work sampling study, survey of records and a cross sectional survey of random sample of 1305 patients attending hospital dental clinics in the district. (who.int)

We aim to compare two different doses of dexamethasone in patients with moderate to severe ARDS undergoing mechanical ventilation regarding efficacy and safety. (biomedcentral.com)

The knowledge gained has been used to design multicentre, randomised, placebo-controlled trials in order to investigate agents with different mechanisms of action. (ersjournals.com)
In another placebo-controlled study with 331 subjects with active Crohn's Disease, alicaforsen failed to demonstrate efficacy in any of its primary outcome measures. (wikipedia.org)

participants were nonsmoking female patients aged 18-50 years and scheduled for laparoscopic appendectomy or cholecystectomy, ASA at I-III, with no serious physical or mental diseases. (biomedcentral.com)
T0 features among dropout, stable and healed participants were compared. (biomedcentral.com)
We included 30 studies with 8257 participants. (cochrane.org)
This small but important multicentre UK trial of 204 participants found that agitation scores at 12 weeks (using the Cohen-Mansfield Agitation Inventory, CMAI) didn't differ significantly in patients given mirtazapine (titrated up to 45 mg) compared with placebo and raised a warning that there were more deaths in the mirtazapine group compared with placebo (7 v 1). (bmj.com)

Regarding the clinical management of enterococcal bacteraemia, the evidence on the duration of antibiotic treatment is scarce and the studies do not discriminate between complicated and uncomplicated bacteraemia. (bmj.com)
Six patients (10%) experienced clinical worsening, including death in two (not study drug-related). (ersjournals.com)
OBJECTIVE: The aim of the present study was to evaluate the clinical features, Hepatocellular Carcinoma (HCC) screening, treatment modalities, and Overall Survival (OS) in a series of Non-Alcoholic Fatty Liver Disease-Related Hepatocellular Carcinoma (NAFLD-HCC) Brazilian patients. (bvsalud.org)
In a Phase III randomised clinical trial with 299 patients with steroid dependent Crohn's disease, clinical response was correlated with drug exposure, with significant efficacy versus placebo being observed in the subgroup with greatest area under the curve, hence pharmacodynamic modelling suggests that alicaforsen (ISIS 2302) may be an effective therapy at adequate dose levels. (wikipedia.org)
In a subsequent multicentre Phase 3 clinical trial in 138 subjects with Active, Chronic, Antibiotic Refractory Primary Idiopathic Pouchitis, showed a clinically relevant 34% remission in stool frequency with 8% delta vs placebo. (wikipedia.org)
A multidisciplinary group of experts, including pulmonary, surgical, dentistry and ear-nose-throat specialists, methodologists and patient representatives considered the most relevant clinical questions (for both clinicians and patients) relating to the management of OSA. (researchgate.net)
8 , - , 10 Nevertheless, looking at clinical trial patients attaining stringent remission who have no activity governing disability, the residual HAQ is closely related to joint damage 11 and apparently not importantly influenced by other factors. (bmj.com)
A cancer research trial, or clinical trial, is a study of recruited patients to determine whether a new or existing cancer treatment is safe and effective or can be improved. (trog.com.au)
Approval given by a Human Research Ethics Committee (HREC) for a clinical trial to be conducted with patients. (trog.com.au)
Further clinical data permitted a change in the licence to "the treatment of narcolepsy with cataplexy in adult patients" in 2008 [ 6 ]. (omicsonline.org)
Greater reporting of patient safety incidents tend to occur in organizations in which the staff feels sufficiently safe and secure to report and discuss negative clinical events without fear of reprisal or punishment. (uottawa.ca)
More data are still required from longer-term clinical studies examining measures of disease progression or time to needing full time care. (cochrane.org)
Studies were excluded if they did not utilise the American College of Rheumatology classification criteria, were not clinical trials, or included patients with chronic fatigue syndrome or myalgic encephalomyelitis. (bmj.com)
13 However, since the development of the ACC/AHA/ESC Guidelines many additional studies have been published on the comparative safety and effectiveness of the different available medications used for ventricular rate control in clinical practice. (ahrq.gov)
Patients with preoperatively staged T3 or T4 N1 disease should be considered for clinical trials of neoadjuvant chemotherapy. (medscape.com)

REMED is a prospective, open-label, randomised controlled trial testing the superiority of dexamethasone 20 mg (dexamethasone 20 mg on days 1-5, followed by dexamethasone 10 mg on days 6-10) vs 6 mg administered once daily intravenously for 10 days in adult patients with moderate or severe ARDS due to confirmed COVID-19. (biomedcentral.com)
The Bromocriptine Multicentre Trial Group. (curehunter.com)
This trial assessed the preferential Janus kinase 1 (JAK1) inhibitor filgotinib and the spleen tyrosine kinase inhibitor lanraplenib in patients with LMN. (bmj.com)
Private practice patients: 154 adult patients with chronic lateral epicondylosis were recruited, with 136 patients completing the trial. (bmj.com)
A multicentre randomized controlled trial is proposed, with efforts to increase recruitment and retention rate. (lu.se)
Given the positive results from an open-label trial and one case series in patients with chronic refractory pouchitis, US FDA has agreed to a rolling submission for a license application for the treatment of pouchitis. (wikipedia.org)
This means that a trial has met all the requirements of the trial development phase (as determined by TROG Cancer Research), has been allocated a TROG Cancer Research number and given permission to begin the process of submission for ethics review and approval to commence accruing patients. (trog.com.au)
Means a patient selected in accordance with, and who meets, the eligibility criteria specified for the trial. (trog.com.au)
A process by which a patient voluntarily confirms their willingness to participate in a particular trial, after having been informed of all aspects of the trial that are relevant to the patient's decision to participate. (trog.com.au)
The study - dubbed the Explorer trial - reports that a sucrose octasulfate impregnated dressing healed neuro-ischaemic DFUs quicker than a control dressing. (diabetesfeetaustralia.org)
This study was a non-blinded, cluster randomised trial of the healthy eating and lifestyle in pregnancy (HELP) intervention, with a concurrent process and health economic evaluation. (nature.com)
The studies had to be double-blind and randomised, that is, the decision whether people taking part got donepezil or placebo had to be made randomly and neither they nor the researchers should have known which treatment they were getting while the trial was going on. (cochrane.org)
In this phase IIb trial , patients with non-cirrhotic, highly active NASH were randomised to receive 1200 or 800 mg of lanifibranor (an agonist that modulates key pathways in the pathogenesis of NASH) for 24 weeks or placebo. (bmj.com)
Several studies, including the PARP inhibitor trial Ariel2 [5], demonstrated that ovarian cancer patients with wild type BRCA1/2 alleles still responded to PARP inhibitors if greater than 16% of tumor cell genomes exhibited LOH. (ambrygen.com)
In a multicentre Randomized Controlled Trial (RCT), 236 working-age cancer survivors with an employment contract will be randomly allocated to a usual care group or an intervention group receiving a multidisciplinary rehabilitation program, combining occupational therapy facilitating work retention (e.g., energy management and self-efficacy training) and reintegration consultation addressing work-related issues (e.g. (biomedcentral.com)
A prospective randomized control trial of 140 eyes from 140 patients, who underwent phacoemulsification, was conducted to compare the efficacy of subtenon corticosteroids injection with corticosteroids eye drops for controlling postoperative intraocular inflammation. (springer.com)
The Cardiac Rehabilitation In Bowel cancer (CRIB) study was a pilot randomised controlled trial (RCT) of cardiac rehabilitation versus usual care (no rehabilitation) for post-surgical colorectal cancer patients. (biomedcentral.com)
Colorectal patients' and clinicians' perceptions and experiences of the main trial procedures were explored by interview. (biomedcentral.com)
Conducting pilot studies to iron out methodological bias and imprecision in advance of a large-scale trial is critical if that larger trial is to become part of an evidence-base that is then used for recommending policy and changing practice. (biomedcentral.com)
This was a randomized, open-label, parallel group, 12-week trial in mild-to-moderate COPD patients who received TIO 18 μg once daily for ≥12 weeks prior to study initiation. (e-trd.org)

The current analysis was designed to test the impact of seasonal variation on reported exacerbations in relation to other risk factors, using data from the prospective, 3-yr Towards a Revolution in COPD Health (TORCH) study involving 6,112 patients from the northern and southern regions and the tropics [ 21 ]. (ersjournals.com)
This prospective study aims to enroll two hundred and sixty men and women with stages 3 to 5 CKD. (biomedcentral.com)
Inclusion criteria included controlled trials (randomized or not), pre-post-intervention evaluations and observational (retrospective or prospective) studies in which there is a comparator. (bvsalud.org)

This multicentre double-blind study compared the efficacy of low and very low dose bromocriptine in 64 elderly subjects with newly diagnosed Parkinson's disease . (curehunter.com)
TORCH was a multicentre, randomised, double-blind, parallel-group, 3-yr study conducted in 42 countries around the world [ 21 ]. (ersjournals.com)
No difference was seen at 12 months in either serological markers or small-bowel mucosal architecture in this double-blind multicentre study. (canada.ca)

The long-term outcomes of this study are to assess long-term consequences on mortality and quality of life at 180 and 360 days. (biomedcentral.com)
Secondary outcomes include the percentage of severe flare, the percentage of mild-to-moderate flare, time to first disease flare, changes in prednisone dose, SELENA-SLEDAI, as well as BILAG score, the percentage of patients achieving prednisone free and safety analysis. (bmj.com)
Outcomes following liver transplantation improved dramatically for patients with HCC following the implementation of the Milan criteria in the late 1990s. (hindawi.com)
The findings from this study indicate that stability in staffing (i.e. low turnover) and working within a system that encourages reporting and discussing negative events likely has a positive impact on mental health outcomes like suicide. (uottawa.ca)
The study aims are to: 1) evaluate the (cost-)effectiveness of a rehabilitation program for RTW and work retention in cancer survivors, and 2) assess health- and work-related outcomes among cancer survivors' partners. (biomedcentral.com)
A direct switch from TIO to IND/GLY provided improvements in lung function and other patient-reported outcomes with an acceptable safety profile in patients with mild-to-moderate airflow limitation. (e-trd.org)
Other studies of adults reported on the following additional outcomes. (bvsalud.org)
For highly selected patients with early stage (≤3 cm), unresectable hilar cholangiocarcinoma or cholangiocarcinoma arising in the setting of primary sclerosing cholangitis, the sequential combination of high-dose neoadjuvant radiotherapy with chemosensitization, brachytherapy, maintenance chemotherapy, and orthotopic liver transplantation achieves excellent outcomes, with a 65% rate of recurrence-free survival after 5 years. (medscape.com)

Conclusion The number of patients treated in this study was small, and only limited conclusions can be drawn. (bmj.com)
CONCLUSIONS: Pre-transplant selection models similarly predicted HCC dropout. (bvsalud.org)

Patients with moderate-to-severe chronic obstructive pulmonary disease (COPD) experience on average, two to three exacerbation episodes per year [ 1 , 2 ]. (ersjournals.com)
A post hoc meta-analysis of individual data of 200 patients from four phase 2 studies evaluating nightly alicaforsen 240 mg enema for six weeks showed that alicaforsen is effective in patients with active, distal, moderate to severe UC. (wikipedia.org)
All but one study [79] did not exclude patients with severe OSA. (researchgate.net)
cancer patients with severe nausea from chemotherapy. (iflscience.com)
Most of the people in the studies had mild or moderate dementia due to Alzheimer's disease, but in nine studies they had moderate or severe dementia. (cochrane.org)

Eligible patients were randomised 1:1 to receive either filgotinib or lanraplenib in a blinded fashion for up to 52 weeks. (bmj.com)
Eligible patients were stratified by smoking status and were randomised to receive placebo, 50 μg salmeterol, 500 μg fluticasone propionate or 50/500 μg salmeterol/fluticasone propionate combination via the Diskus™/Accuhaler™ inhaler (GlaxoSmithKline, London, UK) (one inhalation twice daily) for 3 yrs. (ersjournals.com)
They rigorously screened all patients to make sure they were eligible. (diabetesfeetaustralia.org)
146 studies were eligible for the review. (bmj.com)
Eligible patients were randomized in a 1:1 ratio to either IND/GLY or TIO. (e-trd.org)
Of the 29 publications (27 distinct studies) included after removal of studies not eligible for inclusion and duplicates, nine were from high-income countries and 18 from low or middle-income countries. (bvsalud.org)

BACKGROUND & AIM: Liver transplantation (LT) selection models for hepatocellular carcinoma (HCC) have not been proposed to predict waitlist dropout because of tumour progression. (bvsalud.org)
Unfortunately due to either tumour stage, size, and/or anatomy, patient comorbidities, or shortage of donor livers from both cadaveric and living donors, only 20% of patients undergo curative treatment [ 6 , 7 ]. (hindawi.com)

Dropouts did not report higher pain (baseline), only 3 dropped out because of lumbar spine-related pain. (lu.se)
5 events/h) identified on a baseline polysomnogram were studied. (researchgate.net)

ABSTRACT This study aimed to assess the predictors of non-adherence to antihypertensive medications in northern United Arab Emirates. (who.int)

A larger, longer phase III study including a more diverse population is now needed. (bmj.com)

The aim of this study was to compare the alpha-foetoprotein (AFP) model and other pre-LT models in their prediction of HCC dropout. (bvsalud.org)
CT-based deep learning radiomics nomogram for the prediction of pathological grade in bladder cancer: a multicenter study. (cdc.gov)

Most currently available interventions have similar overall efficacy, and treatment choices should reflect the situation of individual patients. (psychiatrist.com)
2017) highlighted that the registered nurses in the cardiovascular unit have varying roles in the care process of the patients with MI in the emergency department and this mainly includes nurse-initiated thrombolytic, patient education and adoption and subsequent procurement of the primary health interventions upon admission to the emergency unit. (myassignmenthelp.com)

A total of 252 patients with acute uncomplicated lower UTI (syndrome of dampness-heat in the lower jiao) will be randomly allocated in the ratio of 1:1:1 to three groups: experimental group, control group 1 and control group 2. (researchsquare.com)
In patients with acute respiratory failure, does early delivery of a standardised ICU and hospital rehabilitation programme improve physical function and reduce hospital length of stay? (thebottomline.org.uk)
Among patients hospitalised with acute respiratory failure, Standardised rehabilitation therapy compared with usual care did not decrease hospital length of stay. (thebottomline.org.uk)
In this single centre study of patients with acute respiratory failure, a standardised hospital rehabilitation programme did not reduce hospital length of stay. (thebottomline.org.uk)
One study reported that 19% of patients diagnosed with acute ischemic stroke by neurologists before cranial CT scanning actually had non-cerebrovascular causes for their symptoms. (medscape.com)

However, the AFP model can discriminate a higher risk of dropout among patients within Milan criteria. (bvsalud.org)

There are no clearly effective therapies for lupus membranous nephropathy (LMN), and controlled trials in patients with LMN are lacking. (bmj.com)
These include evaluation of extended criteria, the use of bridging therapies while patients are awaiting a transplant, the concept of allocation and prioritising, the use of living related donor transplants, the implications of using marginal grafts for HCC, and the role of downstaging therapies. (hindawi.com)
Disallowing background maintenance therapies contributed to this high dropout rate in this challenging, heterogenous patient group. (wikipedia.org)

He specialised further in Family Therapy at the Milan Centre for Family Studies and qualified as Member and then Fellow of the London Institute of Psychoanalysis. (ucl.ac.uk)

Exclusion criteria have been described previously [ 21 ] and included long-term oxygen therapy at start of the study, or an exacerbation requiring systemic corticosteroids or hospitalisation during the run-in period. (ersjournals.com)
and, potentially, systemic therapy should be used to bridge patients to transplant or to delay recurrence if possible. (medscape.com)
Following R0 resection of T2-4 disease in N1 gallbladder cancer, patients should be considered for adjuvant systemic chemotherapy and/or chemoradiotherapy. (medscape.com)
Patients with confirmed metastasis to N2 nodal stations (para-aortic, celiac, or superior mesenteric artery) do not benefit from radical resection and should receive systemic and/or palliative treatment. (medscape.com)

After this Zhineng Qigong intervention patients with chronic LBP and/or leg pain, also patients with considerable remaining LBP/sciatica after lumbar surgery, had significantly improved in pain and function. (lu.se)

Patients from orthopaedic clinics were 1-6 years postoperative after lumbar spine surgery or on lumbar surgery waiting list. (lu.se)
Results support involvement of postoperative patients in a future study. (lu.se)
The aim of this study was to investigate whether the application of OFA by using esketamine in intraoperative analgesia could minimize the side effects of postoperative nausea and vomiting (PONV), as well as other short-term side effects related to anaesthesia. (biomedcentral.com)

The authors then used a pre-approved standard treatment study protocol for all patients to try and keep all other DFU treatments the same in both groups. (diabetesfeetaustralia.org)
The researchers collected all demographic, medical history, DFU characteristics and treatments as per those stated in the international standards for reporting DFU studies and our Australian DFU minimum dataset . (diabetesfeetaustralia.org)
Currently the most common treatment (standard care) is to use antidepressants as anti-cataleptics and stimulants for daytime sleepiness symptoms, but this combination of treatments has been observed to be inadequate for some patients [ 5 ]. (omicsonline.org)
Some of the aspects contributing to denial and resistance to treatments can be automatic and unmotivated whilst others are consciously generated by patients who actively oppose to treatment, also on the basis of the biological vulnerability of altered reward and inhibition underlying these disorders [ 7 , 8 ]. (springer.com)
Although physical exercise is recommended to reduce the side effects of adjuvant treatments in breast cancer patients, no randomized study has been conducted to assess the benefits of a physical training program in patients with HER2 overexpressing breast cancer. (biomedcentral.com)
Ultimately, by identifying risk factors for fracture and targeting treatments in this group-before the initiation of renal replacement therapy - we will reduce the burden of disease due to fractures among patients with CKD. (biomedcentral.com)
Both treatments were well tolerated by patients. (e-trd.org)

Patients will be randomised in a 1:1 ratio into one of the two treatment arms. (biomedcentral.com)
The problems of long-term levodopa treatment are well established, and a number of studies describe the use of bromocriptine as a first-line agent in patients under 65 years. (curehunter.com)
Anorexia nervosa and atypical anorexia nervosa are by far the most prevalent eating disorders among patients admitted to child and adolescent psychiatric (CAP) treatment or to paediatric units with a CAP liaison service, whereas patients with bulimia nervosa and avoidant/restrictive food intake disorder (ARFID) are seen comparatively less often. (lww.com)
There may be a therapeutic benefit with filgotinib treatment, which may support future investigations with filgotinib or other JAK inhibitors in patients with LMN. (bmj.com)
Our study demonstrates that 16 weeks of treatment with the Janus kinase 1 (JAK1) inhibitor filgotinib reduced proteinuria in a small number of patients with LMN. (bmj.com)
This short-term dose-ranging study did not demonstrate a treatment effect of a new topical glyceryl trinitrate patch in dosages of 1.44 mg/24 h or 3.6 mg/24 h, which conflicts with previous studies on topical glyceryl trinitrate treatment. (bmj.com)
A proportion of pulmonary arterial hypertension (PAH) patients do not reach treatment goals with phosphodiesterase-5 inhibitors (PDE5i). (ersjournals.com)
32 patients (52%) experienced study drug-related adverse events and 10 (16%) experienced serious adverse events (2 (3%) study drug-related, none during the PDE5i treatment-free period). (ersjournals.com)
HCC treatment was performed in 84.7% of patients. (bvsalud.org)
The purpose of this review is to provide an update on the current role of transplantation in the treatment of HCC and the strategies employed to increase the donor pool, improve the overall survival of patients on the transplant register, and reduce the number of patients dropping out of the waiting lists. (hindawi.com)
There was significant variability in patients in the intervention groups receiving treatment - 13% did not receive passive ROM, 45.4% did not receive physical therapy, and 74.3% did not receive resistance exercises. (thebottomline.org.uk)
Follow-up studies represent the most effective attempt to enlighten treatment effectiveness, outcome predictors and process indicators. (biomedcentral.com)
Pain specialist and lecturer Michael Vagg recently wrote on The Conversation that medicinal cannabis was no more than treatment of patients with tetrahydrocannabinol (THC). (iflscience.com)
Health-related quality of life (HRQoL) is an important outcome measure in patients with COPD, and increasingly used to quantify symptom burden and guide treatment. (bmj.com)
2017) have further argued that the treatment and care for the patients with AMI who are admitted in the emergency department is not solely dependent on the role and performance of the doctors. (myassignmenthelp.com)
The unit provides assessment and community-based psychosocial treatment for personality-disordered (mostly borderline) patients who reside within the London area. (ucl.ac.uk)
His main interest is the treatment and management of patients with personality disorder and patients with psychiatric syndromes with associated personality disorder. (ucl.ac.uk)
Health system changes such as: (a) implementing the National Institute for Health and Care Excellence depression guidelines, (b) making available crisis and home treatment teams, (c) implementing policies on transfer from youth to adult care and (d) new procedures for managing patients with dual diagnosis were all associated with reduced suicide rates during the study period. (uottawa.ca)
One of the most interesting findings was that these changes to the treatment and management of depression, youth, crises, and dual diagnoses were much more effective in reducing suicide rates under two organizational contexts: (1) when non-medical staff turnover was low, and (2) when there was greater reporting of patient safety incidents. (uottawa.ca)
Lower staff turnover likely means that patients in those organizations received greater continuity of care and that suicidal or depressed patients were more likely to receive treatment from highly trained and experienced professionals. (uottawa.ca)
After six months of treatment, there are benefits of donepezil that are large enough to measure in studies. (cochrane.org)
To date, no study has evaluated the benefits of physical activity on the side effects of treatment in patients with HER2 positive breast cancer. (biomedcentral.com)
If these benefits are confirmed, this exercise intervention could be systematically proposed to patients during the course of treatment by trastuzumab in addition to standard oncological care. (biomedcentral.com)
It does mean that bigger, better studies are needed to clarify the optimal type and duration of treatment to encourage smokers to quit forever. (bmj.com)
A total of 424 men entered the study at 4 drug treatment centres in Tehran, Islamic Republic of Iran. (who.int)
In a study the Islamic Republic of Iran in support narcotics abuse in the scope of public conducted in the north-eastern United of parallel treatment of dual addictions. (who.int)
Therefore, a single subtenon triamcinolone injection could be an alternative treatment to control inflammation after cataract surgery, especially in patients with poor drug compliance 12 . (springer.com)

This study aimed to investigate feasibility including evaluation of a Zhineng Qigong intervention for pain and other lumbar spine-related symptoms, disability, and health-related quality of life in patients with chronic LBP and/or leg pain. (lu.se)
Patients received a 12-week training intervention with European Zhineng Qigong. (lu.se)
The Cancer of the Liver Italian Program (CLIP) classification [ 14 ] and the Chinese University Prognostic index (CUPI score) [ 15 ] tend to classify patients who have more advanced disease and are not descriptive enough to be able to distinguish those patients with lower volume of disease who may benefit the most from surgical intervention. (hindawi.com)
In fact, the latest International Diabetic Foot Guidelines simply recommends "select dressings principally on the basis of exudate control, comfort and cost" as "the evidence to support the adoption of any particular (dressing) intervention is poor, because the available studies are small and at high risk of bias. (diabetesfeetaustralia.org)
The primary study objective was to assess whether a theory-based weight management intervention for pregnant women with obesity, which starts during pregnancy and continues into the postpartum period, was effective in reducing women's body mass index (BMI) 12 months after giving birth. (nature.com)
The aim of this study is to evaluate the impact of 3 months' exercise intervention on myocardial function and in particular on the rate of cardiotoxicity. (biomedcentral.com)
Le groupe faisant l'objet d'une intervention a reçu un traitement de substitution nicotinique d'une durée de six semaines bénéficiant d'une prise en charge totale. (who.int)
39 pharmacological intervention studies and 59 non-pharmacological were included in the final recommendation summary tables once those of a lower quality or with insufficient data were separated. (bmj.com)
This study shows that there is likely to be potential recruitment bias and potential imprecision due to sub-optimal completion of outcome measures, missing data, and sub-optimal intervention adherence. (biomedcentral.com)
Rotheram-Borus 2001a) These seven studies are described below, based on type of intervention utilized to support disclosure of positive HIV status. (bvsalud.org)

This study, building on a successful feasibility study [ 19 ] sought to address some of the shortcomings of previous studies. (nature.com)

The study aims were to assess the responsiveness of the CCQ to PR, to compare the responsiveness of the CCQ to other HRQoL questionnaires and to provide estimates for the MCID. (bmj.com)
This study aimed to assess the efficacy and safety of direct switch from once-daily tiotropium (TIO) 18 μg to indacaterol/glycopyrronium (IND/GLY) 110/50 μg once daily in COPD patients in Korea. (e-trd.org)

Many chronic obstructive pulmonary disease (COPD) patients receiving monotherapy continue to experience symptoms, exacerbations and poor quality of life. (e-trd.org)
The prevalence of chronic obstructive pulmonary disease (COPD) is considerably high, affecting 251 million patients globally. (e-trd.org)

Even so, patients still continue to die while waiting for a liver transplant. (hindawi.com)

Fifty-two chronic pain patients (18-75 years) with LBP and/or leg pain (Visual Analogue Scale ≥ 30) were recruited from orthopaedic clinics (spinal stenosis, spondylolisthesis, or segmental pain) and primary healthcare (chronic LBP). (lu.se)
The authors recruited 240 patients with neuro-ischaemic diabetic foot ulcers from 43 diabetic foot clinics across 5 European countries. (diabetesfeetaustralia.org)

widespread smoking-related morbidity from China's National Institute of Ad- and mortality remains a looming pub- diction show that cigarette smoking is Study design and sampling method lic health crisis [2]. (who.int)
Because of the expected paucity of adolescent studies, study design criteria were broadened to include adult studies. (bvsalud.org)

The effect of a GFD with versus without oats was published in the cornerstone study of Janatuinen et al. (canada.ca)
The 2011 Focused Update on the Management of Patients with Atrial Fibrillation-by the American College of Cardiology Foundation (ACCF), the AHA, and the Heart Rhythm Society (HRS)-addressed the issue of strict versus lenient rate control in patients with AF. (ahrq.gov)
At one month after the surgery, full recovery (zero ACI score) was found in 43 patients (63.20%) in the Dexa group versus 47 patients (68.10%) in the TA group ( p = 0.55). (springer.com)
Key themes were benefits for people with colorectal cancer attending cardiac rehabilitation, barriers for people with colorectal cancer attending cardiac rehabilitation, generic versus disease-specific rehabilitation, key concerns about including people with cancer in cardiac rehabilitation, and barriers to involvement in a study about cardiac rehabilitation. (biomedcentral.com)

These dressings were provided with identical packaging and appearance so the patients and treating clinicians could not tell which dressing they received. (diabetesfeetaustralia.org)
Qualitative study: Thirty-eight patients and eight clinicians participated. (biomedcentral.com)

Recent years have evidenced a notable increase in large and methodologically sound studies. (lww.com)
6 - 8 The duration of the average episode is estimated to be between 6 months and 2 years, 9 with 83% of patients either "completely recovered" or "much improved" within 12 months with a wait-and-see policy. (bmj.com)
Thirty patients completed (mean 15 years symptom duration). (lu.se)
While recognizing that a few people with CD seem to be clinically intolerant to oats, this review concludes that uncontaminated oats were safely ingested for several years by most patients with CD and that there is no conclusive evidence that the consumption of uncontaminated oats by patients with CD should be limited to a specific daily amount. (canada.ca)
In a follow up of this work, 23 of the original oats-eating group and 28 patients eating a conventional GFD were re-examined at 5 years ( Janatuinen, Gut, 2002 ). (canada.ca)
2 years depressed), patients with chronic depression experience greater social, physical, and mental impairments. (uottawa.ca)
A recent retrospective study [ 12 ] reported that the incidence of hip fractures in a hemodialysis population was 17.4 times greater and occurred at a younger age compared to the general population (16 and 13 years younger among men and women, respectively). (biomedcentral.com)
1 The prevalence of AF increases with age and approaches 8 percent in patients older than 80 years of age. (ahrq.gov)

Subjective global assessment of change in elbow symptoms, patient-rated tennis elbow evaluation, visual analogue pain at rest, visual analogue pain with activity, visual analogue pain intensity, grip strength, and strength testing using the Orthopaedic Research Institute-Tennis Elbow Testing System. (bmj.com)
Prompted by earlier lines of research, studies have recently focused on several aspects including: neurobiological effects of attachment and primary relationships, complex gene-environment interaction, temperament and deficits in the development of the character, cognitive inflexibility, and those pseudo-positive meaning that patients attribute to their behaviors and symptoms. (springer.com)
There was no deterioration in the mucosal architecture in those in remission and the entire newly diagnosed group had reached resolution of symptoms and mucosal healing with exception of one patient in the control group. (canada.ca)
Whether or not a rhythm-control strategy is adopted, adequate rate control should be achieved in all patients with AF to prevent myocardial infarction (if significant coronary artery disease is present), exacerbation of heart failure, and tachycardia-induced cardiomyopathy and to alleviate symptoms. (ahrq.gov)
13 This recommendation is based on several studies that showed effective heart rate control and improvement in symptoms with AVN ablation and permanent pacemaker implantation in selected patients with AF. (ahrq.gov)

Four patients in the filgotinib group and one patient in the lanraplenib group completed week 16. (bmj.com)
Lower reward dependence and lower cooperativeness characterized the dropout group. (biomedcentral.com)
Those in remission were studied for 6 months and the newly diagnosed group for 12 months. (canada.ca)
Seventy patients received subtenon 20-mg triamcinolone injection (TA group), whereas the other 70 patients received 0.1% dexamethasone eye drops (Dexa group) after the uneventful surgeries. (springer.com)
The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. (medscape.com)

3. Documentation verifying the method of shipment and storage conditions of the comparator product from the time of purchase to the time of study initiation. (who.int)
Decreased bone mass and disruption of microarchitecture occur early in the course of CKD and worsens with the progressive decline in renal function so that at the time of initiation of dialysis at least 50% of patients have had a fracture. (biomedcentral.com)

New England Journal of Medicine, 1995 ) where 52 adults with CD in remission and 40 adults newly diagnosed with CD were studied. (canada.ca)

The true incidence and prevalence of IPF is not well established, due to the lack of a uniform definition of IPF in older studies which provided quantitative data on IPF incidence and/or prevalence, a lack of diagnostic criteria, differences in case finding methodologies and study designs. (ersjournals.com)
Quantitative study. (biomedcentral.com)

The aim of this study was to evaluate the effectiveness of work-focused cognitive-behavioural therapy (CBT) and individual job support for people struggling with work participation due to CMDs. (bmj.com)
A research project was undertaken to evaluate the efficiency and productivity of the hospital dental services as well as the perception of patients and dentists regarding various aspects of the service. (who.int)

Results Nine patients were randomised to receive filgotinib (n=5) or lanraplenib (n=4). (bmj.com)
will allow obtaining results with 194 patients recruited. (bmj.com)
The results of this study will improve the rational use of drugs, especially the rational application of antibiotics. (researchsquare.com)
RESULTS: A total of 131 patients were included. (bvsalud.org)
When it was sensible to do so, we analysed the results of studies together to get an overall result. (cochrane.org)
The main factor reducing our confidence was concern that the results of some studies might have been biased by the way they were done. (cochrane.org)

A multicenter study on the application of artificial intelligence radiological characteristics to predict prognosis after percutaneous nephrolithotomy. (cdc.gov)

I will follow my unit's protocols regarding physiotherapy while awaiting a large multi-centre RCT to provide more information on the best "dose" and timing of physical therapy in ICU patients. (thebottomline.org.uk)

For a 6% non-inferiority margin and considering a 5% withdrawal rate, 284 patients will be included. (bmj.com)
Furthermore, patients with CKD stage 5 who require renal replacement therapy (also known as end stage renal disease (ESRD)) had a one-year mortality rate of 64% following a hip fracture compared with 15 to 20% in the general population. (biomedcentral.com)
There was a high attrition rate (23% of the sample was lost to follow-up, and 9% withdrew) so this study is hardly a game changer. (bmj.com)
Not only is the risk of death in patients with AF twice that of patients without AF, but AF can result in myocardial ischemia or even infarction, heart failure exacerbation, and tachycardia-induced cardiomyopathy if the ventricular rate is not well-controlled. (ahrq.gov)

The data supporting the findings of this study are not publicly available. (bmj.com)
These findings can be served as a benchmark for a multicentre study. (who.int)

In the Global Burden of Disease Study 2013, anorexia nervosa and bulimia nervosa combined were the 12th leading cause of DALYs in 15-19-year-old girls in high-income countries, accounting for 2.2% of all DALYs [1,2▪,3] . (lww.com)
3) specific combinations of high-resolution computed tomography and surgical lung biopsy patterns in patients subjected to surgical lung biopsy [ 1 , 4 ]. (ersjournals.com)
For the definition of positional OSA, all studies shared the criterion of the supine AHI to be at least twice as high as the nonsupine AHI. (researchgate.net)
The first step to decreasing the morbidity and mortality associated with fractures in patients with CKD is to identify those patients at high risk, in order to direct appropriate preventative strategies. (biomedcentral.com)
11 Importantly, when ischemic stroke occurs in patients with AF, it is either fatal or of moderate to high severity in most patients. (ahrq.gov)

This study provides evidence that the CCQ is as responsive as other well established COPD-specific health status instruments, and is a practical alternative compared with more time-consuming questionnaires. (bmj.com)
Recently, two shorter and simpler HRQoL questionnaires for patients with COPD have been described and validated. (bmj.com)

Development and testing of a random forest-based machine learning model for predicting events among breast cancer patients with a poor response to neoadjuvant chemotherapy. (cdc.gov)
NCCN guidelines recommend consideration of a course of neoadjuvant chemotherapy for patients with jaundice. (medscape.com)

Only 29% of patients were in the HCC screening program before diagnosis. (bvsalud.org)
We'd always been taught to give more credence and weight to staining and would dismiss the diagnosis of dry eye if the patient complained but had no staining. (theophthalmologist.com)
In this study we define cancer survivorship as 'a process that begins at the moment of diagnosis and continues through the balance of life' [ 5 ]. (biomedcentral.com)

This quantification is the main objective of this study, searching for an answer to the question of what an increase in TSS of 1, 10 or 100 units may mean in terms of units of physical disability. (bmj.com)

Our study aims to identify prognostic factors for bone loss and fractures in patients with stages 3 to 5 CKD. (biomedcentral.com)
This study is one of the first that aims to identify risk factors for fracture in early stage CKD patients. (biomedcentral.com)

In patients with COVID-19 pneumonia in need of oxygen therapy or mechanical ventilation, dexamethasone 6 mg per day is currently recommended. (biomedcentral.com)

Resectable patients with early HCC and underlying liver disease are however increasingly being considered for transplantation because of potential for better disease-free survival and resolution of underlying liver disease, although this approach is limited by the availability of donor livers, especially in resectable patients. (hindawi.com)
These patients are best treated with surgical resection and as the liver has normal regenerative capacity, they can often tolerate major liver resections (up to 70% of liver volume) [ 9 ] without significant morbidity, achieving a 5-year survival of 60-65% [ 10 - 12 ]. (hindawi.com)

Bromocriptine as initial therapy in elderly parkinsonian patients. (curehunter.com)
Comparative Effectiveness Analysis of Lumpectomy and Mastectomy for Elderly Female Breast Cancer Patients: A Deep Learning-based Big Data Analysis. (cdc.gov)
Moreover, the elderly, who are the majority of patients, may find difficulties in eye drops usage. (springer.com)

Here, the protocol of the STEPS study is described. (biomedcentral.com)

Patients were randomly assigned to a night with a positional device (PD) and a night on CPAP (10 +/- 3 cm H2O). (researchgate.net)
A total of 262 patients with chronic depression were randomly assigned to receive 24 sessions of either CBASP or NSP. (uottawa.ca)

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Psychiatry and Psychology1

Anthropology, Education, Sociology and Social Phenomena1

Named Groups2

Health Care2

Methods13

Randomised multicentre trial1

Cohort7

Cross-sectional6

Regarding efficacy1

Placebo-controlled2

Participants4

Clinical15

Trial20

Prospective3

Double-blind3

Outcomes8

Conclusions2

Severe5

Eligible6

Tumour2

Baseline2

Abstract1

Phase1

Prediction2

Interventions2

Acute5

Discriminate1

Therapies3

Milan1

Systemic4

Significantly1

Postoperative3

Treatments7

Treatment27

Intervention10

Feasibility study1

Assess2

Chronic obstruc2

Transplant1

Clinics2

Design2

Versus4

Clinicians2

Years8

Symptoms5

Group5

Initiation2

Remission1

Quantitative2

Evaluate2

Results6

Multicenter1

Multi-centre1

Rate4

Findings2

High5

COPD2

Neoadjuvant chemotherapy2

Diagnosis3

Objective1

Aims2

Dexamethasone1

Survival2

Elderly3

Protocol1

Randomly2