alpha 1-Antitrypsin Deficiencyalpha 1-AntitrypsinMucusPulmonary EmphysemaEmphysemaCervix MucusPhenotypeLiver DiseasesPulmonary Disease, Chronic ObstructiveForced Expiratory VolumeTrypsin Inhibitorsalpha 1-AntichymotrypsinLungLung DiseasesAirway ObstructionPancreatic ElastaseAirway RemodelingHeterozygoteBronchiectasisHomozygoteProteostasis DeficienciesAirway ResistanceLiverAllelesSmokingHepatitisLiver CirrhosisRespiratory Function TestsMutationSpirometrySerpinsBronchitisGenotypeVital CapacityRespiratory Therapy