Testing for H pylori infection is essential in all patients with peptic ulcers. (medscape.com)
Fecal antigen testing identifies active H pylori infection by detecting the presence of H pylori antigens in stools. (medscape.com)
Urea breath tests detect active H pylori infection by testing for the enzymatic activity of bacterial urease. (medscape.com)
Obtain histopathology, often considered the criterion standard to establish a diagnosis of H pylori infection, if the rapid urease test result is negative and a high suspicion for H pylori persists (presence of a duodenal ulcer). (medscape.com)
It is highly sensitive for the diagnosis of gastric and duodenal ulcers, allows for biopsies and cytologic brushings in the setting of a gastric ulcer to differentiate a benign ulcer from a malignant lesion, and allows for the detection of H pylori infection with antral biopsies for a rapid urease test and/or histopathology in patients with peptic ulcer disease. (medscape.com)
This study was designed to investigate the relationship between H. pylori infection and the grade of GERD in patients with reflux symptoms. (biomedcentral.com)
However, H. pylori infection was not significantly related to the presence of reflux esophagitis. (biomedcentral.com)
Our clinical, endoscopic, manometric and pH-metric data shows no significant role of H. pylori infection in the development of GERD or in the pathogenesis of reflux esophagitis. (biomedcentral.com)
Helicobacter pylori (HP) infection plays a major role in the pathogenesis of peptic ulcer disease, chronic gastritis, gastric mucosa-associated lymphoid tissue lymphoma (MALToma) and the development of gastric cancer. (biomedcentral.com)
Therefore, association between H. pylori infection and development of either hypochlorhydria or hyperacid secretion depends on the inflammatory response of the gastric mucosa. (biomedcentral.com)
Thus, the effect of H. pylori infection on the development of GERD is contradictory and is an intricate relationship [ 8 ]. (biomedcentral.com)
Most patients with peptic ulcer disease are treated successfully with cure of H pylori infection and/or avoidance of nonsteroidal anti-inflammatory drugs (NSAIDs), along with the appropriate use of antisecretory therapy. (medscape.com)
In the United States, the recommended primary therapy for H pylori infection is proton pump inhibitor (PPI)-based triple therapy. (medscape.com)
Weck MN, Gao L, Brenner H. Helicobacter pylori infection and chronic atrophic gastritis: associations according to severity of disease. (medscape.com)
Gao L, Weck MN, Nieters A, Brenner H. Inverse association between a pro-inflammatory genetic profile and Helicobacter pylori seropositivity among patients with chronic atrophic gastritis: enhanced elimination of the infection during disease progression? (medscape.com)
Esophageal sphincter1
There was no statistical difference regarding Lower Esophageal Sphincter (LES) pressure between patients who were H. pylori -positive and H. Pylori -negative (19.2 ± 9.5 (range: 3.7 to 46.2) and 19.7 ± 11.0 (range: 2.6 to 61), respectively). (biomedcentral.com)
Mucosal5
Mucosa-associated lymphoid tissue (MALT) is scattered along mucosal linings in the human body[1, 2, 3] and constitutes the most extensive component of human lymphoid tissue. (medscape.com)
The direct secretion of secretory IgA onto mucosal epithelia represents the major effector mechanism of MALT. (medscape.com)
The presence of H pylori in gastric mucosal biopsy specimens is detected by testing for the bacterial product urease. (medscape.com)
At endoscopy, gastric ulcers appear as discrete mucosal lesions with a punched-out smooth ulcer base, which often is filled with whitish fibrinoid exudate. (medscape.com)
Mannan-binding lectin B allele is associated with a risk of developing more severe gastric mucosal atrophy in Helicobacter pylori-infected Japanese patients. (medscape.com)
Atrophy2
Colonization of gastric mucosa by H. pylori may result in hypochlorhydria in patients with diffuse gastritis and gastric atrophy and who seem to be at less risk of developing GERD [ 8 ]. (biomedcentral.com)
Eradication of Helicobacter pylori prevents cancer development in subjects with mild gastric atrophy identified by serum pepsinogen levels. (medscape.com)
Duodenal ulcers3
Gastric and duodenal ulcers usually cannot be differentiated based on history alone, although some findings may be suggestive (see DDx ). (medscape.com)
Epigastric pain is the most common symptom of both gastric and duodenal ulcers, characterized by a gnawing or burning sensation and that occurs after meals-classically, shortly after meals with gastric ulcers and 2-3 hours afterward with duodenal ulcers. (medscape.com)
[ 3 , 4 ] Prophylactic regimens that have been shown to dramatically reduce the risk of NSAID-induced gastric and duodenal ulcers include the use of a prostaglandin analog or a PPI. (medscape.com)
PPIs1
PPIs do not exhibit anticholinergic or H2 antagonistic activities but suppress acid secretion by specific inhibition of the H + /K + -ATPase enzyme system on the secretory surface of parietal cells. (medscape.com)
Vitro activity1
Sitafloxacin (STX) is a quinolone that possesses potent in vitro activity against H. pylori. (bvsalud.org)
Secretory1
Inhibits gastric acid secretion by inhibiting H+/K+-ATPase enzyme system at the secretory surface of gastric parietal cells. (medscape.com)
A substituted benzimidazole (a compound that inhibits gastric acid secretion) is the active ingredient. (medscape.com)
Combination of ranitidine (inhibits H2 receptor in gastric parietal cells, which reduces gastric acid secretion, gastric volume, and hydrogen concentrations) and bismuth citrate. (medscape.com)
Patients8
Hung et al conducted a retrospective study of 830 records of patients hospitalized for bleeding peptic ulcers and found that 19% of patients were not tested for H pylori . (medscape.com)
Does a relationship still exist between gastroesophageal reflux and Helicobacter pylori in patients with reflux symptoms? (biomedcentral.com)
Further, no significant difference was evidenced in esophageal wave length (mean value: 3.1 seconds in H. pylori -negative patients versus 3.2 seconds in H. pylori -positive patients) or in esophageal wave height (mean value: 72.2 ± 39.3 in H. pylori -negative patients versus 67.7 ± 28.4 in H. pylori -positive patients). (biomedcentral.com)
For patients who must continue with their NSAIDs, proton pump inhibitor (PPI) maintenance is recommended to prevent recurrences even after eradication of H pylori . (medscape.com)
Patients with gastric ulcers are also at risk of developing gastric malignancy. (medscape.com)
Vannella L, Lahner E, Annibale B. Risk for gastric neoplasias in patients with chronic atrophic gastritis: a critical reappraisal. (medscape.com)
In the clinical trial, 28 patients with two eradication failures were treated with STX-based triple therapy [rabeprazole 10 mg twice daily (b.i.d.), amoxicillin 750 mg b.i.d. and STX 100mg b.i.d. for 7 days]. (bvsalud.org)
METHODS: From January 2002 to December 2008, 485 early gastric neoplasms in 418 patients were consecutively treated by using ESD procedure performed by 6 endoscopists in 4 institutions in Tokyo. (bvsalud.org)
Proton1
The 2017 ACG guidelines also recommend posttreatment testing to prove eradication of HPI with the use of a urea breath test, fecal antigen test, or biopsy-based testing at least 4 weeks following the completion of antimicrobial therapy and after proton pump inhibitors have been withheld for 1-2 weeks. (medscape.com)
Therapies2
Best results are achieved with 10- to 14-day protocols using combination therapies, with eradication in 80-95% of the cases. (medscape.com)
The third-line treatment regimen for Helicobacter pylori after failure of clarithromycin- and metronidazole-based therapies is not yet established. (bvsalud.org)
Pepsinogen1
Amongst participants, a low pepsinogen I/II ratio was associated with successful eradication. (bvsalud.org)
Serum1
Antibodies (immunoglobulin G [IgG]) to H pylori can be measured in serum, plasma, or whole blood. (medscape.com)
Endoscopic2
Endoscopic or invasive tests for H pylori include a rapid urease test, histopathology, and culture. (medscape.com)
BACKGROUND AND AIM: The technique of endoscopic submucosal dissection (ESD) was introduced to obtain en bloc specimens of large early gastrointestinal neoplasms. (bvsalud.org)
Increased risk1
Further analysis revealed that failure to test for H pylori within 60 days of endoscopy was associated with increased risk of rebleeding or death within 1 year. (medscape.com)
Active1
These results suggest that STX could be active against most clinical H. pylori isolates and that STX-based triple therapy is a promising and safe third-line therapy. (bvsalud.org)
Results1
Stimulation of CD28 on type 1 THCs by B7 costimulatory molecules results in the secretion of interleukin (IL)-2 and interferon gamma by type 1 THCs. (medscape.com)
Effect5
American College of Gastroenterology American Gastroenterology Association International Association of Surgeons, Gastroenterologist and Oncologist European Crohn's and Colitis Organization Turkish Gastroenterology Association (Türk Gastroenteroloji Derneği) Türk Tıp Derneği Karaciğer Araştırmaları Derneği Gastrointestinal Motilite Derneği Mungan Z, Ertan A, Hammer RA, Arimura A: Effect of pituitary adenylate cyclase activating polypeptide on rat pancreatic exocrine secretion. (wikipedia.org)
Mungan Z, Ozmen V, Ertan A, Coy DH, Baylor LM, Rice JC, Rossowski WJ: Structural requirements for galanin inhibition of pentagastrin-stimulated gastric acid secretion in conscious rats: Effect of potent novel rat galanin agonist. (wikipedia.org)
Rossowski WJ, Zacharia S, Mungan Z, Ozmen V, Ertan A, Baylor LM, Jiang NY, Coy DH:Reduced gastric acid inhibitory effect of a pGIP(1-30) NH2 fragment with potent pancreatic amylase inhibitory activity. (wikipedia.org)
Structure-dependent effect on pancreatic amylase secretion and jejunal strip contraction. (wikipedia.org)
In addition, the effect of H. pylori eradication on RE and gastroesophageal reflux disease (GERD) is unclear. (biomedcentral.com)
Successful1
[ 2 ] Ulcers can recur in the absence of successful H pylori eradication. (medscape.com)
Study1
In this study, the susceptibility of H. pylori isolates to STX was examined and the efficacy of STX-based triple therapy as a third-line regimen was evaluated. (bvsalud.org)
Combination1
Three kits (ie, CLOtest, Hp-fast, Pyloritek) are commercially available for H pylori testing, and each contains a combination of a urea substrate and a pH sensitive indicator. (medscape.com)
Presence1
In the presence of urease produced by H pylori, labeled carbon dioxide (heavy isotope, carbon-13, or radioactive isotope, carbon-14) is produced in the stomach, absorbed into the bloodstream, diffused into the lungs, and exhaled. (medscape.com)
Highly1
Highly insoluble salt of trivalent bismuth and salicylic acid. (medscape.com)