Mucoepidermoid carcinoma tumors are malignant submandibular gland neoplasms. Medical search. Frequent questions

The parotid gland is a major salivary gland in many animals. (wikipedia.org)
The salivary glands are divided into 2 groups: the major salivary glands and the minor salivary glands. (medscape.com)
The major salivary glands consist of the following 3 pairs of glands: the parotid glands, the submandibular glands, and the sublingual glands. (medscape.com)
Major salivary gland surgery is essentially nerve surgery, meaning a critical aspect of the operation is identifying and preserving cranial nerves. (oncologybuddies.com)
These tumours mostly occur in the major salivary glands and the minor salivary glands of the mouth but can also occur where there are other minor salivary glands, such as the nose and sinuses, pharynx, larynx or trachea. (oncologybuddies.com)
Pleomorphic adenoma tumors occur in the major salivary glands of the parotid and the submandibular region. (rdhmag.com)
Schematic showing the major salivary glands. (librepathology.org)

Successful diagnosis and treatment of patients with salivary gland tumors require a thorough understanding of tumor etiology, biologic behavior of each tumor type, and salivary gland anatomy. (medscape.com)
This study is a retrospective descriptive study in which the records of patients with salivary gland tumors referred to the Radiotherapy and Oncology Center of Namazi Hospital from 2005 to 2015 were reviewed. (waocp.com)

She underwent a right scialoadenectomy and received the initial diagnosis of high-grade mucoepidermoid carcinoma. (bvsalud.org)

they are submandibular and sublingual glands. (wikipedia.org)
The sublingual glands, under the tongue, produce about 5% of the total oral saliva. (medscape.com)
[ 7 ] age-related decline in saliva output was found to occur in the stimulated parotid, unstimulated submandibular/sublingual, and stimulated submandibular/sublingual glands. (medscape.com)
Additional research suggests that changes may occur in the viscoelasticity of saliva with aging, particularly in saliva produced by the submandibular and sublingual glands. (medscape.com)

Dentists are involved with aspects of salivary gland function in several ways, such as diagnosing problems involving the major and minor salivary glands, in the management of oral dryness associated with salivary problems, in the treatment of caries and periodontal disease resulting from decreased salivary flow, and in controlling salivation during restorative procedures. (medscape.com)

Eighty percent of salivary gland tumours occur in the parotid gland, 80% of these are non-cancerous and 80% are pleomorphic adenomas. (oncologybuddies.com)
Unfortunately, we don't know the cause of salivary gland tumours. (oncologybuddies.com)
Most tumours in this gland are benign. (librepathology.org)
This study on 279 tumours of the salivary glands was conducted to analyse whether the assessment of DNA ploidy by flow cytometry may assist histopathology in discriminating benign from malignant types of tumours. (researchgate.net)
The malignant tumours consisted of 18 adenoid cystic adenomas, 10 mucoepidermoid carcinomas, 5 acinic cell carcinomas, 5 carcinoma in pleomorphic adenoma as well as of 12 other malignancies belonging to 7 different tumour entities. (researchgate.net)
Twelve of 50 malignant salivary gland tumours were aneuploid. (researchgate.net)
The most obvious value of DNA flow cytometry in salivary gland tumours is thus its contribution to assist histopathology in identifying potentially malignant lesions. (researchgate.net)
MEC is an extremely rare tumour of the minor salivary glands, accounting for less than 1% of tumours of this origin [3]. (cyberleninka.org)
The prognostic value of p63 expression in malignant tumours is controversial. (cyberleninka.org)

Excretory stem cells give rise to squamous cell and mucoepidermoid carcinomas, while intercalated stem cells give rise to pleomorphic adenomas, oncocytomas, adenoid cystic carcinomas, adenocarcinomas, and acinic cell carcinomas. (medscape.com)
Adenoid cystic carcinomas are a high-grade neoplasm that has a propensity to invade and spread along nerves and therefore has a higher rate of local recurrence and/or distant metastasis, particularly to the lungs. (oncologybuddies.com)
Abnormal DNA content has been related to aggressive behavior in Mucoepidermoid Carcinomas (MEC), Adenoid Cystic Carcinomas (AdCC), Acinic Cell Carcinomas (ACC) and oncocytomas (Onc) [8]. (researchgate.net)

Most tumors (65%) are benign, with hemangiomas being the most common, followed by pleomorphic adenomas. (medscape.com)
Squamous cell carcinomas arise from excretory duct cells, pleomorphic adenomas arise from the intercalated duct cells, oncocytomas arise from the striated duct cells, and acinic cell carcinomas arise from acinar cells. (medscape.com)
This theory more logically explains neoplasms that contain multiple discrete cell types, such as pleomorphic adenomas and Warthin tumors. (medscape.com)
After therapy, the incidence of pleomorphic adenomas, mucoepidermoid carcinomas, and squamous cell carcinomas is increased. (medscape.com)
MR images of 22 healthy subjects and 21 patients with histopathologically confirmed disorders of the submandibular gland (five pleomorphic adenomas, two hemangiomas, two malignant lymphomas, one adenoid cystic carcinoma, one squamous cell carcinoma, and 10 cases of sialadenitis) were reviewed. (fdocuments.net)

Half of all hard palate cancers are squamous cell carcinomas (SCCs) as seen in the image below. (medscape.com)

BACKGROUND: NUT carcinoma (NUTc) is a rare and aggressive malignant epithelial tumor characterized by rearrangement of the NUT gene on chromosome 15q14. (bvsalud.org)
A subsequent biopsy confirmed a malignant epithelial tumor, with further imaging assisting in determining the surgical approach. (kaomp.org)

Patients with malignant lesions typically present after age 60 years, whereas those with benign lesions usually present when older than 40 years. (medscape.com)
It constitutes approximately 90% of all benign salivary gland lesions and the parotid is the most affected location. (bvsalud.org)
For lesions located superficially in the parotid gland, superficial parotidectomy - identifying and preserving the facial nerve - is necessary. (bvsalud.org)
PA makes up approximately 90% of all benign lesions of the salivary glands 5,8-11 . (bvsalud.org)
Salivary gland tumors are diverse and rare tumors and consists both benign and malignant lesions [1, 2]. (waocp.com)

Nonsquamous cell cancers, including minor salivary gland cancers, sarcomas, and melanomas, account for the other half (see the histologic distribution of hard palate malignant neoplasms and the histologic types and frequencies of minor salivary gland neoplasms of the palate below). (medscape.com)
Squamous cell carcinoma of the hard palate. (medscape.com)
However, in tumors with posterior soft palate extension, retropharyngeal nodes may be involved. (medscape.com)
Soft palate carcinomas are staged as oropharyngeal cancers according to the American Joint Committee on Cancer (see Staging). (medscape.com)
Almost half of patients present with extension of the tumor beyond the soft palate. (medscape.com)
These tumors may also be found in the palate, affecting minor salivary glands. (rdhmag.com)
The tumor may also be found in the palate and in this location, the growth appears as a bulbous, nonulcerated, firm lesion. (rdhmag.com)
When occurring in the palate, some bone may need to be removed along with the actual tumor. (rdhmag.com)
The aim of this study is to report a case of an unusual minor salivary gland pleomorphic adenoma in the hard palate, describing the most important aspects of this pathology. (bvsalud.org)
Rare: 2.3% of benign salivary tumors 6 th decade M:F = 1:1 Parotid: 78% Submandibular gland: 9% Minor salivary glands: palate, buccal mucosa, tongue. (slideserve.com)

Adenoid Cystic Carcinoma was the most common histological type (30.57%) and Adenocarcinoma with a prevalence of 1.91% had the lowest prevalence rate in this study. (waocp.com)
Other types in order of prevalence were MUC, SCC, carcinoma ex-pleomorphic, acinic cell carcinoma, salivary duct carcinoma, polymorphous low grade adenocarcinoma and adenocarcinoma (Table1). (waocp.com)
Salivary Gland Polymorphous Adenocarcinoma: Clinicopathological Features and Gene Alterations in 36 Japanese Patients. (nagoya-u.ac.jp)

The pleomorphic adenoma is the most common benign salivary gland tumor, accounting for 53 to 57% of parotid tumors and 44 to 68% of submandibular tumors. (rdhmag.com)
It represents between 53% and 77% of parotid tumors, 44% to 68% of tumors of the submandibular gland and 33% to 43% of tumors of the minor salivary glands 2 . (bvsalud.org)

Six of seven benign tumors were well defined, and three of four malignant tumors were poorly defined. (fdocuments.net)
The malignant SGTs had higher SPF than the benign tumors but with no significant difference. (researchgate.net)

Other studies in oral cancer [23,24] reported that there is no relationship between the histopathological grade of oral epithelial dysplasia or oral squamous cell carcinoma and the ploidy status. (researchgate.net)

First, we pointed out that in the setting of rare tumors like salivary gland cancers, the diagnosis should be obtained by expert pathologists, and patients should be referred to tertiary cancer centers for their clinical management. (bvsalud.org)
We almost always recommend excision of salivary neoplasms because even non-cancerous ones can transform into cancers. (oncologybuddies.com)
Tumors or cancers of the KIDNEY. (lookformedical.com)
In the histological classification of salivary gland cancers by WHO in 2005, there were 10 subtypes in the benign group and 24 subtypes in the malignant group, and benign subtypes are 5 to 7 times more common than malignant types and most of them (more than 80%) are PA (pleomorphic adenoma) [4]. (waocp.com)

The parotid glands are a pair of mainly serous salivary glands located below and in front of each ear canal, draining their secretions into the vestibule of the mouth through the parotid duct. (wikipedia.org)
The parotids produce the most fluid saliva, as they are composed of serous acini, with the sublingual gland producing mucus from mucous acini. (medscape.com)
The submandibular glands produce both serous and mucous saliva. (medscape.com)
The minor glands are primarily mucous producing, except those under the tongue, which produce serous fluid. (medscape.com)
Serous glands - lower viscosity, acini (lobules). (librepathology.org)
Serous and mucinous glands. (librepathology.org)
Serous ~90% of gland. (librepathology.org)
Serous demilunes = mucinous gland with "cap" consisting of a serous glandular component. (librepathology.org)

Most series report that about 80% of parotid neoplasms are benign, with the relative proportion of malignancy increasing in the smaller glands. (medscape.com)
That is, as the size of the gland decreases, the incidence of malignancy of a tumor in the gland increases in approximately these proportions. (medscape.com)
Mucoepidermoid carcinoma is the most common salivary gland malignancy in children. (medscape.com)
CONCLUSIONS: We presented a case of NUTc arising from salivary gland aiming to improve the knowledge of this rare malignancy. (bvsalud.org)
Conclusion: DNA aneuploidy may be a key indicator for tumors activity and malignancy in SGTs, while the SPF has a minor role in the evaluation of SGTs activity. (researchgate.net)

The salivary system is composed of 3 major gland sets and multiple minor glands. (medscape.com)
Approximately 1000 minor glands, localized to the cheeks, lips, and other intraoral mucosa, contribute about 7% to the whole saliva volume. (medscape.com)
The minor salivary glands comprise 600-1000 small glands distributed throughout the upper aerodigestive tract. (medscape.com)
Among salivary gland neoplasms, 80% arise in the parotid glands, 10-15% arise in the submandibular glands, and the remainder arise in the sublingual and minor salivary glands. (medscape.com)
Almost half of all submandibular gland neoplasms and most sublingual and minor salivary gland tumors are malignant. (medscape.com)
We have both major and minor salivary glands secreting saliva into the mouth. (oncologybuddies.com)
The minor salivary glands are many, about 8000, and are single salivary units which open directly into the mouth, mostly situated on the inside lips, cheeks, hard and soft palates. (oncologybuddies.com)
The minor salivary glands and submandibular glands are largely responsible for the saliva in your mouth at rest, when you're not eating. (oncologybuddies.com)
In order of frequency, the parotid gland is followed by the submandibular gland and finally the minor salivary glands. (rdhmag.com)
Pleomorphic adenoma is the most common neoplasm in major and minor salivary glands. (bvsalud.org)
When the minor salivary glands are affected, it mostly occurs at the junction of the hard and soft palates. (bvsalud.org)
Pleomorphic adenoma (PA) is the most commonly found neoplasm amongst tumors of the major and minor salivary glands, originally called a mixed benign tumor in 1866 3-5 . (bvsalud.org)
Eighty percent of all salivary gland tumors arise in the parotid gland, 10% in the submandibular gland, and the remaining 10% in the minor salivary gland and sublingual gland (2). (fdocuments.net)
These tumors may arise from 6 major and numerous minor salivary glands. (waocp.com)

MRI gives the best soft tissue definition for salivary neoplasms. (oncologybuddies.com)

Neoplasms that arise in the salivary glands are relatively rare, yet they represent a wide variety of both benign and malignant histologic subtypes as seen in the image below. (medscape.com)
This theory holds that tumors arise from 1 of 2 undifferentiated stem cells: the excretory duct reserve cell or the intercalated duct reserve cell. (medscape.com)
Typically, these tumors arise as firm masses that are slightly compressible. (rdhmag.com)

Significant abnormality or disease of the salivary glands, such as that associated with Sjögren syndrome or neoplasm, necessitates additional evaluation by an otolaryngologist or an otolaryngologist/head and neck surgeon for comprehensive treatment of the gland pathology itself. (medscape.com)
Tumors of the salivary glands, though uncommon, are not that rare and constitute an important field in oralmaxillofacial pathology. (bvsalud.org)
Submandibular gland (ouhsc.edu) - from a Pathology Quiz . (librepathology.org)
Regarding diversity of these tumors and variation in pathology, tumor site and probably behavior, this study has been conducted. (waocp.com)

Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)
Salivary gland neoplasms make up 6% of all head and neck tumors. (medscape.com)
Tobacco and alcohol, which are highly associated with head and neck squamous cell carcinoma, have not been shown to play a role in the development of malignancies of the salivary glands. (medscape.com)
OBJECTIVES: Cisplatin is essential in the curative treatment of locally advanced head and neck squamous cell carcinoma (LA-HNSCC) patients. (bvsalud.org)
Dr Mark Torres-Holmes is a head and neck surgeon and is part of the Mediclinic Morningside head and neck multi-disciplinary team that meet weekly to discuss benign and malignant head and neck diseases. (oncologybuddies.com)
Salivary gland tumors are rare tumors that account for 3 to 4% of head and neck neoplasms. (waocp.com)
They account for 3 to 4% of head and neck neoplasms. (waocp.com)

Given the well-known aggressive behavior of this neoplasm, as well as clinical and radiological features, she underwent adjuvant chemo-radiation (intensity-modulated radiotherapy + concurrent chemotherapy with cisplatin). (bvsalud.org)
The diagnosis is complex because of the great histological variety and biological behavior of this tumor, a histopathological examination being essential. (bvsalud.org)
S-phase value is correlated with the behavior of the tumors [13, 14]. (researchgate.net)
Aim: The aim of this study is to investigate the DNA ploidy and S-Phase Fraction (SPF) of some Salivary Gland Tumors (SGTs) in Egyptian patients and to investigate the correlation between these two biological parameters and the presumptive behavior of these neoplasms. (researchgate.net)

Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. (lookformedical.com)
In addition, p63 and Ki-67 expression levels were associated with myoepithelial carcinoma recurrence and metastasis. (cyberleninka.org)
Conclusions: Recurrence and metastasis in myoepithelial carcinomas are more frequent in p63-positive and Ki-67-positive EMCs, and poor prognosis is associated with overexpression of p63. (cyberleninka.org)

The pleomorphic adenoma is a slow-growing, non-ulcerative benign neoplasm that arises from the proliferation of glandular epithelium and myoepithelial cells. (rdhmag.com)
The tumors may have varying histological appearances consisting of ductal and myoepithelial cells in various stages of development and this fact alone makes a diagnosis very difficult in some cases due to limited or selected tissue samples. (rdhmag.com)
Even though it has an origin which is exclusive to epithelial tissue, the variety of components accords it a mesenchymal appearance as a result of the production of secretions from the tumor cells themselves, which may be ductal or myoepithelial 7 . (bvsalud.org)
Background: Myoepithelial carcinoma is a rare tumour. (cyberleninka.org)
Thus, conclusions regarding prognostic factors and ideal treatment may emerge as the number of investigated myoepithelial carcinoma cases accumulate. (cyberleninka.org)
Methods: Using immunohistochemistry, expression levels of p63 and Ki-67 were determined in 16 myoepithelial carcinoma samples and correlated with clinicopathological characteristics and patient prognosis. (cyberleninka.org)
Myoepithelial carcinoma (MEC) is a rare tumour that was first described by Stromayer et al. (cyberleninka.org)

[ 1 ] This article reviews basic salivary anatomy and physiology, several important diseases affecting the glands, salivary constituents as measures of health, trends in diagnosis, and the management of xerostomia and drooling. (medscape.com)
The patient then sought a second opinion at our cancer center and finally received the correct diagnosis of NUT carcinoma. (bvsalud.org)
presented a case where there was misinterpretation in diagnosis of a mucoepidermoid carcinoma in a 16-year-old female. (rdhmag.com)
There- fore, the differential diagnosis among benign and malignant neoplasms and inflammation is important for patients with problems in the sub- mandibular gland. (fdocuments.net)
Recently, MR imaging has been used in the diagnosis of many patho- logic conditions of the parotid gland (3-7). (fdocuments.net)
Examination of consecutive slides actually revealed small assemblies of carcinoma cells that required a final diagnosis as non-invasive carcinoma in pleomorphic adenoma. (researchgate.net)
This may be due to late diagnosis of these tumors in our patients as most cases diagnosed at advanced stage and the sections were taken from deep tumor tissue to increase the number of tumor cells in our samples. (researchgate.net)

These are close to the main glands and consist of ectopic salivary gland tissue. (wikipedia.org)

The etiology of salivary gland neoplasms is not fully understood. (medscape.com)
Recent evidence suggests that the bicellular stem cell theory is the more probable etiology of salivary gland neoplasms. (medscape.com)
Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C. (lookformedical.com)

The diversity of histological aspects displayed by neoplasms of the salivary glands causes great difficulty in terms of universal classification 1-2 . (bvsalud.org)
Although many factors have been evaluated as potential prognostic indicators, including clinical stage, site and size of the tumour, high proliferative activity, extensive invasion into the surrounding tissue, perineural permeation, the abnormal presence of nuclear DNA content, and marked cellular pleomorphism, there are no definite histological features that clearly correlate with their behaviour. (cyberleninka.org)

Metastatic clear cell carcinoma . (librepathology.org)
Metastatic clear cell renal cell carcinoma . (librepathology.org)

Each gland lies behind the mandibular ramus and in front of the mastoid process of the temporal bone. (wikipedia.org)
Anteromedial relations: The gland is situated posterolaterally to the mandibular ramus, masseter and medial pterygoid muscles. (wikipedia.org)

range, 22 to 54 years) who were examined by precontrast and postcontrast MR imaging for various prob- lems of the face and neck not related to the submandibular gland or to the floor of the mouth. (fdocuments.net)

This study was designed to investigate the factors affecting the prognosis of salivary gland tumors. (waocp.com)

It occurs most frequently in the parotid gland and is more prevalent in women (1.5:1) and in black people 6 . (bvsalud.org)
Mucoepidermoid carcinoma (MEC) is the most prevalent malignant tumor originating from the salivary gland. (kaomp.org)

In all cases of sialadenitis, the submandibular gland showed diffusely different signal intensities from the normal gland on both T1-weighted and T2-weighted images. (fdocuments.net)
Eight cases of chronic sialadenitis showed lower T2-weighted signal intensities than the normal gland, and this can be explained histopathologically by marked fibrosis and cellular infiltration. (fdocuments.net)

An estimated 700 deaths (0.4 per 100,000 for males and 0.2 per 100,000 for females) related to salivary gland tumors occur annually. (medscape.com)
Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)
These tumors are more common in adulthood and older ages and about 5% of cases occur under 16 years of age (8-10). (waocp.com)

A superficial parotidectomy, removing the lobe of the gland containing the tumor is performed. (rdhmag.com)

METHODS: In this article, we present the fifth case worldwide of a young woman affected by a NUTc arising from a submandibular gland, presenting as a rapidly evolving mass. (bvsalud.org)
Methods: Flow cytometric analysis of DNA pliody and S-Phase Fraction (SPF) was done in 50 fresh tumor tissue sections of SGTs which diagnosed as 15 benign and 35 malignant tumors. (researchgate.net)

Mucinous ~10% of gland. (librepathology.org)
Mucinous glands. (librepathology.org)

Moreover, the subman- dibular gland is susceptible to stone formation, inflammation, and sialectasia because the di- rection of salivary flow is against gravity. (fdocuments.net)

Salivary gland neoplasms are rare in children. (medscape.com)
It is rare in other salivary gland carcinomas. (medscape.com)

At rest, the parotid glands, located anterior to the ears, produce approximately 25% of oral saliva. (medscape.com)
[ 4 ] Approximately 1-1.5 liters of saliva are produced by the glands in a day. (medscape.com)
1] The incidence of salivary gland neoplasms as a whole is approximately 1.5 cases per 100,000 individuals in the United States. (medscape.com)

Anatomy11

Diseases33

Chemicals and Drugs5

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes3

Disciplines and Occupations1

Major salivary7

Patients with salivary gland tumors2

High-grade mucoepidermoid carcinoma1

Sublingual glands4

Involving the major and minor saliv1

Tumours9

Cystic carcinomas3

Adenomas5

Squamous cell carcinomas1

Epithelial tumor2

Lesions5

Palate10

Adenocarcinoma3

Parotid tumors2

Benign tumors2

Oral squamous cell carc1

Cancers4

Serous8

Malignancy5

Minor14

Salivary neoplasms1

Arise3

Pathology4

Head and neck7

Behavior4

Metastasis3

Myoepithelial7

Diagnosis7

Main glands1

Etiology3

Histological2

Metastatic2

Mandibular2

Neck1

Prognosis1

Prevalent2

Sialadenitis2

Occur3

Superficial parotidectomy1

Methods2

Mucinous2

Inflammation1

Rare2

Approximately3