Loading...
  • mucus
  • Although some mucins are membrane-bound due to the presence of a hydrophobic membrane-spanning domain that favors retention in the plasma membrane, most mucins are secreted as principal components of mucus by mucous membranes or are secreted to become a component of saliva. (wikipedia.org)
  • Secreted mucins are the main component of mucus protecting the epithelia whereas membrane-bound mucins are thought to play important biological roles in cell-cell and cell-matrix interactions, in cell signaling and in modulating biological properties of cancer cells. (mdpi.com)
  • All mucosal membranes of the body are covered by mucus, largely made up of the family of large glycoproteins called mucins. (pnas.org)
  • In insects, the peritrophic matrix of the gut has a protective role similar to that of the mucus of higher animals, but the insect matrix is made up of chitin and a number of chitin-binding proteins, of which some also contain mucin domains ( 6 ). (pnas.org)
  • They are high molecular weight proteins that are components of mucus and are synthesised and secreted by specialised cells of the epithelium (goblet cells, cells of mucous glands) or non mucin-secreting cells [ PMID: 15190477 ]. (ebi.ac.uk)
  • Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. (ebi.ac.uk)
  • This image shows mucins, large proteins that form a network through bonds to give mucus its thickness and elasticity. (eurekalert.org)
  • CHAPEL HILL, N.C. - UNC School of Medicine researchers have provided the first quantitative evidence that mucins - the protein framework of mucus - are significantly increased in cystic fibrosis patients and play a major role in failing lung function. (eurekalert.org)
  • The research, published today in the Journal of Clinical Investigation , shows that a three-fold increase of mucins dramatically increases the water-draining power of the mucus layer. (eurekalert.org)
  • Our finding suggests that diluting the concentration of mucins in CF mucus is a key to better treatments," said Mehmet Kesimer, PhD, associate professor of pathology and laboratory medicine and co-senior author of the JCI paper. (eurekalert.org)
  • Also, by measuring mucin concentration in patient mucus, doctors could learn whether therapies are working and to what degree. (eurekalert.org)
  • Mucins give mucus its gel-like thickness and elasticity. (eurekalert.org)
  • Without mucins, mucus would have the viscosity of blood," Kesimer said. (eurekalert.org)
  • The vast majority of mucus is water, but 30 to 35 percent of the remaining solid material is made up of mucins. (eurekalert.org)
  • They set out to conduct various novel experiments to physically measure the amount of mucins in CF secretions and normal mucus. (eurekalert.org)
  • Gastric Mucin 5AC antigen is found in columnar mucus cells of surface gastric epithelium and in goblet cells of the fetal and precancerous colon but not in normal colon. (abcam.com)
  • Nevertheless, one of the major components of mucus is mucins. (biology-online.org)
  • The mucus lining the stomachs of pigs may well be a much awaited, copious source of 'mucins' being regarded for use as wide-ranging anti-viral agents to supplement baby formula and for use in personal hygiene and other consumer products to protect against a range of viral infections, report scientists. (medindia.net)
  • That has led to consideration of mucin, the main component of mucus, for use as an anti-viral agent in a variety of products. (medindia.net)
  • The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. (wikipedia.org)
  • Mucin 2, oligomeric mucus gel-forming, also known as MUC2, is a protein that in humans is encoded by the MUC2 gene. (wikipedia.org)
  • Mucin 6, oligomeric mucus/gel-forming, also known as MUC6, is a human gene. (wikipedia.org)
  • Mucin originates from the mucus secretions from submaxillary glands, which are salivary glands that are located under the floor of the mouth. (wikipedia.org)
  • While mucus is mostly composed of water, its structural and rheological properties are characterized by mucin. (wikipedia.org)
  • MUC2
  • Expression of mucins (MUC1, MUC2, MUC5AC, and MUC6) and type 1 Lewis antigens in cases with and without Helicobacter pylori colonization in metaplastic glands of the human stomach. (springer.com)
  • The major secreted airway mucins are MUC5AC and MUC5B, while MUC2 is secreted mostly in the intestine but also in the airway. (wikipedia.org)
  • The cysteine-knot is responsible for dimerization in the endoplasmic reticulum, and, in the case of porcine submaxillary mucin (PSM) and MUC2, the third von Willebrand D (VWD) domain in its N-terminal part is responsible for trimerization in the late secretory pathway ( 1 , 4 ). (pnas.org)
  • Inflammation of the large intestine and the inflammatory bowel disease ulcerative colitis is observed in mice that are deficient in the mucin MUC2 ( 5 ), suggesting that the mucins are important for intestinal handling of bacteria. (pnas.org)
  • Mucin-2 (MUC2) belongs to the mucin family. (ebi.ac.uk)
  • MUC4
  • The evolution of the Muc4 mucin seems to have occurred by recruitment of a PTS domain to AMOP, NIDO, and VWD domains from a sushi domain-containing family of proteins present in lower animals, and Xenopus is the most deeply branching animal where a protein similar to the mammalian Muc4 was identified. (pnas.org)
  • mucosal
  • The dense "sugar coating" of mucins gives them considerable water-holding capacity and also makes them resistant to proteolysis, which may be important in maintaining mucosal barriers. (wikipedia.org)
  • Authoritative and practical, Mucins: Methods and Protocols is designed to be a useful resource for those entering the mucin field and to facilitate those already studying mucins to broaden their experimental approaches to understanding mucosal biology. (springer.com)
  • porcine
  • We envision porcine gastric mucins to be promising antiviral components for future biomedical applications," the report says. (medindia.net)
  • However, it is the mucin from bovine and porcine sources that have been used in several biomaterial applications. (wikipedia.org)
  • oligosaccharides
  • N-linked oligosaccharides are also found on mucins, but in less abundance than O-linked sugars. (wikipedia.org)
  • Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. (wikipedia.org)
  • Expression
  • In this review, we will focus on the altered expression pattern of mucins in pancreatic cancer, from the early neoplastic lesion Pancreatic Intraepithelial Neoplasia (PanIN) to invasive pancreatic carcinomas, and the molecular mechanisms (including genetic and epigenetic regulation) and signaling pathways known to control their expression. (mdpi.com)
  • Analysis of mucins was determined by ELISA and expression of TLR2 and TLR4 by flow cytometry. (dovepress.com)
  • Significant differences were observed neither in the expression of TLRs 2 and 4 in inflammatory cells of IS or peripheral blood, nor in the expression of mucins between both groups. (dovepress.com)
  • however, for many types of cancer, mucin expression becomes altered (down-regulated, up-regulated or newly expressed). (atlasgeneticsoncology.org)
  • Therefore, the over-expression of mucins may be implicated in the exfoliation, dissemination and invasion of the cancer cells (Hollingsworth and Swanson, 2004). (atlasgeneticsoncology.org)
  • The expression of mucin 16 has been shown to be altered in dry eye, cystic fibrosis, and several types of cancers. (wikipedia.org)
  • cystic fibrosis
  • Mucins are also overexpressed in lung diseases such as asthma, bronchitis, chronic obstructive pulmonary disease (COPD) or cystic fibrosis. (wikipedia.org)
  • Overproduction of mucins in the lungs is a key element of both chronic obstructive lung disease and cystic fibrosis. (pnas.org)
  • Mucin is also overly expressed in the presence of lung diseases such as asthma , bronchitis , cystic fibrosis, etc . (biology-online.org)
  • tandem repeat domain
  • Mucins share a common structural feature which is a tandem repeat domain comprising a variable number of tandem repeats (VNTRs) of identical or highly similar sequences rich. (springer.com)
  • Members of the mucin family are characterized by a hallmark feature: the presence of a tandem repeat domain, consisting of a protein backbone which acts as a scaffold for a large number of complex O-linked carbohydrate side chains (Williams et al. (atlasgeneticsoncology.org)
  • All mucins contain a tandem repeat domain that has repeating amino acid sequences high in serine, threonine and proline. (wikipedia.org)
  • human
  • The human gel-forming mucins contain VWD and C-terminal cysteine-knot domains that are responsible for the oligomerization of these molecules. (pnas.org)
  • extracellular
  • When overexpressed, the disorganization of mucins may reduce adhesion to other cells as well as the extracellular matrix, promoting cancer cell migration and metastasis. (wikipedia.org)
  • These receptors have a unique hybrid structure in which an extracellular epidermal growth factor (EGF)-like domain is fused to a GPCR domain through a mucin-like stalk. (wikipedia.org)
  • secretions
  • Back in 2004, however, other researchers used a standard immunologic analysis to show that mucins were decreased in CF secretions. (eurekalert.org)
  • cell
  • These mucins reach far out from the cell, but their functions are so far unknown. (pnas.org)
  • Typically, these mucins are found apically in polarized epithelia, but are distributed over the whole cell in cancer. (pnas.org)
  • As a mucin, MUC-4 also alters adhesive properties of the cell. (wikipedia.org)
  • The repulsive forces applied by the mucin creates anti-adhesive properties which can suppress cell adhesion to surfaces. (wikipedia.org)