• intestinal
  • Although MUC13, a newly identified transmembrane mucin, is known to be aberrantly expressed in ovarian and gastro-intestinal cancers, its role in pancreatic cancer is unknown. (aacrjournals.org)
  • This review will focus on what is known about goblet cell response in various GI infections and the regulatory networks that mediate goblet cell function and mucin production in response to intestinal insults. (mdpi.com)
  • In addition, we describe the current knowledge on the role of mucins in intestinal innate defense. (mdpi.com)
  • mucosal
  • The dense "sugar coating" of mucins gives them considerable water-holding capacity and also makes them resistant to proteolysis, which may be important in maintaining mucosal barriers. (wikipedia.org)
  • Authoritative and practical, Mucins: Methods and Protocols is designed to be a useful resource for those entering the mucin field and to facilitate those already studying mucins to broaden their experimental approaches to understanding mucosal biology. (springer.com)
  • secretion
  • Upon stimulation, MARCKS (myristylated alanine-rich C kinase substrate) protein coordinates the secretion of mucin from mucin-filled vesicles within the specialized epithelial cells. (wikipedia.org)
  • The concept of the mucus layer functioning as a dynamic protective barrier is suggested by studies showing changes in mucins in inflammatory conditions of the GI tract, by the altered goblet cell response in germ-free animals, and by the enhanced mucus secretion seen in response to infections. (mdpi.com)
  • MUC17
  • Membrane mucins, such as MUC17, function in epithelial cells to provide cytoprotection, maintain luminal structure, provide signal transduction, and confer antiadhesive properties upon cancer cells that lose their apical/basal polarization. (wikipedia.org)
  • cancers
  • The expression of mucin 16 has been shown to be altered in dry eye, cystic fibrosis, and several types of cancers. (wikipedia.org)
  • cystic fibrosis
  • Mucins are also overexpressed in lung diseases such as asthma, bronchitis, chronic obstructive pulmonary disease (COPD) or cystic fibrosis. (wikipedia.org)
  • CHAPEL HILL, N.C. - UNC School of Medicine researchers have provided the first quantitative evidence that mucins - the protein framework of mucus - are significantly increased in cystic fibrosis patients and play a major role in failing lung function. (eurekalert.org)
  • Gastric
  • Native mucin extract from normal gastric mucosa and from gastric diffuse carcinoma. (abcam.com)
  • Gastric Mucin 5AC antigen is found in columnar mucus cells of surface gastric epithelium and in goblet cells of the fetal and precancerous colon but not in normal colon. (abcam.com)
  • We envision porcine gastric mucins to be promising antiviral components for future biomedical applications," the report says. (medindia.net)
  • tandem repeat
  • Members of the mucin family are characterized by a hallmark feature: the presence of a tandem repeat domain, consisting of a protein backbone which acts as a scaffold for a large number of complex O-linked carbohydrate side chains (Williams et al. (atlasgeneticsoncology.org)
  • All mucins contain a tandem repeat domain that has repeating amino acid sequences high in serine, threonine and proline. (wikipedia.org)
  • mucus layer
  • The research, published today in the Journal of Clinical Investigation , shows that a three-fold increase of mucins dramatically increases the water-draining power of the mucus layer. (eurekalert.org)
  • The mucin-containing mucus layer coating the GI epithelium is the front line of innate host defense. (mdpi.com)
  • expression
  • In this review, we will focus on the altered expression pattern of mucins in pancreatic cancer, from the early neoplastic lesion Pancreatic Intraepithelial Neoplasia (PanIN) to invasive pancreatic carcinomas, and the molecular mechanisms (including genetic and epigenetic regulation) and signaling pathways known to control their expression. (mdpi.com)
  • Analysis of mucins was determined by ELISA and expression of TLR2 and TLR4 by flow cytometry. (dovepress.com)
  • Significant differences were observed neither in the expression of TLRs 2 and 4 in inflammatory cells of IS or peripheral blood, nor in the expression of mucins between both groups. (dovepress.com)
  • however, for many types of cancer, mucin expression becomes altered (down-regulated, up-regulated or newly expressed). (atlasgeneticsoncology.org)
  • Therefore, the over-expression of mucins may be implicated in the exfoliation, dissemination and invasion of the cancer cells (Hollingsworth and Swanson, 2004). (atlasgeneticsoncology.org)
  • Nineteen of the 21 reacting mucins (90%) were from patients with blood group A (18 patients) or AB (one patient) and expression of A antigen could be demonstrated on the mucin of these patients. (clinsci.org)
  • The resulting two reacting mucins were from patients with type O. However, expression of the blood group antigen could not account for the lack of reactivity of the mucin of other patients. (clinsci.org)
  • inflammatory
  • The purpose of this study is to determine if the formation of mucin balls is a marker for protection from inflammatory events to the cornea and if mucin balls play a role in protection during extended contact lens wear. (clinicaltrials.gov)
  • The percentage of Subjects that experienced Corneal Inflammatory Events within their Mucin Ball classification. (clinicaltrials.gov)
  • Bovine
  • Bovine submaxillary mucin coatings Verotoxin-producing Escherichia coli Marin, F. D. R. (wikipedia.org)
  • Bovine submaxillary mucin (BSM) coatings are a surface treatment provided to biomaterials intended to reduce the growth of disadvantageous bacteria and fungi such as S. epidermidis, E. coli, and Candida albicans. (wikipedia.org)
  • However, it is the mucin from bovine and porcine sources that have been used in several biomaterial applications. (wikipedia.org)
  • extracellular
  • When overexpressed, the disorganization of mucins may reduce adhesion to other cells as well as the extracellular matrix, promoting cancer cell migration and metastasis. (wikipedia.org)
  • These receptors have a unique hybrid structure in which an extracellular epidermal growth factor (EGF)-like domain is fused to a GPCR domain through a mucin-like stalk. (wikipedia.org)
  • human
  • 1. Human gallbladder mucin has been implicated to play a role in gallstone disease. (clinsci.org)
  • In spite of this fact relatively little is known about the structure of human gallbladder mucin. (clinsci.org)
  • 3. We conclude that considerable patient to patient heterogeneity of human gallbladder mucin exists. (clinsci.org)
  • sugars
  • Mucin O-glycans can be branched, and many sugars or groups of sugars are antigenic. (genome.jp)
  • cell
  • It is the aim of this review to provide the readers with an update on goblet cell biology and current understanding on the role of mucins in host defense in enteric infections. (mdpi.com)
  • As a mucin, MUC-4 also alters adhesive properties of the cell. (wikipedia.org)
  • The repulsive forces applied by the mucin creates anti-adhesive properties which can suppress cell adhesion to surfaces. (wikipedia.org)
  • surfaces
  • Mucins interact with surfaces in a unique way due to the amphiphilic properties the molecules exhibit. (wikipedia.org)
  • Most mucins adsorb to solid surfaces fairly easily without surface preparation due to the attractive interaction of the surface with the non-glycosylated region of the molecule. (wikipedia.org)
  • Surface force measurements reveal that long range steric repulsion forces exist between mucin coated surfaces and can be detected at a distance of up 100 nm or more. (wikipedia.org)
  • The efficiency of mucin adherence to hydrophobic surfaces has been analyzed by applying a coating of mucin and measuring the number of mucins remaining on the hydrophobic material after rinsing. (wikipedia.org)
  • Kesimer
  • Our finding suggests that diluting the concentration of mucins in CF mucus is a key to better treatments," said Mehmet Kesimer, PhD, associate professor of pathology and laboratory medicine and co-senior author of the JCI paper. (eurekalert.org)
  • Without mucins, mucus would have the viscosity of blood," Kesimer said. (eurekalert.org)
  • This is why Kesimer and his UNC mentor, the late John Sheehan, PhD, Distinguished Professor of Biochemistry and Biophysics, suspected that something must happen to mucins in the CF lung. (eurekalert.org)
  • Through this separation, Kesimer and Henderson's team isolated the mucins and simultaneously measured their concentration using a refractometer. (eurekalert.org)