Mouse cell adhesion molecules. Medical search. Frequent questions

A novel molecular magnetic resonance imaging agent targeting activated leukocyte cell adhesion molecule as demonstrated in mouse brain metastasis models. (ox.ac.uk)

Note: When using high concentrations of antibody, background binding of this dye to erythroid cell subsets (mature erythrocytes and precursors) has been observed. (bdbiosciences.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Neural Cell Adhesion Molecule (NCAM) in serum, plasma, tissue homogenates and other biological fluids. (srbiosystem.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Neural Cell Adhesion Molecule (NCAM) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (srbiosystem.com)
Multiparameter flow cytometric analysis using BD OptiBuild™ BV786 Mouse Anti-Human CD81 (TAPA-1) antibody (Cat. (bdbiosciences.com)
The section was costained with anti-mouse Podoplanin Antibody (clone PMab-1) Alexa Fluor® 488 at 5 µg/mL (green), anti-mouse CD31 Antibody (clone MEC13.3) Alexa Fluor® 594 at 5 µg/mL (orange), and anti-Tubulin β 3 (TUBB3) Antibody (Clone TUJ1) Alexa Fluor® 647 at 5 µg/mL (magenta). (biolegend.com)
Confocal image of C57BL/6 mouse lung sample acquired using the IBEX method of highly multiplexed antibody-based imaging: CD11c (magenta) in Cycle 1, CD206 (blue) in Cycle 1, and CD31 (green) in Cycle 4. (biolegend.com)

These cells fail to acquire interleukin 2 (IL-2) receptors, produce IL-2, and proliferate when activated with mitogens or monoclonal antibodies (mAbs) against the T cell receptor (TCR). (silverchair.com)
The postsynaptic terminal of vertebrate excitatory synapses contains a highly conserved multiprotein complex that comprises neurotransmitter receptors, cell-adhesion molecules, scaffold proteins and enzymes, which are essential for brain signalling and plasticity underlying behaviour. (nih.gov)
The multiple effects of IL-5 are mediated by binding of the cytokine to specific cell surface receptors expressed on target cells. (rndsystems.com)
Many of these molecules activate G-protein-coupled receptors (GPCRs), which couple to multiple Gα subunits. (medscape.com)

Dysfunctional endothelium leads to increased permeability to lipoproteins and up-regulation of leukocyte and endothelial adhesion molecules. (medscape.com)
Rabbit vascular endothelial adhesion molecules: ELAM-1 is most elevated in acute inflammation, whereas VCAM-1 and ICAM-1 predominate in chronic inflammation. (cdc.gov)

After two, four and 24 hours, fluorescence activated cell sorter (FACS) analysis for vascular cell adhesion molecule-1, intercellular adhesion molecule-1 and E-selectin was performed. (biomedcentral.com)
Exposure of endothelial cells to anti-b2GPI antibodies and their corresponding peptides leads to the inhibition of endothelial cell activation, as shown by decreased expression of the adhesion molecules E-selectin, intercellular adhesion molecule, and vascular cell adhesion molecule and of monocyte adhesion. (medscape.com)
Confocal image of the same artery showing expression of vascular cellular adhesion molecule-1 (VCAM-1, in red). (lu.se)

The spontaneous cytotoxic potential of the DN T cells was further corroborated by demonstrating that the lpr DN T cells constitutively transcribed perforin gene but failed to express granzyme A. The current study suggests that DN T cells are capable of mediating lysis of autologous cells bearing the specific ligands for adhesion molecules involved in the signaling of cytotoxicity. (silverchair.com)

Finally, using real-time polymerase chain reaction to detect the messenger ribonucleic acid expression of intercellular cell adhesion molecule-1 and transforming growth factor-beta1. (ijpsonline.com)
Periplaneta americana extract notably increase the number of bone marrow nucleated cell and peripheral blood cells, increase level of hemoglobin, raise the thymus index, induce bone marrow cells to reenter the proliferation cycle, increase the proliferation index and the messenger ribonucleic acid expression of intercellular cell adhesion molecule-1 and decrease the messenger ribonucleic acid expression of transforming growth factorbeta 1. (ijpsonline.com)
These effects may be mediated by the increase of intercellular cell adhesion molecule-1 and decrease of transforming growth factor-beta 1. (ijpsonline.com)

Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11.5 d post coitum, establishing a link between MAPK signalling in proliferating gonadal somatic cells and regulation of Sry expression. (plos.org)
These data demonstrate that MAP3K4-dependent signalling events are required for normal expression of Sry during testis development, and create a novel entry point into the molecular and cellular mechanisms underlying sex determination in mice and disorders of sexual development in humans. (plos.org)
Our data indicate, for the first time, a requirement for MAPK signaling in the developing XY gonad in order to facilitate normal expression of SRY and the downstream testis-determining genes and also suggest that reduced dosage of MAP3K4 may be the cause of a previously described autosomal sex-reversing mutation in the mouse. (plos.org)
Expression on mast cells allows attachment to neurites and fibroblasts (9, 10). (rndsystems.com)
As SgIGSF (spermatogenic IgSF), expression on developing sperm allows adhesion to an unknown partner on Sertoli cells that is critical for normal development (11, 12). (rndsystems.com)
At the age of defect onset, GPR56 expression is restricted specifically to developing granule cells in the rostral cerebellum, suggesting that GPR56 regulates properties of these cells. (jneurosci.org)
Here we extend evidence in AS model mice ( Ube3a m -/ p + ) of paternal UBE3A expression within the suprachiasmatic nucleus (SCN), the master circadian pacemaker. (nature.com)
Paternal UBE3A-positive cells in the SCN show partial colocalization with the neuropeptide arginine vasopressin (AVP) and clock proteins (PER2 and BMAL1), supporting that paternal UBE3A expression in the SCN is often of neuronal origin. (nature.com)
An early study in mice showed that expression of Ube3a is nearly exclusively maternal in neurons within the CA3 region of the hippocampus and in cerebellar Purkinje cells, with moderate maternal bias in the cerebral cortex 6 . (nature.com)
We previously observed persistent expression of UBE3A in the suprachiasmatic nucleus (SCN) of the hypothalamus, the master circadian regulatory region in the mammalian brain, of AS model mice 15 , thus identifying a novel site for relaxation of maternal expression bias of Ube3a in the adult brain. (nature.com)
CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naïve, effector, and memory T cells. (biolegend.com)
Intracellular metal ion chelators inhibit TNFalpha-induced SP-1 activation and adhesion molecule expression in human aortic endothelial cells. (oregonstate.edu)
Astragaloside IV inhibits NF- κ B activation and inflammatory gene expression in LPS-treated mice. (oregonstate.edu)
To investigate whether tenascin-C and tenascin-R may play important functional roles in the lesioned central nervous system, we have analysed their expression in the olivocerebellar system of the adult rat after 3-acetylpyridine-induced degeneration of nerve cells in the inferior olivary nucleus. (researchgate.net)
Therefore, we investigated the in vitro effect of DHEA on the expression pattern of adhesion molecules of human endothelial cells and neutrophils. (biomedcentral.com)
Neutrophils were freshly isolated from blood of 10 male healthy volunteers, stimulated the same way as endothelial cells and analyzed for surface expression of L-selectin, CD11b and CD18. (biomedcentral.com)
In the present study, we were able to demonstrate effects of DHEA on the expression of every adhesion molecule investigated. (biomedcentral.com)
Thus, we conclude that one mechanism by which DHEA may exert its protection in animal models is via the differential regulation of adhesion molecule expression. (biomedcentral.com)
Serum from MWCNT-exposed mice induced expression of adhesion molecules in primary murine cerebrovascular endothelial cells and, in a wound-healing in vitro assay, impaired cell motility and cytokinesis. (cdc.gov)
Real-time PCR revealed no significant changes in Nphs1, Nphs2, Cd2ap or Trpc6 expression, but Col4a2 message was increased in younger and older mice, while Col4a5 was decreased in older mice. (medscape.com)

Human and mouse IL-5 R alpha are both members of the hematopoietin receptor superfamily characterized by the presence of the WSXWS, and a four cysteine residue motif in the extracellular domain of the transmembrane protein. (rndsystems.com)
Indeed, granule cells from the rostral region of perinatal Gpr56 −/− cerebella show loss of adhesion to extracellular matrix molecules of the pial basement membrane. (jneurosci.org)
Consistent with this hypothesis, developing granule cells from the rostral region of Gpr56 −/− cerebella at birth exhibit a specific defect in cell adhesion to extracellular matrix (ECM) molecules of the pial basement membrane (BM) but no defects in migration, proliferation, or process outgrowth. (jneurosci.org)
Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. (embl.de)
Cadherins form protein complexes with cytoplasmic proteins (catenins) that convert the specific, homophilic-binding capacity of the extracellular domain into stable cell adhesion. (embl.de)
For this purpose, WIN 55,212-2 was injected in pregnant wistar rats from gestation day 5 to 20 and a detailed analysis of the levels of the neurotrophin brain-derived neurotrophic factor (BDNF) as well as of the signaling molecules extracellular signal-regulated kinase (ERK)1/2 and alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) was carried out in adult offspring. (researchgate.net)

Down syndrome cell adhesion molecule like 1 is a protein in humans that is encoded by the DSCAML1 gene. (wikipedia.org)
Here, by using genetically engineered mice and innovative touchscreen-based cognitive testing, we sought to investigate whether loss-of-function mutations in genes encoding key interactors of the PSD-95 protein complex display shared phenotypes in associative learning, updating of learned associations and reaction times. (nih.gov)
Our genetic dissection of mice with loss-of-function mutations in Syngap1, Nlgn3, Dlgap1, Dlgap2 and Shank2 showed that distinct components of the PSD-95 protein complex differentially regulate learning, cognitive flexibility and reaction times in cognitive processing. (nih.gov)
Here we report a role for the phylogenetically ancient mitogen-activated protein kinase (MAPK) signalling pathway in mouse sex determination. (plos.org)
Full length human recombinant protein of human L1CAM (NP_000416) produced in HEK293T cell. (origene.com)
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
IGSF4A is a 75 kDa immunoglobulin superfamily protein that mediates calcium-independent adhesive interactions, either homophilic or heterophilic with CRTAM (class I-restricted T cell-associated molecule), Necl-1 (SynCAM3) or Nectin-3 (1 - 4). (rndsystems.com)
Mouse IGSF4A cDNA encodes 445 amino acids including a signal peptide, three Ig-like domains (a V-type, a divergent C1-type and an I-type), a transmembrane domain and a cytoplasmic domain with protein 4.1 and PDZ domain binding sites. (rndsystems.com)
In addition to the cDNA clone encoding the full-length transmembrane protein, cDNA clones that arise from alternative splicing and that encode soluble secreted forms of IL-5 R alpha have been isolated from mouse as well as human cells. (rndsystems.com)
Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and MAG) and their shared carbohydrate epitope and myelin basic protein in growing sciatic nerve. (glob3.com)
Janeczko K. The proliferative response of S-100 protein-positive glial cells to injury in the neonatal rat mind. (glob3.com)

Because of these poor functions in vitro, the nature and significance of DN T cells in the autoimmune disease process is not clear. (silverchair.com)
We used histological, molecular, and behavioral approaches to characterize the defects caused by loss of GPR56 and also examined the potential cellular functions of this molecule in vitro and in vivo . (jneurosci.org)
Additional reported applications (for the relevant formats) include: immunoprecipitation 1-3 , complement-dependent cytotoxicity 4 , in vivo and in vitro blocking of adhesion 1-3,5 , and immunohistochemical staining of acetone-fixed frozen sections and zinc-fixed paraffin-embedded sections 6 . (biolegend.com)

Additionally, it has also been reported that IL-5 can stimulate the proliferation and/or differentiation of basophils and B cells. (rndsystems.com)
This molecule inhibits the proliferation of IL-5-dependent cell lines and blocks human umbilical cord blood eosinophil differentiation. (rndsystems.com)
Loss of GPR56 does not affect cell proliferation, migration, or neurite outgrowth. (jneurosci.org)
Neural cell adhesion molecule (N-CAM) inhibits astrocyte proliferation after harm to totally different regions of the adult rat brain. (glob3.com)
Rab27b can promote the cell proliferation, migration and invasion of ESCs. (bvsalud.org)
QLα12 LacZ+/Cre+ mice showed no changes in podocyte number, apoptosis, proliferation or Rho/Src activation. (medscape.com)

Description: A sandwich ELISA kit for detection of Neural Cell Adhesion Molecule from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (srbiosystem.com)

In the current study, we describe a surprising finding that mAbs against CD3-TCR-alpha/beta complex can strongly trigger the lytic activity of the DN T cells to induce redirected lysis of Fc receptor-positive targets. (silverchair.com)
Glioblastoma multiforme (GBM) evades immune surveillance by inducing immunosuppression via receptor-ligand interactions between immune checkpoint molecules. (medscimonit.com)
T cell immunoglobulin and mucin domain 3 (Tim-3) is a key checkpoint receptor responsible for exhaustion and dysfunction of T cells and plays a critical role in immunosuppression. (medscimonit.com)
cDNA clones for the alpha chain (IL-5 R alpha ) of both the mouse and human high affinity IL-5 receptor complexes have been isolated. (rndsystems.com)
Serum thrombospondin-1 level was significantly increased after MWCNT exposure, and mice lacking the endogenous receptor CD36 were protected from the neuroinflammatory and BBB permeability effects of MWCNTs. (cdc.gov)
Targeting activated Gα subunits to specific cells in vivo permits identification of downstream effector pathways independent of receptor activation, and thus permits insight into disease mechanisms otherwise impossible to study in vivo . (medscape.com)

In fatal disease, LASV immunostaining was most prominent in the anterior uvea, especially in the filtration angle, ciliary body, and iris and in and around vessels in the bulbar conjunctiva and peripheral cornea, where it co-localized with an endothelial marker (platelet endothelial cell adhesion molecule). (cdc.gov)
CD31 is a 130-140 kD glycoprotein, also known as platelet endothelial cell adhesion molecule (PECAM-1), EndoCAM, and gpIIa. (biolegend.com)

The six reported splice variants include a prominently expressed soluble form of about 45 kDa that inhibits adhesion (13). (rndsystems.com)

Cell adhesion molecules (CAMs) make a kind of "cell" call, sending connecting signals between neurons. (jax.org)
These studies establish a novel role for GPR56 in the adhesion of developing neurons to basal lamina molecules and suggest that this adhesion is critical for maintenance of the pia and proper cerebellar morphogenesis. (jneurosci.org)
Cell adhesion controls many aspects of brain development including growth and structure, and enables neurons to connect with other neurons and supportive proteins. (sciencedaily.com)
Differences in the molecular connections of human neurons compared to the neurons of chimps, mice and other animals, could help explain why the human brain is capable of far more complex cognitive functions. (sciencedaily.com)

At 4 h after MWCNT exposure, broad disruption of the blood-brain barrier (BBB) was observed across the capillary bed with the small molecule fluorescein, concomitant with reactive astrocytosis. (cdc.gov)
Historically, the screening and triaging of small molecule glycomimetics that bind to the galectin-3 CRD has been completed in fluorescence polarisation (FP) assays to determine K D values. (lu.se)
In addition, it can also provide early kinetic characterisation of small molecule galectin-3 glycomimetics with robust k on and k off values generated in a high throughput manner. (lu.se)

Both molecules support neurite outgrowth from several neuronal cell types when presented as uniform substrates. (researchgate.net)

To unravel fundamental genetic mechanisms that control cell fate choice in vivo , we study embryonic development in a simple marine invertebrate, the ascidian Ciona intestinalis , belonging to the vertebrate sister group, the tunicates. (uibk.ac.at)
used a mouse transplantation model with prolonged ex vivo cold storage to explore liver graft protection. (jci.org)
In vivo infusion of each of the anti-b2GPI antibodies into BALB/c mice followed by administration of the corresponding specific peptides prevents the peptide-treated mice from developing experimental APS. (medscape.com)

Analysis of XY byg/byg gonads at 11.5 d post coitum reveals a growth deficit and a failure to support mesonephric cell migration, both early cellular processes normally associated with testis development. (plos.org)
It is strongly recommended that when using a reagent for the first time, users compare the spillover on cells and BD CompBead to ensure that BD CompBeads are appropriate for your specific cellular application. (bdbiosciences.com)
Whats more, ascidian embryos develop with a fixed cellular lineage based on few and large cells allowing cellular resolution of cell fate identity. (uibk.ac.at)
CD81 has a very broad cellular distribution, being expressed on cells of hematopoietic, neuroectodermal and mesenchymal origin. (bdbiosciences.com)
As a result, it can influence a range of cellular processes including cell activation, adhesion and apoptosis. (lu.se)

As SynCAM-1 (synaptic cell adhesion molecule-1) it binds homotypically across synaptic clefts and, like neuroligin/neurexin adhesion pairs, promotes formation of neural cell synapses (7, 8). (rndsystems.com)
Impact of neural cell adhesion molecule deletion on regeneration after mouse spinal cord injury. (uni-koeln.de)
Tenascin-R mRNA was expressed by distinct neural cell types in the unlesioned olivocerebellar system. (researchgate.net)
Chemical characterization of a neural cell adhesion molecule purified from embryonic mind membranes. (glob3.com)
Le Gal La Salle G, Rougon G, Valin A. The embryonic form of neural cell surface molecule (E-NCAM) within the rat hippocampus and its reexpression on glial cells following kainic acid-induced status epilepticus. (glob3.com)

Briefly, IgSFs are adhesion molecules that bind to themselves (homophilic) or compatible IgSFs (heterophilic) across cell-cell junctions. (elifesciences.org)

RGC feature selectivity arises from their synapses with a specific subset of amacrine (AC) and bipolar cell (BC) types, but how RGC dendrites arborize and collect input from these specific subsets remains poorly understood. (elifesciences.org)

In their Science paper, the researchers identified 992 CNSs whose sequences were specifically modified in humans and enriched near genes involved in neuronal cell adhesion. (sciencedaily.com)

Upregulation of endothelial ALCAM (activated leukocyte cell adhesion molecule) is a key element for leukocyte recruitment in neurological disease. (ox.ac.uk)
Subsequently, in a proof-of-concept study, mouse models of brain metastasis were induced by intracardial injection of brain-tropic human breast carcinoma, lung adenocarcinoma or melanoma cells to upregulate endothelial ALCAM. (ox.ac.uk)
At selected time-points, mice were injected intravenously with ALCAM-MPIO, and ALCAM-MPIO induced hypointensities were observed on T2*-weighted images in all three models. (ox.ac.uk)
The study showed that blocking ALCAM in mice lessens the flow of B cells to the brain and slows the progression of MS. (medicalnewstoday.com)

We established an intracranial GBM model using C57BL/6 mice and GL261 cells, and treated the mice with single or combined monoclonal antibodies (mAbs) against Tim-3/CEACAM1. (medscimonit.com)
C57BL/6 mouse splenocytes were stained with CD3e APC and CD62L (clone MEL-14) KIRAVIA Blue 520™ (left) or rat IgG2a, κ KIRAVIA Blue 520™ isotype control (right). (biolegend.com)
C57BL/6 mouse splenocytes were stained with CD31 (clone MEC13.3) Alexa Fluor® 594 (filled histogram) or rat IgG2a, κ Alexa Fluor® 594 isotype control (open histogram). (biolegend.com)
C57BL/6 mouse frozen liver section was fixed with 4% paraformaldehyde (PFA) for 10 minutes at room temperature and blocked with 5% FBS plus 5% rat serum for 1 hour at room temperature. (biolegend.com)
exposure to organophosphate neurotoxicants combined with high circulating glucocorticoids in two inbred mouse strains, C57BL/6J and DBA/2J. (cdc.gov)

This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. (origene.com)
Keeping B cells outside of the brain by blocking their migration but retaining them in the blood could reduce MS symptoms and progression - without the infectious side effects because they are not depleted from the rest of the body. (medicalnewstoday.com)

Double-negative T cells from MRL-lpr/lpr mice mediate cytolytic activity when triggered through adhesion molecules and constitutively express perforin gene. (silverchair.com)
The lpr gene induces in mice, accumulation of large numbers of CD4-CD8- (double negative [DN]) T lymphocytes which bear adhesion molecules not characteristic of normal resting T cells. (silverchair.com)

Interference RNA-mediated knockdown of GPR56 recapitulates the loss of adhesion seen in knock-outs, and reexpression of GPR56 rescues the adhesion defect in knock-out granule cells. (jneurosci.org)
These results support a novel hypothesis that the cerebellar defects in Gpr56 knock-outs, and potentially in human patients with GPR56 mutations, arise from the disrupted adhesion of developing granule cells to the pial BM. (jneurosci.org)

Key molecules in this recognition process are thought to be members of the immunoglobulin superfamily (IgSFs). (elifesciences.org)

ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. (frontiersin.org)
A Disintegrin and Metalloproteases (ADAM), originally named metalloproteinases disintegrin cystein-rich (MDC), are membrane-anchored cell surface proteins containing both disintegrin and metalloproteinase domains. (frontiersin.org)
It is estimated that as much as 10% of the cell surface proteins undergo ectodomain shedding. (frontiersin.org)
Cadherins are a group of transmembrane proteins that serve as the major adhesion molecules located within adherens junctions. (embl.de)
We use basic and clinical research to understand the cells, proteins, and genes that lead to successful recovery of function, and also how complications develop that impact quality of life after stroke. (stanford.edu)

This occurs in insects thanks to Dscam1 (Down syndrome cell adhesion molecule 1). (jax.org)

VCAM1 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 682 amino acids (25-698 a.a) and having a molecular mass of 75.4kDa (Migrates at 70-100kDa on SDS-PAGE under reducing conditions). (angioproteomie.com)
One of nature's strategies is extreme molecular diversity, like giving each neuron a unique cell phone number or bar code. (jax.org)
The team plans further investigation of the cell types in which DSCAM functions and the molecular mechanisms by which DSCAM masks adhesion, to advance understanding of normal development as well as the potential mechanisms underlying neurodevelopmental disorders. (jax.org)
We are using a variety of technical approaches for the study of SCN pacemaker function ranging from the molecular to the behavioral levels in Syrian hamsters and mice. (kent.edu)
Aldred, N. (2021): Omics-based molecular analyses of adhesion by aquatic invertebrates. (uibk.ac.at)
Correspondence with low molecular weight chemicals that results in the priming of chemical-specific, Prof. Dr. Stefan F. Martin, Allergy Research skin-homing CD8+ Tc1/Tc17 and CD4+ Th1/Th17 cells. (cdc.gov)

Endothelial cells derived from human umbilical cord were subjected to an lipopolysaccharide (LPS) challenge. (biomedcentral.com)
Human aCL antibodies cause placental necrosis in BALB/c mice. (medscape.com)
2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
Immunohisto- have been used for positive selection of NSCs from em- chemistry on human embryonic central nervous system bryonic mice (Nagato et al. (lu.se)
CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
Surface plasmon resonance (SPR) has not been widely used for compound screening and in this study it was used to compare human and mouse galectin-3 affinity measures between FP and SPR, as well as investigate compound kinetics. (lu.se)
The K D estimates for a set of compounds selected from mono- and di-saccharides with affinities across a 550-fold range, correlated well between FP and SPR assay formats for both human and mouse galectin-3. (lu.se)
Increases in affinity for compounds binding to human galectin-3 were driven by changes in both k on and k off whilst for mouse galectin-3 this was primarily due to k on . (lu.se)
The reduction in affinity observed between human to mouse galectin-3 was also comparable between assay formats. (lu.se)
1998. Protection of human upper respiratory tract cell lines against sulphur mustard toxicity by hexamethylenetetramine (HMT). (cdc.gov)
1991. Genetic activity of the human carcinogen sulphur mustard towards salmonella and the mouse bone marrow. (cdc.gov)
Photocarcinogenesis in hairless mice induced tumors harbors more UVA than UVB fingerprint by ultraviolet A tanning devices with or without mutations: A role for UVA in human skin car- subsequent solar-simulated ultraviolet irradia- cinogenesis. (who.int)

They serve as recognition molecules between corresponding synaptic partners. (nih.gov)

Involved inflammatory cells produce cytokines and chemokines, and generate ROS, further contributing to graft dysfunction. (jci.org)
Activated by cytokines and chemokines, leukocytes and endothelial cells express distinct adhesion molecules on their cell surfaces [ 9 ]. (biomedcentral.com)

The outer Ig-like domain most likely mediates adhesion, with altered affinity for splice variants that have either shorter spacing of this domain from the plasma membrane or varied glycosylation (1, 6). (rndsystems.com)

It is involved in cell growth and signal transduction. (bdbiosciences.com)
MW) chemicals interact with host cells and molecules and In our daily life, we are confronted with a plethora of natural influence biologic processes such as signal transduction. (cdc.gov)

These macrophages, in addition to smooth muscle cells, activate T cells by presenting antigens, including oxidized LDL. (medscape.com)

As Necl-2 (nectin-like 2), it is expressed on T zone-restricted BDCA3 + dendritic cells, again interacting with CRTAM (3). (rndsystems.com)
It is a member of the Ig superfamily, expressed on endothelial cells, platelets, granulocytes, monocytes/macrophages, dendritic cells, and T and B cell subsets, and is critical for cell-to-cell interactions. (biolegend.com)

They may play an important role in the sorting of different cell types during morphogenesis, histogenesis and regeneration. (embl.de)
and stem cell regeneration. (lu.se)

cancer cell growth and spreading, it has also been proposed that GPR56 regulates cell adhesion, but this has remained untested in the nervous system. (jneurosci.org)
Members of the ADAM family contribute to various physiological and pathophysiological processes by modulation of molecules like growth factors or cytokines. (frontiersin.org)

The mean survival time in the control, anti-Tim-3, anti-CEACAM1, and combined treatment groups was 29.8, 43.4, 42.3, and 86.0 days, respectively, with 80% of the mice in the combined group becoming long-term survivors showing immune memory against glioma cells. (medscimonit.com)
Both cold and warm IRI activate the innate immune system, including liver Kupffer cells and neutrophils. (jci.org)
The adaptive immune system is also triggered, eliciting complement activation and T cell activation. (jci.org)
This effect goes along with reduced amounts of infiltrating immune cells in organs such as lung and liver. (biomedcentral.com)
Ongoing projects focus on glial cells (astrocytes and microglia) and how they coordinate with immune cells from the blood to affect bystander brain injury in the days after stroke. (stanford.edu)
Primary endometrial stromal cells (ESCs), decidual stromal cells (DSCs), decidual immune cells (DICs) and peripheral blood mononuclear cells (PBMCs) were isolated. (bvsalud.org)
Higher magnification of the same region, showing very high levels of VCAM-1 and adhesion of immune cells (arrows) at the plaque edges, also areas of turbulent blood flow. (lu.se)

21955. Immobilized Recombinant Mouse CRTAM Fc Chimera (Catalog # 3687-CR) at 2 µg/mL (100 µL/well) can bind Recombinant Mouse IGSF4A/SynCAM1 with a linear range of 0.2-10 µg/mL. (rndsystems.com)
Recombinant LASV-Josiah, based on the sequence of an isolate obtained in 1976 from the serum of a 40-year-old man hospitalized at Songo Hospital in Sebgwena, Sierra Leone ( 21 , 22 ), was rescued in BSR-T7/5 cells and passaged twice in Vero-E6 cells (GenBank accession nos. (cdc.gov)

DSCAM interacts with other cell adhesion molecules to prevent their running amok. (jax.org)
The researchers focused on DSCAM's self-avoidance function in the mouse retina, but DSCAM and members of the cadherin superfamily have also emerged as key contributors to a variety of neurodevelopmental disorders, including autism, schizophrenia, bipolar disease, Down syndrome and intellectual disability. (jax.org)
DSCAM promotes self-avoidance in the developing mouse retina by masking the functions of cadherin superfamily members. (jax.org)

Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)

The iron chelator, desferrioxamine, reduces inflammation and atherosclerotic lesion development in experimental mice. (oregonstate.edu)
The authors found that liver grafts with absent carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) exhibited increased ischemia-reperfusion injury inflammation and decreased function in wild-type recipients. (jci.org)

We identified a mouse mutant that causes embryonic gonadal sex reversal: the development of ovaries in an XY embryo. (plos.org)
The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)

risk of basal and squamous cell skin cancer. (who.int)

This may allow evasion of antitumor responses, since TSLC-1 interaction with CRTAM on activated NK and CD8 + T cells stimulates cytotoxicity and upregulates IFN-gamma production (3, 6). (rndsystems.com)

Galectin-3 is a beta-galactoside-binding mammalian lectin that is one of a 15-member galectin family that can bind several cell surface glycoproteins via its carbohydrate recognition domain (CRD). (lu.se)

In women with miscarriage, NRP1 was abnormally elevated in DSCs but diminished in decidual macrophages and NK cells. (bvsalud.org)
Other trophic factors, such as IL-2, TNF-α, and granulocyte-macrophage stimulating factor, cause activated T cells to produce interferon-γ, TNF-α, and TNF-β, leading to stimulation of macrophages and further up-regulation of leukocyte adhesion molecules. (medscape.com)

fication and isolation via fluorescence-activated cell sort- ing (FACS). (lu.se)

In this study, we intended to investigate the impact of Rab27b and its downstream molecule in the development of EMS. (bvsalud.org)

In this study, we identified a new player in assembling neural circuits in the outer retina, the L1-family cell adhesion molecule Neurofascin (Nfasc). (nih.gov)
Taken together, our data suggest a new role of Nfasc in rod synapses within the mouse outer retina. (nih.gov)

Dissected C57/B6 mouse stomach was immersed in 4% paraformaldehyde (PFA) overnight followed by 30% sucrose immersion overnight and frozen in OCT. Frozen section was blocked with 5% FBS and 5% mouse serum for 30 minutes at room temperature. (biolegend.com)

Solution structure of the epithelial cadherin domain responsible for selective cell adhesion. (embl.de)

Confocal microscopy revealed disordered collagen IVα1/2 staining in older mice and loss of α5 without changes in other collagen IV subunits. (medscape.com)

Similar redirected lysis was also inducible using mAbs against CD44 and gp90MEL-14, molecules involved in the binding of lymphocytes to endothelial cells. (silverchair.com)
The CD4+, CD8+, and regulatory T cells in brain-infiltrating lymphocytes were analyzed using flow cytometry, and the effector function of T cells was assessed using ELISA. (medscimonit.com)
The presence of B lymphocytes in cerebrospinal fluid is a classic marker of MS, and it is these cells that give MS its progressive nature. (medicalnewstoday.com)

In a study comparing the genomes of humans, chimpanzees and other vertebrates, researchers at the US Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) and Joint Genome Institute (JGI) found a strikingly high degree of genetic differences in DNA sequences that appear to regulate genes involved in nerve cell adhesion molecules. (sciencedaily.com)

of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)

Nearly 50 different mouse retinal ganglion cell (RGC) types sample the visual scene for distinct features. (elifesciences.org)

These functions include coupling cytoskeletal force generation to strongly adherent sites on the cell surface and the regulation of intracellular signaling events. (embl.de)

Anatomy45

Organisms11

Diseases7

Chemicals and Drugs112

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes55

Disciplines and Occupations1

Information Science3

Targeting activated leukocyte cell adhesion1

Antibody6

Receptors4

Endothelial adhesion2

Vascular3

Ligands1

Intercellular3

Expression20

Extracellular6

Protein11

Vitro3

Proliferation6

ELISA Kit1

Receptor6

Platelet2

Inhibits1

Neurons4

Small molecule3

Neurite outgrowth1

Vivo3

Cellular5

Neural cell5

Homophilic1

Poorly understood1

Neuronal cell1

ALCAM4

C57BL5

Migration2

Gene2

Granule cells2

Immunoglobulin1

Proteins5

Syndrome cell1

Molecular6

Human12

Recognition molecules1

Cytokines and chemokines2

Plasma membrane1

Signal Transduction2

Antigens1

Dendritic cells2

Regeneration2

Growth2

Immune7

Recombinant2

DSCAM3

Differentiation1

Inflammation2

Embryonic2

Basal1

Cytotoxicity1

Bind1

Macrophages2

FACS1

Downstream1

Retina2

Serum1

Selective1

Confocal1

Lymphocytes3

Regulate1

Mechanisms1

Distinct1

Regulation1