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  • proteins
  • As intracellular calcium levels rise, the motor proteins responsible for the contractile response are able to interact, as shown in Figure 3, to form cross-bridges and undergo shortening. (lumenlearning.com)
  • Myosins (/ˈmaɪəsɪn, -oʊ-/) comprise a superfamily of motor proteins best known for their roles in muscle contraction and in a wide range of other motility processes in eukaryotes. (wikipedia.org)
  • The discovery of small chemical inhibitors of human Kinesin-5 through a pioneering in vitro phenotypic screening on cancer cell lines has led to both the development of new anticancer therapeutic agents, and to novel tools to probe the mechanism of microtubule motor proteins. (wikipedia.org)
  • microtubule
  • He also created a number of tools that are used today: atypical hydrolysable GTP analog GMPCPP various fluorescent tubulin derivatives assays for motors and microtubule polarity While at the European Molecular Biology Laboratory (EMBL) Hyman along with Rebecca Heald and Eric Karsenti combined their work to create an impact on the current understanding of how the meiotic spindle self assembles. (wikipedia.org)
  • This motor is essential for mitosis in most organisms, wherein it participates in the self-assembly of the microtubule-based mitotic spindle, but is not otherwise required for cell viability. (wikipedia.org)
  • There are many models that attempt to explain the self-assembly of the mitotic spindle based upon microtubules as a structural element, and a set of microtubule motors, including Kinesin-5 to move and order them. (wikipedia.org)
  • Recent data, however, finds that aspects of the 'force balance' model that posit spindle length and stability to be mediated by a balance between the minus-end directed microtubule sliding and plus-end directed microtubule sliding by opposing motors in insect cells, seems not to be the case in mammalian cells. (wikipedia.org)
  • The process of self-assembly of the mitotic spindle remains a major unsolved question in cell biology, and a robust model awaits further details of the regulation and behavior of various microtubule motors and structural elements that compose this machinery. (wikipedia.org)
  • Behavior
  • some of these long-term effects include: increased neuron growth, increased neurological activity (e.g., c-Fos and BDNF signaling), improved stress coping, enhanced cognitive control of behavior, improved declarative, spatial, and working memory, and structural and functional improvements in brain structures and pathways associated with cognitive control and memory. (wikipedia.org)
  • discharge
  • The motor output from lumbosacral segments was characterized by recording the pattern of ventral root and muscle nerve discharge in 6-14-d-old embryos. (jneurosci.org)
  • Following hindlimb muscle innervation, each cycle of activity was initiated by a brief, intense discharge that coincided with the rising phase of the ventral root potential. (jneurosci.org)
  • The developmental changes in the coordination of antagonist activity were documented by recording the pattern of discharge in sartorius (flexor) and caudilioflexorius (extensor) muscle nerves between stage 30 and stage 36. (jneurosci.org)
  • The second discharge was delayed in flexor, but not in extensor, motoneurons, which led to an alternating pattern of activity. (jneurosci.org)
  • opposite
  • This shows that the cargo (Rab6) binding end of BICD2 extends out through the pointed end complex at the opposite end away from the dynein motor domains. (wikipedia.org)
  • dopamine
  • This therapy consists on transferring the TH and GTP cyclohydrolase 1 genes into the MSNs because the endogenous AADC activity is able to convert the L-dopa into dopamine. (wikipedia.org)
  • coordination
  • This could be due to the divergent motor demands associated with postural control and muscle strength on the one hand and the complex coordination of a golf swing on the other. (frontiersin.org)
  • Human motor control is based on the complex interaction of dynamic processes comprising, e.g., diverse sensory systems, intermuscular and intramuscular synergy, and, thereby, coordination of several joints with several degrees of freedom ( Horak, 2006 ). (frontiersin.org)
  • different
  • It is concluded that in healthy subjects taking a regular diet, motor activity is not different between the uncleansed and cleansed colon with PEG, except for the high amplitude propagated contractions, which occur more frequently in the cleansed colon. (bmj.com)
  • Use it in a few different letter recognition and letter sound games AND in-hand manipulation for a little fine motor fun with the kids! (pinterest.com)
  • Presumably this is so the myosins may interact, via their tails, with a large number of different cargoes, while the goal in each case - to move along actin filaments - remains the same and therefore requires the same machinery in the motor. (wikipedia.org)
  • Tasks
  • Constructional apraxia cannot be localized to a specific hemisphere or cerebral area because drawing and constructional tasks require both perceptual and motor functioning. (wikipedia.org)
  • known
  • Charcot-Marie-Tooth disease, also known as hereditary motor and sensory neuropathy, encompasses a group of hereditary disorders that damage peripheral nerv. (reference.com)
  • These receptors open to allow sodium ions to flow in and potassium ions to flow out of the muscle's cytosol, producing a local depolarization of the motor end plate, known as an end-plate potential (EPP). (lumenlearning.com)
  • Still, it is not clear whether all the structural elements required for spindle assembly are known, or how the motors, including Kinesin-5, might be regulated in space and time. (wikipedia.org)
  • function
  • Despite many advances, the precise signaling mechanisms that regulate motor function in the striatum, that part of the brain responsible for motor activity, remain unknown. (medicalnewstoday.com)
  • The primary symptoms of chronic inflammatory demyelinating polyneuropathy include impaired motor function, loss of sensation and a symmetric weakness in th. (reference.com)
  • muscle
  • In recent decades, numerous researches on human motor control have suggested the potential effect of dental occlusion and muscle activity of the craniomandibular system (CMS). (frontiersin.org)
  • human
  • Human motor control is based on complex sensorimotor processes. (frontiersin.org)
  • A manometric method was developed to study the motor activity in the unprepared human colon, and the results in eight healthy subjects were compared with those obtained in the same subjects after bowel cleansing with a non-absorbable solution containing polyethylene glycol 4000 (PEG). (bmj.com)
  • Kids
  • These free printable Christmas play dough mats make a great Christmas gift for students, a nice party favor, or a fun activity for a kids Christmas party. (pinterest.com)
  • complex
  • As students become comfortable with the basic motor design platform, they can expand interest to larger, more complex interpretations. (kelvin.com)
  • essential
  • Dynactin is often essential for dynein activity and can be thought of as a "dynein receptor" that modulates binding of dynein to cell organelles which are to be transported along microtubules. (wikipedia.org)
  • loss
  • People with catatonia may experience an extreme loss of motor skill or even constant hyperactive motor activity. (wikipedia.org)
  • As Alzheimer's disease progresses, the patient's ability to copy objects becomes increasingly impaired and they may lose the ability to correctly draw simple figures due to a motor loss in routine memories. (wikipedia.org)
  • chronic
  • However, some of erythromycin's properties, including antibiotic activity, are not appropriate for a drug designed for chronic use over a patient's lifetime. (wikipedia.org)
  • Development
  • In new findings that could have an impact on the development of therapies for a number of currently untreatable brain disorders such as Parkinson's and Huntington's diseases, scientists from the Florida campus of The Scripps Research Institute (TSRI) have found, for the first time, that a specific signaling circuit in the brain is deeply involved in motor activity. (medicalnewstoday.com)
  • Sports
  • Based on the 2013 agreement of the Ministry of Education (MINED), and Special Olympics called "Sports activity and recreation for people with intellectual disabilities" experiential sessions were developed for Young Athletes Motor Activities Training programs. (specialolympics.org)
  • Because of the multifactorial etiology of parafunctional CMS activity, conclusions about the need for dental treatment to improve sports performance are, however, completely unwarranted. (frontiersin.org)
  • Results
  • Our results demonstrate that multiple UAW motor outputs can be uncoupled from phrenic bursting, and this response is associated with bursting of EI nerve fibers. (biomedsearch.com)
  • simple
  • Developed by Baltimore teacher Fred Nastvogel, this motor kit facilitates a process of discovery that is seated in a simple distinction. (kelvin.com)
  • high
  • Of more than 20 classified pyrrole antibiotics, PBP is the most active member in its class, and demonstrates a high in vitro activity (IC50 = 0.1 μM) against methicillin-resistant Staphylococcus aureus (MRSA). (wikipedia.org)
  • allow
  • By clicking "Accept and Continue" below, (1) you consent to these activities unless and until you withdraw your consent using our rights request form, and (2) you consent to allow your data to be transferred, processed, and stored in the United States. (medicalnewstoday.com)