Motility proteins genes bacterial. Medical search. Frequent questions

Polymorphisms of bacterial virulence elements like pathogenicity isle, and genes for external membrane motility and proteins [33], as well by host genes linked to inflammatory response are essential but cannot completely explain different local, cultural, gender-dependent and specific disease final results [34, 35, 36, 37, 38]. (eprf.ca)
Bacterial type IV pili are critical for diverse biological processes including horizontal gene transfer, surface sensing, biofilm formation, adherence, motility, and virulence. (biorxiv.org)
Type IV pili are ubiquitous surface appendages in Gram-negative bacteria that promote diverse activities including attachment, virulence, biofilm formation, horizontal gene transfer, and twitching motility [ 1 - 5 ]. (biorxiv.org)
Thus, the pyrD gene appears to be essential for several cellular processes involved in AIEC virulence. (rossimicrolab.com)
Altogether, our results suggest that the crucial role played by the pyrD gene in AIEC virulence, and the presence of structural differences between E. coli and human DHOD allowing for the design of specific inhibitors, make E. coli DHOD a promising target for therapeutical strategies aiming at counteracting chronic inflammation in CD by acting selectively on its bacterial triggers. (rossimicrolab.com)
Next-generation therapies against bacterial infections will result from rational exploitation of the genomic sequences of bacterial pathogens, and from a better molecular understanding of their virulence. (cnrs.fr)
Our second research stream focuses on type 4 filaments (T4F), key virulence factors in numerous bacterial pathogens. (cnrs.fr)
T4F have been studied for decades because they are key virulence factors in many human bacterial pathogens. (cnrs.fr)
One pathogenic factor of Xcc that is gaining more notoriety in virulence is motility. (biomedcentral.com)
At present it is assumed that the relationship between an individual's susceptibility and bacterial virulence determines the balance between tolerance of invading pathogens and the mounting of an immune response, which in turn dictates the course of infection and subsequent recurrence. (ncl.ac.uk)
Subramani (2019) said that Quorum sensing (QS) is a process of intercellular signaling or cell-cell communication and a vital regulatory mechanism for coordinating biofilm formation including common activities and physiological processes such as symbiosis, formation of spores or fruiting bodies, antibiotics synthesis, genetic competence, apoptosis, and virulence in many bacterial species using extracellular QS signaling molecules, which is often referred to as autoinducers. (learnlifescience.com)
Virulence in P. aeruginosa is combinatorial, and results from the activation of several genetic programs that regulate motility, attachment to the host epithelium as well as the synthesis of exotoxins. (nih.gov)

Surface topography designed to achieve spatial segregation has shown promise in delaying bacterial attachment and biofilm growth. (rsc.org)
Here, we investigated bacterial attachment, cell alignment and biofilm formation of Pseudomonas aeruginosa on periodic nano-pillar surfaces with different pillar spacing. (rsc.org)
In particular, surface modifications that physically create rational surface topographies have attracted attention in recent years, and have shown to inhibit bacterial attachment and biofilm growth without the use of antimicrobials. (rsc.org)
Additionally, it inhibits the physiological traits of the S. aureus biofilm, including hydrophobicity, motility, eDNA, and PIA associated to the biofilm. (frontiersin.org)
In addition, pyrD inactivation reduced flagellar motility and strongly affected biofilm formation by downregulating transcription of both type 1 fimbriae and curli subunit genes. (rossimicrolab.com)
Despite many insights gained on the structure and functions played by flagellum and pili in motility, biofilm formation, surface attachment and interactions with bacteriophages, we know little about how these appendages are regulated in Xcc . (biomedcentral.com)
The chemical compositions of the cellular components are mainly made up of polysaccharides (40%-95%), proteins (1%-60%), lipids (1%-40%), and nucleic acids (1%-10%), which have a significant effect on growth and metabolism of the biofilm. (learnlifescience.com)
It is a second messenger that modulates a variety of bacterial growth phenotypes including biofilm formation. (learnlifescience.com)
Biofilm is a complex matrix consisting of extracellular polysaccharides, DNA, and proteins that protect bacteria from a variety of physical, chemical, and biological stresses allowing them to survive in hostile environments. (intechopen.com)
Any drug impairing crucial processes for bacterial life will inevitably lead to the development of drug-resistant strains, whereas the inhibition of biofilm formation might prevent the onset of bacterial resistance. (intechopen.com)
In this section, we will focus on proteins involved in biofilm formation as useful targets for the development of new drugs that can effectively and specifically impair biofilm formation with slight effects on cell survival, thus avoiding the generation of drug-resistant strains. (intechopen.com)
The biofilm matrix consists of polysaccharides, proteins, and DNA and constitutes a stubborn source that protects bacteria from a variety of physical, chemical, and biological stresses. (intechopen.com)
Bacterial two-hybrid results showed that the Par-like proteins interact with each other and the chemotaxis system, and that ParP interacts with DipA, a phosphodiesterase which degrades cyclic-di-GMP and is important for biofilm dispersion and chemotaxis. (uwm.edu)
Due to the direct interactions and interdependence of cluster formation of ParP and DipA, and the fact that parP and dipA mutants have similar defects in swimming motility and increases in surface flagellin levels, further investigation into the role of ParP in biofilm dispersion is warranted. (uwm.edu)
These colony variants show great differences in biofilm formation and motility. (hindawi.com)
This indicates that the rpoX gene is involved in biofilm formation and stress response but the effects are controlled by colony phase variation in V. alginolyticus . (hindawi.com)
Based on this, we wanted to identify this protein in V. alginolyticus ZJ-51 and study whether it has a role in biofilm formation and stress response in the two colony phase variants. (hindawi.com)

Our data further support the role of ppGpp participating in the coordinated regulation of the expression of bacterial factors required during infection. (ibecbarcelona.eu)
These results suggest that Esr41 plays important roles in the inverse regulation of LEE and flagellar gene expression. (nih.gov)
Transposable elements (TEs) are an important source of genetic diversity and can be co-opted for the regulation of host genes. (sciencegate.app)
In addition to dissecting these mechanistic aspects of gene regulation, we are interested in the roles and physiological consequences of the products of genes regulated by chromatin proteins. (universiteitleiden.nl)
However, despite the numerous studies on bacterial motility in other Gram-negative bacteria, only limited work has been carried out examining the motility regulation in Xcc . (biomedcentral.com)
Bacterial QS regulation is established through a wide range of signals such as oligopeptides, N-acyl homoserine lactones, furanose borate, hydroxy palmitic acid methyl ester, and methyl decanoic acid. (learnlifescience.com)
In this review, we summarize the current knowledge on the regulation and function of P. aeruginosa sRNAs that titrate regulatory proteins, base-pair with target mRNAs, and which are derived from CRISPR elements. (nih.gov)

The researchers used RNA-seq to show that depletion of PBP1, a bifunctional penicillin-binding protein, results in a "downregulation in transcription of flagellum-dependent motility genes and an upregulation in transcription of type VI secretion and succinoglycan biosynthesis genes, a hallmark of the ChvG-ChvI regulon. (missouri.edu)
By transcriptome analyses (RNA-seq and RT-PCR) we confirm these observations as PilG is shown to upregulate many genes involved chemotaxis and flagellar biosynthesis but these similar genes were downregulated by PilH. (biomedcentral.com)
Taken together, we demonstrate that for the conditions tested PilG and PilH have inverse regulatory effects on flagellum-dependent and pili-dependent motility in Xcc and that this regulatory impact depends on these proteins influences on genes/proteins involved in flagellar biosynthesis and pilus assembly. (biomedcentral.com)
Bacterial Two Crossbreed (BTH) analysis displays DivIVA may connect to proteins that react to metabolic indications of amino-acid biosynthesis or adjustments in redox condition. (bibf1120.com)
The two variants exhibit different capability to form biofilms and to express genes involved in polysaccharide biosynthesis, flagellar synthesis, and the AI-2 quorum-sensing system [ 18 ]. (hindawi.com)

Bacterial biofilms: a common cause of persistent infections. (microbiologyresearch.org)
Bacterial cells can colonize surfaces and form biofilms that consist of microbial cells embedded in extracellular polymeric substances (EPS). (rsc.org)
3 Bacterial biofilms can cause persistent human infections and can foul the surface of medical devices. (rsc.org)
The differentially expressed genes and proteins linked to S. aureus biofilms have been identified using transcriptomic and proteomic investigations ( 14 - 17 ). (frontiersin.org)
The structure of the extracellular polymeric substance (EPS) matrix of biofilms is composed of one or more extracellular polysaccharides, DNA, and proteins. (learnlifescience.com)

In short, the research team has discovered that there is an inverse correlation between glycogen production and the production of structures involved in bacterial pathogenicity. (europa.eu)
In our case we found that the alteration in the expression of glgS, which is only present in the group of enterobacteria ( , species of the Salmonella genus, Yersinia pestis, etc.), has an effect on the production of structures involved in bacterial pathogenicity which, indirectly, affects the capacity to produce glycol gen. (europa.eu)
possesses several features, such as large motility, protease production, and an unusual surface coating (outer membrane), which are associated with pathogenicity [3], [4]. (bioskinrevive.com)
In this way, bacteria gain novel genetic information, for example metabolic traits, pathogenicity determinants and resistance genes as a driving force for bacterial adaptation and evolution. (elifesciences.org)

Transcription analysis of all putative catabolic genes established their role in the metabolism of OPP. (nature.com)
Contributing to the interest of the present topic is the fact that modulation of gene activity involves the sensing of intra- and inter-cellular conditions, DNA binding and DNA dynamics, and interaction with the replication/transcription machinery of the cell. (ibecbarcelona.eu)
Translational gene-reporter fusion experiments revealed that Esr41 regulates ler expression at a post-transcriptional level, and pch transcription, probably via an unknown target of Esr41. (nih.gov)
In addition, Esr41 activated the expression of flagellar Class 3 genes by indirectly inducing the transcription of fliA, which encodes the sigma factor for flagellar synthesis. (nih.gov)
Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced, while others are highly transcribed. (universiteitleiden.nl)
Our interest lies in understanding how architectural proteins act on DNA and how they regulate transcription. (universiteitleiden.nl)
As transcription of many genes and operons responds to environmental changes and as these are often mediated by chromatin proteins, it is expected that 1) the architectural interplay of such proteins and/or 2) their direct response to physicochemical changes determines loop formation and dissolution leading to altered transcription levels. (universiteitleiden.nl)
Chromosome 21 gene dosage effects and truncating mutations of the X-chromosomal transcription factor GATA1 synergize to trigger TMD and AMKL in most patients. (embl.de)

Author Summary Almost all bacterial species use thin surface appendages called pili to interact with their environments. (biorxiv.org)
This researcher, who is of Iranian origin, has studied the mechanism of the action of the glgS gene in bacteria and in various Salmonella species, which in certain cases can cause diseases and acute symptoms in humans. (europa.eu)
CGD patients are unable to produce reactive oxygen species and suffer from life-threatening bacterial and fungal infections due to genetic defects in NADPH oxidase components (16). (bartleby.com)
This can help in the presumptive identification of motile bacterial species based on their flagellation. (stemcelldaily.com)
Therefore, a special technique called flagella stain is used to visualize the presence and arrangement of flagella on different bacterial species. (stemcelldaily.com)
These characteristics can help in the presumptive identification of motile bacterial species, as different bacteria have different types of flagellation. (stemcelldaily.com)
One of our long-standing goals has been to create such a resource in N. meningitidis - one of the most feared human bacterial pathogens that causes meningitis and septicaemia - and to use it for large-scale functional profiling of this species genome. (cnrs.fr)
A significant number of bacterial species encode multiple copies of the filament building block - flagellin. (ncl.ac.uk)
We have studied how bacterial species such as the pathogen Salmonella enterica maintain a discrete number of flagellar per cell during cell growth and division. (ncl.ac.uk)
We complement our study on flagellar abundance with research to understanding how a filament is assembled from multiple flagellins, a trait maintained by many bacterial species. (ncl.ac.uk)
In lots of bacterial species, such as and and display that it is required for efficient predatory growth. (bibf1120.com)
A catalogue of 178 reference bacterial birth, and the delivery type is the first core of species has been identified genomes distributed among different factor that has an impact. (who.int)

Bacterial flagella are thin and delicate structures that extend from the cell membrane and enable motility and chemotaxis. (stemcelldaily.com)
Bacterial chemotaxis is the movement of a cell towards an attractant or away from a repellent. (uwm.edu)
This controlled movement is possible due to the chemotaxis system, which is typically made up of several proteins that collectively sense the stimuli and transduce the signal within the cell to mediate a motility response. (uwm.edu)
The chemotaxis proteins of Pseudomonas aeruginosa are encoded in two clusters, which are located at different regions of the chromosome: che I and che V. These gene clusters are known to control chemotaxis via swimming, or flagellar-based, motility. (uwm.edu)
When expressed, these chemotaxis proteins associate with each other to form tight clusters that are composed of thousands of copies of each protein. (uwm.edu)
Cluster formation of the chemotaxis histidine kinase CheA was reduced by 50% in the absence of either Par-like protein, thus demonstrating a potential mechanism behind the reduced swimming motility. (uwm.edu)

Identification of a gene, pilV , required for type 4 fimbrial biogenesis in Pseudomonas aeruginosa , whose product possesses a pre-pilin-like leader sequence. (microbiologyresearch.org)
A function of Pseudomonas aeruginosa PAO pili: twitching motility. (microbiologyresearch.org)
An interactive web-based Pseudomonas aeruginosa genome database: discovery of new genes, pathways and structures. (microbiologyresearch.org)
The pilG gene product, required for Pseudomonas aeruginosa pilus production and twitching motility, is homologous to the enteric, single-domain response regulator CheY. (microbiologyresearch.org)
We demonstrate that upon hitting a host cell, motile Pseudomonas aeruginosa induce a specific gene expression program. (elifesciences.org)

Within the research in Molecular Biology, one important field along the years has been the analyses on how prokaryotes regulate the expression of their genes and what the consequences of these activities are. (ibecbarcelona.eu)
Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. (cancerindex.org)

Eight mutants deficient in twitching motility were isolated. (microbiologyresearch.org)
These mutants were deficient in twitching motility, showing that both the PA1822 and the PA0171 gene are involved in twitching motility. (microbiologyresearch.org)
However, the function of this protein has remained unclear because pilU mutants exhibit inconsistent phenotypes among type IV pilus systems and because it is relatively understudied compared to PilT. (biorxiv.org)
The key module of NeMeSys is an ordered and complete collection of mutants with mutations in each non-essential gene, the only such collection in a bacterial pathogen. (cnrs.fr)
The main module of NeMeSys is a comprehensive collection of defined meningococcal mutants in strain 8013, consisting of individual mutants in 1,584 non-essential protein-coding genes. (cnrs.fr)
We also statement here within the physiological and pathological functions of the major antigenic proteins, TmpC and Msp, where we looked into using mutants with flaws in these protein. (bioskinrevive.com)

o de, a chromosome segregation proteins, plays a part in bacterial septation in lots of types also. (bibf1120.com)

B) Bacterial uptake (2 h) and persistence (8 h and 24 h) was compared by assessing the percentage of CD45 + leukocytes that were positive for intracellular B. pseudomallei outer membrane protein antibody (BpOMP) staining using flow cytometry. (cdc.gov)
Pathways and functional genes analysis of soil, rhizosphere, and phyllosphere showed that the most abundant functional genes were mapped to membrane transport, DNA repair and recombination, signal transduction, purine metabolism, translation-related protein processing, oxidative phosphorylation, bacterial motility protein secretion, and membrane receptor proteins. (unboundmedicine.com)
Polar targeting of this T4BSS is mediated by two Dot/Icm proteins, DotU and IcmF, that are homologues of the T6SS membrane complex components TssL and TssM, suggesting that the Dot/Icm T4BSS is a hybrid system. (tcdb.org)
The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. (cancerindex.org)
Vesicle-associated membrane proteins 721 and 722 (VAMP721/722) are secretory vesicle-localized arginine-conserved soluble N -ethylmaleimide-sensitive factor attachment protein receptors (R-SNAREs) to drive exocytosis in plants. (molcells.org)

Bacterial small RNAs (sRNAs) are known regulators in many physiological processes. (learnlifescience.com)

By revealing complete repertoires of genes, genome sequences have provided the key to better, and eventually holistic, understanding of the biology of all living organisms. (cnrs.fr)
However, biological resources for identification of gene function on genome-scale, which are necessary to achieve this goal, are often lacking. (cnrs.fr)
As shown in model micro-organisms, the most valuable toolbox for determining gene function on genome-scale is a comprehensive and archived collection with one mutant in each non-essential gene. (cnrs.fr)
This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. (universiteitleiden.nl)

Surface patterning is an important determinant of bacterial attachment. (rsc.org)
Bacterial attachment is favoured on recessed portions of patterned surfaces, and bacteria tend to attach preferentially to patterns in the micro or nanometre range rather than to smooth surfaces. (rsc.org)

These survivor strains must have evolved ways to overcome the problems caused by the outdated protein. (uncommondescent.com)
Bacterial strains and plasmids are described in Table 1 . (hindawi.com)

To carry out their function, pili dynamically extend and retract from the bacterial surface. (biorxiv.org)
Here, we show that retraction of pili in some systems is determined by the combined activity of two motor ATPase proteins. (biorxiv.org)
Type IV pili are composed almost exclusively of a single protein called the major pilin, which forms a helical fiber that extends from the cell surface [ 6 ]. (biorxiv.org)
PilG and PilH antagonistically control flagellum-dependent and pili-dependent motility in the phytopathogen Xanthomonas campestris pv. (biomedcentral.com)
Here we present evidence demonstrating the role of two single domain response regulators PilG and PilH in the antagonistic control of flagellum-dependent (swimming) and pili-dependent (swarming) motility. (biomedcentral.com)
These extracellular protein structures called flagella and pili contribute cellular movement in the form of 'swimming' and 'swarming', respectively. (biomedcentral.com)
Additionally, flagellum-dependent and pili-dependent motility are essential to Xcc 's ability to attach to host surfaces and to elicit disease. (biomedcentral.com)
Given the importance of flagellum-dependent and pili-dependent motility for Xcc survival and ability to cause disease, it is critical that these systems are effectively regulated and controlled. (biomedcentral.com)

A periplasmic flagellar chaperone protein, FlgA, is required for P-ring assembly in bacterial flagella of taxa such as Salmonella enterica or Escherichia coli. (proteopedia.org)

Threadlike structures ("bacterial nanotubes") protruded from the majority of bacterial cells and appeared to link cells directly with the nanopillars. (rsc.org)
Like most bacteria, Xcc uses a variety of extracellular protein structures to interact with their surrounding environment and drives cellular movement. (biomedcentral.com)
Crystal structures of MakA, MakB, and MakE revealed a structural relationship to a superfamily of bacterial pore-forming toxins. (scilifelab.se)

The secretin complex of Thermus thermophilus is an oligomer of the 757-residue PilQ protein, essential for DNA uptake and pilus extrusion. (elifesciences.org)
Many conserved proteins of the bacterial DNA uptake machineries are similar to components of protein secretion and type IV pilus biogenesis systems and often play a dual role ( Hobbs and Mattick, 1993 ). (elifesciences.org)

Those immune defects lead to infections with bacterial, viral, and fungal pathogens that begin during infancy and, if untreated, result in a fatal outcome in the first few years of life. (medscape.com)
During my career I have gained valuable experience working with a range of bacterial pathogens. (ncl.ac.uk)

We demonstrate that not only the presence of pathogen inherent molecular patterns induces immune responses, but that bacterial motility is linked to a host-cell-induced expression of additional immune modulators. (elifesciences.org)
We propose that bacterial nanotubes are produced to aid in cell-surface or cell-cell connections. (rsc.org)
We previously reported an increase in cell motility induced by Esr41. (nih.gov)
This motility enhancement was also observed in EHEC lacking ler, showing that Esr41-mediated enhancement of cell motility is in a ler-independent manner. (nih.gov)
By staining the flagella, one can observe their presence or absence, as well as their number and location on the bacterial cell. (stemcelldaily.com)
Overexpression of this gene is associated with tumor cell proliferation and metastasis. (cancerindex.org)
DRAM2 overexpression also increased proteins CDK4, CyclinD3, and decreased p27 expression, all of which are cell cycle-related factors. (cancerindex.org)
In a new paper in PLOS GENETICS, members of Dr. Pamela Brown's lab identified ChvG-ChvI regulon as an envelope stress response system that confers protection under cell wall stress conditions in the bacterial plant pathogen Agrobacterium tumefaciens . (missouri.edu)
RNA biol, 2012) and cell motility (Shahapure et al. (universiteitleiden.nl)
Pure T-cell deficiencies are caused by defects in either a CD3 subunit (such as CD3 δ, CD3 ζ, CD3 ε ) or in CD45 tyrosine phosphatase, key proteins involved in pre-TCR and/or TCR signaling at the positive selection stage. (medscape.com)
Rotation of the filament is achieved via the action of a universal joint known as the hook and a basal motor anchored into the bacterial cell envelope. (ncl.ac.uk)
few distinguishable bands NVP-BVU972 in western blot analysis, using the bacterial cell lysate as an antigen. (bioskinrevive.com)
That's because EF-Tu is a hub protein, interacting with 50 or more other proteins as it carries out its function in the cell. (uncommondescent.com)
This proteins established fact for its connect to polar cell spore and development development in Gram-positive bacterias, but little is well known about its function within a predatory development context. (bibf1120.com)
we recognize a canonical ParAB set necessary for predatory cell department and display a BTH relationship between a gene item encoded through the same operon as DivIVA using the canonical Em fun? (bibf1120.com)
o de protein are both portrayed in but aren't necessary for predator cell department. (bibf1120.com)
2015). The partitioning of DNA means that cell department does not take place across nucleoids, as the partitioning of proteins means that each little girl cell gets the prerequisite elements for ideal fitness. (bibf1120.com)
Protein phosphatases reverse the covalent modifications of numerous cellular proteins imposed by the activation of protein kinases and, therefore, play key role in cell signaling metabolism, growth and differentiation. (bvsalud.org)

When LEE expression is activated, flagellar gene expression is down-regulated because bacterial flagella induce the immune responses of host cells at the infection stage. (nih.gov)
Flagella stain is a wet mount technique that involves applying a mordant and a primary stain to the bacterial cells on a microscope slide. (stemcelldaily.com)
However, it requires an experienced laboratory scientist and careful handling of the bacterial cells, as the flagella are easily damaged or detached by agitation or environmental factors. (stemcelldaily.com)
The wet mount technique is a simple and useful method for staining bacterial flagella, which are too thin to be seen with ordinary stains under a bright field microscope. (stemcelldaily.com)

Proteins/genes with a putative catabolic role and bacterium adaptation mechanisms during OPP degradation were identified via genomic and proteomic analysis. (nature.com)
The opportunistic pathogen may infect virtually any tissue and has evolved as a model to study bacterial adaptation to the conditions within the human host. (elifesciences.org)
ppGpp is an intracellular sensor that, in response to different types of stress, coordinates the rearrangement of the gene expression pattern of bacteria to promote adaptation and survival to new environmental conditions. (ibecbarcelona.eu)

Furthermore, potential consequences for community functioning were assessed based on 16S V4 rRNA gene profiles by indirectly inferring the abundance of functional genes based on results obtained with Piphillin. (unboundmedicine.com)
We analyzed 16S rRNA gene amplicons to determine the principal environmental factors that shape the structure and function of microbial communities in shrimp cultural enclosure ecosystems from Guangdong and Hainan provinces, in China. (frontiersin.org)
Here, we used 16 S rRNA gene amplicon sequencing and shotgun metagenomics to characterize the microbiome of the freshwater sponge Ephydatia muelleri and identify potential indicators of sponge-microbe mutualism. (nature.com)

Firstly, they are ubiquitous as T4F genes are found in virtually all bacteria and archaea, which underlines an essential ecological role. (cnrs.fr)
Well-known examples are the eukaryotic and archaeal histones that wrap DNA and the nucleoid-associated proteins in bacteria and archaea that bend and bridge DNA. (universiteitleiden.nl)
It is remodeled actively in eukaryotes by motor enzymes that can move or displace nucleosomes, in addition to remodeling mechanisms more ubiquitous in bacteria and archaea that are based on the interplay between multiple architectural proteins. (universiteitleiden.nl)
Models suggest that in bacteria and archaea there are direct effects of physicochemical factors such as osmolarity, temperature and pH on the action of chromatin proteins, in addition to indirect effects by modulating the expression ratios of different types of chromatin proteins. (universiteitleiden.nl)

A variety of bacterial traits and specific genes contribute to this process, but only a few have been identified. (wikipedia.org)

The downstream transformation of BA involved a meta -cleavage pathway, although its genetic organization and function was not revealed and the overall network of genes driving the full metabolic pathway of OPP is still not known. (nature.com)
My laboratory uses, bacterial genetics, protein biochemistry, structural biology, bioinformatics and microscopic techniques to validate our genetic findings. (ncl.ac.uk)

In a piece of work carried out by the Carbohydrate Metabolism Research Team of the Institute of Agrobiotechnology, the discovery has been made of the way in which the glgS gene (now renamed as the "surface composition regulator", scoR) acts in bacteria and how the mechanisms involved in bacterial infection can be altered by manipulating this gene, which indirectly affects glycogen production. (europa.eu)
As Javier Pozueta, director of the Carbohydrate Metabolism Research Team that carried out the work, explained, "We can say that we may have found an additional way of combating bacterial infections and contamination by encouraging the formation of glycogen in bacteria. (europa.eu)

The protein composition of saliva also reflects cellular signal processing that results from day-to-day environmental influences, as well as from acute or chronic stress 9 . (bvsalud.org)

My expertise utilise bacterial genetics to study fundamental aspects of the bacterial life cycle and host-microbe interactions. (ncl.ac.uk)

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. (cancerindex.org)

The purpose of this study was to investigate the activities of the total acid phosphatase (TAP), tartrate-resistant acid phosphatase (TRAP), low molecular weight protein tyrosine phosphatase (LMW-PTP) and alkaline phosphatase (ALP) enzymes, as well as the possible correlation in the serum and in unstimulated whole saliva of children. (bvsalud.org)

The locus of enterocyte effacement (LEE) in EHEC encodes a type three secretion system and effector proteins, all of which are essential for bacterial adherence to host cells. (nih.gov)

Structural flexibility of the periplasmic protein, FlgA, regulates flagellar P-ring assembly in Salmonella enterica. (proteopedia.org)
Using informative mutagenesis, we reveal PilG positively regulates swimming motility while and negatively regulating swarming motility. (biomedcentral.com)
Conversely, PilH negatively regulates swimming behaviour while and positively regulating swarming motility. (biomedcentral.com)

Urinary tract infections (UTIs) are a common bacterial infection with symptoms that include urinary frequency, urgency to void, dysuria and abdominal pain. (ncl.ac.uk)
The flagellar filament is a major antigen recognized by hosts during bacterial infections. (ncl.ac.uk)

Putative large exoproteins and a putative protein with a RTX toxin-type ß-roll could be identified. (dsmz.de)

The flagellum is a unique molecular machine driving bacterial movement through liquid environments. (ncl.ac.uk)
Just as a modern laptop would run poorly if its processor were replaced with an 1980s-era computer chip, the microbes' modern molecular machinery simply wasn't well suited to the ancient version of the protein. (uncommondescent.com)

Clostridium difficile is a gram positive, spore forming anaerobic bacillus, which may or may not carry the genes for toxin A-B production (Nipa, 2010). (bartleby.com)
These two types of protein exotoxins produced by the Clostridium difficile bacillus, toxin A and toxin B, can have an infectious form and a non-active, non-infectious form (Grossman, 2010). (bartleby.com)
In 2014, the MetaHIT consortium by bacteria of the genera Lacto- alytical method used: 66 from 16S published an integrated catalogue bacillus , Prevotella , and Sneathia , rDNA sequencing [11] or 57 from of 10 million bacterial genes de- whereas for infants delivered by whole-metagenome sequencing [5]. (who.int)

Neutrophils that have been exposed to Imperio will be expected to show no motility comparable when Anthrax toxin binds to neutrophils. (bartleby.com)
A tripartite cytolytic toxin formed by Vibrio cholerae proteins with flagellum-facilitated secretion. (scilifelab.se)
The protein MakA was discovered as a motility-associated secreted toxin from Vibrio cholerae Here, we show that MakA is part of a gene cluster encoding four additional proteins: MakB, MakC, MakD, and MakE. (scilifelab.se)
None of these Mak proteins alone or in pairwise combinations were cytolytic, but an equimolar mixture of MakA, MakB, and MakE acted as a tripartite cytolytic toxin in vitro, causing lysis of erythrocytes and cytotoxicity on cultured human colon carcinoma cells. (scilifelab.se)

He also mentions that microorganisms produce a wide variety of QS signaling molecules that can be self-recognized in a concentration-dependent manner and subsequently induce or suppress the expression of QS-controlled genes. (learnlifescience.com)

6 identified a gene cluster, hbpCAD , encoding the upper metabolic pathway of OPP which involves the transformation of OPP to 2-hydroxypenta-2,4-dienoateand benzoic acid (BA). (nature.com)
2016). Dynamic metabolic exchange governs a marine algal-bacterial interaction. (dsmz.de)
First described to modulate metabolic adaptive responses, ppGpp modulates the expression of genes belonging to very diverse functional categories. (ibecbarcelona.eu)

Shotgun metagenomes and metagenome-assembled genomes further revealed that freshwater sponge-associated bacteria share many genomic similarities with marine sponge microbiota, including an abundance of defense-related proteins (CRISPR, restriction-modification systems, and transposases) and genes for vitamin B12 production. (nature.com)
Symbiosis genes" of the epibiont were identified by genomic approaches. (dsmz.de)

The Icm/Dot or Dot/Icm multicomponent protein secretion system. (tcdb.org)
The N-terminal domains of secretins consist of copies of stacked rings which form a periplasmic channel that connects to IM-associated proteins, forming a multi-component secretion system. (elifesciences.org)

Several years ago, Eric Gaucher, a biologist at the Georgia Institute of Technology in Atlanta, even resurrected a 700-million-year-old protein from E. coli. (uncommondescent.com)
Now, in a new twist on paleogenomics, Kacar has engineered that ancient protein into modern E. coli and tracked how the microbe adapted to it. (uncommondescent.com)
Kacar then synthesized that gene and inserted it into E. coli in place of the existing version. (uncommondescent.com)

The entire consortium swims towards the light (scotophobic response), which the epibionts need for anoxygenic photosynthesis, whereas the central bacterium provides the necessary motility. (dsmz.de)

We have used NeMeSys to shed light on the functions of multiple genes, and we expect this toolbox to allow, for the first time, the global functional profiling of a major human bacterial pathogen. (cnrs.fr)

Scope includes mutations and abnormal protein expression. (cancerindex.org)

The top two most abundant Gypsy families in S. alba preferentially insert in gene-poor regions. (sciencegate.app)
Independent of these cytological differences, all genomes are shaped by the action of abundant proteins with architectural function. (universiteitleiden.nl)

T4F are filamentous polymers composed of type 4 pilins, assembled by conserved multi-protein machineries (see Figure). (cnrs.fr)

We report here that a small regulatory RNA (sRNA), Esr41, mediates LEE repression and flagellar gene activation. (nih.gov)
Co-immunoprecipitation, bacterial two-hybrid and pull-down analyses showed that PilH and PilG were able to interact with district subsets of proteins that potentially account for their regulatory impact. (biomedcentral.com)
strongly suggests that at least one regulatory protein should control the SNARE complex formation of VAMP721/722 with a specific Qa-SNARE in a particular biological process in plants. (molcells.org)
In plants, three groups of regulatory proteins such as Sec1/Munc18 (SM), small GTPase and synaptotagmin (SYT) have been studied for modulating the trafficking functionality of SNAREs. (molcells.org)

Among these proteins, 54 had all 3 PTMs regulated by lipopolysaccharide and were enriched in immune signaling pathways, and in particular, the ubiquitin-proteasome pathway. (bvsalud.org)
Most c-di-GMP-dependent signaling pathways control the ability of bacteria to interact with abiotic surfaces or with other bacterial and eukaryotic cells (Romling et al, 2013). (learnlifescience.com)

A flavin-dependent monoxygenase (OppA1), one of the most up-regulated proteins in the OPP-growing cells, was isolated via heterologous expression and its catabolic activity was verified in vitro . (nature.com)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Western blotting confirmed the expression of DRAM2, p53, and the other involved proteins. (cancerindex.org)
Expression pattern of LTR retrotransposons and their nearby genes were examined using RNA-seq data of S. alba under different salt treatments. (sciencegate.app)
Although a considerable number of TEs in S. alba showed differential expression under salt stress, only four copies were significantly correlated with their nearby genes in expression levels. (sciencegate.app)

Anatomy3

Organisms1

Diseases1

Chemicals and Drugs8

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes18

Disciplines and Occupations1

Information Science5

Health Care2

Virulence12

Biofilm17

Regulation7

Biosynthesis5

Biofilms5

Pathogenicity4

Transcription8

Species12

Chemotaxis6

Pseudomonas5

Regulate2

Mutants6

Chromosome1

Membrane5

Physiological1

Genome4

Attachment2

Strains2

Pili8

Escherichia1

Structures3

Uptake2

Pathogens2

Cell18

Flagella4

Adaptation3

RRNA gene3

Bacteria and archaea4

Variety of bacterial1

Genetic2

Metabolism2

Cellular1

Interactions1

Signal transduction1

Tyrosine phosphatase1

Adherence1

Regulates3

Infections2

Putative1

Molecular2

Bacillus3

Toxin4

Induce1

Metabolic3

Genomic2

Secretion system2

Coli3

Photosynthesis1

Functional1

Mutations1

Abundant2

Machineries1

Regulatory4

Pathways2

Expression5