The monomeric gamma-crystallins and oligomeric beta-crystallins have paired homologous double Greek key domains, presumably evolved through gene duplication and fusion. (protabank.org)
Homologous1
Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. (wikipedia.org)
Acidic3
Alpha and beta families are further divided into acidic and basic groups. (wikipedia.org)
Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). (wikipedia.org)
Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. (wikipedia.org)
Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. (lookformedical.com)
Gamma-crystallins are similar in structure to BETA-CRYSTALLINS in that they both form into a Greek key-like structure. (lookformedical.com)
The in vitro refolding of all four domains revealed two kinetic phases, identifying partially folded intermediates for the Greek key motifs. (protabank.org)
Chains2
Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. (lookformedical.com)
We constructed and expressed polypeptide chains corresponding to the isolated N- and C-terminal domains of human gammaD-crystallin, as well as the isolated domains of human gammaS-crystallin. (protabank.org)
Alpha3
Alpha, beta, and delta crystallins occur in avian and reptilian lenses, while alpha, beta, and gamma crystallins occur in all other lenses. (lookformedical.com)
[5] [6] The propeptide region has an open-sandwich antiparallel-alpha/antiparallel-beta fold, with two alpha-helices and four beta-strands with a (beta/alpha/beta)x2 topology. (wikipedia.org)
Basic2
This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B2. (wikipedia.org)
Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. (wikipedia.org)
Mammalian2
Previous attempts to crystallize mammalian γS-crystallin were unsuccessful. (nih.gov)
14. Sequence characterization of gamma-crystallins from lip shark (Chiloscyllium colax): existence of two cDNAs encoding gamma-crystallins of mammalian and teleostean classes. (nih.gov)
Cataracts1
A purified diet (AIN-76A) fortified with 0.4% beta-carotene plus 0.01% BHT also prevented PSO and mature cataracts. (nih.gov)
Protein2
Beta-crystallin B3 is a protein that in humans is encoded by the CRYBB3 gene. (wikipedia.org)
Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. (wikipedia.org)
Sequence1
19. Sequence analysis of frog rho-crystallin by cDNA cloning and sequencing: a member of the aldo-keto reductase family. (nih.gov)
Gene2
This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B2. (wikipedia.org)
13. Comparative analysis of the zeta-crystallin/quinone reductase gene in guinea pig and mouse. (nih.gov)
Similar3
Beta-crystallins are similar in structure to GAMMA-CRYSTALLINS in that they both contain Greek key motifs. (nih.gov)
Las beta-cristalinas poseen una estructura similar a las GAMMA CRISTALINAS al presentar ambas motivos de clave griega. (bvsalud.org)
12. Guinea pig and bovine zeta-crystallins have distinct functional characteristics highlighting replacements in otherwise similar structures. (nih.gov)
Identification1
20. Cloning, genomic organization, alternative transcripts and expression analysis of CD99L2, a novel paralog of human CD99, and identification of evolutionary conserved motifs. (nih.gov)
Classes1
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. (wikipedia.org)