• T-cell/histiocyte-rich large B-cell lymphoma - a distinct clinicopathologic entity or a variant of diffuse large B cell lymphoma? (llu.edu)
  • Diffuse large cell lymphomas and their mimics. (llu.edu)
  • A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
  • Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) with concurrent BCL2 and IRF4 rearrangements are rare. (qxmd.com)
  • The second half of the session focused on mediastinal and non-mediastinal gray zone lymphomas (GZL) with features intermediate between diffuse large B cell lymphoma (DLBCL) and classic Hodgkin lymphoma (CHL). (bvsalud.org)
  • ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
  • These changes can be inherited and are, therefore, found in every cell, but more often, they are somatically acquired and restricted to tumor cells. (medscape.com)
  • The majority of ALK+ ALCL tumor cells have been shown to express at least one T-cell specific marker. (biomedcentral.com)
  • Blastoid and Pleomorphic Mantle Cell Lymphoma Demonstrate Distinct Clinicopathologic and Genetic Features. (viictr.org)
  • The Working Formulation, originally proposed in 1982, classified and grouped lymphomas by morphology and clinical behavior (ie, low, intermediate, or high grade) with 10 subgroups labeled A to J.{Ref 1} In 1994, the Revised European-American Lymphoma (REAL) classification attempted to apply immunophenotypic and genetic features in identifying distinct clinicopathologic NHL entities. (medscape.com)
  • Peripheral T-cell lymphoma (PTCL) is defined as a diverse group of aggressive lymphomas that develop from mature-stage white blood cells called T-cells and natural killer cells (NK cells) (see figure for an overview of PTCL subtypes). (wikipedia.org)
  • We investigated outcomes and prognostic variables in patients registered in the T-Cell Project (TCP) (#NCT01142674) to develop a model to predict overall survival (OS) for the common nodal PTCL subtypes (PTCL-NOS, AITL, ALCL). (bvsalud.org)
  • PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)
  • About 30% of PTCL-NOS cases exhibit malignant T cells that are infected with the Epstein-Barr virus (EBV). (wikipedia.org)
  • A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
  • A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. (lookformedical.com)
  • Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
  • A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes. (lookformedical.com)
  • Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
  • Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation. (lookformedical.com)
  • A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. (lookformedical.com)
  • Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
  • Immunohistochemical staining for cytokeratin 5/6 was applied on cell block sections of 23 cases of benign and 25 cases of malignant breast lesions using avidin biotin peroxidase technique. (ijpmonline.org)
  • Acute Leukemia Diagnosis - A Practical Morphologic, Immunophenotypic, and Cytogenetic Approach. (llu.edu)
  • One half of the session was dedicated to primary mediastinal large B cell lymphoma (PMBL) and included cases with classic clinicopathologic features, as well as cases with either morphologic or immunophenotypic variation, and PMBL-like cases with primary extramediastinal disease. (bvsalud.org)
  • My research interests comprise cutaneous tumors with emphasis in lymphomas and melanoma. (mdanderson.org)
  • The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
  • B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
  • 1 The most frequent primary tumor types of anterior mediastinal masses are thymic tumors and lymphoma, with approximate proportions of 35% and 25% among mediastinal lesions, respectively. (allenpress.com)
  • Murine tumors displayed the phenotypic diversity observed in ALK+ ALCL patients, including CD4+ and CD8+ lymphomas. (biomedcentral.com)
  • The current neuroendocrine classification of cells and tumors uses immunohistochemical (IHC), ultrastructural, and molecular biologic features to define members of the DNS ( 6 , 7 and 8 ). (basicmedicalkey.com)
  • It is thought that leiomyoma is the result of either transformation of normal uterine muscle cells into abnormal cells through somatic mutations , or through the growth of abnormal uterine muscle cells into tumors. (wikidoc.org)
  • This paper reviews the current data underpinning our understanding of the epidemiology of MF and SS, and presents some original findings based on data retrieved from the cutaneous lymphoma registry of the Italian Marche region. (bvsalud.org)
  • The Marche Regional Cutaneous Lymphoma Registry is a multidisciplinary team founded 27 years ago to share the management of these rare disorders. (bvsalud.org)
  • All patients with a clinical and histologically confirmed diagnosis of primary cutaneous lymphoma are centralized in Ancona (Italy) at the Haematology Clinic, Polytechnic University of Marche, for clinical evaluation, staging, treatment, and follow-up. (bvsalud.org)
  • This paper emphasizes the need for a national registry of pCLs in Italy, as no detailed epidemiological information is available in the country except for the Marche Regional Cutaneous Lymphoma Registry. (bvsalud.org)
  • Mycosis fungoides (MF) is the most common cutaneous lymphoma characterized by an indolent course. (bvsalud.org)
  • Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS), is a subtype of peripheral T-cell lymphoma. (wikipedia.org)
  • When associated with EBV, PTCL-NOS is classified as one of the Epstein-Barr virus-associated lymphoproliferative diseases (see Epstein-Barr virus-associated peripheral T cell lymphoma, not otherwise specified) but the relationship of EBV to the development and progression of Epstein-Barr virus-associated PTCL-NOS is unclear. (wikipedia.org)
  • Peripheral T-Cell Lymphoma. (wikipedia.org)
  • Cytologic findings of peripheral T-cell lymphoma (PTCL) with high epitheloid cell content (Lennert's lymphoma) in imprint smear. (wikipedia.org)
  • Miyazaki K, Masuya M, Yamaguchi M, Isaka S, Nakase K, Kobayashi T, Nakamura S, Shiku H: Angioimmunoblastic T-cell lymphoma occurring four months after autologous peripheral blood stem cell transplantation with high-dose chemotherapy for follicular lymphoma. (karger.com)
  • The natural history of limited-stage peripheral T-cell lymphomas (PTCLs) remains poorly defined. (bvsalud.org)
  • The DNS consists of a wide variety of cells that are present in the central and peripheral nervous system and in many classic endocrine organs ( Table 11.1 ). (basicmedicalkey.com)
  • Feyrter ( 2 ) considered the clear cells of the gastrointestinal tract to be peripheral endocrine or paracrine cells. (basicmedicalkey.com)
  • They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (lookformedical.com)
  • A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
  • Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
  • Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. (lookformedical.com)
  • Among primary cutaneous T-cell lymphomas (CTCL), mycosis fungoides (MF) is the most frequent and, along with Sézary syndrome (SS), the best-studied subtype. (bvsalud.org)
  • Swerdlow SH, International Agency for Research on Cancer, World Health Organization: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. (karger.com)
  • In 1988, ALCL was added as a distinct entity to the revised Kiel classification, and in 1994, it was included in the Revised European-American Lymphoma (REAL) classification. (medscape.com)
  • Swerdlow SH, WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 2008 Rezk SA, Zhao X, Weiss LM (June 2018). (wikipedia.org)
  • This classification divides NHL into two groups: those of B-cell origin and those of T-cell/natural killer (NK)-cell origin. (medscape.com)
  • The WHO modification of the REAL classification of NHL is based on morphology and cell lineage. (medscape.com)
  • It is unclear whether such cases should be classified as large B- cell lymphoma with IRF4 rearrangement or FL/DLBCL-not otherwise specified. (qxmd.com)
  • High-grade B-cell lymphoma (HGBL)-NOS is clinicopathologically and genetically more similar to DLBCL/HGBL-DH than DLBCL. (viictr.org)
  • The second group includes large cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC). (springeropen.com)
  • This is followed by lymphocytic infiltration of the thyroid gland with lymphoid follicles replacing thyroid follicles. (radiopaedia.org)
  • in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen. (lookformedical.com)
  • Sixty percent of cases express 1 or more T-cell antigens (CD3 + , CD43, or CD45RO). (medscape.com)
  • On microscopic histopathological analysis, elongated and spindle-shaped cells with a cigar-shaped nucleus are characteristic findings of leiomyoma. (wikidoc.org)
  • One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). (lookformedical.com)
  • From necrosis to regeneration: evolution of morphologic changes in myocardial infarction. (unibo.it)
  • The diagnosis and differential diagnosis of 'small' B cell lymphomas. (llu.edu)
  • Within the B-cell and T-cell categories, two subdivisions are recognized: precursor neoplasms, which correspond to the earliest stages of differentiation, and more mature differentiated neoplasms. (medscape.com)
  • The cells and neoplasms of the neuroendocrine and paracrine systems make up the DNS. (basicmedicalkey.com)
  • The principal cells and neoplasms that form the DNS are listed in Table 11.1 . (basicmedicalkey.com)
  • Histologically, ALCL is characterized by sheets of large pleomorphic cells with abundant cytoplasm, horseshoe- or wreath-shaped nuclei, and multiple prominent nucleoli. (medscape.com)
  • The National Cancer Institute's Working Formulation, originally proposed in 1982, classified and grouped lymphomas by morphology and clinical behavior (ie, low, intermediate, or high grade) with 10 subgroups labeled A to J. (medscape.com)
  • Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
  • Lymphoid cells concerned with humoral immunity. (lookformedical.com)
  • There is autoimmunity to the thyroid gland which bears both humoral- and cell-mediated features. (radiopaedia.org)
  • For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
  • MEN1 maps on chromosome 11 and encodes for menina, a nuclear protein involved in cell replication, DNA repair and transcription process. (springeropen.com)
  • The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
  • Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
  • TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)
  • At the molecular level, low-risk vs. high-risk cases reported a global upregulation of immune genes, enriched in cytokines, and a higher density of dendritic cells and mast cells, possibly associated with a more favorable clinical course. (bvsalud.org)
  • check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)
  • In melanoma, i have focused in acral lentiginous melanoma for which we described KIT mutation and protein expression status in a large series of cases and described TERT amplification in progression to metastasis. (mdanderson.org)
  • The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
  • The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
  • The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)
  • We present an unusual case of monomorphic T cell PTLD with features of angioimmunoblastic T cell lymphoma in an 8-year-old heart transplant patient, presenting with cranial nerve palsy. (karger.com)
  • Thirteen years ago, we pointed out that ovarian transitional cell carcinomas (TCCs) and conventional high-grade serous carcinomas (HGSC) had similar genetic alterations and clinical behavior. (qxmd.com)
  • The steroid-producing endocrine cells of the adrenal cortex, ovary, and testis, as well as the thyroid hormone-producing follicular cells in the thyroid gland, do not form part of the DNS. (basicmedicalkey.com)
  • Some patients may receive a stem cell transplant. (wikipedia.org)
  • T cell PTLD is rare, particularly in pediatric patients. (karger.com)
  • 90%) are squamous cell carcinomas (SCCs) with an incidence of 1 to 3/100,000 in the United States and Europe per year. (entokey.com)
  • The detailed study of neuroendocrine cells by Pearse ( 3 , 4 ) led to the development of the concept of amine precursor uptake and decarboxylation (APUD). (basicmedicalkey.com)
  • They can arise everywhere, since neuroendocrine cells are virtually distributed in each organ. (springeropen.com)
  • They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation. (lookformedical.com)
  • Session 3 of the 2021 European Association for Haematopathology/Society for Hematopathology Workshop focused on mediastinal large B cell lymphomas and surrounding gray areas. (bvsalud.org)
  • In some situations, large nodules may be present, which may be referred to as nodular Hashimoto thyroiditis 10 . (radiopaedia.org)
  • T-zone lymphoma is so named for its involvement in a specific area of the lymph node that consists of a dense accumulation of T-cells. (wikipedia.org)
  • PTCL specifically affects T-cells rather than B-cells, and results when T-cells develop and grow abnormally. (wikipedia.org)
  • Lympho-epithelioid lymphoma, also called Lennert's lymphoma, is rare and generally affects older individuals. (wikipedia.org)
  • This ulcerated nodule of localized primary cutaneous CD30+ anaplastic large cell lymphoma is relatively nonspecific in appearance. (medscape.com)
  • The oncogenic potential of the NPM-ALK fusion gene was first demonstrated in vitro using murine cell lines and primary cells. (biomedcentral.com)
  • Although the APUD concept provided a unifying theory for explaining some endocrine diseases and ectopic hormone productions, the hypothesis that the cells were all of neural crest origin, as postulated by Pearse, was later disproved by the experiments of LeDouarin ( 5 ) and others. (basicmedicalkey.com)