• Not more than 1 mg of difenoxin, not less than 25 micrograms of morphine sulfate per dose, and Dextropropoxyphene. (attorneycarl.com)
  • In man, morphine produces a variety of effects including analgesia, constipation from decreased gastrointestinal motility, suppression of the cough reflex, respiratory depression from reduced responsiveness of the respiratory centre to CO2, nausea and vomiting via stimulation of the CTZ, changes in mood including euphoria and dysphoria, sedation, mental clouding, and alterations of the endocrine and autonomic nervous systems. (rxmed.com)
  • CNS Depression: Morphine should be used only with caution and in reduced dosage during concomitant administration of other opioid analgesics, general anesthetics, phenothiazines and other tranquilizers, sedative-hypnotics, tricyclic antidepressants and other CNS depressants (including alcohol). (rxmed.com)
  • She died in September, with Freud still treating her now-returned depression with chloral hydrate and a new drug called sulfonal. (listverse.com)
  • Coma/central nervous system depression (major), respiratory depression, seizures, ventricular dysrhythmias, intubation, and benzodiazepine administration were less likely in hydroxyzine-poisoned patients, but central nervous system depression (mild) was more likely in exposures reported to the National Poison Data System. (bvsalud.org)
  • Fentanyl-O2 anesthesia is an attractive alternative to morphine anesthesia in patients with little cardiac reserve. (anesthesiaexam.com)
  • It is derived from chloral (trichloroacetaldehyde) by the addition of one equivalent of water. (wikipedia.org)
  • When administered every 12 hours, the sustained-release tablets provide equivalent analgesia to morphine oral solution given 4-hourly. (rxmed.com)
  • The sustained-release suppositories given 12-hourly provide equivalent pain control to the sustained-release tablets given orally at the same dose and frequency, or to morphine administered s.c. at a dose approximately 40% of the daily rectal dose. (rxmed.com)
  • The extent of absorption of sustained-release suppositories at steady-state is equivalent to that of the sustained-release tablets and approximately 40% of that of s.c. morphine. (rxmed.com)
  • About 7 to 10% of a dose of morphine is excreted in the feces via the bile. (rxmed.com)
  • At steady-state, the sustained-release tablets produce peak morphine levels approximately 4 to 5 hours post-dose and therapeutic levels persist for a 12-hourly period. (rxmed.com)
  • The usual recommended starting dose for major depressive disorder is 50 mg once daily on days one and two, then 150 mg once daily on day three and onwards. (medbroadcast.com)
  • Long-term use of chloral hydrate is associated with a rapid development of tolerance to its effects and possible addiction as well as adverse effects including rashes, gastric discomfort and severe kidney, heart, and liver failure. (wikipedia.org)
  • Drug abuse is not a problem in patients with severe pain in which morphine is appropriately indicated. (rxmed.com)
  • Morphine is readily absorbed when given orally, rectally or by s.c. or i.m. injection. (rxmed.com)
  • Inventory data is not as readily available as for the major industries. (avclark.com)
  • Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults in short-term studies with major depressive disorder (MDD) and other psychiatric disorders. (drugs.com)
  • Drug Dependence: As with other opioids, tolerance and physical dependence tend to develop upon repeated administration of morphine and there is potential for abuse of the drug and for development of strong psychological dependence. (rxmed.com)
  • The plasma, serum or blood concentrations of chloral hydrate and/or trichloroethanol, its major active metabolite, may be measured to confirm a diagnosis of poisoning in hospitalized patients or to aid in the forensic investigation of fatalities. (wikipedia.org)
  • Withdrawal symptoms may occur following abrupt discontinuation of morphine therapy or upon administration of an opioid antagonist. (rxmed.com)
  • Morphine is an opioid analgesic which exerts an agonist effect at specific, saturable opioid receptors in the CNS and other tissues. (rxmed.com)
  • If spontaneous ventilation is maintained, the major cardiovascular effect is arterial hypotension (sometimes greater than a 30% decrease) with little or no change in heart rate and no appreciable decrease in cardiac output. (guidelinecentral.com)
  • The plasma, serum or blood concentrations of chloral hydrate and/or trichloroethanol, its major active metabolite, may be measured to confirm a diagnosis of poisoning in hospitalized patients or to aid in the forensic investigation of fatalities. (wikipedia.org)
  • Drinking alcohol, taking prescription or nonprescription medications that contain alcohol, or using street drugs during your treatment with morphine rectal increases the risk that you will experience these serious, life-threatening side effects. (medlineplus.gov)
  • Hiram, er, Hank was born with spinal bifida, and life-long pain led to his consumption of massive amounts of alcohol, morphine, and other painkillers. (cromwell-intl.com)
  • On the day he had died, he had consumed quite a lot of alcohol and chloral hydrate. (cromwell-intl.com)
  • Several years later, Isbell 9 conducted a classic study on 10 former morphine addicts who had consumed large quantities of alcohol for prolonged periods and then abruptly discontinued their alcohol consumption. (psychiatrist.com)
  • It is implicit in this sentence that, back then, Congress took for granted the legality of a free market in drugs, including cannabis, cocaine, heroin, and morphine. (druglibrary.net)
  • Long-term use of chloral hydrate is associated with a rapid development of tolerance to its effects and possible addiction as well as adverse effects including rashes, gastric discomfort and severe kidney, heart, and liver failure. (wikipedia.org)
  • Treatment of Alcoholism § Naltrexone: opioid receptor antagonist § Acamprosate: N-methyl-d-aspartate (NMDA) glutamate receptors antagonist OPIOID ANALGESICS Primary targets underlying the actions of the opioid analgesics: μ, κ, and δ receptors Commonly abused Drugs § § § § § § Heroin Morphine Codeine Oxycodone Meperidine Fentanyl Effects § IV admin: rapid development of tolerance, dependence, and addiction e.g. (studyres.com)
  • Chloral hydrate has not been approved by the FDA in the United States nor the EMA in the European Union for any medical indication and is on the FDA list of unapproved drugs that are still prescribed by clinicians. (wikipedia.org)
  • The major classes of antidepressant drugs include the tricyclic and related antidepressants , selective serotonin re-uptake inhibitors (SSRIs) , the selective serotonin and norepinephrine re-uptake inhibitors (SNRIs) and the monoamine oxidase inhibitors (MAOIs ). (pharmacologyeducation.org)
  • Chloral hydrate was routinely administered in gram quantities. (wikipedia.org)
  • Morphine rectal may be habit forming, especially with prolonged use. (medlineplus.gov)
  • There is a greater risk that you will overuse morphine if you have or have ever had any of these conditions. (medlineplus.gov)
  • Morphine may increase the risk that you will experience breathing problems or other serious or life-threatening breathing problems, sedation, or coma if used along with certain medications. (medlineplus.gov)
  • GABA A receptors including those of the ρ-subclass are ligand-gated ion channels responsible for mediating the effects of gamma-amino butyric acid (GABA), the major inhibitory neurotransmitter in the brain. (wikimili.com)
  • It's at 100 Commerce Street, at its intersection with the major east-west Bibb Street. (cromwell-intl.com)
  • If spontaneous ventilation is maintained, the major cardiovascular effect is arterial hypotension (sometimes greater than a 30% decrease) with little or no change in heart rate and no appreciable decrease in cardiac output. (nih.gov)