Morbidity therapy in autoimmune autoimmune diseases. Medical search. Frequent questions

Therapies for these disorders (eg, intravenous immunoglobulin [IVIG], bone marrow transplantation, gene therapy) are very costly and require highly advanced facilities. (medscape.com)
Interstitial lung disease (ILD) encompasses a heterogeneous group of respiratory disorders characterised by inflammation and/or fibrosis of the lung interstitium. (springer.com)
Cirrhosis is the final stage of chronic and progressive liver disease caused by infection, autoimmune disorders, biliary obstruction, and metabolic disorders. (bsmiab.org)
Secondary OA can be due to neuromuscular diseases, such as in diabetes, or due to metabolic disorders, such as pseudogout, so the patient comorbidities should be carefully evaluated in the differential. (clinicaladvisor.com)
Reference Autoimmune disorders are 5 times more common among women, and incidence tends to peak during reproductive years. (msdmanuals.com)
Common variable immunodeficiency (CVID), one of the most prevalent primary immunodeficiency diseases, is a heterogeneous group of immunologic disorders of unknown etiology. (medscape.com)
Myelodysplastic syndrome (MDS) comprises a heterogeneous group of clonal disorders of haematopoietic stem cells, characterised by dysplastic haematopoiesis and dysregulated apoptosis resulting in various degrees of cytopenia, whereas canonical cytologic, cytogenetic and histopathologic findings guiding the diagnosis MDS are widely accepted, the MDS-phenotype can be masked by coexisting/paraneoplastic immunologic disease. (researcher.life)
Autoimmune disorders have an estimated incidence of 10% among patients suffering from MDS and are causally related to increased morbidity and mortality, younger age at diagnosis and more complex genetics. (researcher.life)
Conversely, systemic inflammatory disorders may be an early manifestation of MDS, show good response to immunosuppressive therapy and frequently disappear during the course of specific haematologic therapy. (researcher.life)
As paraneoplastic syndromes are often mistakenly diagnosed as idiopathic autoimmune disorders, we propose that coexistence of an underlying myelodysplastic syndrome should be considered early in the diagnostic work up. (researcher.life)
Each uveitis subtype is categorized by the affected region of the eye and is associated with different autoimmune disorders with distinct immunopathology (i.e. juvenile arthritis, sarcoidosis and Behcet's disease). (acrabstracts.org)
Chia can be considered as "functional food" because apart from contributing to human nutrition, chia helps to increase satiety index, prevent cardiovascular diseases, inflammatory and nervous system disorders, and diabetes, among others. (ajphr.com)
Peer Insights for the Community Clinician: Complement Inhibition Therapy and Hematologic Disorders CME / ABIM MOC Did you know that thrombotic microangiopathy (TMA) is characterized by the presence of thrombocytopenia, microangiopathic hemolytic anemia, and evidence of organ damage? (medscape.org)
Are Maternal Autoimmune Disorders Linked to Mental Illness in Children? (medscape.org)
Many other clinical conditions present substantial skin fibrosis and may be potentially confused with Scleroderma, sometimes leading to a wrong diagnosis (eosinophilic fasciitis, systemic amyloidosis, scleromyxedema, graft-versus-host disease, progeroid disorders, stiff skin syndrome). (bvsalud.org)

Lupus nephritis is a common manifestation of lupus associated with significant morbidity and mortality. (annals.edu.sg)
Autoimmune uveitis is an inflammatory disorder of the eye that is associated with significant morbidity, including vision-threatening complications and chronic reliance on immunosuppressive therapies. (acrabstracts.org)

Chronically, microvascular and macrovascular complications are the major reasons for increasing morbidity and mortality in patients with diabetes. (spandidos-publications.com)

The prognosis of rheumatic diseases has improved considerably with development of therapy. (fapesp.br)
The objectives of this study are to evaluate the humoral response and safety of the vaccine H1N1 A/California/7/2009-like virus in immunosuppressed patients with rheumatic diseases compared to healthy controls. (fapesp.br)
Impact of the COVID-19 pandemic on the frequency of the pediatric rheumatic diseases. (cdc.gov)

estudio documental, realizado de mayo a julio de 2022, en páginas web de instituciones de educación superior que ofrecieron estos cursos. (bvsalud.org)

All of these fungi can cause invasive disease in a wide-spectrum of immunocompromised patients, such as those with genetic immunodeficiencies, HIV/AIDS, cancer, solid organ, and hematopoietic stem cell transplantation, autoimmune diseases, immunosuppressive treatments, and other predisposing states like diabetes and pregnancy. (frontiersin.org)
Hematopoietic Stem Cell Transplantation in Refractory Crohn's Disease: Should It Be Considered? (mdpi.com)

This study tested the hypothesis that an increased prevalence of left heart disease might explain the higher mortality in patients with PAH-Scl compared with patients with IPAH. (nih.gov)
Dear Editor, Hidradenitis suppurativa (HS) is a common disease with a prevalence of about 1%.1 Patients commonly suffer from pain, disfigurement and psychosocial embarrassment, and. (annals.edu.sg)
Prevalence of Chronic Diseases, Depression, and Stress Among US Childcare Professionals During the COVID-19 Pandemic CME / ABIM MOC Mental illness is just one of several chronic conditions hitting childcare professionals hard. (medscape.org)
dependent on prevalence of disease in a population. (cdc.gov)

Scleroderma, or systemic sclerosis (SSc), is an autoimmune disease characterized by vasculopathy and fibrosis. (the-rheumatologist.org)
STING-associated vasculopathy with onset in infancy (SAVI)] as well as diseases associated with gain of function mutations in inflammasome genes (e.g. (umassmed.edu)
Scleroderma is a relatively rare connective tissue disorder characterized by skin fibrosis, obliterative vasculopathy and distinct autoimmune abnormalities. (bvsalud.org)

Accounting for approximately 10% of blindness in the USA, uveitis refers to a group of heterogeneous diseases that share the features of intraocular inflammation but whose etiologies include idiopathic autoimmune disease, infections, rheumatologic diseases and masquerade syndromes. (medscape.com)

These diseases include, but are not limited to sickle cell and Fanconi's anemia, autoimmune diseases like diabetes and multiple sclerosis, and cancers that originate from the blood system such as leukemias and lymphomas. (ca.gov)
Diabetes mellitus (DM) is a metabolic disease in patients with high blood glucose over prolonged period ( 1 ). (spandidos-publications.com)
Diabetes leads to numerous complications associated with the heart, including ischemic heart disease, peripheral vascular disease, and cerebrovascular disease ( 3 ). (spandidos-publications.com)
In developed countries, cardiovascular disease is the main complication causing death resulted from diabetes ( 5 , 6 ). (spandidos-publications.com)
Type 1 diabetes is an autoimmune destruction of pancreatic B-cells and subsequent dependence upon insulin therapy. (cdc.gov)
Type 2 diabetes accounts for 90% of all cases of the disease, and traditionally it has been a disease of middle-aged or older people. (cdc.gov)
This trend is a serious threat to public health, as diabetes is associated with severe and potentially fatal complications and comorbidities, such as cardiovascular disease, kidney disease, visual impairment, neuropathies, and infectious complications. (cdc.gov)
The person living with diabetes can experience symptoms from such comorbidities which may impact function, emotional well-being, and quality of life as well as morbidity from complications that may limit work productivity, increase absenteeism, and lead to premature loss of employment. (cdc.gov)
Renal inflammatory diseases range from mild to severe, acute to chronic and may be associated with predisposing risk factors like diabetes mellitus, human immunodeficiency virus (HIV), leukemia, vesico- ureteric reflux and staghorn calculi. (egyptianjournal.xyz)
Although people with type 1 diabetes currently have a good life expectancy, statistics for morbidity and increased mortality are still problematic. (diabeterresearch.com)
Delaying or even stopping the onset of the disease is still the Holy Grail of type 1 diabetes research. (diabeterresearch.com)
Since type 1 diabetes is an autoimmune disease, many developments have been in the field of immune therapy, manipulating immune mechanisms directly (e.g. using monoclonal antibodies). (diabeterresearch.com)
However, many studies have not been conclusive, likely due to the heterogeneity of the type 1 diabetes disease process. (diabeterresearch.com)
The autoimmune nature of diabetes and inflammatory cytokine IL-10 (as markers the major contribution of lymphocyte T- of inflammatory changes) and the soluble cells are well established. (who.int)
The diagno- function may play a role in vascular com- sis of type 2 diabetes was established plications such as stroke or ischaemic heart before they were screened for the study disease. (who.int)

Our Disease Team will focus on the treatment of a disorder in children called severe combined immune deficiency (SCID). (ca.gov)
In late 2019, identification of a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was described as the causative pathogen of a pneumonia outbreak, known as coronavirus-induced-disease-19 (COVID-19) [ 1 ]. (medrxiv.org)
Currently, mass vaccination programmes, utilising regulatory-approved vaccines, remains the best way to prevent viral transmission [ 3 , 4 ], severe disease, death [ 5 , 6 ] and overwhelming the already stretched healthcare services. (medrxiv.org)
Moreover, immunosuppressed patients, such as kidney transplant recipients, have been considered as clinically vulnerable to SARS-CoV-2 infection, which is supported by both population-based and registry-based studies which illustrate these patients experience significant rates of hospitalisations, severe disease and death [ 11 - 13 ]. (medrxiv.org)
In particular, children with refractory JIA treated with long-term, multiple, and often combined immunosuppressive and antiinflammatory agents, including the new biological disease-modifying antirheumatic drugs (DMARDs), are at increased risk for severe infections and death. (cdc.gov)
Current therapy has converted the outlook of these diseases from death or severe morbidity to a remitting-relapsing condition in most instances. (uea.ac.uk)
Obesity is a risk factor for both susceptibility to infections including postoperative infections and other nosocomial infections and the occurrence of a more severe disease course. (hrb.ie)
These therapies can have severe adverse events, risks and heavy treatment burden. (diabeterresearch.com)
Comparable bidirectional neutrophil immune dysregulation between Kawasaki disease and severe COVID-19. (cdc.gov)

Rheumatoid arthritis (RA) is a chronic, inflammatory, systemic autoimmune disease of unknown aetiology. (bmj.com)
Abstract The Disease Activity Score 28 (DAS28) shows discrepancies when using erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) scores to assess rheumatoid arthritis (RA). (bvsalud.org)
The vast majority of the ILDs are categorized in some connective tissue disease associated ILD (such as Rheumatoid arthritis, Scleroderma, Sjogren's). (ersnet.org)
All patients with rheumatoid arthritis, spondyloarthritis, SLE, systemic vasculitis, juvenile idiopathic arthritis, juvenile SLE, and juvenile DM were assessed before and 21 days after vaccination for clinical, laboratory parameters of disease activity. (fapesp.br)
Interstitial lung disease related to rheumatoid arthritis : what do we don?t know? (unican.es)

Significant preexisting renal or cardiac complications increase risk of maternal morbidity and mortality. (msdmanuals.com)
The main risk factor raising the mortality and morbidity of type 1 DM is cardiovascular complications. (spandidos-publications.com)

In some instances, fungi have developed mechanisms to evade the consequences of monocyte activation and subvert these cells to promote disease. (frontiersin.org)
We examine the interplay between the activated endothelium, autoimmune mechanisms and treatment factors to produce a direct insult or increased atherogenic potential of primary systemic vasculitis. (uea.ac.uk)
And that's not so easy and that's where the role of research comes in and that's where understanding disease mechanisms come in. (cdc.gov)

Extra-articular manifestations increase its morbidity and severity, and cardiovascular diseases present the greatest risk. (bvsalud.org)
The presenting symptoms, acuity, time course, severity, and subsequent morbidity vary and depend on the type of fiber that is affected and the underlying cause. (bmj.com)
Pediatric cardiologist Allen Everett discusses his research about the identification and use of biomarkers, which are circulating molecules that tell researchers about overall health, disease severity, injury and recovery. (hopkinsmedicine.org)
The severity of the inflammatory process has been correlated with the rapidity of disease progression (11) . (ajnr.org)
This article attempts to paint a picture of the severity of the prescription-drug-induced kidney disease problem across the world, by illustrating why kidneys are important, what common drugs damage kidneys, and how prescription drug use is escalating. (infoholix.net)

Immunocore Limited, the world's leading TCR company developing biological drugs to treat cancer, infectious diseases and autoimmune diseases, today announced an investment from the Bill & Melinda Gates Foundation to support the development of Immunocore's soluble TCR-based therapeutics for infectious diseases. (londonlovesbusiness.com)
The Bill & Melinda Gates Foundation will invest up to $40 million in Immunocore to support development of Immunocore's ImmTAV (Immune mobilising monoclonal TCRs Against Virus) and ImmTAB (Immune mobilising monoclonal TCRs Against Bacteria) therapeutics for infectious diseases that pose a global health challenge. (londonlovesbusiness.com)
This new collaboration is part of a larger initiative within Immunocore to apply its soluble TCR-based therapeutics to areas outside of oncology, including infectious diseases and autoimmune diseases. (londonlovesbusiness.com)
Many infectious diseases continue to represent a huge and growing global challenge. (londonlovesbusiness.com)
We're delighted and honoured that the Bill & Melinda Gates Foundation, one of the most significant forces for positive change in global healthcare, has recognised the potential of Immunocore's platform technology for advancing novel therapeutics for infectious diseases such as TB and HIV. (londonlovesbusiness.com)
Here is a complete guide to understanding and maximizing your natural defenses against various infectious diseases. (squareonepublishers.com)
That same day, he was transferred infection control practices when examining and treating to hospital B, a tertiary care referral hospital, for neurologic patients with suspected infectious diseases. (cdc.gov)

Scleroderma is an autoimmune disease that can affect left and right heart function directly through inflammation and fibrosis and indirectly through systemic and pulmonary hypertension. (nih.gov)
The hallmark feature of the disease process is the formation of antinuclear autoantibodies, and deposition of immune complexes into tissues, contributing to organ inflammation and damage (2). (ashdin.com)
Atopic dermatitis (AD) is a multifactorial, heterogeneous disease associated with epidermal barrier disruption and intense systemic inflammation. (mdpi.com)
The neurodegeneration observed in patients with Alzheimer's disease is a result of inflammation in the brain causing neuronal cell death-especially in regions associated with memory. (umassmed.edu)
Relapsing polychondritis is a rare disease that causes inflammation of your cartilage. (healthline.com)
The primary systemic vasculitides are a group of autoimmune conditions characterised by occlusion, stenosis or aneurysmal dilatation of blood vessels secondary to intra-mural inflammation. (uea.ac.uk)
Uveitis can refer to inflammation of one or all three components, may also include primary inflammations of the retina and vitreous, and is often found in connection with systemic disease. (medscape.com)
[ 1-3 ] The most critical question in evaluating a patient with intraocular inflammation is whether the disease can be classified into a specific, defined syndrome. (medscape.com)
While ophthalmic examinations indicated near-quiet clinical disease activity at the time of surgery, panuveitis patients and a subset of anterior uveitis patients displayed persistent inflammation within their intraocular fluid. (acrabstracts.org)
These terms also show up in references to kidney damage, such as glomerulonephritis (also known as Bright's disease) and interstitial nephritis (which are just fancy words for inflammation of portions of the kidney - they are not diseases, per se). (infoholix.net)

Patients with autoimmune manifestations may require immunosuppressive therapy. (medscape.com)
Clinical manifestations of chronic GVHD are similar to autoimmune collagen vascular disease and the two main types of cutaneous chronic GVHD are lichenoid and sclerodermatous. (bvsalud.org)

Additionally, A. fumigatus can cause chronic pulmonary infections, allergic bronchopulmonary aspergillosis, or allergic disease in immunocompetent hosts. (wikipedia.org)
Parasitic infections caused by Plasmodium species, Toxoplasma, Leishmania and Trypanosomes cause significant morbidity and mortality worldwide. (umassmed.edu)
Researchers in the PII program are examining how these parasites interact with and evade the immune system, to develop new therapies to treat these infections. (umassmed.edu)
However, infections are considered the most important cause of morbidity and mortality in this group of patients. (fapesp.br)
Viral and bacterial infections are among the leading global causes of morbidity and mortality. (londonlovesbusiness.com)
Acute infections include acute pyelonephritis, The study aim to highlight the value of renal and perirenal abscesses, pyonephrosis, multidetecter C.T imaging in assessment of renal emphysematous pyelonephritis and emphysematous inflammatory diseases. (egyptianjournal.xyz)
Atypical mycobacteria or nontuberculous mycobacteria are organisms that cause various diseases such as skin and soft tissue infection, lymphadenitis, pulmonary infection, disseminated infection, and a wide range of more rarely encountered infections. (statpearls.com)

THE OLD PLAYER Except for malaria and genetic metabolic diseases (e.g. (insulin-receptor.info)
Patients with that syndrome are usually infertile, however in about half the cases, it is possible to fi nd spermatozoa in the testes, and have a higher risk of i.e. breast cancer, metabolic syndrome, cardiovascular disease, osteopenia/osteoporosis, autoimmune diseases. (postepyandrologii.pl)

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder that is challenging to diagnose and manage (1). (ashdin.com)
This disorder was initially called Ormond's disease. (the-rheumatologist.org)

10 This review aims to provide an assessment of the nature and extent of complement involvement in the underlying pathophysiology of TMA associated with autoimmune diseases that will help to stratify patients for targeted therapy. (jrheum.org)
If the specific syndrome is elusive, one must take the appropriate steps to try to define the underlying pathophysiology, whether it be autoimmune, infectious, neoplastic or other masquerade syndromes, as the appropriate treatment for these types of diseases vary widely. (medscape.com)

In 2016, Immunocore published preclinical data in Molecular Therapy that demonstrated the potential of Immunocore's ImmTAV molecules to redirect the immune system to kill HIV-infected cells from patients treated with antiretroviral therapy, thus facilitating clearance of reactivated latently infected HIV reservoir cells. (londonlovesbusiness.com)

Acute kidney injury (AKI) is a life-threatening disease with high mortality characterized by an abrupt decrease of the kidney glomerular filtration rate, extra-kidney consequences (cardiovascular diseases, lung injury, neurological impairment) and high risk of secondary chronic kidney disease (CKD). (hrb.ie)

AILDR is an important clinical and research tool providing a platform for epidemiological data that will prove essential in promoting understanding of a rare cohort of lung disease and provide foundations for our aspiration to standardise investigation and treatment pathways of ILD across Australasia. (springer.com)
To establish accurate diagnoses, guidelines mandate thorough clinical history and examination combined with high resolution CT imaging and autoimmune serology. (springer.com)
This regulatory endorsement will provide sponsors with the confidence to use islet autoantibodies in the optimization of clinical trials evaluating novel therapies focused on the delay and/or prevent T1D. (azbio.org)
We're excited to move forward with this important project which will help pave the way for forthcoming therapies with the ability to treat early stages of T1D and delay or prevent the clinical, currently irreversible, stage of the disease. (azbio.org)
These data, coupled with the clinical efficacy and safety profile emerging from the Company's lead programme, IMCgp100 in oncology, set the foundation for the application of the Immunocore platform technology across multiple diseases. (londonlovesbusiness.com)
50%), better clinical models and pipelines for targeted therapies are urgently required. (hrb.ie)
Monocentric report on clinical phenotypes found in MDS or bone marrow failure with paraneoplastic inflammatory disease. (researcher.life)
Furthermore, clinical markers (neurologic and cognitive scores) are relatively insensitive to early nervous system involvement and minor disease progression (9) . (ajnr.org)
In this study, we evaluated the association between contrast enhancement on the T1-weighted spin-echo MR images of patients with X-linked ALD and disease progression based on clinical evaluation and MR imaging scores. (ajnr.org)
Long-Term Risk of Relapse in Immune-Mediated Thrombotic Thrombocytopenic Purpura and the Role of Anti-CD20 Therapy CME / ABIM MOC Lack of early iTTP relapse or treatment failure predictors mandates regular ADAMTS13 monitoring to prevent progression to clinical relapse. (medscape.org)
Systemic treatment in Behcet's disease According to clinical phenotypes. (unican.es)
Due to lesions clinical stabilization and improvement in performance of the stomatognathic functions, the therapy was considered successful. (bvsalud.org)

Of interest, symptoms of autoimmune thyroid diseases tend to improve during pregnancy. (medscape.com)

Diagnostic testing to identify major systemic diseases associated with uveitis. (medscape.com)
Uveitis in axial spondyloarthritis: frequency and relationship to biological therapy. (unican.es)

Alpha-synuclein: Implications for Parkinson's Disease This review summarizes the physiological and pathological roles of alpha-synuclein and its implication in Parkinson's disease pathogenesis. (medscape.com)
MADRID-Research into pharmacodynamic biomarkers has shown that macrophages may have an important role in the pathogenesis of several diseases, including systemic sclerosis, an expert said at the 2017 Annual European Congress on Rheumatology (EULAR). (the-rheumatologist.org)
However, because the ensuing response can damage the host when left unchecked, tight regulation is critical to prevent the pathogenesis of several diseases. (umassmed.edu)

Aspergillus fumigatus is the most frequent cause of invasive fungal infection in immunosuppressed individuals, which include patients receiving immunosuppressive therapy for autoimmune or neoplastic disease, organ transplant recipients, and AIDS patients. (wikipedia.org)

To evaluate annual trends in respiratory disease-related admissions in a large Israeli hospital during and before the pandemic. (ima.org.il)
Interstitial Lung Disease (ILD) is a group of respiratory conditions affecting the lung interstitium often associated with progressive respiratory failure. (springer.com)
What emerged as a local outbreak in Wuhan, China, rapidly progressed into a global pandemic of acute respiratory syndrome evoking mass morbidity, mortality and significant socio-economic turmoil [ 2 ]. (medrxiv.org)
And it's important to understand that because that's how we talk about respiratory disease or respiratory illness in the population that was exposed to World Trade Center dust and fumes, whether it's the responder population or a community population. (cdc.gov)

Thus, DC immunotherapy appears to be a potential novel therapy for SLE that needs to be studied. (journaltocs.ac.uk)
The treatment of these diseases depends on the underlying cause and may include immunotherapy, mitigation of risk factors, symptomatic treatment, and gene therapy, such as the recently developed RNA interference and antisense oligonucleotide therapies for transthyretin familial amyloid polyneuropathy. (bmj.com)

As is expected in a heterogeneous group of diseases, many different immune system defects have been reported in this group of patients. (medscape.com)
Earlier aluminum-formulated intralymphatic glutamic acid decarboxylase (GAD-alum) therapy was developed to train the immune system to tolerate GAD65. (diabeterresearch.com)

Histopathology of Cold Agglutinin Disease Review the characteristics of cold agglutinin disease, a type of autoimmune hemolytic anemia characterized in recent years as a distinct B-cell lymphoproliferative disease. (medscape.com)
7 - 9 A TMA is called "primary" when a genetic or acquired defect in a complement protein is identified (as in atypical hemolytic uremic syndrome [aHUS]) or "secondary" when occurring in the context of another disease process or factor such as infection, autoimmune disease, malignancy, or drugs. (jrheum.org)
Warm Autoimmune Hemolytic Anemia: The Foundations of Diagnosis and Management CME / ABIM MOC Join our expert faculty for a discussion on recognizing the signs and symptoms of wAIHA and appropriately managing this patient population. (medscape.org)

PII faculty members are also focused on understanding how innate immune sensors regulate autoimmune diseases such as systemic lupus erythematosus, inflammatory bowel disease, and vitiligo. (umassmed.edu)

The complement system is a tightly regulated, cascading protein network that performs multiple roles in homeostasis and disease prevention and is a key component of both the innate and the humoral immune systems. (jrheum.org)
Several PII labs are studying monogenic diseases associated with innate immune pathways including diseases associated with nucleic acid signaling [(e.g. (umassmed.edu)
Innate immune response analysis in COVID-19 and kawasaki disease reveals MIS-C predictors. (cdc.gov)

Type 1 DM is caused by the autoimmune destruction of the pancreatic β-cells resulting in reduced insulin production ( 4 ). (spandidos-publications.com)

This article will explain this rare condition and provide more detail on symptoms, why this happens, and how you can treat this disease. (healthline.com)
And what you notice from this list is that there's overlap, that you can have symptoms that are upper airway that are also lower airway, and that a symptom really only tells you a problem, it doesn't tell you a disease. (cdc.gov)

Pulmonary arterial hypertension related to scleroderma (PAH-Scl) is associated with high morbidity and mortality as well as poorer response to therapy and worse outcomes compared with the idiopathic form of PAH (IPAH). (nih.gov)
This review aims to provide an assessment of the nature and extent of complement involvement in TMA associated with autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, and scleroderma renal crisis. (jrheum.org)

2 , 4 - 6 Early recognition is important because TMA is associated with significant mortality and morbidity, including end-stage kidney disease, although prompt initiation of supportive and specific management can transform disease outcomes. (jrheum.org)

Centers for Disease Control and Prevention. (cdc.gov)
The initial action of most medical centers' response to the COVID-19 pandemic was to create a multidisciplinary taskforce ("incident command center") including executive leadership, infectious disease experts, and department leaders to provide oversight, create policy based on available scientific evidence, and allocate resources for managing the crisis. (springer.com)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
The following data comes from a report published by the Centers for Disease Control (CDC). (infoholix.net)
I'm Commander Ibad Khan, and I'm representing the Clinician Outreach and Communication Activity, COCA, with the Emergency Risk Communication Branch at the Centers for Disease Control and Prevention. (cdc.gov)
The findings and conclusions in this presentation are those of the authors and do not necessarily represent the official presentation of the Centers for Disease Control and Prevention. (cdc.gov)

In contrast to ipilimumab monotherapy, anti-PD-1 antibodies are licensed to be continued until disease progression. (biomedcentral.com)
It uses a two-stage recruitment strategy, registering patients before they complete 1 year of first-line anti-PD-1 +/− CTLA-4 therapy and randomising eligible patients who have received 12 months of treatment and are progression-free at 1 year. (biomedcentral.com)
At randomisation, 1208 patients are assigned (1:1) to either 1) continue anti-PD-1 treatment until disease progression/ unacceptable toxicity/ for at least 2 years in the absence of disease progression/ unacceptable toxicity or 2) to stop treatment. (biomedcentral.com)
The overarching goal of these studies is to identify preventive and treatment measures to stop the progression of this devastating disease. (umassmed.edu)
Definitive therapy for cirrhosis is liver transplantation, but it takes time to find a matched donor, and thus, patients have to wait relatively for a long time and should continue to use urso deoxy cholic acid (UDCA) as an effort to slow the disease progression [ 2 , 3 ]. (bsmiab.org)
In their response to the T1D Consortium Letter of Intent (LOI) and Briefing Package, the EMA stated, "[Therapies that preserve endogenous β-cell function and can prevent, halt or slow T1D disease progression in a clinically meaningful way would constitute a significant advancement in T1D care. (azbio.org)
Early assignment of disease progression among patients with X-linked adrenoleukodystrophy (ALD) is critical for the appropriate selection of effective therapy. (ajnr.org)
We evaluated the association between contrast enhancement on T1-weighted spin-echo MR images and disease progression. (ajnr.org)
18 (86%) of the 21 patients had disease progression revealed by the follow-up evaluations based on MR imaging (Loes) and neurologic scores. (ajnr.org)
for 18 (82%) of the 22 patients, no evidence of disease progression was revealed by the follow-up evaluations. (ajnr.org)
Nevertheless, plasma assays have been found to be unreliable markers for disease progression, irrespective of subtype. (ajnr.org)
Our null hypothesis was that there is no association between contrast enhancement and disease progression in X-linked ALD. (ajnr.org)

Idiopathic pulmonary fibrosis (31%) and connective-tissue disease related ILD (21.7%) were the two most common subtypes. (springer.com)
ILD dominates the morbidity and mortality in all these individual categories and while in some cases the disease can be self-limited or controlled by immunosuppression and antigen removal in the case of CHP, in other cases the fibrosis can take its own course, become self-sustained, progressive and fatal. (ersnet.org)

there was no significant change in increased risk of death in PAH-Scl after controlling for left heart disease. (nih.gov)
This inflammatory condition can affect multiple organs with potential for significant morbidity and mortality. (ashdin.com)
It is generally a progressive disease with functional decline, significant morbidity and premature mortality. (bmj.com)
Autoimmune disease affects up to 5% of the population and can cause significant morbidity and mortality. (ucsf.edu)
Many patients require lifelong therapy to treat their autoimmune disease and these therapies often have significant side-effects. (ucsf.edu)

To highlight the unknowns around unclassifiable ILD and to allow further research into the condition, a research group established a new diagnostic entity termed interstitial pneumonia with autoimmune features (IPAF). (ersnet.org)

Dendritic cells (DC) are postulated to play a role in autoimmune diseases such as Systemic Lupus Erythematosus (SLE). (journaltocs.ac.uk)
In the tumor microenvironment, T cells, as crucial immune response against malignant diseases as well as other immune central effector cells, such as natural killer cells, are regulated via co-stimulatory or co-inhibitory signals from immune or tumor cells. (journaltocs.ac.uk)
Primary B-cell immunodeficiencies refer to diseases resulting from impaired antibody production due to either molecular defects intrinsic to B-cells or a failure of interaction between B-cells and T-cells. (medscape.com)
Successful stem cell therapy requires the exchange of diseased or non-functional stem cells with healthy ones. (ca.gov)
These healthy stem cells can come from either a donor or can be stem cells that are modified by gene therapy techniques. (ca.gov)
If the antibody treatment results a stronger blood system originating from a donor in SCID patients, this result would prove that the antibody could be used to optimize engraftment of gene-therapy modified cells and could be applied to the treatment the many other diseases that need a BMT. (ca.gov)
Researchers don't clearly understand why some people develop the rare inflammatory disease known as relapsing polychondritis, but they believe it occurs when your immune cells attack healthy cartilage cells. (healthline.com)
Human mesenchymal stem cells (HuMSC) have low immunogenicity, self-renewal, and are easy to obtain, making it a promising therapy for liver regeneration [ 4 ]. (bsmiab.org)
At the time of sample collection, all patients had near-quiet disease activity on slit-lamp examination with anterior chamber cells grades between 0 and 0.5+ by SUN criteria. (acrabstracts.org)
Th2 cells produce cy- patients which might reduce the morbidity tokine interleukins IL-4 and IL-10, which and mortality due to infection. (who.int)

Current treatment of RA with disease-modifying antirheumatic drugs (DMARD), such as methotrexate, is inadequate in many patients because these drugs only partly control established disease. (bmj.com)
The number of measures taken for comorbidities and the percentage of patients recording a change (initiation, switch or increased dose) in disease-modifying antirheumatic drugs (DMARDs) in the 6 months follow-up period of the study defined the outcomes of the trial. (bmj.com)

Adams and colleagues described the concept of Graves disease as an autoimmune dysfunction of the thyroid gland. (medscape.com)
You might also run across references to "renal failure," "renal dysfunction," "end-stage renal disease" (ESRD) and "nephropathy. (infoholix.net)

Her recent study, conducted with Johns Hopkins oncologists, showed that patients with both an rheumatic disease and lung cancer who were diagnosed earlier had better survival outcomes compared to patients without such rheumatic conditions. (hopkinsmedicine.org)
A Comparative Analysis of Outcomes in Primary Myelodysplastic Syndrome (MDS) and Therapy-Related MDS Reveals Two Subgroups with Differing Risk Profiles: Implications for the Application of a Prognostic Classification. (researcher.life)

IFN and IL-10 were signi cantly elevated in patients with diabetic nephropathy (DN) and end-stage renal disease (ESRD) compared with controls and diabetic patients without DN. (who.int)
stage renal disease (ESRD) [ 2 ] and with impaired immunity in HD patients [ 3 ]. (who.int)

A. fumigatus primarily causes invasive infection in the lung and represents a major cause of morbidity and mortality in these individuals. (wikipedia.org)

The lack of studies evaluating the efficacy and safety of the vaccine against H1N1 A/California/7/2009-like virus in these autoimmune rheumatic patients led to the development of this research. (fapesp.br)

Autoimmune disease affects 10% of adults, most of whom are women, and two of the top five medications with the highest cost globally are used to maintain these recurring conditions in remission. (hrb.ie)

Anatomy30

Organisms12

Diseases73

Chemicals and Drugs71

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes34

Information Science6

Named Groups1

Health Care17

Disorders15

Associated with significant morbidity2

Increasing morbidity and morta1

Rheumatic diseases3

20221

Hematopoietic stem cell trans2

Prevalence4

Vasculopathy3

Idiopathic autoimmune1

Diabetes15

Severe9

Rheumatoid5

Complications2

Mechanisms3

Severity5

Infectious Diseases7

Inflammation10

Manifestations2

Infections7

Metabolic2

Disorder2

Pathophysiology2

20161

Cardiovascular diseases1

Clinical12

Thyroid diseases1

Uveitis2

Pathogenesis3

Neoplastic1

Respiratory4

Immunotherapy2

Immune system2

Hemolytic3

Inflammatory bowel d1

Innate3

Pancreatic1

Symptoms2

Scleroderma2

Kidney disease1

Centers6

Progression12

Fibrosis2

Significant5

Interstitial1

Cells10

Antirheumatic drugs2

Dysfunction2

Outcomes2

Renal Disease2

Lung1

Vaccine1

Affects1