AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Carcinoma, Renal CellKidney NeoplasmsCarcinomaCarcinoma, Squamous CellMorbidityCarcinoma, HepatocellularCarcinoma, PapillaryCarcinoma in SituNephrectomyLiver NeoplasmsImmunohistochemistryCarcinoma, Ductal, BreastPrognosisCarcinoma, Basal CellTumor Markers, BiologicalNeoplasm StagingAdenoma, OxyphilicVon Hippel-Lindau Tumor Suppressor ProteinCell Line, TumorAdenocarcinoma, Clear CellCarcinoma, Transitional CellNeoplasm MetastasisTreatment OutcomeGene Expression Regulation, NeoplasticRetrospective StudiesBenzenesulfonatesAdenocarcinomaNeoplasm InvasivenessAntineoplastic AgentsTumor Cells, CulturedPyrrolesCarcinoma, BronchogenicPhenylurea CompoundsCarcinoma, Intraductal, NoninfiltratingNiacinamideCarcinoma, Adenoid CysticCarcinoma, Small CellLung NeoplasmsCarcinoma, MedullarySurvival RateCarcinoma, LobularBreast NeoplasmsThyroid NeoplasmsSurvival AnalysisNasopharyngeal NeoplasmsCarcinoma, NeuroendocrineNeoplasm ProteinsNeoplasms, Multiple PrimaryLymphatic MetastasisCarcinoma, MucoepidermoidRNA, MessengerTime FactorsCarcinoma, AdenosquamousHead and Neck NeoplasmsIndolesMice, NudeFollow-Up StudiesNeoplasm Recurrence, LocalKidneyRisk Factorsvon Hippel-Lindau DiseaseCarcinoma, EndometrioidEsophageal NeoplasmsDNA, NeoplasmMouth NeoplasmsReverse Transcriptase Polymerase Chain ReactionDisease-Free SurvivalSkin NeoplasmsImmunoenzyme TechniquesCarcinoma, EmbryonalChromosomes, Human, Pair 3Disease ProgressionAntigens, NeoplasmOvarian NeoplasmsTomography, X-Ray ComputedUrinary Bladder NeoplasmsCarcinoma, Merkel CellCarcinoma, DuctalColonic NeoplasmsNeoplasm TransplantationKaplan-Meier EstimateAdrenocortical CarcinomaCarcinoma, VerrucousCarcinoma, Signet Ring CellApoptosisTissue Array AnalysisCell ProliferationStomach NeoplasmsLeiomyomatosisCombined Modality TherapyCarcinoma, Large CellUterine Cervical NeoplasmsProspective StudiesLaryngeal NeoplasmsNeovascularization, PathologicAntibodies, MonoclonalTumor Suppressor ProteinsPancreatic NeoplasmsFumarate HydrataseAdenocarcinoma, Mucinous
TumorsPapillaryHepatocellular carcinomaTumorSignificant morbidity and mortaNephron sparingNeoplasmsProximal renal tubular epitheliumCause of mortality and morbidityTreatment of metastaticMetastatic diseaseSurvivalDiagnosisMetastasesOutcomesNephrectomySquamous cellCystsCancersPancreaticHereditaryKidneySubtypesCancerSickle cell diSurgery for renalInferior venaMetastasisClinicalResectionMedullaryRetinal angiomasPrognosisChemotherapyIncidencePatientsMalignanciesTubular dysfunctionSystemicAcidosis2018CysticApoptosisChronic Renal FInsufficiencyHypertensionLesionsClear cellClassificationSurgicalCentersTumourDisease
Tumors11
  • 2003) Comparative analysis of laparoscopic versus open partial nephrectomy for renal tumors in 200 patients. (medscape.org)
  • 2007) Comparison of 1,800 laparoscopic and open partial nephrectomies for single renal tumors. (medscape.org)
  • Vermooten V (1950) Indications for conservative surgery in certain renal tumors: a study based on the growth pattern of the cell carcinoma. (medscape.org)
  • Multiple or bilateral renal carcinomas have been reported in association with this syndrome, most commonly hybrid oncocytic tumors with features of chromophobe renal carcinoma (50%), followed by chromophobe renal cancer, clear cell renal carcinoma, and renal oncocytoma. (medscape.com)
  • Increasingly, renal cell cancers are diagnosed at an earlier stage, and nephron-sparing surgery and thermal ablation are gaining acceptance as a treatment of choice for smaller tumors. (medscape.com)
  • Once papillary renal cell carcinoma is diagnosed, you may have surgery to remove the tumors from the kidney. (healthyskinworld.com)
  • The downstage migration of kidney cancer and the gained expertise in surgical techniquehave contrib-uted to a wider utilization of nephron sparing surgery and an expansion of its indications to include renal cortical tumors of larger size and in difficult anatomical locations. (prelekara.sk)
  • Cystic renal tumors, overall, have excellent prognosis and less aggressive metastatic behavior compared with solid renal tumors. (radiologykey.com)
  • Mutations in the tumor suppressor gene VHL cause the disease, which commonly manifests as a variety of tumors such as hemangioblastomas of the retina and brain as well as renal cell carcinoma. (eyewiki.org)
  • biological associations with blood sugar fat burning capacity hypoxia and angiogenesis successfully.3 4 7 Soft tissues sarcomas (STSs) certainly are a heterogeneous band of uncommon tumors that occur from mesenchymal cells in any way body system sites and neoadjuvant therapy provides several advantages in the treating STSs.8 Treatment-induced cytoreduction potentially facilitates a much less radical surgical resection lowering the operative and postoperative morbidity ML347 thus. (bioxorio.com)
  • Data for the incidence analysis included all cancers except squamous and basal cell carcinomas and in situ tumors of the uterine cervix. (cdc.gov)
Papillary6
  • The hypoxic, acidotic, and hyperosmolar environment of the inner medulla are known to promote sickling of red blood cells (RBCs) with resultant impairment in renal medullary blood flow, ischemia, microinfarction, and papillary necrosis. (medscape.com)
  • Nevertheless, current data suggest that hematuria and papillary necrosis do not portend greater risk for renal failure. (medscape.com)
  • Other genetically linked conditions also increase the risk of RCC, including hereditary papillary renal carcinoma, hereditary leiomyomatosis, Birt-Hogg-Dube syndrome, hyperparathyroidism-jaw tumor syndrome, familial papillary thyroid carcinoma, von Hippel-Lindau disease and sickle cell disease. (wikipedia.org)
  • Treatment for papillary renal cell carcinoma for each patient is unique. (healthyskinworld.com)
  • Having certain genetic conditions , such as von Hippel-Lindau disease or hereditary papillary renal cell carcinoma . (healthyskinworld.com)
  • Characterizing the outcomes of metastatic papillary renal cell carcinoma. (jamanetwork.com)
Hepatocellular carcinoma3
  • Drug resistance to chemotherapy agents presents a major obstacle to the effective treatment of hepatocellular carcinoma (HCC), a common type of liver cancer. (bvsalud.org)
  • Polyphyllin I (PPI), a promising pharmaceutical candidate, has shown potential therapeutic advantages in the treatment of sorafenib-resistant hepatocellular carcinoma (SR-HCC cells). (bvsalud.org)
  • 1 TKIs are now therapies used routinely in the treatment of many solid tumours such as gastrointestinal stromal tumour (GIST), renal cell carcinoma (RCC), hepatocellular carcinoma (HCC), medullary thyroid cancer, breast cancer and non-small-cell lung carcinoma (Table 1) . (touchoncology.com)
Tumor16
  • We evaluated the morbidity of nephrectomy in patients older than 80 years of age.Between June 2002 and March 2011, 2,530 patients underwent surgery for renal tumor at 5 French academic centers. (elsevierpure.com)
  • 1999) Nephron sparing surgery for localized renal cell carcinoma: impact of tumor size on patient survival, tumor recurrence and TNM staging. (medscape.org)
  • 1997) Patterns of tumor recurrence and guidelines for followup after nephron sparing surgery for sporadic renal cell carcinoma. (medscape.org)
  • Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
  • Treatment of metastatic renal cell carcinoma with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning with fludarabine/total body irradiation is feasible and may induce tumor regression or stabilization in some patients. (aacrjournals.org)
  • CD8 + CTL-recognizing minor H antigens on tumor cells can be isolated posttransplant and could contribute to the graft- versus -tumor effect. (aacrjournals.org)
  • Mutation of the VHL tumor suppressor gene is observed in up to 80% in clear cell kidney cancers, leading to increased rates of VEGF secretion in RCC ( 11 ), thus being a promising candidate for VEGF-targeted therapy. (iiarjournals.org)
  • Renal cell carcinoma is a unique and challenging tumor because of the frequent occurrence of paraneoplastic syndromes, including hypercalcemia, erythrocytosis, and nonmetastatic hepatic dysfunction (ie, Stauffer syndrome). (medscape.com)
  • Genetic studies of the families at high risk for developing renal cancer led to the cloning of genes whose alteration results in tumor formation. (medscape.com)
  • The radiation is aimed at the tumor area to kill the tumor cells and to prevent it from growing back. (healthyskinworld.com)
  • Epigenetic deregulation is an emerging hallmark of cancer that enables tumor cells to escape surveillance by tumor suppressors and ultimately progress. (iu.edu)
  • ISUP Renal Tumor Panel. (jamanetwork.com)
  • Low power image-A. This retinal tumor shows high vessel density with thick walls (arrow) and cyst containing proteinaceous material (asterisk) High power image-B. The stromal cells are foamy and vacuolated (arrowheads) with many small channels resembling capillaries (arrows). (eyewiki.org)
  • So we know that the higher the tumor thrombus, the closer to the heart, the more complicated the surgery, higher blood loss, [and] higher morbidity to the patient. (onclive.com)
  • Genital warts, which are a form of benign tumor of epithelial cells, are also caused by various strains of HPV. (wikipedia.org)
  • A reduction in platelet number or function can occur through a variety of mechanisms, including autoimmune destruction, spleen sequestration, bone marrow infiltration by tumor cells, infection (e.g. dengue fever), and adverse drug reaction. (bvsalud.org)
Significant morbidity and morta2
  • Brain metastases from renal cell carcinoma (RCC) cause significant morbidity and mortality. (cancernetwork.com)
  • Management of VHL disease involves lifelong radiological and biochemical surveillance, often leading to repeat surgical intervention causing significant morbidity and mortality. (figshare.com)
Nephron sparing5
  • 2004) Nephron sparing surgery for appropriately selected renal cell carcinoma between 4 and 7 cm results in outcome similar to radical nephrectomy. (medscape.org)
  • 2000) Long-term results of nephron sparing surgery for localized renal cell carcinoma: 10-year followup. (medscape.org)
  • 2005) Elective nephron sparing surgery should become standard treatment for small unilateral renal cell carcinoma: long-term survival data of 216 patients. (medscape.org)
  • 2007) Morbidity and clinical outcome of nephron-sparing surgery in relation to tumour size and indication. (medscape.org)
  • Licht MR and Novick AC (1993) Nephron sparing surgery for renal cell carcinoma. (medscape.org)
Neoplasms4
  • 1993) Laparoscopic nephrectomy for renal neoplasms. (medscape.org)
  • Renal cell carcinoma (RCC) accounts for approximately 3% of adult malignancies and 90-95% of neoplasms arising from the kidney. (medscape.com)
  • Complex cysts, on imaging, may be seen as part of benign cysts, renal infection, and cystic neoplasms, including cystic renal cell carcinoma (RCC), which can be distinctly identified due to characteristic imaging features. (radiologykey.com)
  • Pathogenic germline mutations in VHL gene cause von Hippel-Lindau (VHL) disease, an autosomal dominant hereditary cancer syndrome associated with high penetrance of benign and malignant neoplasms, including clear cell renal cell carcinoma (ccRCC), central nervous system haemangioblastomas (CNS-HB), retinal angiomas, phaeochromocytomas and pancreatic neuroendocrine tumours (pNET). (figshare.com)
Proximal renal tubular epithelium2
  • The tumour arises from the cells of the proximal renal tubular epithelium. (wikipedia.org)
  • The tissue of origin for renal cell carcinoma (RCC) is the proximal renal tubular epithelium. (medscape.com)
Cause of mortality and morbidity1
  • Coronary atherosclerotic disease is a leading cause of mortality and morbidity due to major cardiovascular events in the United States and abroad. (bvsalud.org)
Treatment of metastatic2
  • Background/Aim: The combination of bevacizumab (BEV) plus interferon alpha-2a (IFN) constitutes an option for first-line treatment of metastatic renal cell carcinoma. (iiarjournals.org)
  • Gender, location of metastases, time between diagnosis of renal cell carcinoma and treatment of metastatic disease, incidence of local recurrence, radiation and chemotherapy did not influence survival. (biomedcentral.com)
Metastatic disease3
  • Approximately 30% of patients with renal carcinoma (RCC) present with metastatic disease. (medscape.com)
  • Surgical resection remains the only known effective treatment for localized renal cell carcinoma, and it is also used for palliation in metastatic disease. (medscape.com)
  • Metastatic bone disease (MBD), which occurs when cancer spreads from the primary site to bone, is a leading cause of cancer-related morbidity and is present in 30% of patients with metastatic disease at cancer diagnosis. (iu.edu)
Survival5
  • 2004) Application of TNM, 2002 version, in localized renal cell carcinoma: is it able to predict different cancer-specific survival probability? (medscape.org)
  • Although patients with Robson stage IIIB renal carcinoma have greatly decreased survival rates, the prognosis for patients with stage Robson IIIA renal carcinoma is not markedly different from that for patients with Robson stage I or II renal carcinoma. (medscape.com)
  • Surgery is the primary treatment of skeletal metastases from renal cell carcinoma, because radiation and chemotherapy frequently are not effecting the survival. (biomedcentral.com)
  • Five-year survival is limited to 60% in renal cancer patients at diagnosis. (drrathresearch.org)
  • This leads to increased morbidity in these patients due to skeletal related events (SREs), and data suggest that these patients also have decreased survival. (journalkidneycancer.com)
Diagnosis3
  • The diagnosis of chronic kidney disease (CKD) in patients with sickle cell disease (SCD) generally occurs between 30 and 40 years of age, with ESRD developing in approximately 11% of patients. (medscape.com)
  • Tremendous transformations have been witnessed over the recent past, in the management and diagnosis of renal cell carcinoma (RCC), or, kidney cancer. (medgadget.com)
  • Appreciate the three major roles of the perinatal pathologist: immediate diagnosis for the care and treatment of the mother and infant, determination of the primary and secondary causes of perinatal morbidity and mortality, and genetic counseling and prediction of recurrence risk. (case.edu)
Metastases5
  • We retrospectively reviewed 101 patients operatively treated for skeletal metastases of renal cell carcinoma between 1980 and 2005. (biomedcentral.com)
  • Factors influencing the choice of surgery included age, disease status, symptoms, morbidity of the patient, the location and extend of bone disease, existence of extraosseous metastases and the patient's wishes. (biomedcentral.com)
  • This NCI-sponsored multi-center Phase II trial evaluates RCC patients with bone metastases, a population with poor outcomes both in terms of morbidity and mortality. (journalkidneycancer.com)
  • Metastatic renal cell carcinoma: Patterns and predictors of metastases-a contemporary population-based series. (jamanetwork.com)
  • Clinical impact of pancreatic metastases from renal cell carcinoma: a multicenter retrospective analysis. (jamanetwork.com)
Outcomes3
  • 2005) Exploring the learning curve, pathological outcomes and perioperative morbidity of laparoscopic partial nephrectomy performed for renal mass. (medscape.org)
  • The accumulated data shows sound oncological, functional and morbidity outcomes with these new technologies. (prelekara.sk)
  • Outcomes of metastatic chromophobe renal cell carcinoma (chrRCC) in the targeted therapy era: results from the International Metastatic Renal Cell Cancer Database Consortium (IMDC). (jamanetwork.com)
Nephrectomy7
Squamous cell6
  • Carbonic Anhydrase III Promotes Cell Migration and Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma. (nih.gov)
  • About 90% of cervical cancer cases are squamous cell carcinomas, 10% are adenocarcinoma, and a small number are other types. (wikipedia.org)
  • Squamous cell carcinoma is the most prevalent histologic subtype of vulvar cancer, accounting for the majority of cases. (bvsalud.org)
  • risk of esophageal squamous cell carcinoma. (who.int)
  • A prospective of five cervical cancer screening tests assessed the risk of esophageal squamous cell carcinoma. (who.int)
  • Based on the clinical examination, hematological disorder due to dengue fever was chiefly considered, while differential diagnoses included oral squamous cell carcinoma of tongue and buccal mucosa and other infections like influenza, measles, rubella and bacterial sepsis. (bvsalud.org)
Cysts5
  • Birt-Hogg-Dubé syndrome (BHDS) is an autosomal dominant disorder clinically manifested by fibrofolliculomas, renal cell carcinoma, lung cysts, and spontaneous pneumothorax. (medscape.com)
  • Renal cysts are common incidental findings on imaging studies performed for nonurologic indications. (radiologykey.com)
  • Commonly encountered cysts on ultrasound (US) and cross-sectional imaging (CT and MR imaging) mostly are benign simple cortical renal cysts. (radiologykey.com)
  • Since its introduction in 1986, Bosniak classification for renal cysts has been used by radiologists and urologists as a method to stratify patients to plan treatment. (radiologykey.com)
  • Bosniak classification is based on findings on contrast-enhanced CT scans, dividing renal cysts into 4 broad categories (I-IV) proposed to distinguish malignant from benign cystic lesions. (radiologykey.com)
Cancers3
  • Renal cell cancer (RCC) is among the 10 most common cancers in both men and women. (biomedcentral.com)
  • L'objectif de cette étude était de déterminer la fréquence des cancers gynécologiques en pratique oncologique à Lomé et d'en étudier les aspects épidémiologiques et histo-cliniques. (bvsalud.org)
  • Il s'agitd'une étude rétrospective et descriptive portant sur tous les cancers gynécologiques reçus en oncologie entre le 1erJanvier 2016 et le 31 Décembre 2021. (bvsalud.org)
Pancreatic2
  • CONCLUSIONS: Pancreatic resection for metastasis should be reserved to patients in good health conditions, with isolated disease from renal cell cancer. (unipd.it)
  • Introduction: Multiple endocrine neoplasia type 1 (MEN 1) is associated with neoplasia and hyperfunction of the parathyroid and pituitary glands, pancreatic islet cells, and neuroendocrine cells of the gut. (endocrine-abstracts.org)
Hereditary1
  • Renal cancer occurs in a sporadic (nonhereditary) and a hereditary form, and both forms are associated with structural alterations of the short arm of chromosome 3 (3p). (medscape.com)
Kidney5
  • Renal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport primary urine. (wikipedia.org)
  • Numerous discoveries, trails, and studies have been taken in active surveillance, renal biopsy, as well as minimally-invasive thermal ablation, on the back of surging rate of kidney cancer diagnostics, observed usually among individuals with high morbidity risks, undergoing operative treatment. (medgadget.com)
  • Renal cell carcinoma (see the image below) is the most common type of kidney cancer in adults. (medscape.com)
  • See also Chronic Kidney Disease and Chronic Renal Failure . (medscape.com)
  • If you do find it early, but treatment doesnât get rid of all the cancer cells, it can come back in your kidney or somewhere else. (healthyskinworld.com)
Subtypes3
  • Next, four molecular subtypes of clear cell renal cell carcinoma were described, their underlying disease biology and their implications in both the localised and metastatic settings. (bjmo.be)
  • Determination of subtypes of cystic renal cell carcinomas by imaging is still challenging due to overlap of common imaging features. (radiologykey.com)
  • Prognostic value of histologic subtypes in renal cell carcinoma: a multicenter experience. (jamanetwork.com)
Cancer15
  • 1] According to the US census and cancer statistics, carcinoma of the kidneys affected approximately 36,160 lives in 2005,[2,3] more than 80% of whom had RCC. (cancernetwork.com)
  • We investigated the presence of aluminium (Al) in human colon cancer samples and its potential association with biological processes involved in cancer progression, such as epithelial to mesenchymal transition (EMT) and cell death. (bvsalud.org)
  • Transmission electron microscopy and energy-dispersive X-ray microanalysis confirmed the presence of Al specifically in intracytoplasmic electrondense nanodeposits adjacent to mitochondria of colon cancer cells. (bvsalud.org)
  • Al-positive samples showed a significant increase in both the number of vimentin-positive and nuclear ß-catenin-positive cancer cells compared to Al-negative samples. (bvsalud.org)
  • Compared to other types of carcinoma frequently affecting bone the prognosis of RCC is better than for lung cancer, but not as good as for breast or prostate cancer [ 2 ]. (biomedcentral.com)
  • Cancer cells that get into a blood vessel can travel to many body parts through your veins and arteries. (healthyskinworld.com)
  • But cancer cells that get into lymph nodes can hitch a ride to other organs. (healthyskinworld.com)
  • We have developed strategies to inhibit cancer by increasing the stability and integrity of connective tissue as the common mechanisms used by all types of cancer cells for their development and spread. (drrathresearch.org)
  • Due to the cancer's resistance to conventional treatments and associated high morbidity, we investigated the antimetastatic effects of a specific nutrient mixture (NM) containing lysine, proline, arginine, ascorbic acid, and green tea extract on human renal adenocarcinoma cell line 786-0 by measuring: cell proliferation, modulation of MMP-2 and -9 secretion, and cancer cell invasive potential. (drrathresearch.org)
  • Based on anticancer properties, we investigated the effect of a mixture of lysine, proline, arginine, ascorbic acid, and green tea extract on human bladder cancer cells T-24 by measuring: proliferation, MMP expression, and cancer cell invasive potential. (drrathresearch.org)
  • A Phase II study of neoadjuvant axitinib for reducing the extent of venous tumour thrombus in clear cell renal cell cancer with venous invasion (NAXIVA). (ox.ac.uk)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • Preliminary results of a multicenter study of prostate cancer Analysis of specialized medical care for patients with gross hematuria, renal colic. (ecuro.ru)
  • In medical research, the most famous immortalized cell line, known as HeLa, was developed from cervical cancer cells of a woman named Henrietta Lacks. (wikipedia.org)
  • Socioeconomic disparities influence patterns of cancer morbidity and mortality (2) and may result in cancer disparities. (cdc.gov)
Sickle cell di1
  • Hemolysis, vaso-occlusion, and ischemia-reperfusion injury are the clinical hallmarks of sickle cell disease (SCD). (medscape.com)
Surgery for renal1
  • 1989) Conservative surgery for renal cell carcinoma: a single-center experience with 100 patients. (medscape.org)
Inferior vena1
  • BackgroundSurgery for renal cell carcinoma (RCC) with venous tumour thrombus (VTT) extension into the renal vein (RV) and/or inferior vena cava (IVC) has high peri-surgical morbidity/mortality. (ox.ac.uk)
Metastasis2
  • In this study, we sought to investigate the mechanism underlying the inhibitory effect of PPI on the invasion and metastasis of SR-HCC cells. (bvsalud.org)
  • Interference with and overproduction of GRP78 in vitro impacted the proliferation, migration, invasion, and metastasis of HCC cells. (bvsalud.org)
Clinical4
  • Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
  • The purpose of this article is to integrate renal and cutaneous aspects of disease as well as highlight some important, although frequently underappreciated, clinical or laboratory findings that ally renal and skin diseases. (medscape.com)
  • Non-responders exhibited lower baseline microvessel density (CD31), higher Ki67 and exhausted or regulatory T-cell phenotype.ConclusionsNAXIVA provides the first Level II evidence that axitinib downstages VTT in a significant proportion of patients leading to reduction in the extent of surgery.Clinical trial registrationNCT03494816. (ox.ac.uk)
  • We report a case of thyroid amyloidosis that was initially misinterpreted as medullary thyroid carcinoma (MTC) clinical and cytological examination.Case: A 24 years old man with c. (endocrine-abstracts.org)
Resection1
  • 2007) Patterns of recurrence and surveillance strategies for renal cell carcinoma following surgical resection. (medscape.org)
Medullary1
  • [ 3 ] The low incidence of hypertension is attributed to reduced vascular reactivity, compensatory systemic vasodilatation associated with microvascular disturbances from sickling of RBCs and thrombotic complications, elevated levels of prostaglandins and nitric oxide, and possibly renal sodium and water wasting associated with suboptimal medullary concentrating activity. (medscape.com)
Retinal angiomas1
  • The most common pathological lesions are hemangioblastomas of the central nervous system, retinal angiomas, renal clear cell carcinomas, and pheochromocytomas. (endocrine-abstracts.org)
Prognosis1
  • The present doctoral thesis manuscript aims to inform disease prognosis and guide therapeutic decision-making at all stages of the renal cell carcinoma disease spectrum. (bjmo.be)
Chemotherapy2
  • Hodgkin Lymphoma treatment is multimodal and includes chemotherapy, radiotherapy and stem cell transplantation. (jcimcr.org)
  • As opposed to cytotoxic chemotherapy, TKIs target specific mutated kinases that promote tumour angiogenesis and neoplastic cells growth, proliferation, and resistance to apoptosis. (touchoncology.com)
Incidence2
Patients13
  • In patients with SCD, supranormal renal hemodynamics-including increased renal blood flow, renal plasma flow, and glomerular filtration rate-occur as early as infancy, but decrease with age. (medscape.com)
  • The risk of complications should be considered in decision making for patients with renal cell carcinoma who were older than age 80 years. (elsevierpure.com)
  • Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
  • Twenty-five to thirty percent of patients are asymptomatic, and their renal cell carcinomas are found on incidental radiologic study. (medscape.com)
  • Dermatologic manifestations of renal disease are not uncommon findings in patients with end-stage renal disease (ESRD). (medscape.com)
  • Many cutaneous disorders experienced by patients undergoing dialysis have little to do with the uremic syndrome and are related to the same underlying pathologic process that caused the renal disease. (medscape.com)
  • Review of the 2019 report reveals that diabetes mellitus remains the most common cause of ESRD, responsible for approximately 42% of all patients on renal replacement therapy. (medscape.com)
  • Alfuzosin should be used with caution in patients with severe renal insufficiency, and should not be prescribed to patients with a known history of QT prolongation or to patients who are taking medications known to prolong the QT interval. (the-medical-dictionary.com)
  • Contrast-enhanced ultrasound evaluation is a safe alternative imaging modality for the assessment of complex cystic renal masses in patients with renal impairment. (radiologykey.com)
  • In total, 20 patients with resectable clear cell RCC and VTT received upto 8 weeks of pre-surgical axitinib. (ox.ac.uk)
  • Secondary endpoints were percentage change in surgical approach and VTT length, response rate (RECISTv1.1) and surgical morbidity.ResultsIn all, 35% (7/20) patients with VTT had a reduction in Mayo level with axitinib: 37.5% (6/16) with IVC VTT and 25% (1/4) with RV-only VTT. (ox.ac.uk)
  • Histological subtype is an independent predictor of outcome for patients with renal cell carcinoma. (jamanetwork.com)
  • We hope you found the OncLive ® Inside the Clinic program to be useful and valuable to your management of patients with renal cell carcinoma. (onclive.com)
Malignancies1
Tubular dysfunction2
  • More distal tubular dysfunction may impair renal acidification and potassium secretion, leading to an incomplete form of distal renal tubular acidosis and hyperkalemia. (medscape.com)
  • Affected males have varying degrees of proximal renal tubular dysfunction of the Fanconi type, including low molecular-weight (LMW) proteinuria, aminoaciduria, bicarbonate wasting and renal tubular acidosis, phosphaturia with hypophosphatemia and renal rickets, hypercalciuria, sodium and potassium wasting, and polyuria. (nih.gov)
Systemic2
  • These systemic disorders and the associated renal diseases and cutaneous manifestations are tabulated in Table 1, below. (medscape.com)
  • Systemic therapy for metastatic renal-cell carcinoma. (jamanetwork.com)
Acidosis1
  • The pathophysiology of TLS is characterised by an extensive breakdown of tumour cells releasing intracellular contents into the bloodstream, leading to acidosis, hyperuricemia, hyperphosphatemia, and hyperkalemia. (touchoncology.com)
20181
  • Renal cell carcinoma (RCC) has been predicted to occur in 9,900 men and 5,200 women in Germany for the year 2018, whereas in 2015, 3,306 deaths from renal carcinoma in men and 2,106 in women were documented by the German Robert Koch Institute ( 1 ). (iiarjournals.org)
Cystic2
  • A 37-year-old man with a history of post-cholecystectomy and a known case of supra renal cystic lesion was referred for contrast-enhanced computed tomography of abdomen, where a supra-renal, well-defined, thick-walled cystic lesion with intense peripheral enhancement on arterial phase measuring 7 Ã- 8.2 Ã- 7.6 cm. (jcimcr.org)
  • Renal diseases: nephrotic syndrome, other glomerular diseases, cystic disease. (case.edu)
Apoptosis1
  • 2014. Asparagus racemosus leaf extract inhibits growth of UOK 146 renal cell carcinoma cell line: simultaneous oncogenic PRCCTFE3 fusion transcript inhibition and apoptosis independent cell death. (raysahelian.com)
Chronic Renal F1
  • Glomerulosclerosis associated with chronic tubular injury usually results in slowly progressive chronic renal failure and end-stage renal disease between the second and fourth decades of life. (nih.gov)
Insufficiency1
  • Most relevant risk factors are active (and passive) smoking, hypertension and overweight, lack of physical exercise and renal insufficiency from any reason ( 1 ). (iiarjournals.org)
Hypertension1
  • MARKET OUTLOOK Pulmonary arterial hypertension (PAH) is a rare and life-threatening disorder marked by considerable morbidity and mortality. (clarivate.com)
Lesions1
  • Abdominal CT reveals the size and quantity of renal lesions in renal cell carcinoma (RCC) [7] . (eyewiki.org)
Clear cell4
  • among these, about 80% are clear cell renal carcinomas histologically ( 2 ). (iiarjournals.org)
  • Go to Clear Cell Renal Cell Carcinoma and Sarcomatoid and Rhabdoid Renal Cell Carcinoma for complete information on these topics. (medscape.com)
  • Comprehensive molecular characterization of clear cell renal cell carcinoma. (jamanetwork.com)
  • Non-clear cell renal cell carcinomas: biological insights and therapeutic challenges and opportunities. (jamanetwork.com)
Classification1
  • The International Society of Urological Pathology (ISUP) Vancouver classification of renal neoplasia. (jamanetwork.com)
Surgical3
  • 2004) Changing concepts in the surgical management of renal cell carcinoma. (medscape.org)
  • 2005) Assessment of surgical margins in renal cell carcinoma after nephron sparing: a comparative study: laparoscopy vs open surgery. (medscape.org)
  • Novel imaging methods to improve pre-surgical characterisation of renal masses were developed, as well as prediction models for the estimation of postoperative renal function. (bjmo.be)
Centers1
  • Because dialysis and transplant centers are required to report specific information regarding each patient diagnosed with end-stage renal disease (ESRD) to the United States Renal Data System (USRDS), data regarding the causes of ESRD are readily available in the Annual Data Report published by the USRDS. (medscape.com)
Tumour2
  • Given the high rate of mortality and the morbidity inherent to TLS, clinicians should be aware that in solid tumour, TKIs may be associated with a delayed onset of TLS. (touchoncology.com)
  • In some cases, such as the c-Kit mutation observed in GIST, tumour cells can be highly "addicted" to one or more oncogenic kinases 2-4 and the inhibition of these kinases with a TKI can lead to a striking tumour response and trigger tumour lysis syndrome (TLS). (touchoncology.com)
Disease4
  • The primary management goals in sickle cell nephropathy (SCN) are the prevention of complications and the reduction of morbidity, primarily from progression to end-stage renal disease (ESRD). (medscape.com)
  • Consequently, dermatologic manifestations of renal disease may be divided into 3 general categories including: (1) dermatologic manifestations of diseases associated with the development of ESRD, (2) dermatologic manifestations of uremia, and (3) dermatologic disorders associated with renal transplantation. (medscape.com)
  • renal disease is the second leading cause of early death. (nih.gov)
  • Endocarditis is an inflammatory disease involving the inner lining ( endocardium Endocardium The innermost layer of the heart, comprised of endothelial cells. (lecturio.com)