Mononuclear growth epithelioid cells. Medical search. Frequent questions

According to a common point of view epithelioid cells (also called epithelioid histiocytes) are derivatives of activated macrophages resembling epithelial cells. (wikipedia.org)
By using the quick=freeze and freeze-substitution methods (prompt freezing, penetrating etching and freeze-substitution) it has been shown that the organizations three-dimensional metastructure cytoskeleton of the epithelioid cells, formed in the focus of granulomatous inflammation, more compatible to cytoskeleton characteristic of typical epithelial cell than to cytoskeleton of active and movable macrophages. (wikipedia.org)
Epithelioid cell granuloma can be defined as specifically and structurally organized collection of epithelioid cells, macrophages, lymphocytes and dendritic cells. (wikipedia.org)
Foreign-body granulomas may be considered an organized collection of macrophages, including mere collections of giant cells surrounding inert substances like suture material - the so-called "non-immune granulomas. (wikipedia.org)
The initial tissue reaction to infection is a focal, intensely suppurative necrosis consisting largely of accumulations of polymorphonuclear leukocytes, followed by invasion of macrophages, epithelioid cells, and lymphocytes. (cdc.gov)
Foreign materials are walled off by macrophages that may metamorphose into epithelioid cells, which are encircled by mononuclear leukocytes, forming granulomas. (medscape.com)
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. (lookformedical.com)
The centre of the tuberculous granuloma may undergo caseous necrosis surrounded by activated macrophages, T-cells and fibroblasts. (ersjournals.com)

Also, an analogous pattern of вЂњreactive lymphocytesвЂќ is sometimes seen on the leukocyte differentials, however identification of such requires the doctor to order a guide differential, as routine automated differential hardly ever distinguish such cells. (ehd.org)
Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
Particularly, NME is an idiopathic inflammatory disease of the CNS that is characterized by prominent necrosis and infiltration of inflammatory cells, including lymphocytes, plasma cells, and monocytes or histiocytes into the cerebral cortex and/or white matter, hippocampus, thalamus, and leptomeninges. (biomedcentral.com)

Structurally, epithelioid cells (when examined by light microscopy after stained with hematoxylin and eosin), are elongated, with finely granular, pale eosinophilic (pink) cytoplasm, and central, ovoid nuclei (oval or elongate), which are less dense than that of a lymphocyte. (wikipedia.org)
A large increase in the number of filaments occurs in these cells, where filaments (90 to 100 A) surround the cytocentrum as a distinctive annular bundle often branching into the cytoplasm. (wikipedia.org)
It is exhibited that the dense webs of intermediate filaments, bound with cores, mitochondrions and other organelles, are supervised everywhere in cytoplasm of epithelioid cells. (wikipedia.org)
Histologically, ALCL is characterized by sheets of large pleomorphic cells with abundant cytoplasm, horseshoe- or wreath-shaped nuclei, and multiple prominent nucleoli. (medscape.com)
Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells. (lookformedical.com)
FNAC showed loose clusters of epithelioid cells with splayed cytoplasm, focal whorling, and occasional psammoma bodies suggestive of meningioma. (bvsalud.org)

The first mention of epithelioid cells as a specific cell form occurred in the 19th-century in works of Koch R and Cornil J, who believed the leukocytes to be the originators of the epithelioid cells of the tuberculosis. (wikipedia.org)
In experiments on rabbits, Yersin A (1888) and Borrel A (1893) showed that epithelioid cells are formed from blood mononuclear leukocytes. (wikipedia.org)
To sustain the vascular changes and attract more immune cells to the site of inflammation, leukocytes and tissue cells secrete a range of inflammatory mediators, including interleukins and chemokines . (amboss.com)

Suppurative lesions become granulomatous, and histopathological examination of the granulomas shows a central necrotic, sometimes caseating, zone surrounded by a layer of epithelioid cells, multinucleated giant cells, and fibroblasts in a radial arrangement, typical of other granulomatous conditions such as tuberculosis and sarcoidosis. (cdc.gov)
They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (lookformedical.com)
Monostotic lesions are mostly asymptomatic, but they may progress during skeletal growth, and they tend to stabilize after puberty. (medscape.com)
OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)
Immunohistochemical staining for cytokeratin 5/6 was applied on cell block sections of 23 cases of benign and 25 cases of malignant breast lesions using avidin biotin peroxidase technique. (ijpmonline.org)

This cells are central in the formation of granulomas, which are associated with many serious diseases. (wikipedia.org)
In granulomas, epithelioid cells perform the functions of delimiting. (wikipedia.org)
The characteristic indication of epithelioid cells is their aggregation with formation tight interdigital triplings as a fastener "lightning", which, apparently, can have the important for the formation of a dense zone of delimitation of the body from the pathogen during the formation of epithelioid cell granulomas. (wikipedia.org)
IHY-1 antibody reacts with epithelioid cells in sarcoid granulomas as well as with epithelioid cells of various granulomatous diseases including tuberculosis. (wikipedia.org)
Epithelioid cells are an essential characteristic of epithelioid cell granulomas. (wikipedia.org)
Granulomas try to wall off these organisms and prevent their further growth and spread. (wikipedia.org)
Sarcoidosis is an evasive multisystem disorder characterized by granulomas of non-caseating giant cells with no significant reported cause. (ijpsr.com)

The term mononuclear phagocyte system has replaced the former reticuloendothelial system, which also included less active phagocytic cells such as fibroblasts and endothelial cells. (lookformedical.com)
Tumors are characterized by fascicles or sheets of spindled fibroblasts &/or nests of histiocytoid cells in a nodular and plexiform growth pattern. (basicmedicalkey.com)

A series of monoclonal antibodies IHY-1, IHY-2, IHY-3 was obtained, which can be used to accurately identify epithelial cells formed in etiologically different forms of granulomatous inflammation. (wikipedia.org)
They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules. (lookformedical.com)
By using Fh1-deficient mouse epithelial kidney cells we have recently demonstrated that in the absence of Fh1, the TCA cycle is definitely truncated causing an build up of fumarate and succinate paralleled by a decrease of malate and citrate. (immune-source.com)
In breast tissue, the luminal epithelial cells express CK 8/18, CK 7 and CK 19, while basal/myoepithelial cells express CK 5/6, CK 14 and CK 17. (ijpmonline.org)
In this study, the new epithelial ovarian cancer cell line CAISMOV24 was described and compared with its original low-grade serous ovarian carcinoma. (biomedcentral.com)
Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. (academicinfluence.com)

Chronic Granulomatous Disease , autoimmune diseases Autoimmune diseases Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides. (lecturio.com)
While long MWCNTs dispersed in 0.5% BSA induced a granulomatous response on the diaphragmatic mesothelium and immune cell recruitment to the peritoneal cavity, GO sheets dispersed under similar conditions did not cause any response, regardless of their lateral dimensions. (springer.com)

Some fascicles of actinic filaments were posed in filopodiums below than membranes of the cells. (wikipedia.org)

Although the change of dispersion did not alter the impact of GO on the mesothelium (i.e. no granuloma), we observed that, when dispersed in protein-free 5% dextrose solution, s-GO elicited a greater recruitment of monocytic cells to the peritoneal cavity than l-GO, or when dispersed in protein-containing solution. (springer.com)

This ulcerated nodule of localized primary cutaneous CD30+ anaplastic large cell lymphoma is relatively nonspecific in appearance. (medscape.com)

When using antibodies to the RFD9, RFD7 and HLA-DR antigens, it was found that all epithelioid cells have an immunological phenotype RFD9+/RFD7-/HLA-DR+. (wikipedia.org)
The IHY-2 and IHY-3 monoclonal antibodies, react with epithelioid cells in sarcoidosis but not in tuberculosis. (wikipedia.org)
Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors synergistically increased the effectiveness of antiprogrammed cell death protein-1 (anti-PD-1)/programmed death-ligand 1 (PD-L1) antibodies in preclinical studies. (bmj.com)
Antibodies recognizing native CLDN6 as displayed on cell surfaces and mediating complement-dependent cytotoxicity were elicited in vaccinated animals. (cusabio.com)

The characteristic nests and aggregates of PFHT, when present, contain plump to epithelioid mononuclear histiocytoid cells. (basicmedicalkey.com)
On microscopic histopathological analysis, elongated and spindle-shaped cells with a cigar-shaped nucleus are characteristic findings of leiomyoma. (wikidoc.org)

Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. (fmu.ac.jp)

They have indistinct shape and often appear to merge into one another, forming aggregates known as giant cells. (wikipedia.org)

Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
In addition, cytoplasmic vacuoles are not uncommon in large cell lymphomas involving body cavities. (cytojournal.com)

It is constitutively expressed in the skin and may play a role in T-CELL trafficking during cutaneous INFLAMMATION. (lookformedical.com)

Due to such cytoskeleton contiguous epithelioid cells display elaborate cytoplasmic interdigitation. (wikipedia.org)
Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)

Results show that DNA methylation down-regulates CLDN6 expression through MeCP2 binding to the CLDN6 promoter, deacetylating H3 and H4, and altering chromatin structure, consequently promoting migratory and invasive phenotype in breast cancer cells. (cusabio.com)

Primary Peritoneal Mesothelioma is a rapidly aggressive and rare neoplasm that arises from the lining of mesothelial cells of the peritoneum and spreads extensively within the confines of the abdominal cavity. (karger.com)

Agents targeting vascular endothelial growth factors, platelet-derived growth factors, and cyclin-dependent kinases 4 and 6 have all shown some efficacy in various STS subtypes. (emjreviews.com)
20,21 The increased efficacy of these agents is due to the complex STS genomic landscape, including alterations to KIT, PDGFR-β, vascular endothelial growth factor receptors (VEGFR), and colony stimulating factor-1. (emjreviews.com)

ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
however, no combination has led to a survival benefit over doxorubicin alone until the recent use of olaratumab, a monoclonal antibody targeting platelet-derived growth factor-α. (emjreviews.com)
Olaratumab, a fully human IgG1 monoclonal antibody that targets platelet-derived growth factor receptor (PDGFR)-α, combined with doxorubicin resulted in a near doubling of overall survival (OS) compared with doxorubicin alone. (emjreviews.com)

The commonest malignant tumors of bone are Meta-analysis of 14 randomized trials revealed a signifiplasma cell tumors (Chap. Side impact: dryness of mouth, pores and skin, blurred vision, loss of lodging constipation, bradycardia followed by tachycardia, difficulty with micturation, flushing [url=https://samoore.com/products/buy-finpecia-online/] hair loss jak inhibitor purchase finpecia 1 mg[/url]. (ehd.org)
Radiation therapy uses high energy to kill tumor cells and shrink tumors. (ucbraid.org)
It is thought that leiomyoma is the result of either transformation of normal uterine muscle cells into abnormal cells through somatic mutations , or through the growth of abnormal uterine muscle cells into tumors. (wikidoc.org)

Sixty percent of cases express 1 or more T-cell antigens (CD3 + , CD43, or CD45RO). (medscape.com)

The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. (lookformedical.com)
MONOCYTES and a variety of other immune cells. (lookformedical.com)

Specialized phagocytic cells of the MONONUCLEAR PHAGOCYTE SYSTEM found on the luminal surface of the hepatic sinusoids. (lookformedical.com)

Its lethality is a consequence of the lack of symptoms or biomarkers enabling the early diagnosis of disease, and the propensity of malignant cells to seed the peritoneal cavity. (biomedcentral.com)

Mononuclear cells with pronounced phagocytic ability that are distributed extensively in lymphoid and other organs. (lookformedical.com)
While the mechanisms of tumorigenesis in FH-deficient cells have been extensively looked into, the metabolic changes caused by the loss of FH activity have only been partially tackled. (immune-source.com)

The CAISMOV24 line was assessed for cell growth, production of soluble biomarkers, expression of surface molecules and screened for typical mutations found in serous ovarian carcinoma. (biomedcentral.com)
Conventional molecular target drugs can selectively inhibit gene mutations which activate prolifiration of cancer cells, but many patients in which gene mutations cannot be detected are not targets of the molecular target drugs. (justia.com)
Some loss-of-function mutations of genes confer druggable vulnerabilities on cancer cells. (justia.com)

PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)
Background Loss of function of fumarate hydratase (FH), the mitochondrial tumor suppressor and tricarboxylic acid (TCA) cycle enzyme, is associated with a highly malignant form of papillary and collecting duct renal cell malignancy. (immune-source.com)
The spontaneous immortalization of primary malignant cells is frequently assigned to their genetic instability during in vitro culturing. (biomedcentral.com)
Additionally, comparative genomic hybridization was employed to compare genomic alterations between the CAISMOV24 cell line and its primary malignant cells. (biomedcentral.com)
The cell surface molecules EpCAM, PVR and CD73 are overexpressed on CAISMOV24 cells compared to the primary malignant cells. (biomedcentral.com)
Although the cell line had developed alongside the accumulation of genomic alterations (28 CNV in primary cells and 37 CNV in CAISMOV24), most of them were related to CNVs already present in primary malignant cells. (biomedcentral.com)
Additionally, CAISMOV24 cell line was characterized as a low-grade serous ovarian carcinoma, which still resembles its primary malignant cells. (biomedcentral.com)
However, cell lines are known for their susceptibility to genetic and metabolic alterations, which can alter their characteristics in relation to the primary malignant cells. (biomedcentral.com)
Ideally, the more a cell line resembles the primary malignant cells, the more useful it will be for scientific research. (biomedcentral.com)

Typically tumor cells secrete a complex milieu of growth factors, cytokines and chemokines, some of which are pro-tumorogenic [ 7 , 8 , 9 ]. (iospress.com)

Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. (academicinfluence.com)

The expression of ASK1 is correlated with the level of claudin-6 in cervical carcinoma cells and tissues. (cusabio.com)

The composition of this fluid is very variable in terms of both the quantity and type of cells present, and the soluble factors and cytokines present. (iospress.com)

To study whether cells and molecules present in pleural effusions provide prognostic information for mesothelioma. (iospress.com)

Cells propagated in vitro in special media conducive to their growth. (lookformedical.com)
The in vitro culture was established with cells isolated from ascites of a 60-year-old female patient with recurrent ovarian cancer. (biomedcentral.com)

TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression. (academicinfluence.com)

Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. (lecturio.com)
It was found that suppressive effects of propolis on AhR transformation were relatively higher than those of resins of its botanical origin in cell-free system and in Hepa-1c1c7 cells. (propoleo.cl)

14-16 Imatinib, cediranib, and pexidartinib have also demonstrated activity in some of the rarest, chemo-refractory STS subtypes, including dermatofibrosarcoma protuberans, 17,18 alveolar soft part sarcoma (ASPS), 19 and tenosynovial giant cell tumour. (emjreviews.com)

Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells. (cusabio.com)
Although claudin-6 and claudin-9 can serve as entry factors in cell lines, hepatitis C virus infection into human hepatocytes is not dependent on claudin-6 and claudin-9. (cusabio.com)

Mesenchymal stem cells (MSCs) are under investigation to treat autoimmune and degenerative disorders due to their immunomodulatory and regenerative properties. (biomedcentral.com)

A monocyte chemoattractant protein that has activity towards a broad variety of immune cell types. (lookformedical.com)

OBJECTIVE: The etiology and pathogenesis of Langerhans cell histiocytosis (LCH) remain poorly understood. (thedoctorsdoctor.com)

it is mutated in about 46% of ovarian clear cell carcinoma (OCCC), 33% of gastric carcinoma, 27% of cholangiocarcinoma and 15% of pancreatic carcinoma [see, NPL 1-4], all of which lack effective molecular targeting therapies. (justia.com)

Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. (lookformedical.com)

They filter bacteria and small foreign proteins out of the blood, and dispose of worn out red blood cells. (lookformedical.com)
Transplanted tissue may be cells (e.g., hematopoietic stem cells Hematopoietic stem cells Progenitor cells from which all blood cells derived. (lecturio.com)
Autoimmune hemolytic anemia Hemolytic Anemia Hemolytic anemia (HA) is the term given to a large group of anemias that are caused by the premature destruction/hemolysis of circulating red blood cells (RBCs). (lecturio.com)

from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed. (lookformedical.com)

This is an open-label, multicenter study to assess safety, tolerability, pharmacokinetics (PK), immunogenicity, pharmacodynamics (PD), and preliminary efficacy of RO7428731 administered as a monotherapy in participants with newly diagnosed or recurrent epidermal growth factor receptor variant III (EGFRvIII)-positive glioblastoma (GBM). (ucbraid.org)

Selinexor blocks a protein called CRM1, which may help keep cancer cells from growing and may kill them. (ucbraid.org)
Growth factors and cancer. (academicinfluence.com)
CLDN6 enhances the chemoresistance to ADM via activating the AF-6/ERK signaling pathway and up-regulating cancer stem cell characters in MDAMB231 cells. (cusabio.com)
High levels of CLDN6 are associated with non-small-cell lung cancer. (cusabio.com)

In large cell lymphoma and leukemia cells involvement of body fluid this concept becomes less challenging. (cytojournal.com)

Synthetic lethality," which is defined by an interdependent relationship between two genes, which means that simultaneous loss of two genes, but not loss of either gene alone, leads to cell death. (justia.com)

It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components. (lecturio.com)

[ 8 , 9 ] Fibrous dysplasia is a slowly growing lesion that usually appears during periods of bone growth, and is thus seen in the early teen and adolescent years. (medscape.com)
Pregnancy can cause increased growth of the lesion, as well as secondary changes of aneurysmal bone cyst formation. (medscape.com)
Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells. (lecturio.com)

Anatomy74

Organisms13

Diseases9

Chemicals and Drugs78

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes49

Disciplines and Occupations2

Information Science3

Macrophages8

Lymphocytes3

Cytoplasm6

Leukocytes3

Lesions5

Granulomas7

Fibroblasts2

Epithelial6

Granulomatous2

Fascicles1

Granuloma1

Anaplastic large ce1

Antibodies4

Characteristic2

Dendritic1

Forming aggregates1

Large cell lymphomas2

Inflammation1

Cytoplasmic2

Phenotype1

Neoplasm1

Endothelial2

Monoclonal antibody3

Tumors3

Antigens1

MONOCYTES2

Luminal1

Peritoneal cavity1

Extensively2

Mutations3

Malignant9

Secrete1

Carcinomas1

Tissues1

Soluble1

Pleural1

Vitro2

TUMOR MICROENVIRONMENT1

Found2

Sarcoma1

Hepatitis2

Mesenchymal1

Immune cell1

Pathogenesis1

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Blood3

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Involvement1

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