Monolayer selectin endothelial cells tissues leukocytes. Medical search. Frequent questions

These findings reveal an unexpectedly intimate collaboration between neutrophils and the lymphatic vessel endothelium, in which these phagocytic leukocytes act as pathfinders for their own transit during inflammation. (ox.ac.uk)
In vascular endothelial cells, the activation of peroxisome proliferator-activated receptor (PPAR) by prostanoids inhibits endothelial inflammation by suppressing transcription of pro-inflammatory genes. (fapesp.br)
Excessive or prolonged increases in permeability of the endothelium, as in cases of chronic inflammation, may lead to tissue swelling (edema). (wikipedia.org)
Endothelial cells actively signal to white blood cells of the immune system during inflammation Formation of new blood vessels (angiogenesis). (wikipedia.org)
During the inflammatory response, immune cells egress from the circulation and follow a chemotactic and haptotactic gradient within the tissue, interacting with matrix components in the stroma and with parenchymal cells, which guide them towards the sites of inflammation. (hindawi.com)
However, many disease-predisposing factors and/or contributing factors have been identified, including inflammation, endothelial cell dysfunction, aberrant vascular wall cell proliferation and mutations in the bone morphogenetic protein-receptor type 2 ( Bmpr2 ) gene [ 1 - 3 ]. (ersjournals.com)
Endothelial inflammation increases the adhesiveness of monocytes to the endothelium in addition to increasing vascular permeability, promoting diabetic atherogenesis. (spandidos-publications.com)
It is constitutively expressed in the skin and may play a role in T-CELL trafficking during cutaneous INFLAMMATION. (lookformedical.com)
Tumor cell-derived spondin 2 (SPON2) is an extracellular matrix glycoprotein that has complicated roles in recruitment of macrophages and neutrophils during inflammation. (biomedcentral.com)
Although the role of the endothelium in the pathogenesis of sepsis is not clearly established yet, coagulopathy has been proposed to play a key role through crosstalk mechanism between inflammation and coagulation as a result of systemic endothelial injury [ 11 , 12 , 13 ]. (biomedcentral.com)

Here, we have investigated these events in an in vivo mouse Mycobacterium bovis bacillus Calmette-Guérin vaccination model, ex vivo mouse dermal explants, and in vitro Transwell system comprising monolayers of primary human dermal lymphatic endothelial cells. (ox.ac.uk)
Our recent work demonstrated that CB-PLA2 induces prostacyclin (PGI2) release by endothelial cells monolayers (in vitro) through activation of COX-1 and -2 enzyme systems. (fapesp.br)
So far, most of the in vivo and in vitro approaches to study leukocyte migration across the tissue parenchyma have addressed the role of each single tissue barrier that immune cells encounter in their journey to the inflammatory focus. (hindawi.com)
Patients with PH exhibited higher circulating levels of microparticles compared to control subjects and in vitro or in vivo generated microparticles can induce endothelial dysfunction, interfere with coagulation pathways or modulate inflammatory phenomenon. (ersjournals.com)
1 One strategy is to seed the appropriate cells on a biodegradable scaffold engineered with the desired mechanical properties, followed by stimulation of cell growth and differentiation in vitro, such that, on implantation in vivo, the engineered construct undergoes remodeling and maturation into functional tissue. (ashpublications.org)
Specifically, the study focused on Kupffer cell proinflammatory cytokines IL-6 and TNF-α and activation of NF-κB after chronic ethanol feeding followed by in vitro stimulation with lipopolysaccharide (LPS). (uni-frankfurt.de)
In the paper titled 'Characterization of Bone Marrow Mononuclear Cells on Biomaterials for Bone Tissue Engineering In Vitro,' there was an error in the Acknowledgments. (uni-frankfurt.de)
HBP elevated permeability of vascular endothelial cell monolayers in vitro, and enzymatic removal of luminal cell surface area glycosaminoglycans (GAGs) using heparinase III and chondroitinase ABC abolished this impact. (bioskinrevive.com)
In vitro migration assays, transendothelial migration assays (iTEM), and cell adhesion assays were used to investigate the effects of SPON2 on monocyte/macrophage migration. (biomedcentral.com)

We demonstrate that neutrophils are reliant on endothelial activation for adhesion, initially via E-selectin and subsequently, by integrin-mediated binding to ICAM-1 and VCAM-1, combined with CXCL8-dependent chemotaxis. (ox.ac.uk)
Moreover, we reveal that integrin-mediated neutrophil adhesion plays a pivotal role in subsequent transmigration by focusing the action of matrix metalloproteinases and the 15-lipoxygenase-1-derived chemorepellent 12(S)-hydroxyeicosatetraenoic acid at neutrophil:endothelial contact sites to induce transient endothelial junctional retraction and rapid, selective neutrophil trafficking. (ox.ac.uk)
However, in the case of injury or infection, ECs control the adhesion and migration of inflammatory cells into the damaged tissue. (fapesp.br)
The role of PGI2 as a immunomodulatory agent is highlighted by its ability to inhibit leukocyte and lymphocyte adhesion to endothelium. (fapesp.br)
Here we review evidence showing that apicobasal polarity regulates the inflammatory response: various polarized epithelia asymmetrically secrete chemotactic mediators and polarize adhesion receptors that dictate the route of leukocyte migration within the parenchyma. (hindawi.com)
We also discuss recent findings showing that the loss of apicobasal polarity increases leukocyte adhesion to epithelial cells and the consequences that this could have for the inflammatory response towards damaged, infected or transformed epithelial cells. (hindawi.com)
On the other hand, these barriers contain damaged or infected cells that are part of the inflammatory focus and the endpoint of the leukocyte migratory journey, so some sort of footprint, which is not completely understood, must exist in these cells to promote a preferential adhesion with infiltrated leukocytes. (hindawi.com)
The parenchymal three-dimensional organization contributes to establish an haptotactic and chemotactic gradient (1) Leukocyte adhesion and transendothelial migration or diapedesis. (hindawi.com)
Functional studies revealed increased expression of ICAM-1 on induced patient-derived endothelial cells (iECs) and of β2-integrins on patient neutrophils that increase neutrophil adhesion and vascular transendothelial migration (TEM). (nature.com)
Microvascular function was determined in the retina as flicker light-induced arteriolar and venular dilation and as central retinal arteriolar and venular equivalents, in plasma as a z score of endothelial dysfunction biomarkers (soluble vascular adhesion molecule 1 and soluble intracellular adhesion molecule 1, soluble E-selectin, and von Willebrand factor), in skin as the heat-induced skin hyperemic response, and in urine as 24-h albuminuria. (bvsalud.org)
The firm adhesion of platelets to the site of injury forms a monolayer which serves as a reactive site for further recruitment of free-flowing platelets. (biomedcentral.com)
Platelets firmly adhere to the sub-endothelial matrix through the engagement of collagen receptors α2β1 and GPVI (Adhesion) . (biomedcentral.com)
ECs were treated with oxLDL under HG conditions in the presence or absence of ROS scavengers mitoTEMPO and NAC, p38 inhibitor SB203580, FOXO1 inhibitor AS1842856 or transfected with the TXNIP siRNA, before protein expression levels of intercellular adhesion molecule 1 (ICAM‑1), vascular cell adhesion molecule‑1 (VCAM‑1), phosphorylated vascular endothelial‑cadherin (VE‑cadhedrin), VE‑cadherin and zonula occludens‑1 (ZO‑1) were measured by western blotting. (spandidos-publications.com)
Subsequently, rosmarinic acid treatment significantly reversed oxLDL‑induced overexpression of adhesion molecules and monocyte‑EC adhesion, oxLDL‑induced endothelial junction hyperpermeability and monocyte transmigration through the endothelial monolayer under HG conditions, in a dose‑dependent manner. (spandidos-publications.com)
A large body of evidence now implicates increased leukocyte-endothelial cell adhesion as a key early event in the development of diabetic retinopathy. (diabetesjournals.org)
We recently reported that raised activity of the glycosylating enzyme core 2 β 1,6- N -acetylglucosaminyltransferase (GlcNAc-T) through protein kinase C (PKC)β2-dependent phosphorylation plays a fundamental role in increased leukocyte-endothelial cell adhesion and capillary occlusion in retinopathy. (diabetesjournals.org)
These effects of diabetic plasma on enzyme activity and cell adhesion, mediated by PKCβ2-dependent phosphorylation of the core 2 GlcNAc-T protein, were found to be triggered by increased plasma levels of tumor necrosis factor (TNF)-α. (diabetesjournals.org)
Furthermore, we noted much higher correlation, as compared with control subjects, between increased values of core 2 GlcNAc-T activity and cell adhesion properties. (diabetesjournals.org)

Materials and Methods: Human umbilical vein endothelial cells (HUVECs) isolated from umbilical cord, cultured in standard conditions, were harvested and passaged in 24-well plates. (iiarjournals.org)
Quantitative analyses showed the microvessel density was significantly superior to that generated by human dermal microvascular endothelial cells (HDMECs) but similar to that generated by human umbilical vein endothelial cells (HUVECs). (ashpublications.org)

The endothelium (PL: endothelia) is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels. (wikipedia.org)
The endothelium is a thin layer of single flat (squamous) cells that line the interior surface of blood vessels and lymphatic vessels. (wikipedia.org)
Many considered the endothelium a specialized epithelial tissue. (wikipedia.org)
Compared to the endothelium, the molecular mechanisms involved in the interaction of infiltrated or tissue-resident immune cells with parenchymal barriers have not been so extensively studied. (hindawi.com)

Endothelial cells in direct contact with blood are called vascular endothelial cells whereas those in direct contact with lymph are known as lymphatic endothelial cells. (wikipedia.org)

In addition, oxLDL‑stimulated ECs under HG conditions exhibited increased phosphorylated VE‑cadherin protein levels and decreased ZO‑1 protein expression levels compared with those in untreated ECs, suggesting increased endothelial permeability. (spandidos-publications.com)

Endothelial dysfunction, or the loss of proper endothelial function, is a hallmark for vascular diseases, and is often regarded as a key early event in the development of atherosclerosis. (wikipedia.org)
Endothelial dysfunction during diabetes has been previously reported to be at least in part attributed to increased oxidized low‑density lipoprotein (oxLDL) levels mediated by high glucose (HG) levels. (spandidos-publications.com)
These results suggest that rosmarinic acid can exert a protective effect against oxLDL‑mediated endothelial dysfunction under HG conditions by reducing the interaction between monocytes and ECs in addition to preventing monocyte diapedesis. (spandidos-publications.com)
A number of studies have previously suggested that vascular endothelial dysfunction caused by increased junctional permeability is a key event in the development and progression of atherosclerosis and atherosclerotic cardiovascular diseases ( 3 , 4 ). (spandidos-publications.com)
Chronic metabolic disorders, such as hyperglycemia and dyslipidemia, promote endothelial dysfunction and eventually leakage, resulting in increased monocyte diapedesis ( 5 - 7 ). (spandidos-publications.com)
Endothelial dysfunction during diabetes is closely associated with increased oxidized low-density lipoprotein (oxLDL) levels mediated by high glucose (HG) conditions ( 8 ). (spandidos-publications.com)
In addition to protective "immune response", sepsis is characterized by destructive "endothelial response" of the host, leading to endotheliopathy and its molecular dysfunction. (biomedcentral.com)

SPON2 may indirectly induce M2-polarization through upregulating cytokines including IL10, CCL2 and CSF1 expression in tumor cells. (biomedcentral.com)
Baringer SL , Lukacher AS , Palsa K , Kim H , Lippmann ES , Spiegelman VS , Simpson IA , Connor JR , Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin Journal of neurochemistry. (vanderbilt.edu)
In the host, MAC also may induce channel formation to innocent bystander endothelial cells (ECs) and ECs cannot be protected. (biomedcentral.com)

Angiopoietin-2 works with VEGF to facilitate cell proliferation and migration of endothelial cells. (wikipedia.org)
The first stage of this immune steeplechase, the leukocyte transendothelial migration, is a multi-step cascade of interactions that have been extensively studied in recent years in different vascular beds and experimental models, and some comprehensive reviews on this topic can be found in this special issue [ 1 - 5 ]. (hindawi.com)
The events that follow leukocyte extravasation are perhaps less well characterized, although significant advances have been made with the advent of high-resolution intravital microscopy and the development of more sophisticated culture systems to investigate leukocyte migration and interactions in three dimensions. (hindawi.com)
We believe that successfully combining our current knowledge about leukocyte extravasation, three-dimensional migration through the stroma and the sequential interactions with parenchymal cell barriers, which include adopting unified experimental models, will help shed light on the entire migratory route of each immune cell type and on the specificity of the innate inflammatory responses in each type of tissue. (hindawi.com)
Endothelial and epithelial barriers determine the different stages of leukocyte migration in its journey towards the inflammatory focus in complex tissues. (hindawi.com)
He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)
It plays an important role in vasculitis and monocyte migration towards inflamed tissues ( 13 ). (iiarjournals.org)
Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. (lookformedical.com)
Overexpression of SPON2 has been shown to promote tumor cell migration in colorectal cancer (CRC). (biomedcentral.com)

The general outline of angiogenesis is activating signals binding to surface receptors of vascular endothelial cells. (wikipedia.org)
The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. (thermofisher.com)
We developed a calcium signaling-based assay, using cultured human embryonic kidney cells (HEK), that evaluates simultaneously, the activation/desensitization or blockade of the proteinase-activated receptors, PAR 1 and PAR 2 . (aspetjournals.org)
Furthermore, we reasoned that, provided receptor cross-desensitization did not occur, it would be advantageous to assess PAR-targeted ligands in a cell that expressed both receptors. (aspetjournals.org)
With both receptors present in the same cell, the selectivity or nonselectivity of a variety of compounds that would affect PAR 1 and/or PAR 2 could be efficiently evaluated in a single experiment. (aspetjournals.org)
Childress KO , Cencer CS , Tyska MJ , Lacy DB , Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for TcdB mBio. (vanderbilt.edu)

pathomechanisms that regulate extravasation of damaging immune cells into surrounding tissues are poorly understood. (nature.com)

Tissue infiltration by activated innate immune cells, including monocytes, macrophages, and neutrophils, if untreated, leads to rapidly progressive organ injury, that can involve many organ systems. (nature.com)
Now, we know that complement system, protecting the host through innate immune system, could trigger harmful endothelial pathogenesis. (biomedcentral.com)

Of note, in a developing thrombus further activation converts platelets from a proaggregatory to a to pro-coagulant phenotype which enables the assembly of the coagulation reaction complexes (the Tenase and Prothrombinase complex) on the cell surface, necessary for thrombin and fibrin generation. (biomedcentral.com)

Signaling through CD19 induces tyrosine phosphorylation, calcium flux and proliferation of B cells. (thermofisher.com)
The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation, and is expressed in all B cell precursor leukemias. (thermofisher.com)
It was postulated that cell proliferation may also be enhanced by fibrinogen binding to CD54 ( 21 ). (iiarjournals.org)

Neutrophils are the first leukocyte population to be recruited from the circulation following tissue injury or infection, where they play key roles in host defense. (ox.ac.uk)
We characterize the role of increased Lyn kinase activity in neutrophils, endothelial cells and lesional liver biopsies and utilized an iPSC-derived endothelial cell platform for disease modeling of neutrophilic vasculitis and to screen and evaluate drug efficacy. (nature.com)

Results: MCP-1 concentration in supernatants from HUVECs was significantly lower 6 h after 4.5 J/cm 2 stimulation compared to IL-1β-stimulated cells. (iiarjournals.org)

MATERIALS AND METHODS: A high-glucose-induced angiogenesis model was established using monkey retinal vascular endothelial (RF/6A) cells. (bvsalud.org)
CONCLUSIONS: LBP attenuates diabetic retinal angiogenesis by rescuing the expression of miR-15a-5p in RF/6A cells. (bvsalud.org)
In the present study, we demonstrate that following exposure to plasma from diabetic patients, the human promonocytic cell line U937 exhibits a significant elevation in core 2 GlcNAc-T activity and increased adherence to cultured retinal capillary endothelial cells. (diabetesjournals.org)
The exact pathogenic mechanism by which capillary nonperfusion, as demonstrated by fluorescein angiography, occurs is still unclear, but recent experimental animal studies ( 3 - 5 ) demonstrate that increased leukocyte entrapment in retinal capillaries of diabetic rats is an early event associated with areas of capillary nonperfusion and the development of endothelial cell damage. (diabetesjournals.org)

Whether or not these new conveyors of biological information contribute to the acquisition and/or maintenance of the altered endothelial phenotype is unexplored in PH and requires further study. (ersjournals.com)
Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. (thermofisher.com)
However, how tumor cells affect TAM accumulation and their pro-tumoral phenotype in invasive CRC has not yet been well established. (biomedcentral.com)

PSGL, P-selectin glycoprotein ligand-1. (rupress.org)
Leukocyte rolling in postcapillary venules of inflamed tissues is reduced in L-selectin-deficient mice and mice treated with L-selectin blocking antibodies, but the glycoprotein ligand for L-selectin in inflamed venules is unknown. (rupress.org)
Here, we show that L-selectin-dependent rolling after P-selectin blockade is completely absent in P-selectin glycoprotein ligand-1 (PSGL-1) −/− mice or wild-type mice treated with a PSGL-1 blocking monoclonal antibody. (rupress.org)

Therefore, the present study aimed to elucidate the mechanisms involved in oxLDL‑induced endothelial permeability and monocyte diapedesis under HG conditions, in addition to the potential effects of rosmarinic acid. (spandidos-publications.com)
Furthermore, monocyte transmigration through the endothelial monolayer was significantly increased by oxLDL treatment under HG conditions. (spandidos-publications.com)
It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. (lookformedical.com)
A monocyte chemoattractant protein that has activity towards a broad variety of immune cell types. (lookformedical.com)

We hypothesize that blood-derived endothelial progenitor cells (EPCs) have the required proliferative and vasculogenic activity to create vascular networks in vivo. (ashpublications.org)
In addition, mtDNA stress in TFAM-deficient mouse melanoma cells produces tumours that are more resistant to doxorubicin in vivo. (regenerativemedicine.net)

Endothelial cells (ECs) form a semi-permeable monolayer that separates the bloodstream from underlying tissues and regulate the infiltration of blood cells and proteins through the vessel wall ( 1 , 2 ). (spandidos-publications.com)

To investigate whether leukocyte-expressed PSGL-1 is mediating L-selectin-dependent rolling, we reconstituted lethally irradiated wild-type mice with PSGL-1 −/− bone marrow cells. (rupress.org)
This research aims to investigate the inhibition of high glucose-induced angiogenesis by LBP in RF/6A cells. (bvsalud.org)

The foundational model of anatomy, an index of terms used to describe anatomical structures, makes a distinction between endothelial cells and epithelial cells on the basis of which tissues they develop from, and states that the presence of vimentin rather than keratin filaments separates these from epithelial cells. (wikipedia.org)
Polarized epithelial cells compartmentalize tissue cavities and are often exposed to inflammatory challenges such as toxics or infections in non-lymphoid tissues. (hindawi.com)
These areas are often made up of polarized parenchymal epithelial cells that form barriers to compartmentalize functions in cavities of the liver, intestine or lungs (Figure 1 ). (hindawi.com)
In humans, CD23 is usually expressed on a range of cells including B cells, T cells, monocytes, follicular dendritic cells, intestinal epithelial cells, bone marrow stromal cells and respiratory epithelial cells. (treatmentforprostatecancer.info)

Through gene knockout studies he has shown that these molecules act as a type of molecular "Teflon" to make cells more mobile and invasive and also facilitate chemotaxis. (ubc.ca)

Background: Regarding recent findings on the proven influence of laser light on healing and endothelial regeneration processes, this study was conducted in order to examine the influence of low-power laser illumination on the endothelial inflammatory response. (iiarjournals.org)
Although it has been shown that low-power laser illumination may stimulate bone healing ( 1 - 3 ), endothelial regeneration ( 4 ), smooth muscle relaxation ( 5 ) and reduce restenosis rate after coronary angioplasty procedures ( 6 - 9 ), little is still known about cellular mechanisms underlying these effects. (iiarjournals.org)
So, the research on renal tissue repair and regeneration has ignited a new field of study that focuses on various regenerative options. (biomedcentral.com)

These genes include critical immune mediators and proteins that facilitate cellular communication with hematopoietic immune cells. (wikipedia.org)
There his work focused on transcriptional control of hematopoietic stem cell maturation and cell fate. (ubc.ca)
In addition, he identified a number of novel hematopoietic stem cell surface proteins and began analyzing their function. (ubc.ca)
His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
In this regard, his lab has identified a novel family of hematopoietic cell surface proteins, called the CD34 family, and shown that these are essential for a number of developmentally important processes. (ubc.ca)

activated endothelial cells release proteases leading to the degradation of the basement membrane endothelial cells are freed to migrate from the existing blood vessels and begin to proliferate to form extensions towards the source of the angiogenic stimulus. (wikipedia.org)
The subsequent neutrophil activation leads to tissue damage via the release of proteases, oxidants, and cationic peptides [ 3 ]. (hindawi.com)

Applications Tested: This HIB19 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
To test this, EPCs isolated from human umbilical cord blood or from adult peripheral blood, and human saphenous vein smooth muscle cells (HSVSMCs) as a source of perivascular cells, were combined in Matrigel and implanted subcutaneously into immunodeficient mice. (ashpublications.org)
Our findings strongly support the use of human EPCs to form vascular networks in engineered organs and tissues. (ashpublications.org)
The abilities of the PAR 1 -targeted agents to desensitize or block PAR 1 in the HEK cell assay were compared with their activities in a human platelet aggregation assay. (aspetjournals.org)
To this end, we developed a calcium-signaling assay, employing cultured human embryonic kidney cells (HEK293) in which the action of PAR 1 and PAR 2 agonists and antagonists could be evaluated simultaneously. (aspetjournals.org)
At present, the phenotypic heterogeneity and functional variation of human γδ T cells are increasing. (explorationpub.com)
In this review, we use the Heilig nomenclature to describe human γδ T cells [ 1 ]. (explorationpub.com)
Extracellular vesicle DNA from human melanoma tissues contains cancer-specific mutations. (gu.se)

The hypoxic tissue microenvironment as a driver of mucosal inflammatory resolution. (ucdenver.edu)
γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
Therefore, an in-depth understanding of γδ T cells that play conflicting roles in the tumor microenvironment is necessary. (explorationpub.com)

Endothelial cells encode important features of the structural cell immune response in the epigenome and can therefore respond swiftly to immunological challenges. (wikipedia.org)

This controls the passage of materials and the transit of white blood cells into and out of the bloodstream. (wikipedia.org)

There he worked with Dr. Max D. Cooper (Howard Hughes Medical Institute, National Academy of Sciences) and his research focused on cell surface proteins expressed by preB cells that regulate B cell maturation and homing. (ubc.ca)

RESULTS: The expression of miR-15a-5p and miR-15a-3p in RF/6A cells decreased significantly after 48 h of 25 or 50 mmol/L high glucose treatment. (bvsalud.org)

These well-regulated processes to transfer information between cells occur through direct cell-cell contact, various soluble bioactive factors and through cellular microparticles [ 6 , 7 ]. (ersjournals.com)

Through the recent use of molecular and cellular assays and knockout animals, considerable progress has been made towards the understanding of the genetic, tissue-specific, and immunological factors that contribute to the development of ALI pathophysiology. (hindawi.com)
Willet AH , Chen JS , Ren L , Gould KL , Membrane binding of endocytic myosin-1s is inhibited by a class of ankyrin repeat proteins Molecular biology of the cell. (vanderbilt.edu)

Bone marrow mononuclear cells (BMCs) are suitable for bone tissue engineering. (uni-frankfurt.de)

Vascular endothelial cells line the entire circulatory system, from the heart to the smallest capillaries. (wikipedia.org)
Both blood and lymphatic capillaries are composed of a single layer of endothelial cells called a monolayer. (wikipedia.org)

The effects of oxLDL‑mediated inflammasome activation on endothelial permeability under HG conditions, in addition to the effects of rosmarinic acid on these oxLDL‑mediated processes, also remain poorly understood. (spandidos-publications.com)

Particular attention has been paid to elucidating how leukocytes can migrate through the stroma, the way these cells remodel their morphology and sense cues that guide them towards dysfunctional tissue areas. (hindawi.com)

These cells have unique functions that include fluid filtration, such as in the glomerulus of the kidney, blood vessel tone, hemostasis, neutrophil recruitment, and hormone trafficking. (wikipedia.org)
Activated γδ T cells exhibit strong cytotoxic activity and cytokine secretion functions and are effective antitumor lymphocytes with simple and direct recognition modes and rapid responses. (explorationpub.com)

Endothelial cells express a variety of immune genes in an organ-specific manner. (wikipedia.org)

Leukocyte recruitment into the inflamed parenchyma requires successive interactions with cellular and stromal barriers that establish mechanical, chemotactic and haptotactic gradients to guide immune cells towards the inflammatory focus. (hindawi.com)
Young KM , Reinhart-King CA , Cellular mechanosignaling for sensing and transducing matrix rigidity Current opinion in cell biology. (vanderbilt.edu)

The process is triggered by decreased tissue oxygen (hypoxia) or insufficient oxygen tension leading to the new development of blood vessels lined with endothelial cells. (wikipedia.org)
2 Examples of this approach include blood vessels and cardiovascular substitutes, where autologous vascular cells have been used for this purpose without immune rejection. (ashpublications.org)

Under the optimized conditions, RF/6A cells were treated with LBP for 48 h, followed by another 48-h culture in high glucose (25 mmol/L) medium. (bvsalud.org)

Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. (lookformedical.com)

Microparticles are plasma membrane vesicle fragments (between 0.1 and 1 μm in size) released from various cell types during activation by agonists or physical or chemical stress, including apoptosis [ 6 , 7 ]. (ersjournals.com)
In a previous study, it was reported that oxLDL treatment induced nucleotide‑binding domain and leucine‑rich repeat containing family, pyrin domain‑containing 3 inflammasome activation in endothelial cells (ECs) under HG conditions, in a manner that could be effectively reversed by rosmarinic acid. (spandidos-publications.com)
We sought to extend the receptor-desensitization paradigm for use with a cultured cell system, in which an intracellular calcium signal rather than a contractile response might be used as an index of receptor activation. (aspetjournals.org)
Finally, it retrospectively analyze the activation strategies and clinical relevance of existing γδ T cell adoptive immunotherapies. (explorationpub.com)
In cultured primary fibroblasts and cancer cells, the chemotherapeutic drug doxorubicin causes mtDNA damage and release, which leads to cGAS STING dependent ISG activation. (regenerativemedicine.net)

Mimic-miR-15a-5p or 600 mg/L LBP could increase the apoptosis of cells and the total length of vascular branches. (bvsalud.org)

Consequently, tissues implanted with a volume more than 2 to 3 mm 3 cannot obtain appropriate provision of nutrients, gas exchange, and elimination of waste products since all these mechanisms are limited by the diffusion distance. (ashpublications.org)
It includes the possible stem cell therapy mechanisms involved and outcomes recorded so far, the limitations of using these regenerative medicines, and the progressive improvement in stem cell therapy by adopting approaches like PiggyBac, Sleeping Beauty, and the Sendai virus. (biomedcentral.com)
First, γδ T cells exposed to complicated cytokine networks are potentially affected by multiple inhibitory mechanisms. (explorationpub.com)

Understanding the components of the TME and their interplay with tumor cells is helpful for developing new strategies against metastatic CRC. (biomedcentral.com)

Crotalus durissus terrificus snake venom and its major toxin, crotoxin or type II PLA2 (CB) subunit of this toxin, modulates immune and inflammatory responses, interfering with the activity of leukocytes. (fapesp.br)

Levels of enzyme activity in plasma-treated U937 cells were closely dependent on the severity of diabetic retinopathy, with the highest values observed upon treatment with plasma of patients affected by proliferative retinopathy. (diabetesjournals.org)
The self-renewal and proliferative nature of stem cells raised the hope to fight against various diseases. (biomedcentral.com)

In order to find more promising treatments to stimulate renal repair, stem cell-based technology has been proposed as a potentially therapeutic option. (biomedcentral.com)

Anatomy16

Organisms3

Diseases3

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes15

Disciplines and Occupations1

Information Science1

Inflammation10

Vitro9

Adhesion18

Umbilical vein endothelial cells2

Endothelium4

Lymphatic endothelial cells1

Increased endothelial permeability1

Dysfunction7

Induce3

Migration9

Receptors6

Extravasation1

Innate2

Platelets1

Proliferation3

Neutrophils2

HUVECs1

Retinal4

Phenotype3

Glycoprotein3

Monocyte4

Vivo2

Vessel wall1

Investigate2

Epithelial cells4

Chemotaxis1

Regeneration3

Hematopoietic5

Proteases2

Human8

Microenvironment3

Immune response1

Bloodstream1

Regulate1

Significantly1

Soluble1

Molecular2

Bone1

Capillaries2

Processes1

Migrate1

Functions2

Variety of immune1

Cellular2

Blood vessels2

Glucose1

Cytokines1

Activation5

Apoptosis1

Mechanisms3

Tumor cells1

Inflammatory responses1

Proliferative2

Stimulate1