• bloodstream
  • However, agonists such as bacterial lipopolysaccharide (LPS) and immune complexes, if present in the bloodstream can induce the expression of TF on monocytes resulting in activation of the clotting process. (bl.uk)
  • receptors
  • Compared to cells from control donors, there was an increase for MHC class II antigens, complement receptors, and Fc receptors on the monocytes in chronic lymphocytic leukemia, in terms of both the percentage of positive cells among the LeuM3 + monocytes and of fluorescence intensity. (aacrjournals.org)
  • There are at least three subclasses of monocytes in human blood based on their phenotypic receptors. (wikipedia.org)
  • Monocytes can perform phagocytosis using intermediary (opsonising) proteins such as antibodies or complement that coat the pathogen, as well as by binding to the microbe directly via pattern-recognition receptors that recognize pathogens. (wikipedia.org)
  • endothelium
  • Also, through the activation of collagenases, ox-LDL contributes to a process which may lead to the rupture of the fibrous plaque Oxidized LDL decreases the availability of endothelial nitric oxide (NO), which, in turn, increases the adhesion of monocytes to the endothelium. (wikipedia.org)
  • bone
  • Monocytes are frequently found adjacent to active bone resorption surfaces in both physiological and pathological situations and may play a key role in bone resorption. (springer.com)
  • The present study shows that monocytes can also resorb bone by stimulation of osteoclasts. (springer.com)
  • Bone matrix sustained comparable resorption as demonstrated by a 2-fold decrement in the extracted dry weights of the bones cultured in monocyte-conditioned medium. (springer.com)
  • Known inhibitors of osteoclastic activity (phosphate 6 × 10 −3 M, cortisol 10 −6 M, and calcitonin 50 mU/ml) inhibited monocyte-conditioned medium-mediated bone resorption. (springer.com)
  • The monocyte-conditioned medium contained sufficient prostaglandin E to account for the bone resorption. (springer.com)
  • Indomethacin 10 −5 M added to the monocyte cultures blocked monocyte-conditioned media-induced bone resorption and prostaglandin release. (springer.com)
  • Monocyte-induced bone resorption is partly reversed by inhibitors of osteoclast function. (springer.com)
  • Monocyte-induced osteoclastic bone resorption may play an important role in physiologic bone remodeling and in bone destruction that occurs in chronic inflammatory diseases such as rheumatoid arthritis and periodontal disease. (springer.com)
  • Monocytes originate in the bone marrow upon which they are released into the blood stream. (wikipedia.org)
  • antigen
  • The increase of antigen expression on LeuM3 + monocytes was more than 50% (1.5-fold) in seven of 22 patients for MHC Class II antigens, in seven of 16 patients for complement receptor and in six of 12 patients for Fc receptor. (aacrjournals.org)
  • differentiate
  • While in humans the level of CD14 expression can be used to differentiate non-classical and intermediate monocytes, the slan cell surface marker was shown to give an unequivocal separation of the two cell types. (wikipedia.org)
  • chronic
  • Monocytosis and increased expression of monocyte cell surface antigens described for a large portion of patients might be causally involved in the immunodeficiency in chronic lymphocytic leukemia. (aacrjournals.org)
  • human
  • Hello, We are interested in metabolic labeling (using 35S-Met) human monocytes stimulated under various conditions. (bio.net)
  • Live fetal rodent bones prelabeled with 45 Ca and cultured for 48-96 h in the presence of human monocytes or monocyte-conditioned medium released 80% more mineral than bones cultured in control medium. (springer.com)
  • Monocytes compose 2% to 10% of all leukocytes in the human body and serve multiple roles in immune function. (wikipedia.org)
  • inflammatory
  • Amyloid enhancing activity can reside in monocytes recovered from mice with AA-amyloidosis and in a prion-like way trigger amyloid formation in conjunction with an inflammatory disorder. (diva-portal.org)
  • response
  • We have investigated the potential of antisense therapy to inhibit specifically the nascent induction of TF in monocytes in response to LPS. (bl.uk)
  • name
  • Monocyte" was created as a concept album and a soundtrack to the comic book of the same name (also created by Menton J. Matthews III and published by IDW Publishing). (wikipedia.org)