• This Accum® technology can be exploited to design a multitude of products including: i) antibody-drug conjugates ("ADCs"), ii) protein/cellular vaccines, and iii) the design of anti-cancer small chemotypes. (defencetherapeutics.com)
  • Antibody-drug conjugates or ADCs are a class of biopharmaceutical drugs designed as a targeted therapy for treating cancer. (wikipedia.org)
  • [3] Antibody-drug conjugates are an example of bioconjugates and immunoconjugates . (wikipedia.org)
  • Anti-TF monoclonal antibodies (mAbs) capable of targeting cancers have been successfully applied to armed antibodies such as antibody-drug conjugates (ADCs) and molecular imaging probes. (elsevierpure.com)
  • Ricart AD (2011) Antibody-drug conjugates of calicheamicin derivative: gemtuzumab ozogamicin and inotuzumab ozogamicin. (springer.com)
  • or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
  • DREAMM-2 is an open label study of belantamab mafodotin, a humanised, immunoconjugate against B-cell maturation antigen (BCMA). (cliniexpert.com)
  • To determine if human leukocyte antigen (HLA) genotypes are associated with antibody responses before and after neoadjuvant therapy and vaccination. (ucsd.edu)
  • We have previously investigated the biodistribution and therapy effect of a humanized monoclonal antibody targeting free prostate-specific antigen (fPSA) intended for theranostics of hormone-refractory prostate cancer. (qxmd.com)
  • In the present study, we evaluated the off-target effect and different linear energy transfer (LET) radionuclides without the effect of PSA targeting by using an antibody with the same scaffold as previously used immunoconjugates but with random, non-specific, antigen binding region. (qxmd.com)
  • The present invention generally relates to antibodies that bind to NKG2D, including multispecific antigen binding molecules e.g. for activation of T cells and/or NK cells. (justia.com)
  • The present inventors discovered that by forming a large immune complex comprising antigens containing two or more antigenic binding units (epitopes) and two or more antigen-binding molecules (for example, antibodies), elimination from the plasma of the antigens containing two or more antigenic binding units can be accelerated. (justia.com)
  • Such therapy functions through mediating alterations in antigen or receptor function, modulating the immune system or delivering a specific drug that is conjugated to an antibody that targets a specific antigen. (justia.com)
  • Antibodies against a specific antigen on a cancerous tissue can be used to target and kill the cancerous tissue. (justia.com)
  • Suitability of an antigen for therapy is dependent on various factors including but not limited to the nature of the antigen (e.g. accessibility, abundance, location of expression on cancerous cells etc.), therapeutic approach, antibody affinity and other pharmacokinetic properties. (justia.com)
  • An anticancer drug is coupled to an antibody that targets a specific tumor antigen (or protein ) that, ideally, is only found in or on tumor cells. (wikipedia.org)
  • Tolcher AW, Ochoa L, Hammond LA et al (2003) Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen: a phase I, pharmacokinetic, and biologic correlative study. (springer.com)
  • The antibody recognizes a unique molecule of the pathogen, called an antigen . (wikipedia.org)
  • [2] [3] Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision. (wikipedia.org)
  • To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. (wikipedia.org)
  • The class hence determines the function triggered by an antibody after binding to an antigen, in addition to some structural features. (wikipedia.org)
  • After an antigen binds to a BCR, the B cell activates to proliferate and differentiate into either plasma cells , which secrete soluble antibodies with the same paratope, or memory B cells , which survive in the body to enable long-lasting immunity to the antigen. (wikipedia.org)
  • Structurally an antibody is also partitioned into two antigen-binding fragments (Fab), containing one V L , V H , C L , and C H 1 domain each, as well as the crystallisable fragment (Fc), forming the trunk of the Y shape. (wikipedia.org)
  • The fundamental basis of antibody-based cancer therapy is the fact that cancerous tissues express an array of antigens that may be overexpressed, selectively expressed or mutated compared to normal, non-cancerous tissue. (justia.com)
  • However, a key challenge in developing candidate therapeutic antibodies for cancer is the identification of antigens suitable for antibody-based therapy. (justia.com)
  • Antibodies attach themselves to the antigens on the surface of cancerous cells. (wikipedia.org)
  • Here, we describe preclinical data for a novel antibody-drug conjugate (ADC), SAR408701, which consists of an anti-CEACAM5 antibody (SAR408377) coupled to a maytansinoid agent DM4 via a cleavable linker. (nih.gov)
  • The present study was undertaken to determine the antitumor effects of an antibody-conjugate against fibroblast activation protein-α, a cell surface protease of activated tumor fibroblasts. (aacrjournals.org)
  • A novel antibody-maytansinoid conjugate, monoclonal antibody (mAb) FAP5-DM1, was developed to target a shared epitope of human, mouse, and cynomolgus monkey fibroblast activation protein-α, enabling preclinical efficacy and tolerability assessments. (aacrjournals.org)
  • However this conjugate has been passed over appropriate immunoadsorbents to remove antibodies cross-reacting with Human immunoglobulins. (nordicmubio.com)
  • Justia Patents Drug, Bio-affecting And Body Treating Compositions Patents Immunoglobulin, Antiserum, Antibody, Or Antibody Fragment, Except Conjugate Or Complex Of The Same With Nonimmunoglobulin Material Patents Structurally-modified Antibody, Immunoglobulin, Or Fragment Thereof (e.g. (justia.com)
  • In July 2018, Daiichi Sankyo Company, Limited and Glycotope GmbH have inked a pact regarding the combination of Glycotope's investigational tumor-associated TA-MUC1 antibody gatipotuzumab and Daiichi Sankyo's proprietary ADC technology for developing gatipotuzumab antibody drug conjugate. (wikipedia.org)
  • One way to enhance therapeutic potential of antibodies is to conjugate them to small molecule drugs. (springer.com)
  • Lessons learned from the first-generation antibody-drug conjugate (ADC) and improvement of the technology guided the design of improved compounds which are now in clinical trials. (springer.com)
  • Teicher BA (2009) Antibody-drug conjugate targets. (springer.com)
  • Human tissue/Mouse monoclonal antibody to a Human tissue constituent/anti Mouse Ig isotype-specific immunoconjugate. (nordicmubio.com)
  • The strip wells contain immobilized mouse monoclonal antibody and the immunoconjugate contains rabbit polyclonal antibodies conjugated to horseradish peroxidase. (pro-lab.co.uk)
  • Idealized molecular ribbon diagram of the appearance of an immunotoxin with saporin coupled covalently via a disulfide bond to a mouse monoclonal antibody. (atsbio.com)
  • The lack of binding of mIgG to hFcRn explains why murine antibodies are rapidly removed from the circulation in humans, despite long half-life in mice 32 . (nature.com)
  • Although the 211 At-conjugated clone 1084 ( 211 At-anti-TF mAb) was disrupted by an 211 At-induced radiochemical reaction, we demonstrated that astatinated anti-TF mAbs eluted in 0.6% or 1.2% sodium ascorbate (SA) solution were protected from antibody denaturation, which contributed to the maintenance of cellular binding activities and cytocidal effects of this immunoconjugate. (elsevierpure.com)
  • The major antibody class found in the blood, IgG, has a remarkable persistence, with a serum half-life of 20-23 days, compared with only hours or a few days for other circulating proteins 5 . (nature.com)
  • Although Defence is using this approach to optimize commercially available ADCs such as Enhertu®, the company is actively working on developing two in-house ADCs using its own proprietary monoclonal antibodies targeting two tumor-specific cell surface proteins and payloads. (defencetherapeutics.com)
  • Antibodies are heavy (~150 k Da ) proteins of about 10 nm in size, [7] arranged in three globular regions that roughly form a Y shape. (wikipedia.org)
  • Arcitumomab is a Fab' fragment of IMMU-4, a murine IgG1 monoclonal antibody extracted from the ascites of mice. (wikipedia.org)
  • abstract = "Two kinds of immunoconjugate (T‐3M and T‐11M) of murine monoclonal antibody with mitomycin C (MMC) were developed using spacers containing a disulfide (T‐3M) or thiocarbamate (T‐11M) bond. (elsevierpure.com)
  • A murine monoclonal antibody (NCC‐LU‐243) raised against a human small cell lung carcinoma cell line, Lu‐24, in nude mice, is an IgG2a monoclonal antibody that recognizes a 145‐kDa protein on the cell surface membrane. (elsevierpure.com)
  • Moreover, PEP is a promising candidate for the generation of agents that can enhance the delivery of antibodies and drugs to tumors. (nih.gov)
  • As such, CEACAM5 is an attractive target for antibody-based therapies designed to selectively deliver cytotoxic drugs to certain epithelial tumors. (nih.gov)
  • In this dissertation, the goal was to enhance our knowledge on how new recombinant antibodies might be tailored to optimize localization to experimental tumors in mice. (projectsparadise.com)
  • We conclude that radioimmunotherapy for occult metastatic prostate cancer using 90 Y- capromab-pendetide at the dose described does not lower serum PSA, is associated with significant hematologic toxicity, and leads to complexation of the immunoconjugate following subsequent capromab pendetide infusion. (elsevierpure.com)
  • Heider K, Kuthan H, Stehle G et al (2004) CD44v6: a target for antibody-based cancer therapy. (springer.com)
  • It consists of the Fab' fragment of a monoclonal antibody (arcitumomab, trade name CEA-Scan) and a radionuclide, technetium-99m. (wikipedia.org)
  • The enzyme pepsin cleaves the F(ab')2 fragment off the antibody. (wikipedia.org)
  • Clinical utility of external immunoscintigraphy with the IMMU-4 technetium-99m Fab' antibody fragment in patients undergoing surgery for carcinoma of the colon and rectum: results of a pivotal, phase III trial. (wikipedia.org)
  • Structurally-modified Antibody, Immunoglobulin, Or Fragment Thereof (e.g. (justia.com)
  • The present invention provides methods of treating, ameliorating, or inhibiting tumor growth, cancer, or pathological angiogenesis by administering to a subject in need thereof a human antibody or fragment thereof that specifically binds to human delta-like ligand 4 (hDll4) and blocks hDll4 binding to a Notch receptor. (justia.com)
  • The anti-hDll4 antibody or fragment thereof of the present invention have a high affinity with the KD of 500 pM or less, as measured by surface plasmon resonance. (justia.com)
  • This immunoconjugate is not species-specific since inter-species cross-reactivity is a normal feature of antisera to immunoglobulins. (nordicmubio.com)
  • One hybridoma, producing the monoclonal antibody H7, against placental alkaline phosphatase was adopted to offer CDR-containing regions for new recombinant constructs. (projectsparadise.com)
  • Unsatisfactory results were also obtained with the recombinant humanized monoclonal antibody, pertuzumab (Perjeta), that target specifically the extracellular domain of HER2 (4). (iranpath.org)
  • This radiotracer comprises an IgG1 monoclonal antibody, known as VG76e, that binds to human VEGF, labeled with a positron-emitting radionuclide, iodine-124 ([(124)I]-SHPP-VG76e). (ox.ac.uk)
  • Moreover, the antitumor activities of the protected immunoconjugate in gastric cancer xenograft models were dependent on the level of TF in cancer cells. (elsevierpure.com)
  • Antibodies, Immobilized" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • Intact IL-2 or overlapping synthetic peptides of IL-2 that were chemically conjugated to tumor-targeting monoclonal antibodies (TNT-1 or Lym-1) were injected into groups of mice (n = 4) that had previously been xenotransplanted with human tumor cells (ME-180 cervical carcinoma and Raji lymphoma). (nih.gov)
  • Two hours later, mice received intravenous injections of radiolabeled tracer antibody, and 3 days later they were subjected to biodistribution analysis to measure the ability of each immunoconjugate to enhance tumor uptake of the tracer antibody (i.e., vasopermeability activity). (nih.gov)
  • Pretreatment of mice with an antibody/IL-2 immunoconjugate resulted in an approximately fourfold increase in radiolabeled tracer antibody uptake in the xenograft tumor as compared with uptake in mice injected with antibody alone. (nih.gov)
  • MATERIALS AND METHODS: The anti-endothelial monoclonal antibody VG76e was labeled with Samarium-153 and Technetium-99m. (ox.ac.uk)
  • ADCs are complex molecules composed of an antibody linked to a biologically active cytotoxic (anticancer) payload or drug. (wikipedia.org)
  • Previous studies in our laboratory described the in vitro cytotoxicity and specificity of an immunoconjugate composed of mAb ZME-018 and the plant toxin gelonin. (houstonmethodist.org)
  • Antibody engineering has added substantial new technologies to modify size, affinities, solubility, stability and biodistribution properties for immunoconjugates. (projectsparadise.com)
  • Patients in the trial received a median of seven prior lines of treatment, were refractory to an immunomodulatory drug and a proteasome inhibitor and were refractory and/or intolerant to an anti-CD38 antibody. (cliniexpert.com)
  • GSK also confirmed submission of a Biologics License Application to the US Food and Drug Administration (FDA) seeking approval of belantamab mafodotin for the treatment of patients with relapsed or refractory multiple myeloma whose prior therapy included an immunomodulatory agent, a proteasome inhibitor and an anti-CD38 antibody. (cliniexpert.com)
  • immune reaction mediated by T cells, in contrast to humoral immunity, which is antibody mediated. (womenshealthsection.com)
  • Because these fluids were traditionally known as humors , antibody-mediated immunity is sometimes known as, or considered a part of, humoral immunity . (wikipedia.org)
  • T cells are involved in cell-mediated immunity whereas B cells are primarily responsible for humoral immunity (relating to antibodies). (wellnessadvantage.com)
  • Laureate To Manufacture Alopexx's Product Candidate On April 10, 2008, Laureate Pharma, Inc., a large company engaged in biopharmaceutical development and protein production reported that it has concluded a contract manufacturing agreement with Alopexx Pharmaceuticals on the production of Alopexx's mAb F598 antibody under cGMP conditions. (laureatepharma.com)
  • An antibody ( Ab ), also known as an immunoglobulin ( Ig ), [1] is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses . (wikipedia.org)
  • To determine if augmenting CD4 helper T cell immunity augments HER2-specific antibody immunity induced by trastuzumab. (ucsd.edu)
  • This distinction for teclistamab, an off-the-shelf, T-cell redirecting, a bispecific antibody targeting both BCMA and CD3 receptors, follows a PRIME designation from the EMA received earlier this year. (mississippichronicle.com)
  • Provided herein are multispecific antibodies, e.g. bispecific antibodies, which are modified such that the desired chain pairing takes place and/or can be selected for. (justia.com)
  • Samarium-153 and technetium-99m-labeled monoclonal antibodies in angiogenesis for tumor visualization and inhibition. (ox.ac.uk)
  • Our studies are focused on the detection of VEGF by use of radiolabeled anti-endothelial monoclonal antibodies, which have the ability to localize in newly-formed vasculature of a cancerous origin. (ox.ac.uk)
  • Different antibody derived constructs are speedily evolving as putative tools for management of cancerous diseases . (projectsparadise.com)
  • CONCLUSION: Monoclonal antibodies raised against epithelial growth factors or their receptors, when labeled with appropriate radionuclides, may be a useful tool for early tumor detection and eventually for therapy. (ox.ac.uk)
  • To determine whether HER2 monoclonal antibody therapy induces HER2 loss and modulation of HER2-specific adaptive immune responses. (ucsd.edu)
  • Antibody-based therapy has in recent years become an important treatment strategy for cancer. (justia.com)
  • We have accelerated development of our inhaled COVID-19 antibody cocktail therapy, leveraging our antibody platform to address the ongoing challenges of the pandemic" said Dr. HoUng Kim, Ph.D., Head of Medical and Marketing Division at Celltrion Healthcare. (pipelinereview.com)
  • However, designing an ADC is more complex than a simple meccano game, requiring thoughtful combination of antibody, linker, and drugs in the context of a target and a defined cancer indication. (springer.com)
  • They gave coherent results, which are reported here: EDIAs bind to a different ErbB2 epitope than Herceptin and the other human/humanized antibodies against ErbB2 reported so far. (cnr.it)
  • However, none of these available anti-AXL antibodies bind to both surface and soluble AXL. (justia.com)
  • Specifically, the present invention relates to anti-AXL tyrosine kinase receptor antibodies and their uses thereof. (justia.com)
  • Antibodies that are chemically bound to a substrate material which renders their location fixed. (umassmed.edu)
  • Polypeptides, such as antibody molecules and TCR molecules, and methods of making the same, are disclosed. (justia.com)
  • Whether using an antibody, cell-based vaccine or small molecule therapeutics, the common denominator in all of Defence's development products is the Accum® technology, a platform specifically designed to strategically enhance and increase the efficacy of any existing bio-drug against cancer. (defencetherapeutics.com)
  • [4] Soluble antibodies are released into the blood and tissue fluids , as well as many secretions . (wikipedia.org)
  • Initially, all antibodies are of the first form, attached to the surface of a B cell - these are then referred to as B-cell receptors (BCR). (wikipedia.org)
  • The terms antibody and immunoglobulin are often used interchangeably, [1] though the term 'antibody' is sometimes reserved for the secreted, soluble form, i.e. excluding B-cell receptors. (wikipedia.org)
  • Some patients develop human anti-mouse antibodies, so there is the theoretical possibility of anaphylactic reactions. (wikipedia.org)
  • These two immunoconjugates of monoclonal antibody with mitomycin C are thought to be useful for targeting cancer chemotherapy against human small cell lung carcinomas. (elsevierpure.com)
  • Antibody ZME-018 is directed against the gp240 glycoprotein on the surface of more than 80% of human melanoma cell lines and fresh biopsy specimens. (houstonmethodist.org)
  • The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease. (justia.com)
  • Also disclosed herein are nucleic acids encoding for these antibodies, expression vectors comprising these nucleic acids, cells expressing them, and further to pharmaceutical compositions comprising the antibodies, as well as methods of isolating the antibodies. (justia.com)
  • Using this binding mechanism, an antibody can tag a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). (wikipedia.org)
  • Pharmacokinetic studies of 125 I-labeled ZME-018 and ZME-gelonin demonstrated a shorter terminal-phase plasma half-life of the immunoconjugate than native ZME (20.6 h compared to 41.3 h). (houstonmethodist.org)
  • PEP had vasopermeability activity only when conjugated to a tumor-targeting antibody, had maximal activity as a dimer, and was devoid of cytokine activity. (nih.gov)
  • Dive into the research topics of 'Targeting cancer chemotherapy using a monoclonal antibody (NCC‐LU‐243) conjugated with mitomycin C'. Together they form a unique fingerprint. (elsevierpure.com)
  • Targeting cancer chemotherapy using a monoclonal antibody (NCC‐LU‐243) conjugated with mitomycin C . Journal of Surgical Oncology , 51 (2), 75-80. (elsevierpure.com)
  • In addition, Defence is partnering with Orano, a world-renowned multinational company, to develop the next-generation radio-immunoconjugates using Defence's intracellular targeting Accum® technology to provide distinctive best-in-class ADC therapies. (defencetherapeutics.com)
  • Riechelmann H, Sauter A, Golze W et al (2008) Phase I trial with the CD44v6-targeting immunoconjugate bivatuzumab mertansine in head and neck squamous cell carcinoma. (springer.com)
  • This antibody will be used in clinical trials and also for fighting Staphylococcus aureus infections. (laureatepharma.com)