• Monocytic leukemia is a type of myeloid leukemia characterized by a dominance of monocytes in the marrow. (wikipedia.org)
  • When the monocytic cells are predominantly monoblasts, it can be subclassified into acute monoblastic leukemia. (wikipedia.org)
  • Patients with acute monoblastic and monocytic leukemia may present with bleeding disorders, as well as with extramedullary masses, cutaneous and gingival infiltration, and central nervous system involvement. (medscape.com)
  • Patients with acute monocytic leukemia also have a high incidence of clinically significant DIC. (medscape.com)
  • Myeloid malignancies and acute lymphoblastic leukemia (ALL). (atlasgeneticsoncology.org)
  • Deletion of 7p as the sole abnormality occurs in disorders with myelodysplastic or myeloproliferative features and acute lymphoblastic leukemia, and may therefore affect early hematopoietic progenitor cells. (atlasgeneticsoncology.org)
  • AML-M0, acute myeloblastic leukemia with minimal differentiation , ALL, acute lymphoblastic leukemia/lymphoblastic lymphoma. (atlasgeneticsoncology.org)
  • Teardrop cells in a peripheral blood smear from a patient whose bone marrow was extensively replaced by B lymphoblastic leukemia. (askhematologist.com)
  • B-cell acute lymphoblastic leukemia with t(4;11)(q21;q23) in a young woman: evolution into mixed phenotype acute leukemia with additional chromosomal aberrations in the course of therapy. (unipi.it)
  • Acute lymphoblastic leukemia (ALL), Multiple myeloma (MM), and Chronic lymphocytic leukemia (CLL), and Diffuse Large B-Cell Lymphoma (DLBCL). (codemap.com)
  • A hallmark of AML is maturation arrest of myeloid cells, which accumulate in the peripheral blood and bone marrow. (biomedcentral.com)
  • Acute myeloid leukemia (AML) and related neoplasms. (oncolink.org)
  • Therapy-related myeloid neoplasms. (oncolink.org)
  • Myeloid neoplasms with germline predisposition without a preexisting disorder or organ dysfunction. (oncolink.org)
  • Myeloid neoplasms with germline DDX41 mutation. (oncolink.org)
  • Myeloid neoplasms with germline predisposition and preexisting platelet disorders. (oncolink.org)
  • Myeloid neoplasms with germline predisposition and other organ dysfunction. (oncolink.org)
  • Some case reports identified MYC or MLL gene amplification performing as dmin in myeloid neoplasms. (hindawi.com)
  • FLT3 ( FMS -related tyrosine kinase 3) acts as an oncogene in myeloid neoplasms which is associated with several signal transduction pathways. (hindawi.com)
  • Vardiman JW, Harris NL, Brunning RD. The World Health Organization (WHO) classification of the myeloid neoplasms. (medscape.com)
  • 5 Hematopoietic disruptions in the myeloid lineage can lead to 3 major disease categories: acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN), and myelodysplastic syndrome (MDS). (oncomine.com)
  • Myeloproliferative neoplasms present with the clonal proliferation of 1 or more myeloid cell lineages.10 The role of genetic and genomic aberrations in pathogenesis has been well documented for these disorders. (oncomine.com)
  • Acute myelogenous leukemia (AML) is a blood cancer that affects white blood cells, red blood cells, and/or platelets. (oncolink.org)
  • NCCN Clinical Practice Guidelines in Oncology: Acute Myelogenous Leukemia. (medscape.com)
  • Recently, two pediatric patients with recurrent acute myelogenous leukemia presenting with leukemia cutis (LC) were treated at the University of Texas Southwestern (UTSW) Medical Center at Dallas using TSEI. (biomedcentral.com)
  • Although patients with acute megakaryoblastic leukemia may present with evidence of bone marrow failure associated with pancytopenia, in some cases, thrombocytosis is present. (medscape.com)
  • Cytogenetic studies performed on bone marrow provide important prognostic information and can guide treatment by confirming a diagnosis of acute promyelocytic leukemia (APL). (medscape.com)
  • Acute promyelocytic leukemia (APL), also known as M3, is the most common subtype of AML associated with DIC. (medscape.com)
  • Immunophenotyping is required to determine myeloid lineage. (medscape.com)
  • Acute leukemias of ambiguous lineage. (oncolink.org)
  • Acute myeloid leukemia (AML) results from the over-proliferation of progenitor cells of the myeloid lineage in the bone marrow. (ghrnet.org)
  • In addition, it is also important to exclude other, more specific AML categories (ie, AML with myelodysplasia-related changes, therapy-related myeloid neoplasm, AML with germline predisposition, myeloid proliferations related to Down syndrome) before classifying a condition as AML NOS. (medscape.com)
  • Myeloid proliferations related to Down syndrome. (oncolink.org)
  • Chronic myeloid leukemia ( CML ), BCR-ABL1-positive, is a myeloproliferative neoplasm (MPN) in which granulocyte s are the major proliferative component. (cancer.gov)
  • Acute myeloid leukemia (AML) is a neoplasm of myelopoiesis with variable involvement of myeloid cell lineages. (altmeyers.org)
  • The current study attempts to demonstrate the existence of double minute chromosomes via FLT3 gene amplification in a patient diagnosed with chronic myelomonocytic leukemia (CMML). (hindawi.com)
  • Here, to our best knowledge, we present the first case of amplification encompassing the FLT3 gene acting as dmin in a patient with chronic myelomonocytic leukemia (CMML). (hindawi.com)
  • Acute myeloid leukemia (AML) comprises a spectrum of myeloid malignancies which are often associated with distinct chromosomal abnormalities, and the analysis of such abnormalities provides us with important information for disease classification, treatment selection and prognosis. (biomedcentral.com)
  • This case of acute monoblastic leukemia presents a combination of rare chromosomal abnormalities including the unbalanced translocation der(19)t(17;19)(q23;p13.3), hitherto un-reported in AML. (biomedcentral.com)
  • 1q23.1 homozygous deletion and downregulation of Fc receptor-like family genes confer poor prognosis in chronic lymphocytic leukemia. (cancerindex.org)
  • The identification of chromosome 1 translocations and deletions is a rare and poorly investigated event in chronic lymphocytic leukemia (CLL). (cancerindex.org)
  • 1,2 The 4 primary disorders of MPNs are chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). (oncomine.com)
  • Characterized by excessive, abnormal white blood cell (granulocyte) production and the presence of the Philadelphia chromosome/BCR-ABL mutation, chronic myeloid leukemia (CML) is a slow-growing cancer of the blood-forming tissue (bone marrow). (oncomine.com)
  • In contrast to chronic myeloid leukemia (CML), different cytogenetic aberrations are found in AML. (altmeyers.org)
  • Here we report a unique case of acute monoblastic leukemia with gain of i(5)(p10), tetrasomy 8, an unbalanced translocation der(19)t(17;19)(q23;p13.3) and mutated NPM1 . (biomedcentral.com)
  • Morphologic and immunophenotypic features of a case of acute monoblastic leukemia with unusual positivity for Glycophorin-A. (unipi.it)
  • Acute myeloid leukemia (AML) comprises a spectrum of hematologic malignancies with variable outcomes. (biomedcentral.com)
  • 2015). 5 patients with myeloid malignancies had secondary disorders treated for a previous malignancy (Mecucci et al. (atlasgeneticsoncology.org)
  • Deletion of 7p, appears to confer increased risk of treatment failure and inferior outcome, same as it observed with monosomy 7 in myeloid malignancies. (atlasgeneticsoncology.org)
  • With an ever-growing list of biomarkers, inherent genetic complexity, and the risk of rapid progression, myeloid malignancies challenge the current iterative testing paradigm and call for a streamlined testing approach that yields rapid results. (oncomine.com)
  • 3 Results can be available within hours or days, depending on the platform.3 With its demonstrated clinical utility in myeloid malignancies, NGS is transforming the testing paradigm and enabling better outcomes for patients. (oncomine.com)
  • Myeloid malignancies arise from mutations in hematopoietic stem or progenitor cells. (oncomine.com)
  • This clinical trial uses a laboratory test called a high throughput sensitivity assay in planning treatment for patients with relapsed or refractory acute myeloid leukemia. (clincosm.com)
  • Leukemia cutis in a patient with relapsed refractory AML with t(10;11)(p11.2;q23) occurring two weeks after achieving CR2 with FLAG-IDA indicating extra-medullary relapse. (hematology.org)
  • Patients with acute myeloid leukemia (AML) with minimal differentiation, AML without differentiation, and AML with differentiation usually present with evidence of bone marrow failure (ie, anemia , neutropenia , and/or thrombocytopenia ). (medscape.com)
  • The natural process of blood cell formation, hematopoietic stem cell differentiation, and generation of myeloid and lymphoid cell lineages. (oncomine.com)
  • This section briefly discusses the morphologic features of the subtypes of acute myeloid leukemia (AML) not otherwise categorized (NOS). (medscape.com)
  • OBJECTIVES: I. Determine whether mixed or full donor chimerism can be safely established in older patients with acute myeloid leukemia (AML) treated with nonmyeloablative conditioning comprised of low dose total body irradiation, followed by allogeneic peripheral blood stem cell transplantation, followed by unrelated donor lymphocyte infusion (DLI). (knowcancer.com)
  • Molecular profiling and clinical implications of patients with acute myeloid leukemia and extramedullary manifestations. (nih.gov)
  • Immunophenotyping by flow cytometry of bone marrow or peripheral blood samples can be used to help distinguish AML from acute lymphocytic leukemia (ALL) and further classify the subtype of AML. (medscape.com)
  • There are 2 staging systems that are commonly used during diagnosis of acute myeloid leukemia (AML). (medscape.com)
  • Myeloid Sarcoma: Presentation, Diagnosis, and Treatment. (nih.gov)
  • Myeloid sarcoma. (oncolink.org)
  • Myeloid sarcoma is a rare solid tumor of the myelogenous cells occurring in an extramedullary site. (nih.gov)
  • Myeloid sarcoma, chloroma, or extramedullary acute myeloid leukemia tumor: A tale of misnomers, controversy and the unresolved. (nih.gov)
  • Origin is the pathological proliferation of clonal myeloid cells, mostly belonging to the highly proliferative progenitor pool (i.e. (altmeyers.org)
  • An aggressive disease (rapid onset and progression) that occurs primarily in adulthood and is marked by an abnormal increase and accumulation of myeloblasts (immature myeloid cells) in the bone marrow and blood, which leads to impaired hematopoiesis and bone marrow failure. (oncomine.com)
  • Interestingly, chemotherapy, including hydroxyurea, has been associated with acute leukemia in JAK2 V617F-negative stem cells in some PV patients. (basicmedicalkey.com)
  • Myeloid leukemia associated with Down syndrome. (oncolink.org)
  • BACKGROUND: The number of exposures to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to vaccine antigens affect the magnitude and avidity of the polyclonal response. (bvsalud.org)
  • A New Complex Karyotype Involving a KMT2A-r Variant Three-Way Translocation in a Rare Clinical Presentation of a Pediatric Patient with Acute Myeloid Leukemia. (cancerindex.org)
  • 1,2 Consequently, the clinical value of next-generation sequencing (NGS) is most apparent today in myeloid molecular testing. (oncomine.com)