If antibodies against LDH-C4 do indeed inhibit fertilization, then this result highlights how the difference in the functioning of mucosal immunity from humoral immunity may be critical to the efficacy of contraceptive vaccines. (wikipedia.org)
Although the primate model of human smallpox had been refined, further improvement was needed before it could be used in assessing the efficacy of new antiviral drugs and safer vaccines. (who.int)
WHO should prepare and make widely available guidelines for assessing the quality, safety and efficacy of new generation smallpox vaccines. (who.int)
Dengvaxia, licensed in several countries where DENV is endemic, has shown low efficacy profiles and there are safety concerns prohibiting its administration to children younger than 9 years old, and the live-attenuated tetravalent vaccine (LATV) developed by NIAID has proven too reactogenic during clinical trialing. (bvsalud.org)
As AIDS vaccine recipients will not be exposed to strains exactly matching any immunogens due to multiple HIV-1 quasispecies circulating in the human population worldwide, heterologous SHIV challenges are essential for realistic vaccine efficacy testing in primates. (biomedcentral.com)
Antibodies are a key component of the human adaptive immune system, and the elicitation of antibodies has been correlated with vaccine efficacy in many diseases ( 1 ). (frontiersin.org)
Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ca Suffit! (prolekarniky.cz)
In a vaccine efficacy study, in which virosomes displaying HIV gp41 antigens protected most rhesus monkeys (RMs) against simian-human immunodeficiency virus (SHIV), protection correlated with vaginal IgA capable of blocking HIV transcytosis in vitro. (biomedcentral.com)
Antibodies4
For instance, in the second LDH-C4 primate trial that had negative results, all of the immunized macaque monkeys developed high antibody titers against LDH-C4 in serum, but antibodies against LDH-C4 were not found in the monkeys' vaginal fluids. (wikipedia.org)
Although the two evaluated prime-boost regimes were equivalent to a single administration of TV005 in terms of the development of virus-binding and neutralizing antibodies as well as the protection against viral challenge, both regimes reduced vaccine viremia to undetectable levels. (bvsalud.org)
Containing B- and T-cell epitopes, these proteins form aggregates after the incubation with an immunostimulatory oligodeoxynucleotide, and their tetravalent formulation induces neutralizing antibodies and cellular immune response in mice and monkeys. (bvsalud.org)
We propose that additional investigation into the role of ADCP in protective viral responses, the specific virus epitopes targeted by ADCP antibodies, and the types of phagocytes and Fc receptors involved in ADCP at sites of virus infection will provide insight into strategies to successfully leverage this important immune response for improved antiviral immunity through rational vaccine design. (frontiersin.org)
Antiviral5
The primate model of human smallpox needs further refinement in order to facilitate the development of antiviral drugs and vaccines. (who.int)
Research leading to the development of new antiviral drugs and safer vaccines should be given high priority. (who.int)
Nowadays, no vaccine or specific antiviral treatment is available, and the development of safe and effective vaccines is yet a challenge. (bvsalud.org)
In this study, we observed that Tetra DIIIC was able to boost the antiviral and neutralizing antibody responses previously generated in monkeys during an experimental DENV infection, demonstrating that domain III is targeted by B cells during the viral infection. (bvsalud.org)
Overall, each model has its advantages and disadvantages and is differentially suited for studies of dengue pathogenesis and immunopathogenesis and/or pre-clinical testing of antiviral drugs and vaccines. (mdpi.com)
Recombinant1
In this study, we propose a novel vaccine candidate against the zika disease based on a recombinant protein that can stimulate both arms of the immune system. (bvsalud.org)
Rhesus monkeys2
We assessed whether polyclonal IgG, isolated from rhesus monkeys (RMs) with high-titer nAbs (termed SHIVIG), could protect RMs against the R5-tropic tier-2 SHIV-2873Nip, which was heterologous to the viruses or HIV-1 envelopes that had elicited SHIVIG. (biomedcentral.com)
Anti-HIV-1 envelope (Env) Abs have also been evaluated in rhesus monkeys (RMs) challenged with SHIVs encoding HIV-1 env , tat , rev and vpu . (biomedcentral.com)
Protein7
Instead of the classical types of vaccines such as live and inactivated viruses, several novel immunogens including protein subunit and DNA vaccines as well as viral and bacterial vectors are currently being examined. (aerzteblatt.de)
In this study, we obtained a novel subunit vaccine that combines two regions of zika genome, domain III of the envelope and the capsid, in a chimeric protein in E. coli bacteria. (bvsalud.org)
The chimeric protein ZEC was able to self-assemble after combination with an immunomodulatory specific oligonucleotide to form aggregates. (bvsalud.org)
Tetra DIIIC is a vaccine candidate against dengue virus (DENV) composed by four chimeric proteins that fuse the domain III of the envelope protein of each virus to the corresponding capsid protein. (bvsalud.org)
It confirms the predictions of retired US Army Colonel Lawrence Sellin , an expert on bacteriological weapons at the most important American military research center, Fort Detrick, who advanced the hypothesis that the Spike protein enhanced in the laboratory for the artificial construction of SARS- Cov-2 if used as a sample for vaccines could transfer its dangerous and sometimes lethal toxicity into them. (gospanews.net)
Protein phosphatase 1 regulatory subunit 35 (PPP1R35) encodes a centrosomal protein required for recruiting microtubule-binding elongation machinery. (bcm.edu)
Our findings reveal a potential molecular mechanism by which the spike protein might impede adaptive immunity and underscore the potential side effects of full-length spike-based vaccines. (thetenpennyreport.com)
Viruses2
Australian doctors confirm that terrible prophecy and make any investigation even more urgent to identify those responsible who, together with the notorious virologist Anthony Fauci and the Wuhan Institute of Virology financed by Bill Gates , played with the SARS chimeric viruses to the point of causing - voluntarily according to US patent expert David E. Martin and attorney Robert F. Kennedy jr. - humanity's most devastating pandemic. (gospanews.net)
He hypothesized that because WI-38 was free from contaminating viruses, it could replace the then widely used primary monkey kidney cells, which contained several dangerous contaminating viruses. (historyofmedicine.com)
Approaches1
In this work we examined whether the combination of TV005, a LATV-derived formulation, with Tetra DIIIC, a subunit vaccine candidate based on fusion proteins derived from structural proteins from all four DENV serotypes, can overcome the respective limitations of these two vaccine approaches. (bvsalud.org)
Induces2
Typically immunocontraception involves the administration of a vaccine that induces an adaptive immune response which causes an animal to become temporarily infertile. (wikipedia.org)
ConspectusDevelopment of vaccine expertise that induces lengthy lasting and potent adaptive immune responses is of significant significance to fight rising pathogens and to design the subsequent era of most cancers immunotherapies. (elmo1.com)
Viral3
The role of non-viral antigens in the cotton rat model of respiratory syncytial virus vaccine-enhanced disease. (southernbiotech.com)
Even if vaccines do not prevent infection, a vaccine strategy that reduces the viral load and thus transmission and slows down the disease process would be epidemiologically useful and probably feasible. (aerzteblatt.de)
Also, Tetra DIIIC protects mice after challenge with each DENV, and the monovalent formulation obtained from DENV-2 protects monkeys upon homologous viral challenge. (bvsalud.org)
Strains1
HIV-1 strains with chimeric information may degenerate into gibberish. (cdc.gov)
Isolates1
However, the first compelling evi- mutations can be lethal--an organism may be dence for lentivirus recombination in nature was trapped on a fitness peak because locations in the discovery that isolates from sabeus monkeys sequence space near the peak may all be non- in western Africa were chimeras between the viable. (cdc.gov)
Ebola2
this study describes the pathogenesis of the ebola-reston (ebo-r) subtype of ebola virus for experimentally infected cynomolgus monkeys. (liverpool.ac.uk)
Even when exposed to the exact same vaccine, some animals will produce abundant antibody titers to the vaccine's antigen, while others produce relatively low antibody titers. (wikipedia.org)
In the Eppin trial that attained 100% infertility, a small sample size (only 9 monkeys) was used, and even among this small sample 2 monkeys were dropped from the study because they failed to produce sufficiently high antibody titers. (wikipedia.org)
The phase II clinical trial of hCG vaccines was quite successful among women who had antibody titers above 50 ng/mL, but quite poor among those with antibody titers below this threshold. (wikipedia.org)
The target of an antibody plays a significant role in the success of antibody-based therapeutics and diagnostics, and to an extent, that of vaccine development. (preprints.org)
Candidates1
Several vaccine candidates are currently undergoing clinical evaluation. (aerzteblatt.de)
Infection2
Thus far, there is no experimental or clinical evidence that any vaccine will be able to completely prevent HIV infection. (aerzteblatt.de)
An effective vaccine, used alone or in combination with a drug, could play a critical role in the overall elimination strategy by preventing disease progression in individuals in the early stages of infection. (internationaltextbookofleprosy.org)
Experimental1
While observational studies yield results more quickly and do not deprive subjects of what could be protective measures, the reported discrepancies in protection between experimental and observational studies suggest that, due to year-to-year variances in leprosy incidence rates, experimental studies are better suited to distinguish protective vaccines [4] . (internationaltextbookofleprosy.org)
Development5
Basic and clinical research institutions in Germany are increasingly involved in HIV vaccine development. (aerzteblatt.de)
Recombination also poses theoretical problems for the development of a safe HIV vaccine. (cdc.gov)
The development of live-attenuated vaccines against Dengue virus (DENV) has been problematic. (bvsalud.org)
Thus, the combination of Tetra DIIIC with TV005 offers a potential solution to the reactogenicity problems, which have beset the development of the latter vaccine candidate. (bvsalud.org)
RV can be grown in a wide variety of cell culture systems, andthis has been the cornerstone of vaccine development. (vdocuments.net)
Clinical1
This not only reveals deficiencies or limitations in leprosy control programs because of the dependency upon the emergence of clinical symptoms, but also serves to highlight opportunities for vaccines to positively impact leprosy. (internationaltextbookofleprosy.org)
Virus1
Indeed, WI-38 became used worldwide for human virus vaccine manufacture, to the benefit of billions of people" (Wikipedia article on Leonard Hayflick). (historyofmedicine.com)
Effective1
The production of 'safe and effective' vaccines was a key public health target. (gospanews.net)
Specific2
Among the global fear due to the rapid spread of the COVID-19 and absence of specific treatment or vaccine, the first case of human-to-animal transmission was recorded in Hong Kong, where a 17-years-old Pomeranian dog was affected [ 20 ]. (biomedcentral.com)
In a secondary analysis of RV144, plasma IgA decreased the in vitro ADCC activity of vaccine-induced, Env-specific IgG with the same epitope specificity. (biomedcentral.com)
Human1
111) infected African green monkey kidneycells with throat washings from patients with rubella and indi-rectly demonstrated the presence of RV by resistance to chal-lenge with an echovirus, while Weller and Neva (154) detectedcytopathic effects in human amnion cells infected with RVfrom blood and urine specimens. (vdocuments.net)
Research1
We thank Adimmune Corporation Chairman Dr. Chi-Hsien Chan for his intensive support this research work and lead a team to develop the H7N9 influenza vaccine in Taiwan. (chk1inhibitor.com)
High1
After review-ing a fas-ci-nat-ing sci-en-tif-ic dis-cus-sion about the "tone" that may very well have start-ed the Big Bang ori-gin of the uni-verse, Mr. Emory high-lights a book that has influ-enced him greatly-"The Physics of Immor-tal-i-ty. (spitfirelist.com)
Studies2
Modelling studies have estimated that 80% vaccine coverage will result in a 63% decrease in cervical cancer incidence in 20-29 year old women by 2025 [4]. (chk1inhibitor.com)
For these studies, we use the common marmoset ( Callithrix jacchus ), a New World monkey. (nih.gov)