• recognition
  • Endogenous type I IFN production after innate immune recognition of tumor cells is critical for generating natural adaptive immune responses against tumors in vivo. (jimmunol.org)
  • We have recently uncovered a critical role for endogenous type I IFN production in the innate immune recognition of tumors, which serves as a bridge to a spontaneous adaptive T cell response ( 3 , 4 ). (jimmunol.org)
  • This type I IFN-dependent innate tumor recognition pathway appears crucial for directing the initial adaptive immune response against several murine tumors but is not always sufficient to enable tumor regression, largely because of the upregulation of immune inhibitory mechanisms that also come into play ( 6 - 8 ). (jimmunol.org)
  • membrane
  • Platelet activation (through agonists such as thrombin, Type II collagen and ADP) results in "membrane flipping" where the platelet releases α- and dense granules and the inner walls of the granules are exposed on the outside of the cell. (wikipedia.org)
  • dendritic
  • Dendritic cells are present in those tissues that are in contact with the external environment, such as the skin (where there is a specialized dendritic cell type called the Langerhans cell) and the inner lining of the nose, lungs, stomach and intestines. (wikipedia.org)
  • surfaces
  • In addition, many of acquired nonself surfaces e.g. carcinoembryonic/oncofetal type neoantigens carrying "internal danger source"/"self turned nonself" type pathogen pattern are also identified and destroyed (e.g. by complement fixation or other cytotoxic attacks) or sequestered (phagocytosed or ensheathed) by the immune system by virtue of the CLRs. (wikipedia.org)
  • types
  • Three types of influenza viruses affect people, called Type A, Type B, and Type C. Usually, the virus is spread through the air from coughs or sneezes. (wikipedia.org)
  • signal
  • Interestingly, while genistein and diadzein are signal molecules involved in the root nodulation process, the same compounds can attenuate osteoporosis in post-menopausal women. (intechopen.com)
  • array
  • Here we present a new integrated and automated microfluidic lectin barcode platform to substantially improve the performance of lectin array for focused glycomic profiling. (readbyqxmd.com)
  • increases
  • A catch bond is a type of noncovalent bond whose dissociation lifetime increases with tensile force applied to the bond. (wikipedia.org)
  • several
  • Their functions include phagocytosis and pinocytosis , presentation of antigens to T and B lymphocytes, and secretion of a variety of products, including enzymes, several complement components and coagulation factors, some prostaglandins and leukotrienes, and several regulatory molecules. (thefreedictionary.com)
  • Dengue is spread by several species of mosquito of the Aedes type, principally A. aegypti. (wikipedia.org)
  • class
  • A hallmark of this class is the presence of a von Willebrand factor type A domain (Pfam:PF00092) (I-domain) of approximately 200 amino acid residues at the N terminus, which confers divalent cation binding properties. (githubusercontent.com)
  • various
  • These techniques initially relied upon the direct physical injection of various visualizable tracer molecules (e.g. (wikipedia.org)
  • These molecules are absorbed locally by the soma (cell body) of various neurons and transported to the axon terminals, or they are absorbed by axons and transported to the soma of the neuron. (wikipedia.org)
  • upon
  • This nomenclature was agreed upon and has been adopted by almost all investigators working on these molecules (by convention, Siglecs are always capitalised. (wikipedia.org)
  • Multiple
  • Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule. (githubusercontent.com)
  • Indeed, multiple other working mechanisms have been proposed for the therapeutic effect of type I IFNs in the cancer context. (jimmunol.org)
  • form
  • MyD88 attracts the IRAK4 molecule, IRAK4 recruits IRAK1 and IRAK2 to form a signaling complex. (wikipedia.org)
  • The type II cultures are generally easier to perform, which has resulted in an imbalance of experiments performed with many studies about type II (even though it is a far less common form). (wikipedia.org)
  • networks
  • Other tracer molecules allow for the visualization of large networks of axonal projections extending from the neurons exposed to the tracer. (wikipedia.org)
  • activity
  • Therefore, the major component of the antitumor activity of sustained high doses of type I IFNs occurs through a direct antiangiogenic effect. (jimmunol.org)
  • negative
  • This type of negative feedback slows the production line when products begin to build up and is an important way to maintain homeostasis in a cell. (wikipedia.org)
  • high
  • However, sustained high doses of type I IFNs in the tumor microenvironment, which are potently therapeutic alone, may function through distinct mechanisms. (jimmunol.org)
  • In the current report, we demonstrate that high-dose intratumoral type I IFNs indeed exerted a profound therapeutic effect in the murine B16 model, which unexpectedly did not increase T cell responses. (jimmunol.org)
  • This type of inhibition can be overcome by sufficiently high concentrations of substrate (Vmax remains constant), i.e., by out-competing the inhibitor. (wikipedia.org)
  • production
  • As one strategy to boost this type I IFN production in the tumor microenvironment, we generated conjugates of IFN-β coupled to tumor-targeting mAbs. (jimmunol.org)
  • complex
  • This type of inhibition causes Vmax to decrease (maximum velocity decreases as a result of removing activated complex) and Km to decrease (due to better binding efficiency as a result of Le Chatelier's principle and the effective elimination of the ES complex thus decreasing the Km which indicates a higher binding affinity). (wikipedia.org)