Whole-genomeGenesProteinDiploid genomeRegions of the genomeSequenceGenomicsSequencingProteins2019ChromatinBioactive moleculesBiolGenomicChromosomeCellularBiologyOrganic moleculesHuman1,000BacterialTargetsMutationsBehaviorPrecisionHaploidReceptorAdaptor2021Including species2017MicrobesCondensationViralEnzymeContentMolecularEpigeneticGeneticAnalysesAtomsInteractionDetection2020DetectChemistryConsistsNucleotidesSmallAdenineAnalysisDrugsDifferentiationSingleSpecific
Whole-genome10
- We analyzed whole-genome sequencing data from 2,511 individuals in the Pan-Cancer Analysis of Whole Genomes (PCAWG) study as well as 489 individuals from four prospective cohorts and found distinct regional mutation type-specific frequencies in tissue and cell-free DNA from patients with cancer that were associated with replication timing and other chromatin features. (nature.com)
- While whole exome sequencing (WES) remains popular and effective as a method of genetically profiling different cancers, advances in sequencing technology has enabled an increasing number of whole-genome based studies. (frontiersin.org)
- Compared to whole genome sequencing (WGS), exome sequencing covers only the 1% of the genome that is translated into protein, greatly reducing the technical burden of data collection and analysis. (frontiersin.org)
- performed the first whole-genome sequencing study on AML cells collected from a single patient. (frontiersin.org)
- Single-molecule DNA-mapping and whole-genome sequencing of individual cells. (ox.ac.uk)
- This added support will help us accelerate the development of the platform, which we believe could add significantly to the understanding of genetic diseases by increasing access to whole genome analysis and by allowing researchers to view and analyze the critical haplotype information that is currently difficult to obtain. (news-medical.net)
- BioNanomatrix has previously been awarded grants to accelerate the development of its single-molecule whole genome imaging platform, to use its nanoscale platform to identify and quantify damage caused to DNA by ionizing radiation and to develop chip-based nanofluidics systems for cell fractionation for applications in cancer diagnostics and research. (news-medical.net)
- In a typical year, CDC performs whole genome sequencing on about 7,000 influenza viruses from original clinical samples collected through virologic surveillance. (cdc.gov)
- Dr Kathie Grant is an internationally recognised expert in the field of foodborne pathogens with 30 years experience in clinical and public health microbiology and a research interest in exploiting whole genome sequencing (WGS) of bacterial pathogens to improve the understanding and control of foodborne bacterial illness. (nottingham.ac.uk)
- Once prohibitively expensive, whole genome sequencing (WGS) was, until recently, only available to the very wealthy and accomplished and/or to researchers with unique access. (cdc.gov)
Genes14
- 1 It turns out that the bacterial genome has a few high-level instructions that control a few middle-level processes, that in turn control a massive number of protein-coding genes. (creation.com)
- It turns out that most of the genes are inactivated through DNA methylation that attaches hydrocarbon molecules to the genetic material. (mpg.de)
- No more than roughly 2% of the human genome is composed of protein-coding genes, while the rest, some 98-99%, constitutes non-coding genome. (helsinki.fi)
- This process allowed us to identify not only what genes were present, but also their order in the genome and the ways they differ from bacterial genes known today - key information to uncovering their evolutionary history and function. (nflbulletin.com)
- G3, Genes/Genomes/Genetics. (usda.gov)
- In addition, these findings provide further support for models in which conflicts between different genes in genomes can drive the process of speciation. (elifesciences.org)
- An influenza virus' genome consists of all genes that make up the virus. (cdc.gov)
- A, C, G and T/U) in each of the genes present in the virus's genome. (cdc.gov)
- Full genome sequencing can reveal the approximately 13,500-letter sequence of all the genes of the influenza virus' genome. (cdc.gov)
- Although genes can be visualized routinely and their positions determined using fluorescence in situ hybridization, or FISH, this mapping method has traditionally been limited to the analysis of a few samples at a time and cannot be used for large-scale genome mapping. (nih.gov)
- Current diagnostic PCR assays target a variety of SARS CoV-2 genes and the vast majority target sequences in regions of the SARS CoV-2 genome that are highly conserved. (who.int)
- The heavy chain of the class I molecule is encoded by genes at HLA-A, HLA-B, and HLA-C loci. (msdmanuals.com)
- Some class I MHC genes encode nonclassical MHC molecules, such as HLA-G (which may play a role in protecting the fetus from the maternal immune response) and HLA-E (which presents peptides to certain receptors on natural killer [NK] cells). (msdmanuals.com)
- DNA methylation is a chemical process through which methyl groups attach to the DNA molecule, affecting the function of genes. (lu.se)
Protein14
- Although BIND currently only accepts protein-protein and protein-nucleic acid interactions, tools are being developed for the site to accept small-molecule data. (biomedcentral.com)
- Serrate RNA effector molecule homolog (SRRT) also known as arsenite-resistance protein 2 (ARS2) is a protein that in humans is encoded by the SRRT gene. (wikipedia.org)
- It enables the binding activity of the mRNA cap binding complex and the adaptor activity of certain protein molecules. (wikipedia.org)
- Nucleus with chromosomes, DNA molecule (double helix), telomere and gene (length of DNA that codes for a specific protein). (istockphoto.com)
- Protein-coding RNA molecules in human embryos have been studied earlier , but research on non-coding RNA molecules is extremely limited. (helsinki.fi)
- In this study, we revealed that Homer3 was phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) in Purkinje cells, and the phosphorylation reduces the affinity for Homer target molecules, resulting in change of the solubility. (jneurosci.org)
- The association of a protein and a molecule can be determined from their co-occurrences in biomedical abstracts. (biomedcentral.com)
- Extensive semantically related co-occurrences of a protein's name and a molecule's name in the sentences of biomedical abstracts can be considered as indicative of the association between the protein and the molecule. (biomedcentral.com)
- PPFBM represents each protein by the other molecules that associate with it in the abstracts referenced in the protein's entries in reliable biological databases. (biomedcentral.com)
- It automatically extracts each co-occurrence of a protein-molecule pair that represents semantic relationship between the pair. (biomedcentral.com)
- Towards this, we present novel semantic rules that identify the semantic relationship between each co-occurrence of a protein-molecule pair using the syntactic structures of sentences and linguistics theories. (biomedcentral.com)
- A demo of PPFBM that annotates each input Yeast protein (SGD (Saccharomyces Genome Database). (biomedcentral.com)
- The viral S gene is important as it codes for the Spike protein which is the molecule that makes contact with, and allows entry of the virus into susceptible host cells, causing infection. (who.int)
- To address this problem, we combine Fab-based labeling of endogenous protein modifications with single-molecule tracking to quantify the dynamics of chromatin enriched with histone H3 lysine-27 acetylation (H3K27ac) and RNA polymerase II serine-5 phosphorylation (RNAP2-Ser5ph). (bvsalud.org)
Diploid genome3
- Phased diploid genome assembly with single-molecule real-time sequencing. (crossref.org)
- These observations claim that a diploid chromosome arranged is not Droxinostat needed for cell success and deviations from a normal diploid genome may be beneficial in tradition and tumors. (molecularcircuit.com)
- 3 However it is unlikely that haploidy is a requirement for loss Droxinostat of tumor suppressor activity since Droxinostat this could also be achieved by selective loss of few chromosomes and maintenance of a largely diploid genome. (molecularcircuit.com)
Regions of the genome2
- Current technologies and methods are largely limited to coding regions of the genome. (frontiersin.org)
- Mutations in other regions of the genome may also be informative for known VOI/VOC detection. (who.int)
Sequence10
- Sequence alterations are abundant in cancer genomes but the proportion of fragments in cell-free DNA (cfDNA) that harbor tumor-specific (somatic) mutations is often low 8 , 9 , making it difficult to detect bona fide variants amidst background noise from sequence changes introduced in library construction and sequencing. (nature.com)
- Second, we highlight the importance and potential of complete or 100% genome sequencing, i.e., the ability to sequence highly repetitive non-coding sequences beyond the reach of current NGS technologies. (frontiersin.org)
- The large black area is a repeat that the human genome project skipped over (they did not yet have the technology to sequence highly repetitive DNA). (creation.com)
- The recently acquired genome sequence of globe artichoke (Cynara cardunculus var. (researchgate.net)
- The same search parameters were applied to reveal the SSR content of 14 other plant species for which genome sequence is available. (researchgate.net)
- The platform is designed to accommodate massively parallel analyses of individual DNA molecules to permit standardized, high-throughput mapping of sequence motifs or polymorphic sites along the DNA. (news-medical.net)
- Genome sequencing is a process that determines the order, or sequence, of the nucleotides (i.e. (cdc.gov)
- Genome sequencing reveals the sequence of the nucleotides in a gene, like alphabet letters in words. (cdc.gov)
- So it is not surprising that in a time of the "Me Me Me Generation " that there might be interest in possessing the ultimate description of "me"- the literal sequence of one's own genome that can be carried in hand. (cdc.gov)
- Francis Collins, Director of the National Institutes of Health described the human genome sequence as "… our own instruction book previously only known to God. (cdc.gov)
Genomics4
- Genome Alberta is a convenor and a catalyst, bridging knowledge and the academic sector to government and industry partners in order to realize the potential of Alberta-made genomics solutions for all. (genomealberta.ca)
- As the integration of NGS in the study and treatment of cancer continues to mature, we believe that the field of cancer genomics will need to move toward more complete 100% genome sequencing. (frontiersin.org)
- DeepOM improves the yield, sensitivity, and throughput of optical genome mapping experiments in applications of human genomics and microbiology. (tau.ac.il)
- In fact, the very first individual genome sequenced, belonging to acclaimed genomics pioneer Craig Venter, was completed in 2007 at a cost of $2.7 billion . (cdc.gov)
Sequencing13
- Real-time DNA sequencing from single polymerase molecules. (crossref.org)
- Highly accurate long-read HiFi sequencing data for five complex genomes. (crossref.org)
- Nanopore sequencing and the Shasta toolkit enable efficient de novo assembly of eleven human genomes. (crossref.org)
- Thus, D-R mapping directly, from a single molecule, revealed characteristics of the single-cell genome that were challenging for short-read sequencing. (ox.ac.uk)
- In a paper published in the journal Nature Biotechnology , University of Cambridge researchers have outlined a new DNA sequencing method which can detect where and how small molecule drugs interact with the targeted genome. (awebfind.biz)
- For the first time, we have identified short non-coding RNA molecules in ova at different stages of maturity, in fertilised ova and in early embryos with the help of sequencing, as well as determined their editing on the molecular level in embryos. (helsinki.fi)
- See how the University of Washington used HiFi sequencing to uncover a key finding about ALS and the human genome. (pacb.com)
- Our revolutionary sequencing technologies combine the completeness of long reads with the accuracy of short reads to provide the most comprehensive view of genomes, transcriptomes, and epigenomes. (pacb.com)
- Sequencing tasks have revealed the information of many animal genomes and thereby enabled the exploration of genome evolution. (molecularcircuit.com)
- The advancement of genome sequencing techniques and the recent high-throughput technologies that study molecular mechanisms have led to exponential explosion of biomedical literatures. (biomedcentral.com)
- The company is also the co-recipient of a five-year grant from the U.S. National Institute of Standards and Technology Advanced Technology Program to co-develop a platform enabling sequencing of the human genome at a cost of $100. (news-medical.net)
- During this time, he pioneered the use of single-molecule sequencing for the reconstruction of complete genomes. (nottingham.ac.uk)
- His research focuses on the efficient analysis of large-scale genomic datasets and new methods for metagenomic analysis and assembly of high-noise single-molecule sequencing data. (nottingham.ac.uk)
Proteins11
- Fratricidal behavior has been found in another bacterium with enzymes or large proteins, but never before in a small molecule. (princeton.edu)
- This detects the binding site in the genome where a small molecule binds to genomic DNA or DNA-associated proteins. (awebfind.biz)
- Professor Sir Shankar Balasubramanian, who led the research, said: 'Chem-map is a powerful new method to detect the site in the genome where a small molecule binds to DNA or DNA-associated proteins. (awebfind.biz)
- Homer proteins are components of postsynaptic density (PSD) and play a crucial role in coupling diverse target molecules. (jneurosci.org)
- Small molecules that behave like drugs can be used to explore the function of various proteins and large molecules, acting as chemical probes. (news-medical.net)
- All proteins associate with other molecules. (biomedcentral.com)
- These associated molecules are highly predictive of the potential functions of proteins. (biomedcentral.com)
- They can be used for determining the textual relations between proteins and molecules. (biomedcentral.com)
- We introduce an information extraction system called PPFBM that predicts the functions of unannotated proteins from the molecules that associate with these proteins. (biomedcentral.com)
- First, it determines the set S r of annotated proteins that is semantically similar to p by matching the molecules representing p and the annotated proteins. (biomedcentral.com)
- RNAi knockdown uses RNA molecules to block the production of specific proteins in cells. (nih.gov)
20191
- Recent achievements highlight the accelerated development of epigenetics, such as the definition of a human DNA methylome at single-nucleotide resolution, the various discoveries of histone variants and modifications, the study of the CpG island in the genome, and the progress of genome-wide nucleosome positioning maps ( Baldi, 2019 ). (frontiersin.org)
Chromatin1
- In this review, we summarize the basic principles manipulating the abovementioned epigenetic pathways and highlight the evidence of the promising clinical and preclinical results using small-molecule inhibitors against chromatin regulators for cancer treatment. (frontiersin.org)
Bioactive molecules3
- Writing Sept. 2 in the journal Science , teams led by Guosheng Liu of the Shanghai Institute of Organic Chemistry (SIOC) and Shannon Stahl of the University of Wisconsin-Madison describe a way to convert carbon-hydrogen bonds into nitriles, common components of bioactive molecules used in medicinal and agricultural applications. (phys.org)
- The new method will help break the stranglehold of carbon-hydrogen bonds present in the chemical feedstocks used to make bioactive molecules . (phys.org)
- The new method described by Liu and Stahl gives chemists prospecting for bioactive molecules a new tool in the search for novel drugs or chemicals for agriculture. (phys.org)
Biol1
- Genome Biol 2 , reports2011 (2001). (biomedcentral.com)
Genomic5
- Motivation: Efficient tapping into genomic information from a single microscopic image of an intact DNA molecule is an outstanding challenge and its solution will open new frontiers in molecular diagnostics. (tau.ac.il)
- Utilization of a convolutional neural network, trained on simulated images of labeled DNA molecules, improves the success rate in the alignment of DNA images to genomic references. (tau.ac.il)
- The powerful method, called Chem-map, lifts the veil of this genomic black box by enabling researchers to detect where small molecule drugs interact with their targets on the DNA genome. (awebfind.biz)
- We are pleased that the NIH has again recognized the potential of our revolutionary nanoscale single-molecule imaging and analysis technology by awarding us this new grant, which is explicitly intended to support the development of a platform to produce consistent linearization and imaging of individual DNA molecules, allowing for high resolution mapping of labeled genomic sites," said Han Cao, Ph.D., chief scientific officer of BioNanomatrix. (news-medical.net)
- The goal of the project is to develop a fully integrated nanochannel chip and reader capable of single-molecule mapping of linearized genomic material extracted directly from a sample, enabling direct visualization and analysis of long strands of DNA in context and at very high resolution. (news-medical.net)
Chromosome3
- The beginning of the human Y chromosome as seen with the Skittle Genome Visualization Tool. (creation.com)
- The necessity of an individual energetic X chromosome per diploid group of autosomes outcomes within an X chromosome to autosome percentage of just one 1:2 that can't be approximated within a haploid genome and causes immitigable dose results for haploid advancement in mammals (Shape? (molecularcircuit.com)
- In addition to addressing basic questions about the mechanisms of how genomes are organized in intact cells, the ability to map gene positions in a large number of samples and cells has already been used to detect very rare chromosome translocation events in cancer and to ask what cellular factors determine where chromosomes break. (nih.gov)
Cellular2
- Picornaviruses replicate their genomes in colaboration with cellular membranes. (researchensemble.com)
- These spatial locations play important roles in gene expression, DNA repair, genome stability, and other cellular activities. (nih.gov)
Biology2
- The researchers say this heralds the application of these molecules as chemical probes to explore viral biology and produce specific antivirals targeting RNA regions of the coronavirus genome. (news-medical.net)
- HIPMap will be a powerful tool in many ongoing efforts to map the genome in 3D space and to translate the findings from these studies to cancer biology," Misteli concluded. (nih.gov)
Organic molecules2
- Opening a broad vista in the search for effective pharmaceuticals, a collaboration of Chinese and U.S. chemists has laid out a highly efficient new method to convert abundant organic molecules into new medicines. (phys.org)
- Nucleotides are organic molecules that are building blocks of nucleic acids, such as RNA and DNA. (cdc.gov)
Human18
- Scientists can use metabolomics, the study of small molecules known as metabolites present in biological samples such as cells, tissues, or organisms to understand human health. (genomealberta.ca)
- A new bacterial molecule with the unsavory tendency to track down and kill others of its own kind has been discovered in the human microbiome by researchers at Princeton's Department of Chemistry . (princeton.edu)
- The first cancer exomes were sequenced soon after the completion of the Human Genome Project in 2001. (frontiersin.org)
- Results: The method is evaluated on acquired images of human DNA molecules stretched in nano-channels. (tau.ac.il)
- The human genome is the most complex computer operating system anywhere in the known universe. (creation.com)
- The human genome operates in four dimensions. (creation.com)
- The genome, though, runs a hyper-complex machine called the human body. (creation.com)
- The human genome is about 1.8m long. (creation.com)
- It provides enormous insights on how some drug therapies interact with the human genome, and makes it easier to develop more effective and safer drug therapies. (awebfind.biz)
- The researchers found that most of the short RNA molecules in human ova belong to a class of molecules that was identified only recently in the ova of humans and primates. (helsinki.fi)
- Improved assembly and variant detection of a haploid human genome using single-molecule, high-fidelity long reads. (pacb.com)
- The virus enters human cells via endocytosis by binding the ACE2 receptor and releasing its positive-sense RNA genome. (news-medical.net)
- BioNanomatrix, Inc. has announced receipt of a grant from the National Human Genome Research Institute of the U.S. National Institutes of Health (NIH). (news-medical.net)
- Chiral molecules have mirror-image versions of themselves, similar to a pair of human hands. (phys.org)
- In 2015, he joined the National Human Genome Research Institute as a founding member of the Genome Informatics Section. (nottingham.ac.uk)
- Ewan led the analysis of the Human Genome gene set, mouse and chicken genomes and the ENCODE project, focusing on non-coding elements of the human genome. (nottingham.ac.uk)
- However, recently it became apparent that the mitochondrial genome, despite its small size, is crucial for the study of human evolution and disease, as mtDNA mutations lead to some serious diseases. (bartleby.com)
- Aim: To detect the expression of molecules associated with Notch signaling pathway in stem cells from human exfoliated deciduous teeth (SHED) cultured in specific differentiation medium, namely, keratinocyte growth medium (KGM). (bvsalud.org)
1,0001
- Kevin is the author of several popular science books including Cracking the Genome and The $1,000 Genome . (nottingham.ac.uk)
Bacterial1
- After bioinformatic prediction and characterization of the biosynthetic enzymes, Brett Covington, a postdoctoral researcher in the Seyedsayamdost lab, managed to pinpoint the molecule in bacterial culture extracts. (princeton.edu)
Targets1
- To understand the molecular-genetic basis of functional specialization and identify potential drug targets specific to each neuron subtype, we performed a genome wide assessment of both gene expression and splicing across EXC, PV, SST and VIP neurons from male and female mouse brains. (jneurosci.org)
Mutations4
- Here, we considered whether identifying somatic mutations genome-wide could enable the detection of an increased number of circulating tumor DNA (ctDNA) alterations and increase the detection of early stage disease. (nature.com)
- Meningococci have a dynamic genome that evolves rapidly through point mutations and frequent recombination. (cdc.gov)
- The VOC differ from the original Wuhan virus as they have mutations across the genome. (who.int)
- Overall, these assays and approaches detect specific mutations or features such as insertions, deletions and point mutations in the SARS CoV-2 genome that are characteristic of a particular VOC/VOI using PCR. (who.int)
Behavior2
- This "genome-first" approach allowed them to screen molecules for two key characteristics: community behavior (thus uncovering the fratricide), and structural or topological novelty. (princeton.edu)
- This is very powerful, because you are basically coding the behavior of molecules leaving the pores," Yaghi said. (scitechdaily.com)
Precision5
- It controls a super-complex biochemistry that acts with single-molecule precision . (creation.com)
- We show that the seBE strategy facilitates robust regulated editing with BE scaffolds containing diverse deaminases, offering a generalizable solution for temporally controlling precision genome editing. (nature.com)
- Rees, H. A. & Liu, D. R. Base editing: precision chemistry on the genome and transcriptome of living cells. (nature.com)
- Chem-map allows researchers to conduct in situ mapping of small molecule-genome interactions with unprecedented precision, by using a strategy called small-molecule-directed transposase Tn5 tagmentation. (awebfind.biz)
- We have seen the journal evolve along with the changing landscape of health and disease, including the increasing use of genome-scale approaches in medical research and clinical practice, the generation and analysis of patient- and population-level data, and the clinical implementation of these approaches in precision medicine and public health. (cdc.gov)
Haploid1
- Here we review the recent literature on haploid genomes and dosage effects and try to embed recent findings in an evolutionary perspective. (molecularcircuit.com)
Receptor1
- It encodes cell surface molecules specialized to present antigenic peptides to the T-cell receptor (TCR) on T cells. (msdmanuals.com)
Adaptor1
- Chemokine secretion was reduced upon inhibition of NF-kappaB, as predicted by upstream regulator analysis of the transcriptomics data, and Toll-like receptors (TLRs) and their adaptor molecule, MyD88 were shown to be important for CCL5 secretion. (cdc.gov)
20211
- Genome Research, 2021. (helsinki.fi)
Including species1
- This method allowed us to take an unprecedented look at the genomes of microbes living up to 100,000 years ago, including species not known to exist today. (nflbulletin.com)
20173
- Genome research 27, 5 ( 2017 ), 722–736. (crossref.org)
- He is also the recipient of a 2017 Guggenheim Foundation Fellowship and is working on a new book on genome editing. (nottingham.ac.uk)
- Multiscale Modelling of Materials and Molecules 2017 will take place at the Biomedical Center of Uppsala University from 12th to 14th of June. (lu.se)
Microbes2
- Natural products chemists like those in the Princeton lab try to discover and understand the molecules that microbes use to interact with their environments: to work together, to acquire food material, to compete and even to kill each other. (princeton.edu)
- By generating previously unknown chemical compounds from the reconstructed genomes of ancient bacteria, our newly published research provides a proof of concept for the potential use of fossil microbes as a source of new drugs. (nflbulletin.com)
Condensation1
- and viral genome condensation for virion assembly. (news-medical.net)
Viral2
- A host of viral RNAs and other RNAs involved in disease processes have also been demonstrated to be targeted effectively by small molecules. (news-medical.net)
- Specifically, we investigate energetics, structure and mobility of the intra-capsid genome as well as mechanical properties of viral capsids, influenced by changes in physiological environment that are important for viral replication. (lu.se)
Enzyme1
- For drug molecules to be effective, they must fit-like a hand into a glove-the targeted molecular niche of an enzyme. (phys.org)
Content1
- There is a lot of information packed into the four letters used to spell out the first dimension of the genome, but this is not even the tip of the iceberg of the total information content in the genome. (creation.com)
Molecular3
- A Molecular Complex is taken to be a stable aggregate of molecules that function when linked together (the ribosome, for example), and the Molecular Complex record lists the series of Interaction records that are present in the complex. (biomedcentral.com)
- But despite decades of clinical use and research, the molecular mode of action with the genome is still not well-understood. (awebfind.biz)
- This list provides the basis for further investigation of the molecular mechanisms of genome organization. (nih.gov)
Epigenetic1
- This article reviews current anticancer small-molecule inhibitors targeting epigenetic modified enzymes and displays their performances in different stages of clinical trials. (frontiersin.org)
Genetic4
- After fertilisation, the genetic material in the mother's ovum and the father's sperm are combined, forming the genome of the embryo. (helsinki.fi)
- Such capabilities could transform biological analyses, permitting highly sensitive detection of genetic information for genome-wide association studies, especially where crucial haplotype information is required. (news-medical.net)
- These capabilities would result in a greater understanding of genetic variation and genetic diseases and also enable applications such as rapid mapping of pathogen genomes. (news-medical.net)
- Until recent years, the mitochondrial genome, located in the mitochondrion, and the genetic information encoded by it have been given little attention. (bartleby.com)
Analyses1
- The first high-quality genome assembly of the globe artichoke has been produced within the Compositae Genome Project and the resequencing analyses of four globe artichoke genotypes, representative of the core varietal types, as well as a genotype of the related taxa cultivated cardoon was, later on, carried out. (researchgate.net)
Atoms1
- Exchanging hydrogen atoms in such molecules for more useful elements is difficult without damaging or destroying the rest of the molecule. (phys.org)
Interaction2
- These 'Interaction' records describe the binding event between two molecules. (biomedcentral.com)
- The 'related databases' page contains links to over 60 interaction and small-molecule databases. (biomedcentral.com)
Detection3
- This approach lays the groundwork for non-invasive cancer detection using genome-wide mutation features that may facilitate cancer screening and monitoring. (nature.com)
- To address these challenges, we developed an approach, called GEnome-wide Mutational Incidence for Non-Invasive detection of cancer (GEMINI), that can identify a much larger number of somatic alterations in cfDNA (Fig. 1 ). (nature.com)
- CoV-2 genome and can be targeted as a region for detection of VOC/VOI. (who.int)
20201
- Genome research 30, 9 ( 2020 ), 1291–1305. (crossref.org)
Detect2
- We used a genome-wide analysis which not only examined differential gene expression levels but could also detect differences in splice isoform usage. (jneurosci.org)
- The aim of this study was to detect the expression of molecules associated with Notch signallng pathway in SHED cultured in specific differentiation medium, namely, KGM. (bvsalud.org)
Chemistry2
- We need more efficient ways to convert feedstocks into useful molecules," explains Stahl, a UW-Madison professor of chemistry. (phys.org)
- It is important to be able to synthesize only one of two mirror images of the molecule, and development of new catalytic methods that achieve this goal, starting with carbon-hydrogen bonds , is highly desired," says Liu, a professor of chemistry at SIOC. (phys.org)
Consists1
- A couple of days from fertilisation, when the embryo consists of four cells, the embryonic genome is already active, producing for the first time several RNA molecules. (helsinki.fi)
Nucleotides1
- The researchers investigated what kind of RNA molecules of 18 to 30 nucleotides ova and embryos contain in different stages of development. (helsinki.fi)
Small8
- Named Streptosactin, it is the first small molecule found to exhibit fratricidal activity. (princeton.edu)
- These findings allow for the development of split-engineered BEs (seBEs), which newly enable small-molecule control over targeted mutator activity. (nature.com)
- Fig. 2: Split-engineered BEs represent a generalizable strategy to enable small-molecule-controlled editing. (nature.com)
- Small molecules are now entering the field, such as baricitinib (Olumiant), which inhibits the inflammatory cascade associated with disease severity. (news-medical.net)
- The current study shifts to small molecules that target RNA. (news-medical.net)
- Small molecules that are directed against RNA are slowly making their appearance as therapeutics, with one drug targeting non-ribosomal RNA approved a few months ago to help patients with spinal muscular atrophy (SMA). (news-medical.net)
- Mitochondrial DNA is just a small part of the genome. (bartleby.com)
- Main tools in our laboratory are: Atomic Force Microscopy (AFM), microcalorimetry, high resolution cryo electron microscopy, fluorescence microscopy (single-molecule FM and Super-Resolution FM), small angle x-ray and neutron scattering (SANS and SAXS). (lu.se)
Adenine1
- The research group also observed that, especially in fertilised ova, miRNA molecules are edited by adding one or more adenine bases to the other end of the molecule. (helsinki.fi)
Analysis3
- Resynthesizing these molecules in the lab from scratch confirmed their structure and allowed us to produce larger quantities for further analysis. (nflbulletin.com)
- Under the direction of BioNanomatrix principal investigator Dr. Ming Xiao, the two-year $399,020 project will develop a nanoscale platform for single-molecule haplotyping imaging and analysis of long strands of DNA at ultra-high resolution in a massively parallel format. (news-medical.net)
- Knowledge on the expression analysis of Notch signaling pathway molecules in SHED cultured in KGM could highlight its involvement in controlling the biological activity of these stem cells, particularly during odontogenesis and other developmental process. (bvsalud.org)
Drugs2
- Each year, millions of cancer patients receive treatment with genome-targeting drugs, such as doxorubicin. (awebfind.biz)
- Our new method can precisely map where drugs bind to the genome, which will help us to develop better drugs in the future. (awebfind.biz)
Differentiation2
- These molecules probably have a key role in, for example, the silencing of specific genome regions and the differentiation of embryonic cells," Vuoristo adds. (helsinki.fi)
- Since the Notch signaling pathway molecules play an important role in differentiation of epithelial cells, it is important to identify the presence of notch signaling molecules in SHED during the process of cell differentiation. (bvsalud.org)
Single2
- Processing of single cells from the LS174T colorectal cancer cell line showed that D-R mapping of single molecules can reveal structural variation (SV) in the genome of single cells. (ox.ac.uk)
- A single ancient tooth preserves the genomes of millions of ancient bacteria. (nflbulletin.com)
Specific3
- These oocyte-specific piwi-interacting RNA (piRNA) molecules, or RNA molecules originating in the ovum, are not found in mice, which are used as the model animal," Vuoristo says. (helsinki.fi)
- As the fertilised ovum develops and the genome of the embryo is activated, the number of oocyte-specific piRNA molecules drops dramatically and the share of the better known micro-RNA (miRNA) molecules in the embryo increases. (helsinki.fi)
- RNA was reverse-transcribed to obtain the cDNA and then proceeded with PCR using specific primers for the Notch signaling pathway molecules (Notch1, Jagged-1, Jagged-2 and, Hes1) as well as stem cell marker (Nanog). (bvsalud.org)