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AntigensAntigens, CDAntigens, CD8Antigens, SurfaceAntigens, NeoplasmAntigens, CD3Antigens, BacterialAntigens, CD38Antigens, CD34Antigens, CD40Antigens, CD19CD40 LigandAntigens, ViralAntigens, CD20Antigens, CD28Antigens, CD44Antigens, CD14Antigens, CD7Antigens, CD2Antibodies, MonoclonalAntigens, DifferentiationCD4-Positive T-LymphocytesAntigens, CD5CD4-CD8 RatioAntigens, CD1Molecular Sequence DataAntigens, Differentiation, T-LymphocyteAntigens, CD56T-LymphocytesAntigens, Differentiation, MyelomonocyticADP-ribosyl CyclaseAntigens, CD53Antigens, CD80Flow CytometryAntigens, CD24Antigens, CD86B-LymphocytesAmino Acid SequenceAntigens, CD13Antigens, ProtozoanHLA AntigensAntigens, Differentiation, B-LymphocyteAntigens, CD95Lymphocyte ActivationAntigens, Polyomavirus TransformingMembrane GlycoproteinsCell LineImmunophenotypingAntigens, CD45H-2 AntigensCell Adhesion MoleculesEpitopesReceptors, Antigen, T-CellNAD+ NucleosidaseAntigens, FungalCD8-Positive T-LymphocytesBase SequenceHistocompatibility Antigens Class IISialic Acid Binding Ig-like Lectin 3Antigens, HelminthAntigens, CD18HLA-DR AntigensAntigens, CD30Carcinoembryonic AntigenAntigens, CD9Cells, CulturedAntigens, CD15Antigens, CD43Antigens, CD11Antigens, Viral, TumorHistocompatibility AntigensHistocompatibility Antigens Class IAntigens, CD36Recombinant ProteinsLectins, C-TypeAntigens, CD58Antigens, CD59ImmunohistochemistryAntigens, CD4Receptors, Antigen, B-CellMice, Inbred BALB CEnzyme-Linked Immunosorbent AssayTumor Cells, CulturedTransfectionCell DifferentiationProliferating Cell Nuclear AntigenAntigens, CD57Antigens, CD46Antigens, CD70HLA-A2 AntigenAntigens, CD11bImmunoglobulin GDendritic CellsAntigens, CD47Antigens, CD11cAntigens, CD31RNA, MessengerCell SeparationMonocytesO Antigens
ReceptorsGlycoproteinProteinAPCsIntercellularCarcinoembryonicAntibodiesDifferent antigensIntracellularCD44LeukocyteDifferentiation AntigensAntibodyGeneProteinsMeSHHumansAdhesion moleculesSignal transductionSurfaceSubstancesHumanSoluble moleculesCellsPolypeptideRecognitionSpecificityMolecularPrecursorImmune responseLymphocytesMarkersPathwaysCeliacCD24Cytoplasmic
Receptors7
  • discuss the role of integrins in T cell- mediated immunity, with a focus on how these receptors participate in lymphocyte recirculation and T cell activation, how antigen stimulation regulates integrin activity, and how integrins define functionally unique subsets of T cells and APCs. (scielo.br)
  • Diaclone offers a large portfolio in the areas of T-cell Immunology, CD antigens, Cytokines, cytokine/chemokine receptors, adhesion molecules and apoptosis related antigens. (caltagmedsystems.co.uk)
  • As the original manufacturer of the highly respected 'B-clones', Diaclone SAS provides highly specific, high quality mouse monoclonal antibodies for the detection of a broad range of Human proteins, including: human CD antigens, cytokines, cytokine/chemokine receptors, adhesion molecules and apoptosis related antigens. (caltagmedsystems.co.uk)
  • Besides the secretion of pro-inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6), the increased expression of receptor repertoire (pattern recognition receptors, PRR) on APCs, mostly macrophages and dendritic cells, occurs as a result of the release of endogenous and exogenous antigens (damage-associated molecular patterns, DAMPs, and pathogen-associated molecular patterns, PAMPs). (hindawi.com)
  • The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. (ningbobio.com)
  • It interacts with SIALIC ACIDS and mediates signaling from B-CELL ANTIGEN RECEPTORS. (bvsalud.org)
  • They can be distinguished by antigen-specific surface receptors and other cell surface molecules called clusters of differentiation (CDs), whose presence or absence define some subsets. (msdmanuals.com)
Glycoprotein3
  • CD1b is a non-polymorphic type 1 integral glycoprotein with a similar structure to MHC class I molecules. (hcdm.org)
  • 9 is a transmembrane glycoprotein that is selectively expressed on the cell surface of B-lymphocytes,where it activates intracellular signaling cascades involving both Ras and phosphatidylinositol 3-kinase pathways.Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. (ningbobio.com)
  • Immunoglobulins (Igs), the term is sometimes used interchangeably with "antibodies," are glycoprotein molecules produced by B lymphocytes and plasma cells in response to an immunogen or after recognition of specific epitopes on the antigen. (medscape.com)
Protein5
  • CMRF35-like molecule 6 (CLM-6) also known as CD300 antigen-like family member C (CD300c) is a protein that in humans is encoded by the CD300C gene. (wikipedia.org)
  • The GL7 antigen, also known as Ly77, is a 35 kD protein. (biolegend.com)
  • The CD9 antigen is also known as p24, tetraspanin-29 (Tspan-29), motility-related protein-1 (MRP-1), and leucocyte antigen MIC3. (bdbiosciences.com)
  • CD166 antigen (Protein name ) , CD166_CANFA from NCBI database. (eiaab.com)
  • LOCUS AB665364 7542 bp RNA linear VRL 27-SEP-2016 DEFINITION Norovirus Hu/GII.4/Osaka/NV2210/2007/JP genes for nonstructural polyprotein, capsid protein, minor capsid protein, partial and complete cds. (cdc.gov)
APCs5
  • Efficient recognition of foreign pathogens by T cells requires adhesive interactions between T cells and other cell types, such as endothelial cells and antigen-presenting cells (APCs), and with components of the extracellular matrix. (scielo.br)
  • Cytotoxic T lymphocytes were determined as the cellular effectors of GVHD, and the key role of antigen-presenting cells (APCs) in T-lymphocyte activation was established during the following years [ 11 , 12 ]. (hindawi.com)
  • Although some antigens (Ags) can stimulate the immune response directly, T cell-dependent acquired immune responses typically require antigen-presenting cells (APCs) to present antigen-derived peptides within major histocompatibility complex (MHC) molecules. (msdmanuals.com)
  • Extracellular antigens (eg, from many bacteria) must be processed into peptides and complexed with surface class II MHC molecules on professional APCs (which specialize in presenting antigens to T cells) to be recognized by CD4 helper T (Th) cells. (msdmanuals.com)
  • Dendritic cells in the skin act as sentinel APCs, taking up antigen, then traveling to local lymph nodes where they can activate T cells. (msdmanuals.com)
Intercellular5
  • The crystal structures of the glycosylated N-terminal two domains of ICAM-1 and ICAM-2 provided a framework for understanding the role of glycosylation in the structure and function of intercellular adhesion molecules (ICAMs). (nih.gov)
  • A cell adhesion molecule of the immunoglobulin superfamily that is expressed by ENDOTHELIAL CELLS where it functions to stabilize INTERCELLULAR JUNCTIONS . (nih.gov)
  • The lymphocyte function-associated antigen 1 I domain is a transient binding module for intercellular adhesion molecule (ICAM)-1 and ICAM-3 in hydrodynamic flow. (ox.ac.uk)
  • The I domain of lymphocyte function-associated antigen (LFA)-1 contains an intercellular adhesion molecule (ICAM)-1 and ICAM-3 binding site, but the relationship of this site to regulated adhesion is unknown. (ox.ac.uk)
  • All of the lines possess surface human leukocyte antigen (HLA) class I and intercellular adhesion molecule-1 (ICAM-1). (medscape.com)
Carcinoembryonic2
  • Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8. (cusabio.cn)
  • Diagnostic features distinguishing malignant mesothelioma from adenocarcinoma include negative test results for periodic acid-Schiff stain, mucicarmine stain, carcinoembryonic antigen, and Leu M1 and positive test results for calretinin, vimentin, and cytokeratin. (medscape.com)
Antibodies4
  • Cross-reactivity with bovine cells of monoclonal antibodies submitted to the 6th International Workshop on Human Leukocyte Differentiation Antigens. (ox.ac.uk)
  • Twelve subpanels of monoclonal antibodies (MAb) included within the 6th International Workshop on Human Leukocyte Differentiation Antigens (6th HLDA) were assayed for reactivity with bovine peripheral blood leukocytes. (ox.ac.uk)
  • The cellular response is mainly a lymphocyte-mediated reaction, whereas the humoral response includes production of antibodies against the antigen by the plasma cells. (medscape.com)
  • The antibodies then specifically bind to only those particular antigens. (medscape.com)
Different antigens1
  • Variable region constitutes the antibody binding region of the molecule to the different antigens as it consists of about 110 amino acids that vary widely among the different antibody molecules. (medscape.com)
Intracellular1
  • Intracellular antigens (eg, viruses) can be processed and presented to CD8 cytotoxic T cells by any nucleated cell because all nucleated cells express class I MHC molecules. (msdmanuals.com)
CD443
  • CD44 antigen isoform 1 precursor. (biossusa.com)
  • We aimed to determine the significance of detecting expression of some antigens that might be pivotal to the process, namely CD44 and CD117, in patients with active pemphigus vulgaris. (who.int)
  • Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
Leukocyte1
  • Clark GJ, Ju X, Tate C, Hart DN: The CD300 family of molecules are evolutionarily significant regulators of leukocyte functions. (exbio.cz)
Differentiation Antigens1
Antibody7
  • The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes. (wikipedia.org)
  • The GL7 antigen has an epitope containing non-sulfated α2-6-sialyl-LacNAc recognized by the GL7 antibody. (biolegend.com)
  • GL7 high-expressing B cells show higher antibody production and antigen presenting capacity. (biolegend.com)
  • Furthermore, determination of hepatitis B antibody titers could be useful in newly diagnosed CD subjects regardless of age at diagnosis. (mdpi.com)
  • CD79B is a component of the multimeric B cell antigen receptor (along with CD79A and a membrane-bound antibody that acts as the antigen recognition moiety). (guidetoimmunopharmacology.org)
  • [ 17 ] These cell lines express vimentin, cytokeratins 8 and 18, and mesothelial antigen recognized by HBME-1 monoclonal antibody. (medscape.com)
  • ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
Gene1
  • This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. (ningbobio.com)
Proteins1
  • These may be different molecules within the cells like proteins, polysaccharides, or nucleoproteins and may also be the whole cell, like a tumor cell or organisms like bacteria, viruses, fungi, parasites, or agents containing genetic material such as nucleic acids or lipids. (medscape.com)
MeSH1
  • Junctional Adhesion Molecule B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
Humans3
  • These were investigated further by two-colour immunofluorescence to compare the cellular expression of the antigen on cattle cells with that reported for the different CD antigens in humans. (ox.ac.uk)
  • Four of the MAb that belonged to CD23, CD39, CD47, and CDw149 stained bovine cells in a manner that indicated an almost identical cellular distribution of the antigen to that reported in humans. (ox.ac.uk)
  • Other cross-reacting MAb either recognized antigens already defined in cattle or antigens not yet clustered in humans. (ox.ac.uk)
Adhesion molecules1
Signal transduction1
Surface2
  • T-cell surface antigen Leu-12. (ningbobio.com)
  • CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. (exbio.cz)
Substances1
  • A substance or combination of substances used in conjunction with a vaccine antigen to enhance (for example, increase, accelerate, prolong and/or possibly target) or modulate a specific immune response to the vaccine antigen in order to enhance the clinical effectiveness of the vaccine. (who.int)
Human4
  • Experiments with soluble molecules having the N-terminal two domains of human ICAMs identified glycans of the high mannose type N-linked to the second domain of the dendritic cell-specific ICAM-grabbing nonintegrin lectin-ligands ICAM-2 and ICAM-3. (nih.gov)
  • Diaclone ELISA Kits are highly sensitive assays designed for the in-vitro quantitative and qualitative determination of cytokines, CD antigens, apoptosis markers and other analytes from human serum, plasma and cell culture supernatant. (caltagmedsystems.co.uk)
  • His research focuses on functions of several key signaling molecules during development and progression of human diseases, particularly in breast cancer and leukemia. (sc.edu)
  • These MAb represented 30 different human CD groups. (ox.ac.uk)
Soluble molecules1
  • The range of kits from Diacone extends across different species with high specificity and affinity for a number of different cytokines and soluble molecules. (caltagmedsystems.co.uk)
Cells17
  • The GL7 antigen is expressed by pre-B and immature B cells, activated T and B cells, and about 20% of TCR-bright thymocytes. (biolegend.com)
  • The authors also argue that memory B and T cell responses are long-lived in the absence of antigen, but they are modulated and influenced by other infections and that memory B and T cells can either provide protective immunity or contribute to immunopathology on infection with homologous or heterologous viruses. (scielo.br)
  • The CD1 family: serving lipid antigens to T cells since the Mesozoic era. (hcdm.org)
  • Recognition of a lipid antigen by CD1-restricted alpha beta+ T cells. (hcdm.org)
  • Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells. (hcdm.org)
  • Failure of trafficking and antigen presentation by CD1 in AP-3-deficient cells. (hcdm.org)
  • Diaclone ELISpot Kits (Enzyme-Linked Immunospot Assays) are highly specific immunoassays for the analysis of cytokine and other soluble molecule production and secretion from T-cells at a single cell level in conditions closely comparable to the in-vivo environment with minimal cell manipulation. (caltagmedsystems.co.uk)
  • Utilising sandwich immuno-enzyme technology, Diaclone ELISpot and Dual ELISpot assays can detect both secreted cytokines and measure the frequency of single cells that simultaneously produce multiple cytokines or other effector molecules. (caltagmedsystems.co.uk)
  • The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkynje cells in the cerebellum. (exbio.cz)
  • Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)
  • Follicular dendritic cells are a distinct lineage, do not express class II MHC molecules, and therefore do not present antigen to Th cells. (msdmanuals.com)
  • More than 300 CDs have been identified many of which are absent from lymphocytes but present on other cells of the immune system. (msdmanuals.com)
  • CD117 by immunohistochemical methods sion molecules, involved in cell-cell and in order to clarify the role of the infiltrating cell matrix interactions and thought to take inflammatory cells in the pathomechanisms part in cell motility [ 2,3 ]. (who.int)
  • The immune system is an inherent self-defense system consisting of cells that helps the body distinguish between self and non-self molecules. (medscape.com)
  • Antigens are the molecules that are recognized and stimulate the cells of immune system. (medscape.com)
  • Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
  • or (f) living vectored cells expressing specific heterologous antigens. (who.int)
Polypeptide1
  • The Ig molecule is a polypeptide heterodimer that is composed of 2 identical light chains and 2 identical heavy chains connected by disulfide bonds (see the image below). (medscape.com)
Recognition1
Specificity1
  • However, the poor sensitivity and specificity of those markers and many other molecules are serious limitations for their routine use in both early (AJCC stage I and II) and advanced stages of melanoma (AJCC stage III and IV). (hindawi.com)
Molecular1
  • Molecular Components of the Immune System The immune system consists of cellular components and molecular components that work together to destroy antigens (Ags). (msdmanuals.com)
Precursor1
  • Inducible T-cell co-stimulator precursor (Activation-inducible lymphocyte immunomediatory molecule) (CD278 antigen). (lu.se)
Immune response2
  • Regarding the hepatitis B virus, a booster dose of the vaccine is often required due to the low or the lost immune response rate in CD. (mdpi.com)
  • CD), wheat allergy (WA), and non-celiac tion and the immune response it presents gluten sensitivity (NCGS)2. (bvsalud.org)
Lymphocytes1
Markers1
  • Each clinicopathologic subtype can be further classified with respect to morphology, immunophenotype, and antigen markers. (medscape.com)
Pathways1
  • The body's immune system can react adaptively against the antigen via 2 pathways: cellular or humoral. (medscape.com)
Celiac3
  • However, in reality, there is only one condition where gluten is definitively the culprit: celiac disease (CD), affecting approximately 1% of the population in the Western world. (karger.com)
  • Consequently, wheat gluten and the gluten-like hordeins and secalins from barley and rye, respectively, are quite similar to each other, and this causes their toxicity for patients with celiac disease (CD). (karger.com)
  • However, some aspects of the relationship between celiac disease (CD) and vaccines are still unclear. (mdpi.com)
CD241
  • We believe that CD24 is a key molecule of metastatic progression in the epithelial-mesenchymal-transition phenomenon and a promising therapeutic target for advanced ovarian cancer. (cusabio.com)
Cytoplasmic1
  • T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. (exbio.cz)