• This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dendritic cells and T cells during inflammatory and immunological responses. (wikipedia.org)
  • Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif. (lookformedical.com)
  • CCR receptors with specificity for a broad variety of CC CHEMOKINES. (lookformedical.com)
  • The ligand of this receptor is CCL20 or in the other name - macrophage inflammatory protein 3 alpha (MIP-3 alpha). (wikipedia.org)
  • Proinflammatory Th17 cells express CCR6 and its ligand CCL20. (wikipedia.org)
  • This protein belongs to family A of G protein-coupled receptor superfamily. (wikipedia.org)
  • The receptors are members of the seven-transmembrane G protein-coupled receptor family. (lookformedical.com)
  • Interleukin 4 (IL-4) and interferon gamma (IFNγ) suppress expression of CCR6 in langerhans cells development and interleukin 10 (IL-10) induces the expression. (wikipedia.org)
  • Colorectal carcinoma cells express CCR6 and CCL20. (wikipedia.org)
  • All four adenosine receptors are expressed on the surface of mouse invariant NKT (iNKT) cells. (guidetomalariapharmacology.org)
  • CCR6 has a key role in connection between immature DC an adaptive immunity. (wikipedia.org)
  • Complement C3a receptor 1 is the receptor for complement factor C3a, a component of the alternative complement cascade. (guidetomalariapharmacology.org)
  • This chemokine receptor is special because it binds only one chemokine ligand CCL20 in compare to other chemokine receptors. (wikipedia.org)
  • A variety of chemokine receptors are expressed on the surface of both tumor and immune cells rendering them sensitive to multiple stimuli that can subsequently influence their migration and function. (frontiersin.org)
  • Indeed, particular chemokine receptors expressed on tumor and immune cells are strongly associated with patient prognosis. (frontiersin.org)
  • Thus, potential targeting of chemokine receptors is highly attractive as a means to quench or eliminate unconstrained tumor cell growth. (frontiersin.org)
  • Beyond this, atypical chemokine receptors also exist and most act as decoy receptors that compete for ligand binding but are unable to deliver normal chemokine receptor signals. (frontiersin.org)
  • On the other hand, overexpression of chemokine receptors on cancer cells facilitates tumor dissemination. (frontiersin.org)
  • Chemokine receptors and their corresponding ligands. (frontiersin.org)
  • Chemokine receptors (red) influence melanoma tumor cell migration/invasion or immune cell trafficking to the tumor lesions. (frontiersin.org)
  • The expression of these receptors and ligands is finely regulated, both spatially and temporally, revealing distinct functions at steady-state and during inflammatory responses. (frontiersin.org)
  • Both immune and non-immune cells express these receptors and ligands, and the impact of this expression differs according to cell types. (frontiersin.org)
  • Colorectal carcinoma cells express CCR6 and CCL20. (wikipedia.org)
  • Expression of CCR6 was found to be up-regulated in colorectal cancer. (wikipedia.org)
  • Novel research has identified a microRNA that is able to downregulate CCR6 in cancer cell lines. (wikipedia.org)
  • WikiMD is the world's largest encyclopedia on nutrition , weight loss , wellness and obesity with a focus on preventing insulin resistance , metabolic syndrome , type 2 diabetes and weight gain . (wikimd.com)