• Muscles is an international, peer-reviewed , open access journal on muscle biology and physiology published quarterly online by MDPI. (mdpi.com)
  • Nature Reviews Molecular Cell Biology 2012;13(2):127-33. (scielo.br)
  • On the importance of these discoveries, Pura Muñoz-Cánoves says: "This finding constitutes an important advance in the understanding of muscle biology, in physiology and muscle dysfunction. (scitechdaily.com)
  • In addition to its implications for muscle research, this study also introduces more general concepts for cell biology, such as the nuclear movement to injury sites. (scitechdaily.com)
  • This study was funded by the Association Française contre les Myopathies, the European Molecular Biology Organization, the Human Frontiers Science Program, MINECO-Spain and the European Research Council. (scitechdaily.com)
  • is a compilation of several examples of molecular biology protocols. (benthamscience.com)
  • The group uses in vitro, ex vivo and in vivo cell and molecular approaches to delineate the signalling pathways controlling gene expression and functional responses of human and murine large vessel and microvascular endothelial cells.Caroline was an associate editor of the Biochemical Journal for over 10 years and is a founder member of the European Vascular Biology Organisation and of the London Vascular Biology Forum. (rvc.ac.uk)
  • After a post-doc at Childrens' Hospital, Boston, where he started to work on muscle structure, he joined to the newly opened Laboratory of Molecular Biology in Cambridge where he stayed for six years. (webofstories.com)
  • John Finch is a retired member of staff of the Medical Research Council Laboratory of Molecular Biology in Cambridge, UK. (webofstories.com)
  • I think, we were the first people to really do combined X-ray work, electron microscope work, and that was the beginning of the basis of structural molecular biology. (webofstories.com)
  • Critical Reviews in Biochemistry and Molecular Biology. (cdc.gov)
  • We are interested in basic mechanisms of striated muscle biology. (hopkinsmedicine.org)
  • What are RNA species are involved in this pathology and what is their role in muscle biology? (lumc.nl)
  • New efforts in understanding the molecular biology and carcinogenesis of laryngeal malignancies have given us knowledge in the evolution of this disease and have shown therapeutic potential. (medscape.com)
  • American Journal of Respiratory Cell and Molecular Biology. (lu.se)
  • This study elucidated effects of glutamine (Gln) supplementation on the cellular muscle development of LBW and normal birth weight (NBW) piglets. (nature.com)
  • We observed a temporarily increased intramuscular availability of free Gln that could have influenced cellular processes in skeletal muscle. (nature.com)
  • Therefore, we complemented our investigations into the cellular development of the skeletal muscle of neonatal piglets with in vitro studies using a primary porcine myogenic cell culture model with Gln supplementation. (nature.com)
  • Cellular and molecular mechanisms regulating skeletal muscle development. (scielo.br)
  • Cellular and molecular regulation of muscle regeneration. (scielo.br)
  • William Roman, main author of the study and researcher at iMM and UPF Barcelona, explains: "Even in physiological conditions, regeneration is vital for muscle to endure the mechanical stress of contraction, which often leads to cellular damage. (scitechdaily.com)
  • Now, we showed a functional relevance for this phenomenon in adulthood during cellular repair and regeneration," says Edgar R. Gomes, group leader at the Instituto de Medicina Molecular and Professor at Faculdade de Medicina da Universidade de Lisboa, who co-led the study. (scitechdaily.com)
  • Her research group (funded by the BBSRC, The Wellcome Trust and the British Heart Foundation) is investigating the molecular mechanisms important for regulating pro- and anti-inflammatory gene expression and downstream cellular functions in response to a range of external stimuli, including ligands for G protein-coupled receptors and growth factor receptors, and exogenous lipoproteins. (rvc.ac.uk)
  • Complex I is the first enzyme of the respiratory chain and has a central role in cellular energy production, coupling electron transfer between NADH and quinone to proton translocation by an unknown mechanism. (mpg.de)
  • Much research has focused on trying to understand the cellular and molecular mechanisms of injury demarcation and activation of repair processes unique to the skeletal muscle. (cdc.gov)
  • Our team is working on the molecular and cellular actors involved in human muscle regeneration , in muscle ageing and in muscular dystrophies including oculopharyngeal muscular dystrophy (OPMD) and Duchenne muscular dystrophy (DMD). (institut-myologie.org)
  • MicroRNA: an emerging predictive, diagnostic, prognostic and therapeutic strategy in ischaemic stroke Cellular and Molecular Neurobiology. (nottingham.ac.uk)
  • We utilize and develop different models: cellular, organoid (muscle-on-a-chip) and mouse models. (lumc.nl)
  • I am molecular and cellular biologist with expertise in virus and microRNAs. (researchgate.net)
  • Cellular Components of the Immune System The immune system consists of cellular components and molecular components that work together to destroy antigens. (msdmanuals.com)
  • This protective mechanism opens the road to a broader understanding of muscle repair in physiology and disease. (scitechdaily.com)
  • Groups led by Stefan Raunser of the Max Planck Institute for Molecular Physiology in Dortmund, Germany, and John Whitney of McMaster University in Canada have now jointly elucidated the high-resolution 3D structure of such an effector from Pseudomonas protegens using cryo-electron microscopy. (mpg.de)
  • We employ an array of imaging techniques to study "structural physiology" of cardiac and skeletal muscle. (hopkinsmedicine.org)
  • The techniques that we use range from single molecule mechanics, (immuno) electron microscopy, exon microarray analysis, in vitro motility assays, low angle X-ray diffraction, cell physiology (including calcium imaging), muscle mechanics, and isolated heart physiology. (bio5.org)
  • The thin myofilaments are filaments of mostly actin and the thick filaments are of mostly myosin and they slide over each other to shorten the fiber length in a muscle contraction. (wikipedia.org)
  • In striations of muscle bands, myosin forms the dark filaments that make up the A band. (wikipedia.org)
  • The goal of this project is to examine the mechanism by which the myosin molecular motor functions in striated muscle. (hopkinsmedicine.org)
  • Using a transgenic model system, the fruit fly Drosophila melanogaster, we will produce models of human myosin-based muscle disease (distal arthrogryposis) and heart disease (hypertrophic cardiomyopathy) to determine the molecular defects that cause abnormal skeletal and cardiac muscle function. (hopkinsmedicine.org)
  • Polarization-resolved microscopy reveals a muscle myosin motor-independent mechanism of molecular actin ordering during sarcomere maturation. (mpg.de)
  • Although, the non-muscle myosin II holoenzyme (myosin) is a molecular motor that powers contraction of actin cytoskeleton networks, recent studies have questioned the importance of myosin motor activity cell and tissue shape changes. (elifesciences.org)
  • Work done using smooth muscle myosin and mammalian non-muscle myosin have demonstrated that phosphorylation of the RLC at conserved Serine and Threonine sites ( Figure 1B , Serine-19 and Threonine-18) activates myosin motor activity, enhances the affinity of myosin for actin, and promotes myosin filament assembly ( Heissler and Sellers, 2016 ). (elifesciences.org)
  • Myosin binding protein-C (MyBP-C) is a muscle regulatory protein that speeds actomyosin cycling kinetics in response to adrenaline (b-adrenergic stimuli) and is one of the two most commonly affected proteins linked to HCM. (bio5.org)
  • The Online Metabolic and Molecular Bases of Inherited Disease. (medscape.com)
  • More proliferation was observed in muscle tissue of LBW-GLN than LBW-ALA piglets at 5 dpn, but there was no clear effect of supplementation on related gene expression. (nature.com)
  • Overall, Gln supplementation stimulated cell proliferation in muscle tissue and in vitro in myogenic cell culture, whereas muscle growth regulatory genes were barely altered. (nature.com)
  • Glutamine is regarded as the most abundant amino acid in the body, is mainly synthesized in skeletal muscle 10 , and muscle tissue is the most important site for Gln storage 11 . (nature.com)
  • Skeletal muscle cells and cardiac muscle cells both contain myofibrils and sarcomeres and form a striated muscle tissue. (wikipedia.org)
  • However, since there are many different non-muscle cell populations that reside within the tissue, these experiments cannot easily distinguish true myonuclei from those of neighboring mononuclear cells. (frontiersin.org)
  • Skeletal muscle is the largest tissue in the body. (frontiersin.org)
  • The use of a muscle creatine kinase germline knockout of the gene encoding Ire1/Ern1 shifts the focus from traditional studies of tissue repair toward the regenerating myofibers. (elifesciences.org)
  • The findings shed new light on mechanisms of regeneration of healthy myofibers after severe tissue injury and suggest interplay between these fibers and muscle satellite cells though mechanisms remain to be elucidated. (elifesciences.org)
  • Skeletal muscle, the most abundant tissue of the body, has remarkable regenerative capacity mainly due to its resident muscle stem cells, also known as satellite cells. (elifesciences.org)
  • A buildup of proteins in this tissue can cause stroke and bleeding in the brain, an accumulation of fluid in the brain (hydrocephalus), difficulty coordinating movements (ataxia), muscle stiffness and weakness (spastic paralysis), seizures, and loss of intellectual function (dementia). (medlineplus.gov)
  • Total nucleic acids were retrospectively extracted from lar mechanisms related to the switch from the acute to the flash-frozen cardiac tissues by using NucliSens easyMAG persistent CV-B infection in human cardiac tissue are still instrument protocols (bioMérieux, Marcy l'Etoile, France) unknown, but they could be related to terminal deletions according to the manufacturer's instructions. (cdc.gov)
  • Skeletal muscle tissue, the organ responsible for locomotion, is formed by cells that have more than one nucleus, an almost unique feature in our body. (scitechdaily.com)
  • third, whole tissue culture was also performed to further demonstrate the different effect of R- and S-albuterol on migration of airway smooth muscle cells. (scirp.org)
  • After removal of blood vessels, connective tissues and cartilage, pure airway smooth muscle tissue was rinsed with PBS twice and cut into small pieces. (scirp.org)
  • It is in general clinical use as a biomarker for muscle tissue injury. (cdc.gov)
  • We investigate conserved myopathic (muscle disease) processes and perform hierarchical and integrative analysis of muscle function from the level of single molecules and macromolecular complexes through the level of the tissue itself. (hopkinsmedicine.org)
  • We will produce several new models of actin and troponin-T-based cardiomyopathies to determine the molecular defects that drive diverse and complex tissue remodeling. (hopkinsmedicine.org)
  • Activation of myostatin signaling in muscle tissue has been demonstrated to be critical to enhancing muscle catabolism, which causes muscle wasting in cancer cachexia ( 22 ). (spandidos-publications.com)
  • Myophosphorylase, the deficient enzyme in McArdle disease, is found in muscle tissue. (medscape.com)
  • During embryonic myogenesis, migration of skeletal myogenic progenitors is essential to generate the anlagen of limbs, diaphragm and tongue, whereas in post-natal skeletal muscles, migration of muscle satellite (stem) cells towards regions of injury is necessary for repair and regeneration of muscle fibres. (crick.ac.uk)
  • Here, we review mechanisms of myogenic stem/progenitor cell migration during skeletal muscle development and post-natal regeneration. (crick.ac.uk)
  • However, the role of individual arms of the UPR in skeletal muscle regeneration remain less understood. (elifesciences.org)
  • Myofiber-specific ablation of IRE1α or XBP1 in mice diminishes skeletal muscle regeneration that is accompanied with reduced number of satellite cells. (elifesciences.org)
  • Finally, targeted ablation of IRE1α also reduces Notch signaling, abundance of satellite cells, and skeletal muscle regeneration in the mdx mice, a model of Duchenne muscular dystrophy. (elifesciences.org)
  • Collectively, our experiments suggest that the IRE1α-mediated signaling promotes muscle regeneration through augmenting the proliferation of satellite cells in a cell non-autonomous manner. (elifesciences.org)
  • However, the mechanisms of muscle regeneration are not yet fully understood. (elifesciences.org)
  • Satellite cells are essential for skeletal muscle regeneration:the cell on the edge returns centre stage. (scielo.br)
  • In vivo , a single administration of agrin promotes cardiac regeneration in adult mice after myocardial infarction, although the degree of cardiomyocyte proliferation observed in this model suggests that there are additional therapeutic mechanisms. (nature.com)
  • Spain) and published on October 15, 2021, in the scientific journal Science describes a new mechanism for muscle regeneration after physiological damage relying on the rearrangement of nuclei. (scitechdaily.com)
  • Although muscle regeneration has been deeply investigated in the past decades, most studies were centered on mechanisms involving other cells, including muscle stem cells, which are required upon extensive muscle damage. (scitechdaily.com)
  • In this study, we found an alternative mechanism of regeneration that is muscle cell autonomous," says Pura Muñoz-Cánoves, group leader at the University Pompeu Fabra, and study leader. (scitechdaily.com)
  • More precisely we are working on RNA metabolism , muscle regeneration , muscle stem cells , and fibrosis , with the final aim of developing innovative therapeutic approaches. (institut-myologie.org)
  • These cell lines are shared in collaboration with many international teams, either to study physiological or pathophysiological mechanisms, or to test innovative therapeutic approaches. (institut-myologie.org)
  • Our research group seeks to understand the underlying mechanisms of heart muscle disease and dysfunction, identify effective preventive and therapeutic strategies, and facilitate the transition from population-level to individual-level cardiovascular medicine. (lu.se)
  • There is a longstanding belief that a given nucleus controls a defined volume of cytoplasm, so when a muscle grows (hypertrophy) or shrinks (atrophy), the number of myonuclei change accordingly. (frontiersin.org)
  • There is a general agreement that hypertrophy is accompanied by the addition of new nuclei from stem cells to help the muscles meet the enhanced synthetic demands of a larger cell. (frontiersin.org)
  • That is, whether acute transient changes in skeletal muscle PRO turnover induced by nutrient manipulation after a single bout of resistance exercise translates into greater gains in lean mass, muscle hypertrophy, and/or exercise performance after chronic training. (lww.com)
  • Airway smooth muscle (ASM) hypertrophy is a cardinal feature of severe asthma, but the underlying molecular mechanisms remain uncertain. (nih.gov)
  • Forced protein kinase B/Akt 1 activation is known to induce myocyte hypertrophy in other muscle types, and, since a number of mediators present in asthmatic airways can activate Akt signaling, we hypothesized that Akt activation could contribute to ASM hypertrophy in asthma. (nih.gov)
  • Although physiological and pathological hypertrophy often involve distinct signaling mechanisms, miR-222 is an exercise-induced. (researchgate.net)
  • Feeding with amino acids can stimulate protein synthesis in all tissues, especially in skeletal muscle as reviewed by Davis et al. (nature.com)
  • A striated muscle fiber contains myofibrils consisting of long protein chains of myofilaments. (wikipedia.org)
  • The unfolded protein response (UPR) is a major mechanism that detects and alleviates protein-folding stresses in the endoplasmic reticulum. (elifesciences.org)
  • These protein deposits most frequently occur in the peripheral nervous system, which is made up of nerves that connect the brain and spinal cord to muscles and sensory cells that detect sensations such as touch, pain, heat, and sound. (medlineplus.gov)
  • Protein deposits in these nerves result in a loss of sensation or in muscle weakness in the extremities (peripheral neuropathy). (medlineplus.gov)
  • During this time he completed the structure of tobacco mosaic virus and solved the structures of a number of protein molecules including the structure of the muscle protein actin and the actin filament. (webofstories.com)
  • Cancer cachexia is characterized by selective depletion of skeletal muscle protein reserves. (aacrjournals.org)
  • Soleus muscles from mice bearing a cachexia-inducing tumor (MAC16) showed an increased protein degradation in vitro , as measured by tyrosine release, when compared with muscles from nontumor-bearing animals. (aacrjournals.org)
  • Treatment of mice bearing the MAC16 tumor with the polyunsaturated fatty acid, eicosapentaenoic acid (EPA), attenuated loss of body weight and significantly suppressed protein catabolism in soleus muscles through an inhibition of an ATP-dependent proteolytic pathway. (aacrjournals.org)
  • Cancer patients with cachexia show a specific depletion of their skeletal muscle mass, whereas the visceral protein compartment remains unchanged (1) . (aacrjournals.org)
  • This loss of muscle protein forms part of the syndrome of cancer cachexia, which results in the loss of function of the cancer patient and eventually death from hypostatic pneumonia, attributable to the loss of respiratory function. (aacrjournals.org)
  • The effector protein, called RhsA, has a toxic component that sits unlocked and ready to fire in a molecular cocoon sealed by a cork-like structure. (mpg.de)
  • Myostatin binding to type IIB activin receptor (ActRIIB) on muscle surface induces the recruitment and activation of activin receptor-like kinase 5 (ALK5), and eventually leads to forkhead box O3 (FoxO3a)-dependent transcription to promote muscle protein breakdown via the ubiquitin-proteasome system ( 23 ). (spandidos-publications.com)
  • Next, the team dissected the molecular mechanism of this observation: "Our experiments with muscle cells in the laboratory showed that the movement of nuclei to injury sites resulted in local delivery of mRNA molecules. (scitechdaily.com)
  • Her laboratory specialises in investigating the functional relevance of molecular signalling pathways in human and animal endothelial cells and a range of other vascular cell types. (rvc.ac.uk)
  • Her laboratory investigates the molecular mechanism of muscle-kidney crosstalk through a muscle-enriched myokine, MG53. (osu.edu)
  • The research in my laboratory is focused on identifying the components and molecular mechanisms regulating actin architecture in cardiac and skeletal muscle during normal development and disease. (bio5.org)
  • Vascular Ageing: Mechanisms, Risk Factors, and Treatment Strategies International Journal of Molecular Sciences. (nottingham.ac.uk)
  • In terms of molecular and physiologic factors, central nervous system dysfunction (inflammation, hypothalamic-pituitary-adrenal axis) leads to perceived reduced physical and mental capacity with no clear motor or cognitive deficiencies. (medscape.com)
  • Plus, the MHA has been strongly supported by the recent developments of molecular genetics. (antiaging-systems.com)
  • A recent study from the Wilkens lab in collaboration with Seoul National University uncovered a novel mechanism of yeast V-ATPase regulation based on biochemical experiments and cryo electron microscopy (cryo-EM) structures of holo V-ATPase and Oxr1 bound V 1 subcomplex. (upstate.edu)
  • Understanding the mechanisms involved in guiding at least under homeostatic or physiological conditions. (lu.se)
  • Fusion depends on muscle-specific proteins known as fusogens called myomaker and myomerger. (wikipedia.org)
  • These mRNA molecules are translated into proteins at the site of injury to act as building blocks for muscle repair," explains William Roman. (scitechdaily.com)
  • Thus EPA antagonizes loss of skeletal muscle proteins in cancer cachexia by down-regulation of proteasome expression, and this may also be the mechanism for inhibition of tumor growth. (aacrjournals.org)
  • Our research is focused on elucidating the structure and function of titin and nebulin, two large filamentous proteins found in muscle. (bio5.org)
  • The question is important from both basic science and clinical perspectives because mutations in sarcomere proteins of muscle are a leading cause of hypertrophic cardiomyopathy (HCM), the most common cause of sudden cardiac death in the young and a prevalent cause of heart failure in adults. (bio5.org)
  • The results uncover a molecular mechanism underlying rosemary vasorelaxant effects and identify new chemical spaces for KCNQ-dependent vasorelaxants . (bvsalud.org)
  • We combine various genome-wide research approaches to identify molecular pathways and biomarkers that are associated with muscle aging, muscle degeneration and OPMD pathology. (lumc.nl)
  • As well, many older individuals suffer from sarcopenia, a protracted muscle wasting disorder that typically begins after the age of 50 and involves a loss of about 1% of muscle mass per year ( Woo, 2017 ). (frontiersin.org)
  • This means that by the age of 80, sarcopenic individuals have lost about 40% of their muscle mass, a key factor in falls, frailty, and nursing home admissions. (frontiersin.org)
  • Loss of muscle mass and frailty are prevalent in many chronic diseases such as chronic obstructive pulmonary disease, cardiac insufficiency, cancer, and chronic kidney disease (CKD) [ 6 ]. (hindawi.com)
  • Most treatments that have been investigated to alleviate this terminal decline have not succeeded in attenuating the loss of muscle mass. (aacrjournals.org)
  • Furthermore, the structure of a complex I assembly intermediate and mutant (structure solved at 4.0 Å resolution) provide detailed molecular insights into complex I assembly and the cause of a hereditary complex I-linked disease, which has been shown to cause the Leigh's disease in humans with various types of mutations. (mpg.de)
  • Here, we propose to use a transgenic animal model system, Drosophila melanogaster (the fruit fly), to define the mechanisms by which mutations in various thin filament components lead to human cardiac disease. (hopkinsmedicine.org)
  • Currently, the major research focus in my lab is understanding the mechanisms by which cMyBP-C regulates contractile speed and mechanisms by which mutations in cMyBP-C cause disease. (bio5.org)
  • GSD type V is an autosomal recessive disease resulting from mutations in the PYGM gene that encodes for the muscle isoform of glycogen phosphorylase (myophosphorylase). (medscape.com)
  • OPMD patients develop muscle weakness from midlife onwards that gradually limit mobility and independence. (lumc.nl)
  • OPMD is recognized by the specific pattern of muscle involvement initially causing ptosis and dysphagia. (lumc.nl)
  • Currently, there are no medical options to prevent or delay muscle weakness in OPMD. (lumc.nl)
  • We investigate the molecular mechanisms that are associated with Reduced PABPN1 levels, and our ultimate goal is to develop a therapy for OPMD. (lumc.nl)
  • Bober E, Franz T, Arnold HH, Gruss P, Tremblay P. Pax-3 is required for the development of limb muscles:a possible role for the migration of dermomyotomal muscle progenitor cells. (scielo.br)
  • Moreover, the expression of some molecules was altered in the muscles from the LCC mice but not in those from the ECC mice compared with their CN mice. (spandidos-publications.com)
  • In conclusion, the molecules with altered expression in the muscles from the ECC and LCC mice were not exactly the same. (spandidos-publications.com)
  • Our research has resulted in the finding of several novel molecular insights into heart muscle disease, including several molecules that are being pursued further towards clinical application. (lu.se)
  • The review also explored a combination of single-cell sequencing technologies and multi-dimensional and multi-molecular analysis approaches in targeting the molecular mechanisms of AID, which would provide a basis for examining the pathogenesis and molecular markers of autoinflammatory and autoimmune disorders in the future. (news-medical.net)
  • Although administration of various myogenic cell types has been done intramuscularly or intravascularly, functional restoration has not been achieved yet in patients with degenerative diseases affecting multiple large muscle. (crick.ac.uk)
  • Muscle samples were collected and myogenic cells were isolated and cultivated. (nature.com)
  • The delayed growth of LBW piglets is mainly due to a slower development of skeletal muscle as the myogenic activity is usually impaired in these animals during the fetal and early postnatal period 3 , 4 . (nature.com)
  • Cachexia has two well-known features: weight loss (mainly due to loss of skeletal muscle and body fat) and inflammation. (spandidos-publications.com)
  • lipid- and inflammation-mediated insulin resistance in skeletal muscle and vasculature. (rvc.ac.uk)
  • CPK levels in the serum may be elevated in a number of health conditions, including muscle degeneration, muscle inflammation, certain endocrine disorders, and as a side effect of prescription medications, such as the "statins" (Wu et al. (cdc.gov)
  • Also, a single question was asked about a personal history of muscle pain not due to physical exertion or injury, which can occur in instances such as chronic muscle inflammation (myositis). (cdc.gov)
  • The IAL aims to synergise the expertise in muscle and neuromuscular diseases of French teams and the expertise in immunology and inflammation of the Brazilian teams . (institut-myologie.org)
  • [ 2 , 3 ] Mild proximal muscle weakness occurs in approximately one third of patients and is more common in older patients. (medscape.com)
  • A fatal infantile form of McArdle disease, characterized by hypotonia, generalized muscle weakness, and progressive respiratory insufficiency, has been reported. (medscape.com)
  • How a germline mutation leads to adult-onset disorder, what protects muscle weakness during early adulthood and what are the signal that leads to the late onset? (lumc.nl)
  • Most patients experience muscle symptoms, such as weakness and cramps, although certain GSDs manifest as specific syndromes, such as hypoglycemic seizures or cardiomegaly. (medscape.com)
  • Although at least 14 unique GSDs are discussed in the literature, the 4 that cause clinically significant muscle weakness are Pompe disease ( GSD type II , acid maltase deficiency), Cori disease ( GSD type III , debranching enzyme deficiency), McArdle disease (GSD type V, myophosphorylase deficiency), and Tarui disease ( GSD type VII , phosphofructokinase deficiency). (medscape.com)
  • Proximal muscle weakness may progress with time, and no specific treatment exists. (medscape.com)
  • When skeletal muscle is injured due to physical or chemical insult, a pool of self-renewing muscle stem cells residing within the skeletal muscles, called satellite cells, can give rise to differentiated myofibers to repair injured muscle ( Charge & Rudinicki, 2004 Chargé SBP, Rudnicki MA. (scielo.br)
  • Günther S, Kim J, Kostin S, Lepper C, Fan CM, Braun T. Myf5-positive satellite cells contribute to Pax7-dependent long-term maintenance of adult muscle stem cells. (scielo.br)
  • In vitro , recombinant agrin promotes the division of cardiomyocytes that are derived from mouse and human induced pluripotent stem cells through a mechanism that involves the disassembly of the dystrophin-glycoprotein complex, and Yap- and ERK-mediated signalling. (nature.com)
  • Muscle is known to regenerate through a complex process that involves several steps and depends on stem cells. (scitechdaily.com)
  • ABDULKADIR, RR, ALWJWAJ, M, RAKKAR, K and OTHMAN, OA, Outgrowth Endothelial Cell Conditioned Medium Negates TNF-alpha-Evoked Cerebral Barrier Damage: A Reverse Translational Research to Explore Mechanisms Stem Cell Reviews and Reports. (nottingham.ac.uk)
  • The SPH Portal provides a comprehensive one-stop platform for partners and donors to identify gaps in a country's health security capacities, assess opportunities to target their financial and technical resources for the maximum public health benefit, and explore mechanisms for collaboration with countries. (who.int)
  • Level of PI(3,5)P2 elevates by 20X its basal level, under hyperosmotic stress, helping cells to sustain salt toxicity, the mechanism of which is incompletely understood. (upstate.edu)
  • The mechanisms underlying these differences remain incompletely understood. (researchgate.net)
  • Muscle cells (including myocytes and muscle fibers) develop from embryonic precursor cells called myoblasts. (wikipedia.org)
  • Skeletal muscle cells are the individual contractile cells within a muscle and are more usually known as muscle fibers because of their longer threadlike appearance. (wikipedia.org)
  • A single muscle such as the biceps brachii in a young adult human male contains around 253,000 muscle fibers. (wikipedia.org)
  • Skeletal muscle fibers are the only muscle cells that are multinucleated with the nuclei usually referred to as myonuclei. (wikipedia.org)
  • In skeletal muscle, at the end of each muscle fiber, the outer layer of the sarcolemma combines with tendon fibers at the myotendinous junction. (wikipedia.org)
  • Recently, two independent models, one from rodents and the other from insects, have demonstrated that nuclei are not lost from skeletal muscle fibers when they undergo either atrophy or programmed cell death. (frontiersin.org)
  • A muscle cell is also known as a myocyte when referring to either a cardiac muscle cell (cardiomyocyte) or a smooth muscle cell, as these are both small cells. (wikipedia.org)
  • Cardiac muscle cells form the cardiac muscle in the walls of the heart chambers, and have a single central nucleus. (wikipedia.org)
  • Cardiac muscle cells are joined to neighboring cells by intercalated discs, and when joined in a visible unit they are described as a cardiac muscle fiber. (wikipedia.org)
  • The cell membrane of a cardiac muscle cell has several specialized regions, which may include the intercalated disc, and transverse tubules. (wikipedia.org)
  • Cardiac muscle like the skeletal muscle is also striated and the cells contain myofibrils, myofilaments, and sarcomeres as the skeletal muscle cell. (wikipedia.org)
  • Although myophosphorylase is present in cardiac muscle and the brain, it is the only isoform present in skeletal muscle. (medscape.com)
  • These findings may provide some clues for therapy which could prevent the muscle wasting in cancer cachexia from progression to the late stage. (spandidos-publications.com)
  • During disease progression most skeletal muscles are affected. (lumc.nl)
  • Medicinal plant rosemary relaxes blood vessels by activating vascular smooth muscle KCNQ channels. (bvsalud.org)
  • KCNQ4 and KCNQ5 regulate vascular smooth muscle excitability and contractility and are implicated as antihypertensive drug targets. (bvsalud.org)
  • Cancer-induced muscle wasting, which commonly occurs in cancer cachexia, is characterized by impaired quality of life and poor patient survival. (spandidos-publications.com)
  • Thus far, studies on muscle wasting using cancer cachectic models have generally focused on early cancer cachexia (ECC), before severe body weight loss occurs. (spandidos-publications.com)
  • This syndrome is prevalent in cancer patients, and muscle wasting is the most prominent symptom of cancer cachexia. (spandidos-publications.com)
  • It is well known that muscle wasting in cancer cachexia is directly related to the poor quality of life of cancer patients and even impacts their survival ( 1 ). (spandidos-publications.com)
  • In the present study, we demonstrate that IRE1α (also known as ERN1) and its downstream target, XBP1, are activated in skeletal muscle of mice upon injury. (elifesciences.org)
  • 2009). However, CPK may also be elevated simply as a result of direct injury to muscle or as a result of recent strenuous physical activity (Clarkson et al. (cdc.gov)
  • The CKQ recall period for whether a participant had a history of a muscle injury or heavy physiclal exertion was the three-day period immediately preceeding NHANES phlebotomy. (cdc.gov)
  • CKQ also collected data on whether the injury or physical exertion caused symptoms of muscle pain. (cdc.gov)
  • Early markers of skeletal muscle injury revealed by cDNA array. (cdc.gov)
  • Here, a cDNA array was used to examine differential gene expression in a tibialis anterior (TA) muscle injury mouse model in ( order to gain an insight to the early mediators involved in skeletal muscle injury/repair mechanisms. (cdc.gov)
  • These results provide insight into the initial events of skeletal muscle injury. (cdc.gov)
  • In this review, we will specifically address the effect of vitamin D on skeletal muscles and its clinical implications, especially frailty and the risk of fall. (hindawi.com)
  • Our latest collaborative work now provides molecular insights into the arming process of Rhs effectors and its importance for toxin release. (mpg.de)
  • To determine their possible roles in tissues and satellite cells in vitro, their expression pattern was examined in tissues from 40-day-old chickens and in satellite cells from the breast muscles of 1-week-old and 2-week-old chickens using RT-PCR and immunocytochemistry analyses. (scielo.br)
  • However, the ubiquitary nature of vitamin D receptor (VDR) suggests potential for widespread effects, which has led to new research exploring the effects of vitamin D on a variety of tissues, especially in the skeletal muscle. (hindawi.com)
  • The discovery that a variety of tissues can express vitamin D receptor (VDR) has opened new ways of research related to vitamin D biological effects and molecular pathways [ 1 - 3 ]. (hindawi.com)
  • Non-muscle cell contractility is critical for tissues to adopt shape changes. (elifesciences.org)
  • RNA sequencing data revealed a high expression of CHL1 in pancreatic islets and adipose tissues compared to liver and muscles tissues. (lu.se)
  • Researchers at the Max Planck Institute for Biophysical Chemistry in Göttingen and the Julius Maximilians University Würzburg have elucidated the underlying molecular mechanisms by which the antiviral compound Molnupiravir blocks the replication of the coronavirus in the event of infection. (mpg.de)
  • Many researchers worldwide have attempted to elucidate the molecular mechanism underlying muscle wasting using the two models ( 5 - 16 ). (spandidos-publications.com)
  • Drosophila melanogaster , the fruit fly, expresses both forms of striated muscle and benefits greatly from powerful genetic tools. (hopkinsmedicine.org)
  • 2) Investigate the effect of aging on passive mechanical properties of Drosophila myocardium with cardiac-specific overexpression of the transcription factor FOXO, which is known to rejuvenate cardiac performance and promote muscle proteostasis in senescent flies. (hopkinsmedicine.org)
  • Tension and Force-Resistant Attachment Are Essential for Myofibrillogenesis in Drosophila Flight Muscle. (mpg.de)
  • studies have shown that the R- and S-enantiomers of racemic albuterol, a β 2 -adrenergic receptor agonist used in asthma treatment, have differential effects on the contractile properties of airway smooth muscle. (scirp.org)
  • By monitoring migratory properties of airway smooth muscle cells in the presence of albuterol isomers, the different effect of albuterol on proliferation and migration of airway smooth muscle cells is probed. (scirp.org)
  • As a kind of well mature pharmaceutical for asthma treatment, it would be very important to distinguish the effect of two different isomers of albuterol on proliferation and migration activities of airway smooth muscle cells. (scirp.org)
  • Primary culture of rat airway smooth muscle cells was performed by enzyme digestion. (scirp.org)
  • Isolation and culture of individual myofibers and their satellite cells from adult skeletal muscle. (scielo.br)
  • Alternative splicing eliminates exon 2 in 0.6-2% of AMPD1 mRNA transcripts in adult skeletal muscle. (jci.org)
  • The BioAge platform has implicated multiple mechanisms in brain aging, including chronic activation of the NLRP3 inflammasome and declining apelin pathway activity. (businesswire.com)
  • These factors are central to the Pathway of Adaptation Model and influence the sequence of events responsible for exercise-induced muscle growth and increased strength expression after nutrient ingestion. (lww.com)
  • 2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)
  • In this review, the clinical trials about curcumin supplementation on diabetes and DCM are presented, and the specific mechanisms by which curcumin might mitigate diabetes and DCM are fully discussed. (frontiersin.org)
  • More than 3 decades ago, the clinical observation that patients with rickets and osteomalacia displayed proximal myopathy suggested a direct link between hypovitaminosis D and muscle function [ 7 ]. (hindawi.com)
  • Alternative splicing of exon 2 in individuals who have inherited this defect provides a mechanism for phenotypic rescue and variations in splicing patterns may contribute to the variability in clinical symptoms. (jci.org)
  • The current clinical therapy for muscle wasting contributes to the recovery of cancer patients, but the mortality rate of cancer is still rising. (spandidos-publications.com)
  • Consequently, a novel strategy for the clinical treatment of cancer-induced muscle wasting is urgently required, and research on this subject is highly necessary ( 2 ). (spandidos-publications.com)
  • RICHMOND, Calif.--( BUSINESS WIRE )--BioAge Labs, Inc. ("BioAge"), a privately held clinical-stage biotechnology company developing therapeutics that target the molecular causes of aging to extend healthy human lifespan, today announced that the company will provide updates on the company's progress in novel target identification and drug development in the brain aging area at upcoming conferences in the US and UK. (businesswire.com)
  • BioAge is a clinical-stage biotechnology company developing a pipeline of treatments to extend healthy lifespan by targeting the molecular causes of aging. (businesswire.com)
  • The mechanisms at play in cancer-related fatigue are clinical, molecular, and psychological, stated Scotté. (medscape.com)
  • While studies have deciphered the genetic and immunological mechanisms of some AID, the pathogenesis and molecular or environmental drivers of most AID are still unclear. (news-medical.net)
  • More important, people found that, during the pathogenesis of asthma, smooth muscle cells could differentiate into the migration phenotype. (scirp.org)
  • The results support the theory that adiponectin might be part of a feedback mechanism improving insulin sensitivity and cardiovascular health in pre-eclamptic patients. (who.int)
  • Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia. (scielo.br)
  • Expression of muscle growth related genes was quantified with qPCR. (nature.com)
  • The cDNA is amplified through in vitro transcription, the addition of a homopolymer tail, or a template-switching mechanism. (news-medical.net)
  • Upon increasing culture times in chicken´s primary skeletal muscle satellite cells, SULF1 and SULF2 expression in 1-week-old chickens was significantly higher than in 2-week-old chickens, suggesting that sulfatases play a key role in satellite cell development. (scielo.br)
  • Therefore, our findings increase our knowledge of sulfatase expression diversity and provide a solid basis for further research concerning this molecular mechanism. (scielo.br)
  • EPA also inhibited growth of the MAC16 tumor in a dose-dependent manner, and this correlated with suppression of the expression of the 20S proteasome α-subunits in tumor cells, suggesting that this may be the mechanism of tumor growth inhibition. (aacrjournals.org)
  • The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression. (mpg.de)
  • RNA-sequencing was used to investigate the expression of CHL1 in human adipose, liver, muscle, and human islets. (lu.se)
  • In addition, gene set enrichment analysis (GSEA) was performed to identify possible molecular signatures that associate with Chl1 expression silencing. (lu.se)
  • A skeletal muscle cell is long and threadlike with many nuclei and is called a muscle fiber. (wikipedia.org)
  • Skeletal muscle is fairly unique in that the mature cells are syncytial and can contain hundreds of nuclei. (frontiersin.org)
  • Gros J, Manceau M, Thomé V, Marcelle C. A common somitic origin for embryonic muscle progenitors and satellite cells. (scielo.br)