• American Journal of Human Genetics. (wikipedia.org)
  • 17 Institute of Human Genetics, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany. (nih.gov)
  • Human molecular genetics. (upf.edu)
  • At Olin she studies the molecular biology and genetics of viruses of mycobacteria. (bepress.com)
  • Dr Sayers has maintained his research interest in the molecular basis of asthma and allergy spending time with the Asthma Genetics Group in Southampton, UK (1998-2001) and in pre-clinical drug development in New Zealand at Genesis Research and Development Corporation and the Malaghan Institute (2001-2003). (nottingham.ac.uk)
  • Realizing the benefits of human genetics and genomics research for people everywhere. (ashg.org)
  • The contest aims to challenge students to examine, question, and reflect on important ideas and issues related to human genetics. (ashg.org)
  • This love encouraged me to pursue a degree in veterinary medicine, followed by a doctorate in molecular genetics and research interests in the field of gene mapping, stem cell biology, and regenerative medicine. (wpi.edu)
  • Prerequisites: genetics or molecular biology. (columbia.edu)
  • Human genetics 2018 10 138 (1): 21-35. (cdc.gov)
  • LGMD classification has been revolutionized with the advent of molecular genetics. (medscape.com)
  • Human Mutation. (wikipedia.org)
  • The majority and most severe FH cases are associated to mutations in the receptor for low-density lipoproteins receptor (LDL-r), but the molecular basis explaining the connection between mutation and phenotype is often unknown, which hinders early diagnosis and treatment of the disease. (upf.edu)
  • We incorporate diverse approaches in experimental evolution, mathematics, systems microbiology, engineering and instrumentation to understand how interactions between cells shape bacterial community behaviours, the value of environmental sensing and phenotypic variation in fluctuating environments, and how phenotypes broadly respond to mutation. (exeter.ac.uk)
  • Notably, LGMD subtypes are phenotypically highly variable, limb-girdle weakness may not be the predominant presentation, and mutation in genes assigned to LGMD subtypes may cause allelic conditions with a different phenotype. (medscape.com)
  • Human Mutation, 36: 638-647. (lu.se)
  • We posit that using human tumor molecular and mutation data as a foundation for functional studies will lead us to novel insights about the fundamental biology of melanoma as well as provide us with inspiration for designing novel therapeutic strategies. (lu.se)
  • Recent genetic studies have identified hundreds of susceptibility genes for common human diseases but genetic effects are small and identifying underlying mechanisms remains challenging. (europa.eu)
  • Genes will be prioritised for study by statistical and informatic analyses using our extensive physiological, gene expression and linkage data in these rat strains, and by comparative analysis with data from human genome-wide association studies. (europa.eu)
  • Confirmed rat disease genes will be tested for conserved functions in humans. (europa.eu)
  • Large human genetic studies showed that genes encoding chromatin and transcriptional regulatory proteins are among the most commonly mutated genes in ASD. (sc.edu)
  • Using co-expression correlation analysis, we identified an overrepresentation of genes associated with neuronal projection development or morphogenesis that are highly correlated with ASH1L in the developing human cerebral cortex. (sc.edu)
  • To identify mutations in COL2A1 and COL11A1 genes and to examine the genotype-phenotype correlation in a cohort of Chinese patients with Stickler syndrome. (molvis.org)
  • COL2A1 and COL11A1 are common candidate genes for Stickler syndrome, and both are related to the form of Stickler syndrome with an obvious ocular phenotype. (molvis.org)
  • More interestingly, PTEN was identified to be one of the downstream genes of miR-29a-3p and participated in the regulation of this miRNA during human diseases [ 21 , 22 ]. (hindawi.com)
  • As a scientist she has been involved in mapping the human genome and identifying genes and mutations, which give rise to heritable disorders. (bepress.com)
  • Atherosclerotic plaques consist mostly of smooth muscle cells (SMC), and genes that influence SMC phenotype can modulate coronary artery disease (CAD) risk. (stanford.edu)
  • The identification of causal or predictive variants/genes/mechanisms for disease-associated traits is characterized by 'complex' networks of molecular phenotypes. (researchgate.net)
  • These diseases are discussed here in part because mutations in 2 genes can present with either an LGMD or a myofibrillar myopathy phenotype. (medscape.com)
  • Analysis of the genotype-phenotype correlation showed that the early onset of high myopia with vitreous abnormalities may serve as a key indicator of Stickler syndrome, while the existence of mandibular protrusion in pediatric patients may be an efficient indicator for the absence of mutations in COL2A1 and COL11A1 . (molvis.org)
  • ARHGEF9 disease: Phenotype clarification and genotype-phenotype correlation. (mpg.de)
  • Background: Smooth muscle cells (SMC) transition into a number of different phenotypes during atherosclerosis, including those that resemble fibroblasts and chondrocytes, and make up the majority of cells in the atherosclerotic plaque. (stanford.edu)
  • The researchers quantified genetic overlap across 25 psychiatric and neurologic disorders from genome-wide association studies (GWAS) of 265,218 patients and 784,643 control persons and assessed the relationship of those disorders to physical and cognitive phenotypes from nearly 1.2 million individuals. (medscape.com)
  • Within the cognitive phenotypes, genetic factors that predispose individuals to certain psychiatric disorders - namely, anorexia, autism, bipolar disorder, and OCD - correlated significantly with factors associated with higher childhood cognitive measures, including more years of education and attending college. (medscape.com)
  • Cbs overdosage is necessary and sufficient to induce cognitive phenotypes in mouse models of Down syndrome and interacts genetically with Dyrk1a. (bvsalud.org)
  • According to the locus heterogeneity and differences in the vitreous phenotype, Stickler syndrome is primarily classified into six subtypes. (molvis.org)
  • Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. (cancerindex.org)
  • To our knowledge, there are no prospective data on the combined effects of parity and breastfeeding by molecular phenotype (e.g., luminal subtypes, HER2-enriched, basal-like). (biomedcentral.com)
  • MiR-29a-3p was enriched in hBMSC-derived Exo, and the Exo from miR-29a-3p mimics transfected hBMSCs could inhibit laryngocarcinoma cell malignant phenotypes in vitro and prevent tumor progression in vivo . (hindawi.com)
  • Ex vivo analysis of human tumor cells complements both in vivo monitoring, which generally measures far fewer features or lacks single cell resolution, and laboratory models, which incur cell type losses, signaling alterations, and genomic changes during establishment. (uib.no)
  • In addition, the transformed cells induced tumor formation in mice and exhibited an apoptosis resistant phenotype, a key characteristic of cancer cells. (cdc.gov)
  • PRDM14 promotes malignant phenotype and correlates with poor prognosis in colorectal cancer. (nih.gov)
  • Our previous study reported a long-term in vitro exposure model for CNT carcinogenicity and showed that 6-month sub-chronic exposure of single-walled carbon nanotube s (SWCNT) causes malignant transformation of human lung epithelial cells. (cdc.gov)
  • WormBase is supported by grant #U24 HG002223 from the National Human Genome Research Institute at the US National Institutes of Health , the UK Medical Research Council and the UK Biotechnology and Biological Sciences Research Council . (wormbase.org)
  • Here, we further examined the gene expression profile by using genome microarrays to profile molecular mechanisms of SWCNT oncogenesis. (cdc.gov)
  • Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology (2015) 185: 33. (biologists.com)
  • These proposals provide a systematic route to elucidating the molecular and functional basis of disease phenotypes in SHR and WKY rats, and for translating these findings to advance understanding of common human diseases. (europa.eu)
  • Illness networks arise from functional interdependencies between the molecular components within human cells. (ed.ac.uk)
  • Dekkers BG , Bos IS, Zaagsma J, Meurs H. Functional consequences of human airway smooth muscle phenotype plasticity. (rug.nl)
  • The functional relevance of a select few novel lncRNAs were verified in vitro.We identified 4579 known and 13 655 de novo lncRNAs in human coronary artery SMC. (stanford.edu)
  • Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach. (mpg.de)
  • The applications to living systems I am interested in include biophysical modelling (active transport and organelle dynamics in cell biology), cognition (perceptual rivalry, computational aspects of networks), molecular networks, functional dynamics in neural and biomedical systems and tipping points in nonautonomous systems. (exeter.ac.uk)
  • Here we show that co-engagement of CD3 and the complement regulator CD46 in the presence of IL-2 induces a Tr1-specific cytokine phenotype in human CD4 + T cells. (nature.com)
  • These CD3/CD46-stimulated IL-10-producing CD4 + cells proliferate strongly, suppress activation of bystander T cells and acquire a memory phenotype. (nature.com)
  • The exosomes (Exo) from human bone marrow mesenchymal stem cells (hBMSCs) after the transfection of miR mimics/inhibitor/si-PTEN were isolated and used to stimulate M4E and Hep2 cells. (hindawi.com)
  • Previous studies indicated that exosomal miR-29a-3p derived from human bone mesenchymal stem cells (hBMSCs) could efficiently suppress cell migrative ability and vasculogenic mimicry in glioma [ 15 ]. (hindawi.com)
  • The discovery opens the possibility that fat cells could be prompted to expend energy by targeting distinct molecular mechanisms in adipose tissue. (eurekalert.org)
  • Pera T , Atmaj C, van der Vegt M, Halayko AJ, Zaagsma J, Meurs H. Role for TAK1 in cigarette smoke-induced proinflammatory signaling and IL-8 release by human airway smooth muscle cells. (rug.nl)
  • Arginase-1+ bone marrow myeloid cells are reduced in myeloproliferative neoplasms and correlate with clinical phenotype, fibrosis, and molecular driver. (nih.gov)
  • PRDM14 mediates chemosensitivity and glycolysis in drug‑resistant A549/cisplatin cells and their progenitor A549 human lung adenocarcinoma cells. (nih.gov)
  • Single-cell transcriptomic analyses revealed that loss of Smad3 altered SMC transition cell state toward two fates: a SMC phenotype that governs both vascular remodelling and recruitment of inflammatory cells, as well as a chondromyocyte fate. (stanford.edu)
  • Human induced pluripotent stem cells--from mechanisms to clinical applications. (mpg.de)
  • Comparative molecular portraits of human unfertilized oocytes and primordial germ cells at 10 weeks of gestation. (mpg.de)
  • The LARGE principle of cellular reprogramming: lost, acquired and retained gene expression in foreskin and amniotic fluid-derived human iPS cells. (mpg.de)
  • Preparation of mouse embryonic fibroblast cells suitable for culturing human embryonic and induced pluripotent stem cells. (mpg.de)
  • Viral and non-viral generation and characterization of induced pluripotent stem cells from human amniotic fluid cells. (mpg.de)
  • During neuronal differentiation of human embryonic stem cells, CAT7 impacts expression and PcG-binding of the MNX1 locus, which encodes a master regulator of motor neuron development. (nih.gov)
  • One candidate, CAT7 was also knocked down in developing (motor) neural cells (grown from human embryonic stem cells). (nih.gov)
  • He is also creating detailed cell phenotypes and vivid images of cell neighborhoods from CyTOF, Codex and MIBI machines, allowing the visualization of cells and tissues with multiple markers and the development of network models of signaling pathways. (stanford.edu)
  • This talk will survey the use of mass cytometry for systems level characterization of cells in healthy human tissues, including blood, bone marrow, and tonsillar tissue, as well as diseases including melanoma, glioblastoma, lymphoma, leukemia, bone marrow failure and myelodysplastic syndromes, and graft vs. host disease. (uib.no)
  • 2 Leelatian, N., Diggins, K. E. & Irish, J. M. Characterizing Phenotypes and Signaling Networks of Single Human Cells by Mass Cytometry. (uib.no)
  • Gene expression profile of human lung epithelial cells chronically exposed to single-walled carbon nanotube s. (cdc.gov)
  • This four-credit course will present a quantitative description of the molecular networks that underlie the myriad phenotypes of living cells, from yeast to human. (columbia.edu)
  • Unlike earlier transcriptomics analyses using single-cell technologies, we observe that cells derived from human embryonic stem cells (hESCs) in the grafts adopt mature dopaminergic signatures. (lu.se)
  • These findings further support the preferred environmental niche of TH-positive cells and confirm their dopaminergic phenotype through the presence of multiple dopaminergic markers. (lu.se)
  • 2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
  • 2002). In humans, SSEA4 is expressed by building the nervous system but also for their prospec- nonneural cells such as the erythrocytes (Kannagi et al. (lu.se)
  • In this study, evidence shows that EVs can fuel hypoxic glioma cells to acquire a lipid droplet (LD+) phenotype and such effect is associated with increased EV internalization through a hypoxia-sensitive mechanism dependent on heparan sulfate proteoglycan (HSPG) receptor and lipid raft-mediated endocytosis. (lu.se)
  • Recent evidence indicates that ciliary defects can lead to a broader set of developmental and adult phenotypes, with mutations in ciliary proteins now associated with nephronophthisis, Bardet-Biedl syndrome, Alstrom syndrome, and Meckel-Gruber syndrome. (nih.gov)
  • The biallelic deletion of Trsp in mice (which impedes selenoprotein synthesis) resulted in cerebellar hypoplasia, seizure, and developmental delay ( 4 )-phenotypes that are congruent with those described in previous clinical reports of SEPSECS mutations ( 5 - 11 ). (frontiersin.org)
  • Although harboring different mutant alleles, patients presented remarkably similar phenotypes typified by an autosomal recessive progressive microcephaly with profound developmental delay, progressive brain atrophy, and hypotonia ( 6 , 7 , 9 ). (frontiersin.org)
  • Advances in sequencing technologies may allow for more efficient diagnosis of disease by combining analyses of phenotypes and gene mutations. (molvis.org)
  • Overlap exists with Congenital Muscular Dystrophy (CMD) as several gene mutations can cause both a LGMD and CMD phenotype. (medscape.com)
  • Specificity evaluation of antibodies against human beta3-adrenoceptors. (rug.nl)
  • The Human Phenotype Ontology (HPO) was created to serve as a standardized vocabulary of phenotypic abnormalities that have been seen in human disease. (wikipedia.org)
  • The molecular data linking seemingly unrelated clinical entities are beginning to highlight a common theme, where defects in ciliary structure and function can lead to a predictable phenotypic pattern that has potentially predictive and therapeutic value. (nih.gov)
  • The immunobiology focus of my lab are the phenotypic and molecular changes in T and B lymphocytes during critical illness and resolution from critical illness, to determine modifiable changes that could improve patient outcomes. (ed.ac.uk)
  • Combining transcriptional data and in silico modeling along with in vitro validation, we identified CAD gene ZEB2 as a target through which these lncRNAs exert their function in SMC phenotypic transition.Expression of a large and diverse set of lncRNAs in human coronary artery SMC are highly dynamic in response to CAD-related stimuli. (stanford.edu)
  • The dynamic changes in expression of these lncRNAs correspond to alterations in transcriptional programs that are relevant to CAD, suggesting a critical role for lncRNAs in SMC phenotypic transition and human atherosclerotic disease. (stanford.edu)
  • The research themes rank around molecular mechanisms matrix proteins and fibers exert in disorders affecting blood vessels, bone, skin and adipose tissue. (mcgill.ca)
  • Topics covered will include high-throughput assay development, screening, chemical library creation, high-throughput chemistry, affinity purification of target proteins and target validation, protein microarrays, molecular evolution, protein engineering and synthetic biology. (columbia.edu)
  • Workplace exposures equivalent to no or low observable proteins and other molecular chaperones (valosin-containing pro- adverse effect concentrations in animals: Step by step tein or VCP) are up-regulated to handle the increase of misfolded approach and damaged proteins which are causing oxidative stress. (cdc.gov)
  • However, in the mid 1990s, other proteins were also found to accumulate in the abnormal muscle fibers, and molecular genetic studies revealed several chromosomal loci. (medscape.com)
  • These sequence variants, along with variants controlling dysregulated gene expression that we characterised previously, most likely include the major determinants of SHR cardiovascular and metabolic disease phenotypes. (europa.eu)
  • Seeing the same study results in the separate models indicates the potential of eventually translating the findings from the bench to the bedside to treat obesity and metabolic disease in humans, McKinsey says. (eurekalert.org)
  • Effects of Deletion of Mutant Huntingtin in Steroidogenic Factor 1 Neurons on the Psychiatric and Metabolic Phenotype in the BACHD Mouse Model of Huntington Disease. (lu.se)
  • Given the essential role of the mitochondria in skeletal muscle and since the derived allele at rs1047626 is known to be associated with greater susceptibility to several neuropsychiatric traits, we propose that adaptation to cold may have driven this selection event, while also impacting predisposition to neuropsychiatric disorders in modern humans. (bvsalud.org)
  • Imbalance of the oxytocin-vasopressin system contributes to the neuropsychiatric phenotype in the BACHD mouse model of Huntington disease. (lu.se)
  • [ 7 ] Full-length human ferritin heavy chain protein (FTH1), which has a DNA-protective role in the nucleus, has been identified as an interacting protein partner for ALADIN in vitro. (medscape.com)
  • The overall objectives of my research are to develop clinically translatable tissue regeneration and drug delivery strategies, and three-dimensional, in vitro human disease models using biologically-derived biomaterials. (wpi.edu)
  • As a scientist and artist I investigate the complex relationship between genotype and phenotype," says Dr. Donis-Keller. (bepress.com)
  • The genetic potential (genotype) is modified by the environment to produce the observable self (phenotype). (bepress.com)
  • Referenced article focusing on the relationship between phenotype and genotype. (cancerindex.org)
  • First of Two COB Talks for 11/14: Can Differential Geometry of Fitness Landscapes Solve the Genotype-Phenotype Problem? (nyu.edu)
  • For example, mutations in TTN gene may present with a wide range of phenotypes ranging from congenital myopathy to late-onset distal myopathy. (medscape.com)
  • Pathogenic copy number variants in patients with congenital hypopituitarism associated with complex phenotypes. (cdc.gov)
  • Specifically, how to best use existing data, what kind of questions we can even ask of it without introducing bias, and how we could combine different datasets to get deeper insights into human biology and disease. (lu.se)
  • It may also provide new insights into the molecular pathways that go awry in common forms of conditions such as obesity and diabetes, which represent major public health concerns [ 8 , 9 ]. (springer.com)
  • Our findings shed light on potential molecular mechanisms and signaling pathways involved in SWCNT oncogenic potential. (cdc.gov)
  • Consistent with their stringent evolutionary conservation, defects in cilia are associated with a range of human diseases, such as primary ciliary dyskinesia, hydrocephalus, polycystic liver and kidney disease, and some forms of retinal degeneration. (nih.gov)
  • McKinsey and his colleagues plan to continue their study of HDAC11 inhibition, with the ultimate goal of developing innovative approaches to treat human diseases. (eurekalert.org)
  • Using two different models of ASH1L haploinsufficiency, we find that reduction in ASH1L leads to altered morphological phenotypes, including decreased neurite outgrowth and enlarged "growth cone-like" structures in human neurons. (sc.edu)
  • We also investigated the extent to which ASH1L pathogenic mutations alter the expression of the transcription factor FOXP1 and its transcriptional regulator RUNX1 in human neurons. (sc.edu)
  • In summary, our work in human neurons demonstrates that ASH1L is an essential regulator of neuronal morphogenesis and maturation and begins to investigate how regulation of FOXP1 by ASH1L contributes to the mechanisms underlying ASH1L-related neuronal deficits. (sc.edu)
  • In addition, our work on iPSCs starts to uncover the role of the ASH1L/FOXP1 axis in the modulation of human pluripotency. (sc.edu)
  • Rodent models offer significant advantages for analysis of disease phenotypes. (europa.eu)
  • The creation of these compendia provided a systemic view of an organelle previously studied primarily in a reductionist fashion and has accelerated both basic scientific discovery and the diagnosis and treatment of human disease. (nature.com)
  • The ontology contains over 50,000 annotations between phenotypes and hereditary disease. (wikipedia.org)
  • Molecular, genetic and cellular mechanisms underlying Asthma & Chronic Obstructive Pulmonary Disease. (nottingham.ac.uk)
  • However, SMC lncRNAs have not been comprehensively characterized, and their regulatory role in SMC state transition remains unknown.A discovery pipeline was constructed and applied to deeply strand-specific RNA sequencing from perturbed human coronary artery SMC with different disease-related stimuli, to allow for the detection of novel lncRNAs. (stanford.edu)
  • My laboratory aims to investigate the molecular and genetic basis of neural circuit function and dynamics, to develop bioinformatic tools for analysis of high-content neural data, and to design rapid cellular and whole-organism screens for therapeutic drugs and genetic modulators affecting neural disease. (wpi.edu)
  • Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes. (mpg.de)
  • The presentations spanned basic science research, deciphering disease signatures using the latest technologies, methods of studying the human immune system directly, taking a systems immunology view, and providing the investment ecosystem to support and realize the research. (stanford.edu)
  • The ability to control the direction of filamentous growth in order to penetrate relevant substrates is fundamental across most environmental fungi but, in the context of human disease, the ensuing tissue damage leads to hyper-inflammation, organ failure and mortality. (exeter.ac.uk)
  • Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition. (lu.se)
  • Two‐dimensional electrophoresis of human placental mitochondria and protein identification by mass spectrometry: toward a human mitochondrial proteome. (nature.com)
  • Some studies have suggested a role for this protein in maintaining centriole-nucleated sensory organelles termed primary cilia, and AS is now considered to belong to the growing class of human genetic disorders linked to ciliary dysfunction (ciliopathies). (springer.com)
  • Snap freezing of the tissue directly after explantation prevents further changes of the biological material, thereby allowing subsequently downstream measurement of cellular parameters, such as mRNA or protein levels in a state that is almost identical to that inside the human body. (tu-dresden.de)
  • KinMutBase is a comprehensive knowledge base for human diseaserelated variations in protein kinase domains. (lu.se)
  • wKinMut: an integrated tool for the analysis and interpretation of mutations in human protein kinases. (lu.se)
  • The paper, titled "Hypoxic Induction of Exosome Uptake through Proteoglycan-Dependent Endocytosis Fuels the Lipid Droplet Phenotype in Glioma" and published at Molecular Cancer Research, shows that exosome-like extracellular vesicles (EVs) may serve anabolic functions by transforming hypoxic, patient-derived human glioblastoma cell lines into a lipid loaded phenotype. (lu.se)
  • The CU-led team studied the effects of inhibiting HDAC11 in mice and in human fat tissue that had been removed from obese patients undergoing bariatric surgery. (eurekalert.org)
  • A new review article published in "Molecular Metabolism" explains how this platform may represent a paradigmatic shift for the study of human islets and diabetes research. (tu-dresden.de)
  • Molecular Metabolism. (lu.se)
  • Applications for the data in the ontology include clinical diagnostics, mapping between phenotypes of model organisms, and as a standard vocabulary for clinical databases. (wikipedia.org)
  • Manu's core hypothesis is that modifiable biological networks generate clinical phenotypes, and such networks could be determined by integration of clinical and immunobiology data. (ed.ac.uk)
  • Marked yield of re-evaluating phenotype and exome/target sequencing data in 33 individuals with intellectual disabilities. (cdc.gov)
  • Dr Heidi Mattock and use genetic data to identify the etiology of human canceRs. (who.int)
  • It's actually a bit of an art, I would say, to really do a data driven approach that lets the data speak without human biases, but also be aware of the methodological biases. (lu.se)
  • Both psychiatric and neurologic disorders showed robust correlations with cognitive and personality phenotypes. (medscape.com)
  • The cytotoxic and immunogenic hurdles associated with non-viral mRNA-mediated reprogramming of human fibroblasts. (mpg.de)
  • FBN2 silencing recapitulates hypoxic conditions and induces elastic fiber impairment in human dermal fibroblasts. (mcgill.ca)
  • Methods presented in the review are being actively used in collaborative efforts within the IMI Consortium RHAPSODY , striving to provide a broad insight into the molecular characteristics of diabetes on European level. (tu-dresden.de)
  • Methods in molecular biology 1346 , 99-113, doi:10.1007/978-1-4939-2987-0_8 (2015). (uib.no)
  • Several investigators identified mutations in human SEPSECS as the cause of severe, early-onset neurological symptoms that were later characterized as causing pontocerebellar hypoplasia type 2D (PCH2D) ( 5 - 11 )-with or without signs of mitochondrial deficiencies that include elevated blood lactate ( 7 ), visual impairment, and myopathy ( 9 ). (frontiersin.org)
  • Asking students to investigate the genetic and environmental components of a complex trait engaged them in deeper thinking about heritability and other influences on human trait development. (ashg.org)
  • The most common classification scheme is based on clinical and molecular characteristics. (medscape.com)
  • MiR-125b participates in the oncogenic role of lncRNA MALAT1 in the phenotypes including cell proliferative and invasive rates in laryngocarcinoma [ 6 ]. (hindawi.com)
  • Evaluation of differentiated human bronchial epithelial cell culture systems for asthma research Journal of Allergy. (nottingham.ac.uk)
  • A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons. (nih.gov)
  • Discovery of Transacting Long Noncoding RNAs That Regulate Smooth Muscle Cell Phenotype. (stanford.edu)
  • We have an opportunity to intervene at the relevant time points, and perhaps guide T cell differentiation towards a desirable phenotype," Good said. (stanford.edu)
  • My group uses a number of biophysical approaches to elicit growth responses from fungal hyphae at the molecular and whole-cell levels. (exeter.ac.uk)
  • CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
  • Journal of computational biology : a journal of computational molecular cell biology, 23(12), 969-975. (lu.se)
  • Gechev TS , Hille J. Molecular basis of plant stress. (rug.nl)
  • He stayed at Sheffield and undertook research into the molecular basis of Immunoglobulin E (IgE) receptor interactions with a focus on therapeutic intervention in allergy graduating with a PhD in 1997. (nottingham.ac.uk)
  • If the molecular or biological basis of the interaction between the genetic and environmental factors is known, be sure to discuss it. (ashg.org)
  • Understanding the molecular basis of AS is critical for the development of specific therapies. (springer.com)
  • A. With these findings we communicate the first Chinese SEPSECS mutant case, and our report indicates that SEPSECS mutations can give rise to a milder phenotype. (frontiersin.org)
  • Immunohisto- have been used for positive selection of NSCs from em- chemistry on human embryonic central nervous system bryonic mice (Nagato et al. (lu.se)
  • the phenotype is complex and all the clinical features are progressive, suggesting a degenerative process. (medscape.com)
  • For ONE complex human trait of your choosing, identify and explain the contributions of at least one genetic factor AND one environmental factor. (ashg.org)
  • Molecular insights into reprogramming-initiation events mediated by the OSKM gene regulatory network. (mpg.de)