Molecular host pathogen interactions. Medical search. Frequent questions

We therefore invite research and review articles for this Special Issue on preclinical and clinical research findings that shed light on the mechanistic details of host-pathogen interactions, molecular pathogenesis, and host-directed therapies, on the development of vaccines and therapeutic agents against mycobacterial infections, and on strategies to diagnose and effectively manage the disease. (mdpi.com)
Additionally, research is encouraged on the mechanism of pathogenesis of Candida species including inter-kingdom microbial interactions. (nih.gov)
Detection of host-pathogen interactions (HPIs) and mapping the re-wired HPI network - along with its structural details - is critical for in-depth understanding of the underlying pathogenesis mechanisms of infections, pathogen-triggered cancers, and developing efficient therapeutics. (nih.gov)
In conclusion, HPIs can help us unravel which human pathways are targeted by pathogenic proteins and how they contribute to pathogenesis of infections and pathogen-triggered cancer. (nih.gov)
Collectively, our data provide evidence for antagonistic roles of individual CDPK paralogs in the control of host cell entry during the early phase of powdery mildew pathogenesis. (apsnet.org)
Her current research focuses on the molecular epidemiology, evolutionary genetics, and pathogenesis of foodborne pathogens such as STEC, Salmonella , and Campylobacter . (asm.org)
The work has examined the pathogenesis of specific gut pathogens (in particular Listeria monocytogenes and Clostridium difficile ) as well as the specific interactions that occur between gut commensals and the host organism. (ucc.ie)
Jacob's current research is focused on identifying mechanisms of type VI secretion system-mediated pathogenesis in Burkholderia pseudomallei and its contribution to host cell death. (utmb.edu)
The mechanisms by which P. gingivalis and its virulence factors interact with host immune cells and contribute to the pathogenesis of periodontitis and CVD are far from completely understood. (intechopen.com)
Aspects to be discussed will include the biology of the pathogen, the pathogenesis of its infection, the pathophysiology of the. (edu.gh)
Advances in Molecular Tools and in Vivo Models for the Study of Human Fungal Pathogenesis. (exeter.ac.uk)

Now molecular methods are enabling much closer inspection of pathogen-host interactions and bridging the fields of microbiology and immunology. (cdc.gov)
Molecular mycology, Immunology of Host pathogen interaction during Candida infection. (exeter.ac.uk)
His career goals include becoming an independent researcher in the fields of immunology and virology, investigating the molecular interactions between hosts and viruses, and understanding how these connections are important for pathogen clearance or establishment of infection. (utmb.edu)
Dr J. Claire Hoving is Associate Professor at the University of Cape Town and Wellcome Trust Intermediate Fellow in Public Health and Tropical Medicine and Senior Lecturer in the Division of Immunology, whose research aims at understanding host immune responses to HIV-related fungal infections. (exeter.ac.uk)
The programme included public health, novel prevention and treatment strategies, basic science of host-pathogen interactions, immunology, antifungal resistance and genomics. (exeter.ac.uk)
In this context, the DTU will focus on animal health topics such as, models for investigation on host-pathogen interaction, immunology, molecular epidemiology, whole genome sequencing and metagenomic analysis. (bund.de)

These single-molecule analyses contribute to shed new light into the molecular mechanisms of bacterial pathogenicity and may help in the search for novel antiadhesive drugs. (medscape.com)
In order to decipher regulatory networks and molecular mechanisms involved in the pathoecology, we use experimental approaches that bridge the fields of bacterial genetics, infection biology, and microbial ecology. (epfl.ch)
Plants host at the contact zone with soil a distinctive root-associated bacterial microbiota believed to function in plant nutrition and health. (nih.gov)
Currently Dr. Arciniega is a member of the Laboratory of Respiratory and Special Pathogens, Division of Bacterial, Parasitic, and Allergenic Products, where he works on the development and improvement of quality control methods for bacterial vaccines. (nih.gov)
In the two years I have been in the program, I have learned a host of molecular biology and bacterial genetics lab techniques," Crigler says. (mtsu.edu)
Bacterial pathogen Legionella pneumophila is the causative agent of Legionnaires' disease, which is associated with intracellular replication of the bacteria in macrophages of human innate immune system. (rcsb.org)
Together, our identification of a unique family of Legionella PI phosphatases highlights a common scheme of exploiting host PI lipids in many intracellular bacterial pathogen infections. (rcsb.org)
Despite the prevalence of asymptomatic bacteriuria and urinary tract infections, the course of bacterial colonization of the urinary tract and the molecular-physiological consequences of human host immune system reactions towards the microbial challenge and progression towards disease symptoms are not fully understood. (jcvi.org)
Gabriel Gomila's Nanoscale Bioelectrical Characterization group and that of Antonio Juárez, Microbial Biotechnology and Host-pathogen Interaction, combined their expertise on microscopic electrical measurements and bacteria respectively to come up with a way to study the response to external electrical fields of just a single bacterial cell. (ibecbarcelona.eu)

AFM single-molecule force spectroscopy analyzes the localization and interactions of the individual cell wall constituents, thereby providing new insight into the molecular mechanisms of pathogen-host adhesion, the role of protein nanomechanics in cell adhesion and mechanosensing, and the assembly and organization of the cell nanosensosomes and nanoadhesomes. (medscape.com)
NIDCR encourages research on the molecular mechanisms that underlie viral pathogenicity and viral interactions with oral cells and tissues caused by viruses including, but not limited to the following oral pathogens:, Epstein Barr virus (EBV), cytomegalovirus (CMV), herpes simplex virus (HSV), and human papillomavirus (HPV) and Kaposi's sarcoma-associated herpesvirus (KSHV). (nih.gov)
Research is needed on characterizing host factors and the underlying immune, molecular and cellular mechanisms for the elimination of opportunistic pathogens in oral reservoirs. (nih.gov)
Studies to determine the mechanisms of action of these factors and to model biologically active peptide regions within the pathogens are supported. (nih.gov)
Adam's research will initially focus on dissecting the mechanisms governing coagulopathy in yellow fever, with the goal of developing broadly-applicable host-directed therapies to treat viral hemorrhagic fever. (nih.gov)
His scientific observations have advanced our understanding of the genetic basis for cardiovascular disease, characterized molecular disease mechanisms and identified both the promise and limitations of translating genomic findings into routine medical practice. (nih.gov)
Scientists continue to populate comprehensive molecular maps that are critically necessary to understand the complex regulatory mechanisms underlying normal hearing. (nih.gov)
In addition, investigation of mechanisms of lung injury including innate immune responses, stretch and mechanically-induced damage, as well as oxidant, cytokine, and enzyme-induced molecular mediators. (nih.gov)
Specific research areas include investigations of cellular and molecular interactions between the infectious agents and lung cells, immune mechanisms important in the pulmonary pathophysiology of pneumonia, HIV and associated opportunistic infections, targeted delivery of therapeutic agents, and behavioral interventions. (nih.gov)
However, the molecular mechanisms how they trigger cancer in the host is generally unknown/incomplete. (nih.gov)
Our results shed light on the molecular mechanisms of resistance to apoptosis, immune evasion and loss of cell junctions that are seen in H. pylori-infected host cells. (nih.gov)
We are committed to the in-depth analysis of mechanisms that allow L. pneumophila to exploit the human host and cause disease. (nih.gov)
This Review discusses the integration of signalling pathways at the lysosome and highlights the interaction of lysosomes with other organelles and mechanisms that ensure lysosome homeostasis. (nature.com)
Subobjective 1B: Develop molecular markers and characterize stripe rust pathogen populations to identify factors and mechanisms of pathogen dynamics for developing new management strategies. (usda.gov)
A complete understanding of the mechanisms governing host-pathogen interactions in the GI tract can be used to inform vaccine or DNA delivery strategies, to combat infections or to exploit the unique properties of these organisms as live vectors for the delivery of novel therapeutics. (ucc.ie)
This course will aim to teach the biology of eukaryotic pathogens with an emphasis on the molecular mechanisms underlying pathogen success. (edu.gh)
Active projects include those focused on the molecular mechanisms underpinning microbial virulence and immune evasion, the origins and mechanisms of antimicrobial resistance (AMR), the adaptation of pathogens to hostile environments, host-microbe interactions, the epidemiology and evolution of disease-causing microbes, and the biotechnological or pharmaceutical applications of microbes and their products. (bath.ac.uk)
Overview of host immunity and fungal pathogens, mechanisms of action of antigungal drugs and drug resistance, sessions of the physiopathology and management of the major pathogenic fungi present in Africa, with a specific focus on Cryptococcosis. (exeter.ac.uk)

Microbial infection is often initiated by the specific adhesion of pathogens to host tissues via cell adhesion proteins referred to as adhesins. (medscape.com)
[ 27 ] Antiadhesive strategies aimed at blocking this interaction offer an attractive means of preventing infection at an early stage. (medscape.com)
Her research programme looks at epiphytic colonisation of leaf surfaces during early infection of wheat by the fungal pathogen Zymoseptoria tritici , using a mix of microscopy, genomics, and metabolomics. (biomedcentral.com)
The Institute supports research on early detection, of oral fungal and viral opportunistic pathogens as well as the development of novel strategies for treating and preventing infection. (nih.gov)
5. Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 (BSL-3) Conditions. (nih.gov)
For example, the authors of a recent article suggested that tolerance-based treatment of HIV infection -focused on increasing the infected patient's ability to remain well despite high HIV load (host tolerance) rather than reducing viral load (host resistance)-could be "evolution-proof," although evolution of the virus toward greater virulence remains a possibility. (cdc.gov)
The Lung Response to Pulmonary Infections, Microbiome, and AIDS Program supports research on the course and pulmonary manifestations of HIV infection, the manifestations of lung disease in people living with HIV, as well as the lung responses to a variety of pathogens that cause pneumonia. (nih.gov)
Intracellular survival of L. pneumophila depends on the activity of more than 300 proteins, or effectors, that are injected into the host cell, where they create conditions favorable for infection. (nih.gov)
We have produced infectious clones of RBDV and have studied some of the molecular aspects of RBDV infection. (hutton.ac.uk)
Genetic variation associated with infection and the environment in the accidental pathogen Burkholderia pseudomallei. (cdc.gov)
Especially epithelial models are suited for infection research to investigate the interaction between pathogens and host surfaces. (fraunhofer.de)
Using the genetically defined flax-flax rust system, he isolated the first rust avirulence protein and showed it is secreted into the host plant cell during infection. (science.org.au)
Scientists working on this problem use innovative technologies to study molecular interactions essential for viral infection, which then guides drug and vaccine development. (sartorius.com)
Sarah's current work focuses on elucidating factors that contribute to pteropine bats' tolerance to infection with henipaviruses and the molecular regulation of pteropine bat innate antiviral pathways. (utmb.edu)
Adam's current work focuses on elucidating how unanchored ubiquitin regulates the DExD/H-box RNA helicase DHX16 in the recognition of viral infection and regulation of host immune responses. (utmb.edu)
Definitive Hosts of Versteria Tapeworms (Cestoda: Taeniidae) Causing Fatal Infection in North America. (cdc.gov)
Research within the group draws upon particular strengths in molecular microbiology, microbial genomics, transcriptomics, bioinformatics, and models of infection. (bath.ac.uk)
Institute of Infection Disease and Molecular Medicine, University of Cape Town, South Africa. (exeter.ac.uk)
His research interests include host-pathogen interaction utilizing the Drosophila model system, specifically innate immune response and stem cell division upon microbial infection. (msj.edu)

Sackler Institute of Molecular Medicine, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. (nih.gov)
Sam's research interest is centered on molecular genetics and plant pathology, focusing on understanding the interaction between cereal crops and its pathogens. (biomedcentral.com)
Weill Institute for Cell and Molecular Biology and Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA. (rcsb.org)
This review discusses C. beticola genetics, genomics and biology and summarizes our current understanding of the molecular interactions that occur between C. beticola and its sugar beet host. (usda.gov)
Research Assistant at Molecular Mycology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India. (exeter.ac.uk)
Dr. Shannon Manning is a Michigan State University (MSU) Foundation Professor in the Department of Microbiology and Molecular Genetics (MMG). (asm.org)
He holds a Ph.D. in Microbiology and Molecular Genetics from Emory University and completed his postdoctoral training at the Yale University School of Medicine. (msj.edu)
The project aims to elucidate genetic interactions between Fusarium graminearum and wheat through a combination of transcriptomics, computational biology, and molecular genetics. (rothamsted.ac.uk)

Her primary research interests include host-pathogen interactions and molecular characterization of diversity and evolution of small RNA viruses. (cdc.gov)

The present study aims to rapidly identify Periplaneta americana fungal pathogens from sewer systems of public hospitals in Esfahan using the polymerase chain reaction (PCR) technique. (iwaponline.com)
Our results show that the use of a combination of morphological, molecular techniques, and phylogenetic analysis can lead to the identification of pathogenic fungal agents in American cockroaches and also knowledge of fungal pathogens-arthropod host relationships. (iwaponline.com)
Periplaneta americana acts as a potential mechanical vector of medically important fungal pathogens from inside sewer systems to hospitals and conversely. (iwaponline.com)
We also discuss the use of animal models in modelling disease of human fungal pathogens, focusing on zebrafish, the silkworm, Galleria mellonella and the murine model. (exeter.ac.uk)
This lecture and practical course focused on the key fungal pathogens in Africa and covered the microbiological, immunological and clinical aspects of fungal diseases. (exeter.ac.uk)

Dimensions of Horizontal Gene Transfer in Eukaryotic Microbial Pathogens. (cdc.gov)
Our main research goal is to obtain mechanistic insight into the virulence strategies of microbial pathogens. (nih.gov)

Through the Oral Opportunistic Pathogens and Viral Disease Program, NIDCR supports basic and translational research on the role of fungi and viruses in oral disease. (nih.gov)
The interplay of opportunistic pathogens of the urinary and vaginal tracts, commensal microbes at the urinary and vaginal tract meatus and the human host will be elucidated. (jcvi.org)
Evidence suggests that it is the early host-inflammatory and immune responses to the oral microbiota that changes the subgingival environment and favors the emergence of periodontal opportunistic pathogens during the development of periodontitis. (intechopen.com)

The COVID-19 pandemic necessitates rapid research to characterize SARS-CoV-2, understand host-pathogen interactions, and develop functional vaccines and therapeutics. (sartorius.com)
We collaborate with Shady Grove Adventist Hospital, Rockville, MD. The objectives are to understand host-pathogen interactions and to determine if the methods are of diagnostic value to provide an alternative to commonly used urine analysis and urine culture tests. (jcvi.org)

Dr. Matzinger received a BA in Biophysics, Biochemistry, and Molecular Biology from Whitman College and her doctorate in Microbiology from the University of California, Davis. (cdc.gov)
BMC Biology together with BMC Plant Biology and BMC Microbiology announce the launch of the collection 'Plants and their Pathogens', for which we invite submissions of manuscripts relevant to the research topic. (biomedcentral.com)
Dr. Brown has a background in biochemistry and molecular biology, as well as over 31 years of experience in industrial research for large traditional pharmaceutical/biological companies. (nih.gov)
The Lung Biology and Disease Branch supports research and research training in lung vascular biology including pulmonary hypertension, lung development and regeneration, acute lung injury and critical care, pulmonary fibrosis and other interstitial lung diseases, rare lung diseases, lung transplantation, and lung host responses to HIV/AIDS and other infections. (nih.gov)
Finally, we discuss future prospects for studying and managing C. beticola infections in the context of newly employed molecular tools to uncover additional information regarding the biology of this pathogen. (usda.gov)
We are introducing Tools of the Trade articles to showcase the role of ECRs in driving technological advancements in molecular cell biology. (nature.com)
Nature Reviews Molecular Cell Biology is committed to facilitating training in peer review and to ensuring that everyone involved in our peer-review process is appropriately recognised. (nature.com)
Stripe rust is one of the most important diseases of wheat throughout the U.S. and stripe rust of barley causes significant yield losses in western U.S. Significant progress has been made in understanding biology of the pathogen, virulence compositions of the pathogen population, identification of new sources of resistance, disease forecasting, and control of the disease using fungicides. (usda.gov)
Erika's PhD Project is titled "Fusarium disease of wheat - exploring tissue specific host-pathogen interactions using a systems biology approach" and is supervised by Dr Martin Urban. (rothamsted.ac.uk)

Biomarker identification from next-generation sequencing data for pathogen bacteria characterization and surveillance. (cdc.gov)
HPI data including structural details is far from complete and experimental characterization of the large-scale inter-species interactions is challenging. (nih.gov)
Identification and molecular characterization of Wolbachia strains in natural populations of Aedes albopictus in China. (cdc.gov)

The host-pathogen interaction is defined as how microbes or viruses sustain themselves within host organisms on a molecular, cellular, organismal or population level. (wikipedia.org)
On the molecular and cellular level, microbes can infect the host and divide rapidly, causing disease by being there and causing a homeostatic imbalance in the body, or by secreting toxins which cause symptoms to appear. (wikipedia.org)
Further research to identify the molecular and cellular basis for inhibition of oral opportunistic infections by factors expressed in saliva and oral mucosal tissues is encouraged. (nih.gov)
Decades of molecular and cellular investigations have advanced all fields of hearing research. (nih.gov)
Research topics include investigation of cellular responses to inflammation, fluid exudation and resorption, and interactions of coagulation pathways with inflammatory mediators in the lung. (nih.gov)
This includes gene, protein and metabolic networks, cellular architecture and intracellular dynamics, cell communication and motility, cell division and differentiation, tissue formation and organogenesis, tissue and organ functions, changes in population characteristics as a consequence of interaction of organisms with their physical environment, with individuals of their own species, and with organisms of other species. (nih.gov)
Our goal is to obtain a detailed mechanistic insight into the regulation and function of L. pneumophila effectors by investigating host-pathogen interactions at a molecular, cellular, and structural level. (nih.gov)
The Department of Immunobiology at Yale is a multi-disciplinary group of investigators committed to understanding the cellular, genetic and molecular basis of these processes. (yale.edu)
Research focuses on the molecular, cellular, and genetic underpinnings of immune system function and development, on host-pathogen interactions, and on a variety of autoimmune disorders. (yale.edu)

We applied our interface-based approach to H. pylori, dominant species in gastric microbiome that greatly increases gastric cancer risk in order to understand how they modulate host immunity and lead to tumorigenesis. (nih.gov)
Dodds showed that this pathogen protein triggers immunity by direct protein-protein interaction with a host resistance protein. (science.org.au)
Immunological reaction is about keeping balance in immunity, so that it protects the host, but doesn't cause too much damage. (cuni.cz)
These non-immune resistance genes usually don't contribute to immunity, but they are crucial in certain interactions (for example the binding of pathogen and host cell). (cuni.cz)
RNA-protein interactions in antiviral immunity and autoimmune diseases. (virginia.edu)

Dr. Bhattacharyya is working with Dr. Deborah Hung to develop rapid, non-culture based diagnostics for a variety of pathogens and from a range of human samples. (massgeneral.org)

Between 2017-2019, Sam took a secondment position at the Australian National University to complete the Australian Research Council Discovery Early Career Research Award project, where he extended his research further to understand the molecular interaction between Myrtaceae tree species and the myrtle rust pathogen. (biomedcentral.com)
Therefore, this project has the following objectives for the next five years: Objective 1: Monitor and characterize stripe rust pathogen populations for providing essential information to growers for implementing appropriate measures to reduce damage on wheat and barley. (usda.gov)

Three thousand four hundred ninety-eight genes were identified, which we call the macrophage intracellular pathogen response (macIPR) gene set. (nih.gov)

Breeding for high-yielding cultivars with improved host resistance is an ongoing effort and prudent cultural practices, such as crop rotation, weed host management and cultivation to reduce infested residue levels, are widely used to manage disease. (usda.gov)
Subobjective 1A: Identify virulent races of stripe rust pathogens to determine effectiveness of resistance genes in wheat and barley. (usda.gov)
Dr Peter Dodds has made internationally acclaimed contributions to understanding the molecular basis of fungal rust resistance in plants. (science.org.au)
This work provided the first evidence for a postulate, based on the long standing gene-for-gene hypothesis that direct and specific protein interactions occurred between flax resistance and flax rust avirulence proteins. (science.org.au)
This research, published in Molecular Plant-Microbe Interactions in September, explored the relationship between nodulation and systemic resistance, the process through which plants protect themselves against pathogens. (sciencedaily.com)
Genetic and molecular analysis of plant disease resistance. (soybiotechcenter.org)
Over the decades, numerous tools have been developed to expedite the study of pathogenicity, initiation of disease, drug resistance and host-pathogen interactions. (exeter.ac.uk)

On February 26, 2019, NIH Director Francis Collins attended an annual congressional reception hosted by The Children's Inn at NIH. (nih.gov)
I joined Prof. Neil Gow's group in Exeter as a post-doctoral researcher in 2019 after completing my PhD in Molecular Microbiology from University of Aberdeen. (exeter.ac.uk)

will be responsible for the food safety topics such as risk assessment on foodborne pathogens, usage of quantitative data for modelling tools and predictive microbiology, monitoring on zoonoses and investigation of foodborne outbreaks. (bund.de)

However, it is not sufficient during the Marburg hemorrhagic fever outbreak in Angola when larger numbers of known pathogens must be consid- in 2004-2005. (cdc.gov)
Because of this, the definition has been expanded to how known pathogens survive within their host, whether they cause disease or not. (wikipedia.org)

The pathogenicity of the periodontal biofilm is highly dependent on a few key species, of which Porphyromonas gingivalis is considered to be one of the most important pathogens. (intechopen.com)

Mitchell and colleagues measured the molecular strength of fibronectin- S. aureus interactions and explored the genetic regulation of the binding process on the surface of living bacteria. (medscape.com)
20 dif- firmed the presence of viruses and bacteria identified by ferent pathogens with high sensitivity, has proven useful other methods, and implicated Plasmodium falciparum in for differential diagnoses of respiratory disease and viral an unexplained fatal case of hemorrhagic feverlike disease hemorrhagic fevers ( 1 - 3 ). (cdc.gov)
Many pathogenic bacteria, such as food-borne Staphylococcus aureus and Clostridium botulinum, secrete toxins into the host to cause symptoms. (wikipedia.org)
This causes an immune response, resulting in common symptoms as phagocytes break down the bacteria within the host. (wikipedia.org)
Many of the bacteria aid in the breaking down of nutrients for the host and, in return, our bodies act as their ecosystem. (wikipedia.org)
10. Creating a More Perfect Union: Modeling Intestinal Bacteria-Epithelial Interactions Using Organoids. (nih.gov)
The treatment of multi-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) or Extended Spectrum β-lactamase (ESBL) producing pathogens is of particular importance today. (fraunhofer.de)
State-of-the-art metagenomics and metaproteomics analysis techniques now allow profiling the complexity of such interactions among the bacteria that colonize the urinary tract and those that cause disease symptoms, as well as the respective inflammatory and microbicidal responses of the human host in more depth. (jcvi.org)
His research group is dedicated to understanding the molecular interactions between bacteria and the host in the gastrointestinal tract. (ucc.ie)
The work demonstrates the potential for gut bacteria to significantly alter host physiological parameters (including immune function, lipid metabolism and circadian rhythm) by coordinating changes to host bile acid profiles. (ucc.ie)

Urinary metaproteomics of urine sediments can be used to characterize host-pathogen interactions and diagnose urinary tract infections and non-infectious inflammatory conditions of the urinary system. (jcvi.org)

Among these, microbial nanoscopy has emerged as a powerful molecular tool for analyzing microbes, including pathogens. (medscape.com)
These drugs are specifically designed to kill microbes or inhibit further growth within the host environment. (wikipedia.org)
I am a molecular microbiologist interested in clinically and industrially important microbes, particularly fungi. (exeter.ac.uk)

PLoS pathogens. (jcvi.org)

In the contest between humans and pathogens, each faction has an evolutionary advantage: we have the brains to plot antimicrobial strategies but they have the means to defeat them through rapid reproduction, genetic selection, and recombination. (cdc.gov)

My research interest was cell cycle regulation by protein kinase and epigenetic regulation of biofilm formation by minor histone variants in human fungal pathogen Candida albicans . (exeter.ac.uk)
The topic of my PhD thesis was to elucidate the role of fungal eicosanoid molecules and micronutrient acquisition in the virulence of human fungal pathogen Candida parapsilosis . (exeter.ac.uk)
My current research focus is the regulation of Zn homoeostasis in human fungal pathogen Candida albicans . (exeter.ac.uk)

HIV and hepatitis B are viral infections caused by blood-borne pathogens. (wikipedia.org)
Molecular epidemiology tools in the management of healthcare-associated infections: towards the definition of recommendations. (cdc.gov)
This similarity in interfaces permits pathogenic protein to compete with host proteins to bind to a target protein, alter physiological signaling and cause persistent infections, as well as cancer. (nih.gov)
She is also studying the impact of pathogen invasion on the gut microbiome and host-pathogen interactions in Streptococcus agalactiae , a leading cause of neonatal infections. (asm.org)
I am currently working on Candida albicans , an opportunistic fungal pathogen that can cause superficial and life-threatening invasive infections in humans. (exeter.ac.uk)

1 Department of Plant Microbe Interactions, Max Planck Institute for Plant Breeding Research, 50829 Cologne, Germany. (nih.gov)
The research targets pathogens that pose high risks to public health and national security. (nih.gov)
NIAID conducts and supports research on basic microbiology of and host response to these pathogens as well as development of medical countermeasures. (nih.gov)
Although toxicity evaluations using human airway ALI models require further standardization and validation, this approach shows promise in supplementing or replacing in vivo animal models for conducting research on respiratory toxicants and pathogens. (cdc.gov)
Her pioneering research on host-pathogen interactions is redefining our definition of health. (worldsciencefestival.com)
The Molecular Biosciences doctorate program aims to produce graduates who are fully prepared to pursue research careers in academia, industry, and at national labs. (mtsu.edu)
The College of Basic and Applied Sciences awards the Doctor of Philosophy (Ph.D.) in Molecular Biosciences through a rigorous, research-oriented course of study. (mtsu.edu)
I started my research career in the field of molecular mycology as a Junior Research Fellow in Jawaharlal Nehru Centre for Advanced Scientific Research, a premier research institute in India under the supervision of Prof. Kaustuv Sanyal. (exeter.ac.uk)
In this webinar sponsored by Sartorius, Dmitri Svergun, Pedro Beltrao, and Christian Loew will discuss how they fast-track COVID-19 virology research by identifying molecular targets and assessing their structure and function for antiviral therapies. (sartorius.com)
For her postdoctoral training, she served as an Emerging Infectious Diseases research fellow through the Centers for Disease Control and Prevention where she studied the molecular epidemiology of Shiga toxin-producing Escherichia coli (STEC) at the Michigan Department of Health and Human Services. (asm.org)
His research interests focus upon host-microbe signalling in the gut mediated via microbial bile acid metabolism (see Joyce et al. (ucc.ie)
Dr. Gahan also has a long history of research work on the foodborne pathogen Listeria monocytogenes (in collaboration with Prof. Colin Hill) resulting in a number of key papers in the area (for example see Corr et al. (ucc.ie)
Her career goals include becoming an independent scientist, pursuing research on zoonotic pathogen-reservoir host interactions that integrates field work and animal conservation, and teaching at the university level. (utmb.edu)
The University of Exeter AFRICA CMM Unit, directed by Professor Gordon Brown, is based at UCT's Institute of Infectious Disease and Molecular Medicine, headed by Professor Valerie Mizrahi, and will give our experts a centre of operations in Africa where they can work in collaboration with UCT experts to establish research programmes that can target the priority areas in fungal diseases that are relevant to the African continent. (exeter.ac.uk)
As an Associate Member of the Institute of Infectious Disease and Molecular Medicine and a contributing investigator of the Wellcome Centre for Infectious Diseases Research in Africa, her current major focus is understanding the immune response to Pneumocystis jirovecii, which is a common cause of pneumonia and death in patients with HIV/AIDS in Africa and which is estimated to kill over 250 000 worldwide every year. (exeter.ac.uk)

We report establishment of a microarray platform for tion is necessarily dependent on the extent to which probes pathogen surveillance and discovery, the GreeneChip sys- are complementary to their targets. (cdc.gov)
The complement cascade comprises over 30 proteins that can mark (opsonize) targets such as pathogens, debris or foreign cells for removal by phagocytes. (frontiersin.org)
Weissleder, R. & Ntziachristos, V. Shedding light onto live molecular targets. (nature.com)

The innate immune response against pathogens are strongly dependent on the communication of different cell types in a three-dimensional tissue structure. (fraunhofer.de)

We investigated the diversity of the root microbiota within a phylogenetic framework of hosts: three Arabidopsis thaliana ecotypes along with its sister species Arabidopsis halleri and Arabidopsis lyrata, as well as Cardamine hirsuta, which diverged from the former ∼ 35 Mya. (nih.gov)
The composition of this root microbiota depends more on interactions with the environment than with host species. (nih.gov)
Host species-specific microbiota were identified at the levels of individual community members, taxonomic groups, and whole root communities. (nih.gov)
However, the branching order of host phylogeny is incongruent with interspecies root microbiota diversity, indicating that host phylogenetic distance alone cannot explain root microbiota diversification. (nih.gov)
Our work reveals within 35 My of host divergence a largely conserved and taxonomically narrow root microbiota, which comprises stable community members belonging to the Actinomycetales, Burkholderiales, and Flavobacteriales. (nih.gov)

Viruses can also infect the host with virulent DNA, which can affect normal cell processes (transcription, translation, etc.), protein folding, or evading the immune response. (wikipedia.org)
this is when the virus inserts its DNA or RNA into the host cell, replicates, and eventually causes the cell to lyse, releasing more viruses into the environment. (wikipedia.org)
Between 2015 and 2017, routine molecular surveillance in the United States detected multiple mumps viruses (MuVs) with mutations in the small hydrophobic (SH) gene compared to a reference virus of the same genotype. (nih.gov)
The oral/nasal route serves as point of entry into the host for many viruses and thus plays a pivotal role in viral, onset, spread and progression. (nih.gov)

The lysogenic cycle, however, is when the viral DNA is incorporated into the host genome, allowing it to go unnoticed by the immune system. (wikipedia.org)

Dr. Gahan directed the SFI funded UREKA summer school programme entitled Microbe-Host Interactions that provided laboratory training for 84 undergraduate students from 2006-2011. (ucc.ie)
My laboratory has additional secondary projects that include two broad investigations with multi-institutional interactions. (soybiotechcenter.org)
The course aims to teach the principles and practical approaches for the use of molecular laboratory techniques to address problems in the epidemiology of infectious diseases. (edu.gh)

We have adopted a staged strategy for molecular primed PCR amplification, and labeling were optimized to allow the sensitivity required for application with nucleic pathogen surveillance and discovery. (cdc.gov)
She is currently working to expand the use of next-generation sequencing (NGS) surveillance for pathogens of public health concern for the state of Colorado. (cdc.gov)

The innate immune system decides especially at the human epithelial barrier whether a pathogen can invade and subsequently infect the body. (fraunhofer.de)
Cockroaches are known as mechanical vectors of some pathogens that can infect humans. (iwaponline.com)

The human microbiome has an important role in protecting the human host against colonization by harmful invaders and keeping their numbers in check. (cdc.gov)
or how the host microbiome, their expressed genes, and their metabolites may directly affect lung development, health, and disease. (nih.gov)

Immune system genes are one of the most rapidly evolving and their sequences are diverse both across and within species, mostly due to adaptations induced by previous interactions of the host immune system and pathogens. (cuni.cz)

By using whole cells or even tissue samples, simple receptor-ligand-interactions can be analyzed and very complex interactions within the cell or tissue aggregate can be recorded. (fraunhofer.de)

The development of rapid diagnostic methods for important human pathogens has the potential to revolutionize early diagnosis and treatment, particularly in resource-poor settings, with enormous impact on the control and prevention of transmission of infectious diseases. (massgeneral.org)
Host-directed therapies for infectious diseases: current status, recent progress, and future prospects. (cdc.gov)

Repeating interactions with certain types of pathogens during phylogeny might cause the development of structurally similar molecules in unrelated organisms. (cuni.cz)

Host range: Well-known pathogen of sugar beet (Beta vulgaris) and most species of the Beta genus. (usda.gov)
This group showed that RNA expression signatures can be used to identify a variety of common pathogens rapidly and specifically using RNA probes that target sequences highly conserved within but not shared between pathogenic species. (massgeneral.org)
Despite their proximity to each other, related species can react very differently to the same pathogen. (cuni.cz)

13. Differential Salmonella Typhimurium intracellular replication and host cell responses in caecal and ileal organoids derived from chicken. (nih.gov)
18. Using Human Induced Pluripotent Stem Cell-derived Intestinal Organoids to Study and Modify Epithelial Cell Protection Against Salmonella and Other Pathogens. (nih.gov)
Recentment, hem demostrat que els plasmidis presents en la resistència a múltiples fàrmacs de la Salmonella requereixen que es mantinguin de manera estable proteïnes de plasmidi específiques en aquest microorganisme. (ibecbarcelona.eu)

There is a strong correlation of some pathogens with various cancer types, such as Helicobacter pylori with gastric cancer. (nih.gov)

Exciting applications are expected in nanomedicine, particularly for understanding pathogen-drug and pathogen-host interactions, and for designing new antimicrobial therapies (e.g., drug screening and antiadhesive molecules). (medscape.com)

By providing quantitative insights into the binding strength of cell-adhesion proteins, [ 28-30 ] SMFS offers a means to understand pathogen-host adhesion at the single-cell and single-molecule levels. (medscape.com)
AFM imaging enables researchers to observe microbial cell walls at high resolution, as well as their remodeling upon interaction with drugs. (medscape.com)
We found that its proteins interfere with the functioning of host apoptosis pathway, cytokine and chemokine pathways, and also cell-cell adhesions. (nih.gov)
Within this intravacuolar niche, L. pneumophila can replicate to high numbers before it kills the host cell and infects neighboring cells. (nih.gov)

The Molecular Biosciences Ph.D. interdisciplinary program focuses on the study of biological problems at the molecular level using chemical, computational, mathematical, physical, and statistical approaches as well as conventional biological approaches. (mtsu.edu)

probes, molecular reporters and fluorescent indicators for structural or functional imaging or microscopy/nanoscopy. (nih.gov)

Instead of being degraded by these cells, the pathogen establishes a protective membrane compartment, the Legionella-containing vacuole (LCV). (nih.gov)

The goals of this study were to (a) define which host genes are of particular importance during the interactions between macrophages and intracellular pathogens, and (b) use this knowledge to gain fresh, experimental understanding of how macrophage activities may be manipulated during host defense. (nih.gov)
Its goal is to understand molecular adaptations in immune genes that were caused by an interaction with a pathogen. (cuni.cz)
They could be explained by categorizing genes based on their functional interactions with other molecules. (cuni.cz)

The primary JEV vectors feed mainly on cows (a dead-end host for JEV), pigs (an amplifying host), and, occasionally, humans (a dead-end host). (bioone.org)

RLBV has many similarities in molecular structure to the family of bunyaviruses, which cause many important diseases in humans and animals. (hutton.ac.uk)

M proteins have antiphagocytic properties, bind various host proteins and are involved in adherence and invasion of host cells ( 6 - 12 ). (frontiersin.org)
Pathogens interact with the host mainly through proteins. (nih.gov)
It can be also expected that constitutively expressed proteins will have lower adaptive genetic variation than defense proteins, whose production starts after contact with the pathogen. (cuni.cz)

As pathogens continue to evolve in response to interaction with their hosts, gathering a more complete picture through paired epidemiology and genomic sequencing data will help to better understand this interaction and lead to even swifter responses to events of public health concern. (cdc.gov)

Pathogenesis11

Immunology6

Bacterial9

Mechanisms18

Infection19

Genetics8

Interests include host-pathogen1

Fungal pathogens5

Microbial pathogens2

Opportunistic pathogens3

Understand host-pathogen interactions2

Biology9

Characterization3

Cellular9

Immunity5

Variety of pathogens1

Rust pathogen2

Intracellular pathogen1

Resistance7

20192

Foodborne pathogens1

Known pathogens2

Pathogenicity1

Bacteria10

Characterize1

Microbes3

PLoS1

Evolutionary1

Human fungal3

Infections5

Research15

Targets3

Innate immune r1

Microbiota5

Viruses4

Viral1

Laboratory3

Surveillance2

Infect2

Microbiome2

Immune system1

Tissue1

Infectious diseases2

Phylogeny1

Species3

Salmonella3

Helicobacter1

Therapies1

Cell4

Approaches1

Probes1

Legionella1

Genes3

Vectors1

Humans1

Proteins3

Responses1