Molecular gene inositol 1 4 5 trisphosphate receptors. Medical search. Frequent questions

The synthesis of PI involves CDP-activated 1,2-diacylglycerol condensation with myo-inositol. (hmdb.ca)
Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. (drugbank.com)
Ca2+ launch from internal stores in neurons is definitely controlled via the activation of phospholipase C (PLC), hydrolysis of phosphatidylinositol IMD 0354 tyrosianse inhibitor 4,5-bisphosphate (PIP2) into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and activation of IP3 receptors located in the endoplasmic reticulum (ER), which leads to the launch of Ca2+ from your ER5. (bioinbrief.com)
DG(24:0/18:1(9Z)/0:0) is a diglyceride, or a diacylglycerol (DAG). (hmdb.ca)
PLCB1: an enzyme that catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. (assaygenie.com)

From this constantly expanding appreciation for the role of calcium outside the muscle, we predict that calcium-induced-calcium-release ryanodine receptors could also be involved in determining cell fate. (biomedcentral.com)
Plus, Inositol trisphosphate receptor (IP3R) and Ryanodine receptors. (epiphanyasd.com)
Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors. (omicsdi.org)

PI(16:1(9Z)/18:0) is a phosphatidylinositol. (hmdb.ca)
The inositol group that is part of every phosphatidylinositol lipid is covalently linked to the phosphate group that acts as a bridge to the lipid tail. (hmdb.ca)
Phosphatidylinositol can be phosphorylated by a number of different kinases that place the phosphate moiety on positions 4 and 5 of the inositol ring, although position 3 can also be phosphorylated by a specific kinase. (hmdb.ca)
Seven different isomers are known, but the most important in both quantitative and biological terms are phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. (hmdb.ca)

Metabotropic glutamate receptor 5 is an excitatory Gq-coupled G protein-coupled receptor predominantly expressed on the postsynaptic sites of neurons. (wikipedia.org)
The amino acid L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. (wikipedia.org)
The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacological properties. (wikipedia.org)
The effects of ginseng oligosaccharides (GSOs) on neuronal oxidative injury induced by glutamate (GLU) and the molecular mechanisms involved were investigated. (sdbonline.org)
Furthermore, both robust phosphorylation of Homer3 and its dissociation from metabotropic glutamate receptor 1α (mGluR1α) were triggered by depolarization in primary cultured Purkinje cells, and these events were inhibited by CaMKII inhibitor. (jneurosci.org)
We analyzed the molecular mechanisms leading to glutamate release from rat primary cultures of RPE cells, under isosmotic conditions. (molvis.org)
Primary cultures of rat RPE cells were preloaded with 1 µCi/ml 3 H-glutamate in Krebs Ringer Bicarbonate (KRB) buffer for 30 min at 37 °C. Cells were rinsed and super-perfused with 1 ml/min KRB for 15 min. (molvis.org)
This study showed for the first time that thrombin promotes specific, dose-dependent glutamate release from RPE cells, induced by the activation of protease-activated receptor 1 (PAR-1). (molvis.org)

Levels of proteins, including Cyt C, Bcl-2/BAX, and Nrf2 /HO-1-associated proteins, were determined by western blotting and immunofluorescence. (sdbonline.org)
Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
This highly complex 'protein biogenesis' process is assisted by a diverse network of folding catalysts and protein-modifying enzymes and is scrutinized by molecular chaperones and other 'quality control' factors which ensure that only correctly folded and assembled proteins exit the ER and proceed to distal compartments of the secretory pathway. (stanford.edu)
These observations claim that modifications in 5-HT2A-R trafficking and G proteins signaling donate to the advancement and manifestation of neuropsychiatric disorders. (bioinbrief.com)
The PIRP family consists of at least two types of proteins, PRIP-1 and PRIP-2. (biomedcentral.com)
The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. (embl.de)
In this study, we will examine the ability of microglia/macrophages to express SOCS proteins, both constitutive and cytokine-inducible expression (AIM 1). (grantome.com)
Lastly, the ability of SOCS proteins to modulate IFNgamma-induction of class II MHC and CD40 in microglia/macrophages will be tested by stable transfection of SOCS-1 and SOCS-3 proteins in these cells (AIM3). (grantome.com)
After process membrane and during S mitosis, FANCD2 dissociates to viral such others that cycle with proteins taken in molecular type trans-membrane, neutral as BRCA1 and RAD51. (erik-mill.de)
POLK and POLZ have in the receptor of proteins reused multiple to such anions by POLK. (erik-mill.de)
These include global regulation of chlamydial gene expression via histone-like proteins, vesicular trafficking, cytoskeletal interactions, cell signaling, chlamydial modification of the inclusion membrane, and interactions mediated by Type III secreted protein effectors, which control entry and subsequent events. (nih.gov)

Damaged or stressed cells, cardiomyocytes, in particular, emit damage-associated molecular patterns (DAMPs) including HMGB1, S100 A8/A9, HSP70, and other molecules, unfolding paracrine mechanisms that induce an innate immune response. (highwire.org)
Equally important are the innovative experimental systems that have emerged to interrogate molecular mechanisms underlying those effects. (mdpi.com)
One factor contributing to these contradictory theories is the lack of comprehensive understanding of the molecular mechanisms of calcium intake, serum homeostasis, and cytoplasmic function (Fig. 1 ). (biomedcentral.com)
Blumenthal D.K. Blumenthal, Donald K. Pharmacodynamics: Molecular Mechanisms of Drug Action. (mhmedical.com)
But the underlying molecular mechanisms of Rhizoma coptidis are still far from being fully elucidated. (springer.com)
In this review, we studied on the effects and molecular mechanisms of Rhizoma coptidis on NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways. (springer.com)
There are many researches on Rhizoma coptidis, but most of them are only a small part of the whole molecular mechanisms. (springer.com)
As a traditional Chinese medicine, Rhizoma coptidis has excellent therapeutic effects on various diseases, but the underlying systematic molecular mechanisms are still far from being fully elucidated. (springer.com)
The focus of efforts here is understanding the molecular mechanisms involved in the pathogenesis of RMSF. (nih.gov)

CaSR is a member of sub-family C in the superfamily of G protein-coupled receptors (GPCRs). (biomedcentral.com)

Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7, and GRM8. (wikipedia.org)
Activation of mAChRs is relatively slow (milliseconds to seconds) and, depending on the subtypes present (M1-M5), they directly alter cellular homeostasis of phospholipase C, inositol trisphosphate, cAMP, and free calcium. (genome.jp)
Phospholipase C-related inactive protein (PRIP) plays important roles in trafficking to the plasma membrane of GABA A receptor, which is involved in the dominant inhibitory neurotransmission in the spinal cord and plays an important role in nociceptive transmission. (biomedcentral.com)

Since diacylglycerols are synthesized via phosphatidic acid, they will usually contain a saturated fatty acid at the C-1 position on the glycerol moiety and an unsaturated fatty acid at the C-2 position. (hmdb.ca)

Applying minigene assays for all observed exon 3 haplotypes in the patients, we demonstrated that the novel exon 3 haplotype L-I-V-V-A induces a strong but incomplete splicing defect with 3-5% of residual correctly spliced transcripts. (bvsalud.org)
Transcriptome analyses revealed that Caco-2 BBE cells respond to stimulation with IL-8 supporting the hypothesis that IL-8 induces G protein-coupled receptor signalling. (biomedcentral.com)
These results show that IL-8 induces autocrine signalling via an apical CXCR1 in Caco-2 BBE intestinal epithelial cells and that this receptor is also expressed on the apical surface of differentiated human intestinal epithelial cells in vivo , suggesting an autocrine function for IL-8 secreted in the lumen. (biomedcentral.com)
The opening of small groups of IMD 0354 tyrosianse inhibitor IP3 receptors induces a puff of Ca2+. (bioinbrief.com)

Together, these findings suggested that Homer3 in Purkinje cells might function as a reversible coupler regulated by CaMKII phosphorylation and that the phosphorylation is capable of regulating the postsynaptic molecular architecture in response to synaptic activity. (jneurosci.org)
These results suggest that the phosphorylation may regulate postsynaptic molecular architecture and Ca 2+ signaling of Purkinje cells in response to synaptic activity. (jneurosci.org)
The CaMello technique may be expanded to every GPCR coupling towards the Gq/11 pathway to greatly help unravel brand-new receptor-specific functions according to synaptic plasticity and GPCR localization. (bioinbrief.com)
Launch Adjustments in the intracellular Ca2+ focus in neurons regulate several cellular procedures including synaptic transmitter discharge, gene transcription, and different types of synaptic plasticity1. (bioinbrief.com)
When released in the synaptic cleft, ACh binds to two distinct types of receptors: Ionotropic nicotinic acetylcholine receptors (nAChR) and metabotropic muscarinic acetylcholine receptors (mAChRs). (genome.jp)
Deficient Wnt Signaling and Synaptic Vulnerability in Alzheimer's Disease: Emerging Roles for the LRP6 Receptor. (ucl.ac.uk)

Molecular Reproduction and Development (2019) 86 (8): 1053. (biologists.com)

The central nervous system (CNS) depends on a complex and intricate network of molecular and cellular interactions to maintain appropriate function and homeostasis. (frontiersin.org)
Disturbances in mitochondrial dynamics may influence many cellular and molecular pathways, as calcium-dependent immune activation, transcription factors phosphorylation, cytokine secretion, organelle transference and even cell death. (frontiersin.org)
Large single-cell transcriptomic datasets have opened up many possibilities for new analyses, but their potential to inform parameter inference of molecular or cellular dynamics has not yet been realized. (biorxiv.org)
Through the analysis of large populations of posterior distributions we are able to quantify the relationships between single-cell transcriptional states and dynamic cellular responses, paving the way for more detailed mappings between gene expression states and dynamic cell fates. (biorxiv.org)
This leads us to the central question underlying this work: can the integration of singlecell gene expression data into a framework for dynamic modeling and inference improve our understanding of the cellular phenotypes of interest? (biorxiv.org)
The Host-Parasite Interactions Section studies the basic molecular and cellular biology of chlamydiae and other obligate intracellular parasites. (nih.gov)

2018). Deletion of in adult mice impairs basal AMPA receptor transmission and LTP in hippocampal CA1 pyramidal neurons. (tcdb.org)
International Journal of Molecular Sciences (2018) 19 (3): 698. (biologists.com)

The reason is because many immune-related receptors and molecules are extensively produced by these cells, not only during disease but also during physiological processes ( 3 , 9 ). (frontiersin.org)
The inflammatory process in asthma involves the increased expression of various pro-inflammatory chemokines, cytokines, growth factors, lipid mediators, adhesion molecules, enzymes, and receptors for the same inflammatory mediators 21 . (ersjournals.com)

Science China Life Sciences (2020) 63 (1): 18. (biologists.com)
2020;16(5):e1008582. (nih.gov)

These regulators include canonical genes that control lipid metabolism as well as genes involved in ubiquitination, transcription, and mitochondrial function. (stanford.edu)
The T-box family genes are evolutionarily conserved transcription factors. (keio.ac.jp)
Intriguingly, Fpr1 promotes the binding of Fhl1/Ifh1 (forkhead-like 1/interacts with forkhead 1), two key regulators of RPG transcription, to certain RPG promoters independently of and/or cooperatively with Hmo1. (prolekarniky.cz)
The expression of class II MHC genes is regulated by a non-DNA binding protein, class II transactivator (CIITA) the """"""""master control factor"""""""" for class II MHC transcription. (grantome.com)
AP) activity structure, TLS is mismatched by the DNA mechanism transcription receptor( POLZ). (erik-mill.de)

enzyme domain p75NTR( POLK) is a family domain integration recognition that is most unrelated in synthesis polymerase origin( TLS) across nucleosome trans of Release points, last as purine insulin( Tg) and active( OGUA), back not as selected mast binds, enhanced as receptor stretch while person play( BPDE-G)( Zhang et al. (erik-mill.de)

Can the calcium-regulating hormones counteract the detrimental impact of pro-inflammatory damage-associated molecular patterns in the development of heart failure? (highwire.org)
However, the lack of comprehensive understanding on the molecular rationale of calcium intake, serum homeostasis, and cytoplasmic function, is critically hindering our ability to propose a mechanism based technique for targeting calcium in PrCa. (biomedcentral.com)
Recently, studies performed on PrCa samples have shown that calcium-sensing receptor regulates cytoplasmic calcium levels in relation to extracellular calcium concentrations. (biomedcentral.com)
A 4-year dietary assessment of 47,750 men revealed that increased calcium intake is associated with an elevated risk of advanced and poorly differentiated PrCa, indicating that high levels of dietary calcium and supplemental calcium should be avoided [ 4 ]. (biomedcentral.com)
Current known regulators of calcium homeostasis include calcium-sensing receptor (CaSR) responsible for adjusting cytoplasmic calcium level based on extracellular concentrations, and inositol 1,4,5-trisphosphate receptors (IP3Rs) responsible for balancing cytoplasmic, mitochondrial, and endoplasmic reticulum (ER) calcium storage via the ryanodine receptors (RyRs). (biomedcentral.com)
Five independent studies have demonstrated that serum calcium is regulated by the CaSR gene. (biomedcentral.com)
This gene controls calcium homeostasis by regulating the release of parathyroid hormone (PTH), whose gene is located on human chromosome 3 122.18 (NM_000388) and mouse chromosome 16 36.49 (NM_013803). (biomedcentral.com)
For example, in Timothy Syndrome the mutation in the gene produces too much of the protein, in this case the L-type calcium channel Cav1.2. (epiphanyasd.com)

5-HT2A-Rs are indicated on apical dendrites of cortical pyramidal neurons and cerebellar Purkinje cells. (bioinbrief.com)

Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. (wikipedia.org)

IL-8 can signal through two receptors, CXCR1 and CXCR2 both of which are members of the G-protein-coupled receptor (GPCR) family [ 2 ]. (biomedcentral.com)
We present that the precise localization from the GPCR to its receptor domains significantly alters the dynamics and localization from the intracellular Ca2+ indicators in various neuronal populations in vitro and in vivo. (bioinbrief.com)

These findings indicate that GSOs protect against GLU-induced neuronal oxidative damage through Nrf2/HO-1 activation. (sdbonline.org)
A common feature of neurodegenerative and neuroinflammatory diseases is the activation of CNS resident cells ( 2 - 4 ). (frontiersin.org)
Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. (drugbank.com)
These peripheral cold receptors, both Aδ- and C-fibers, have thermal thresholds (i.e., the temperature at which nerve impulses are generated) for cold activation between 30-20°C, temperatures considered to be innocuously cool [ 4 , 6 ]. (nih.gov)
In seminal studies conducted by Hensel and Zotterman in the 1950s, menthol elicited its "cool" sensation by increasing the threshold temperature for activation of cold receptors [ 13 ]. (nih.gov)
Activation of 5-HT2A has been associated with changes in spine and dendritic morphology8, changes in BDNF levels in the hippocampus and neocortex11 and normally results in an improved neuronal activity12,13. (bioinbrief.com)

The key members of this group are the high mobility group box 1 (HMGB1), a ubiquitous structural component of the chromatin complex with multiple regulatory functions, molecular chaperone HSP70, cytokine S100 A8/A9, and others. (highwire.org)

This study demonstrated that the Receptor for Activated C-Kinase 1 (RACK1) is important in SC function. (sdbonline.org)
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. (drugbank.com)
For example, metabotropic mGluRs assemble into a macromolecular complex with IP3 receptors via the scaffolding protein Homer and co-purify with protein phosphatases and protein kinase A (PKA)1,4. (bioinbrief.com)

Inositol triphosphate receptor (IP3R) is an intracellular Ca2+ release channel located on the membrane of the sarco/endoplasmic reticulum (SR/ER), a major intracellular storage site for Ca2+. (keio.ac.jp)

Upon an environmental signal, Membrane receptors transfer information from the environment to the cell's interior. (axonmedchem.com)
However, evidence is now accumulating for rapid corticosteroid actions 25 , 26 , and the existence of membrane-bound steroid receptors that may mediate these rapid actions 27 , 28 . (ersjournals.com)
The CXCR1 receptor for IL-8 was expressed only on the apical membrane of Caco-2 BBE cells and differentiated epithelial cells in the human small intestine and colon. (biomedcentral.com)
It has been suggested that improved activity of 5-HT2A-Rs might be responsible for some of the psychotic symptoms in schizophrenia14 and that atypical antipsychotic providers may antagonize the hyperactivity and membrane focusing on of 5-HT2A-Rs15. (bioinbrief.com)

The tripartite TLRs are type I integral transmembrane receptors that are involved in recognition and conveying of pathogens to the immune system. (tcdb.org)
Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. (drugbank.com)

Zygote (2017) 25 (4): 480. (biologists.com)

mGluR5 receptors are also expressed outside the central nervous system, and mGluR5 antagonists have been shown to be hepatoprotective and may also be useful for the treatment of inflammation and neuropathic pain. (wikipedia.org)
consequently, final results from the present study support the use of angiotensin receptor antagonists to normalize astrocytic and vascular functions in these diseases. (caspaseinhibitor.com)

Toll-like receptors (TLRs) control immune functions. (tcdb.org)

This study uses the Pde6ccpfl1 mouse model of achromatopsia, a cone-specific vision loss IRD (Inherited retinal disease), to investigate the potential gene-independent therapeutic benefits of a histone demethylase inhibitor GSK-J4 on cone cell survival. (bvsalud.org)
It can be now recognized that to treat brain ailments, the entire neurovascular unit, such as μ Opioid Receptor/MOR Inhibitor manufacturer astrocytes and blood vessels, should be regarded as. (caspaseinhibitor.com)

In situ hybridization studies of GABA A receptors revealed significantly decreased expression of γ2 subunit mRNA in the dorsal and ventral horns of the spinal cord in PRIP-1 -/- mice, but no difference in α1 subunit mRNA expression. (biomedcentral.com)
These results suggest that PRIP-1 -/- mice exhibit the changes of the function and subunits expression of GABA A receptor in the spinal cord, which may be responsible for abnormal pain sensation in these mice. (biomedcentral.com)
This prompted us to examine the possible involvement of PRIP in GABA A receptor function. (biomedcentral.com)

Signal-transduction pathways follow a broadly similar course that can be viewed as a molecular circuit. (axonmedchem.com)
1] Signal-Transduction Pathways: An Introduction to Information Metabolism. (axonmedchem.com)
In addition, depending on the cell-type and agonist 5-HT2A-Rs not merely stimulate the NOS3 Gq-PLC pathway, but various other pathways like the G12/13-PLA2 and Gi/o-Src pathway16C18 also. (bioinbrief.com)

Ser/Thr protein kinases such as the Akt/Rac family, the beta-adrenergic receptor kinases, the mu isoform of PKC and the trypanosomal NrkA family. (embl.de)

Additionally, we determined the localization of the CXCR1 receptor in Caco-2 BBE cells and human intestinal tissue samples and investigated the role of IL-8 autocrine signalling using transcriptomics. (biomedcentral.com)
The focusing on and subcellular localization of 5-HT2A-Rs involve a PDZ binding website in the C-terminus (CT) of the 5-HT2A-R9,10. (bioinbrief.com)

Fpr1 inhibits calcineurin and TORC1 (target of rapamycin complex 1) when bound to FK506 and rapamycin, respectively. (prolekarniky.cz)

These molecular circuits detect, amplify, and integrate diverse external signals to generate responses such as changes in enzyme activity, gene expression, phenotypic alterations, or ion-channel activity. (axonmedchem.com)
Thus, although previously solely seen as power suppliers to organelles and molecular processes, it is now well established that mitochondria have many other important roles, including during immune responses. (frontiersin.org)
A) Duration of licking and biting responses for each 5-min interval after intraplantar injection of formalin in PRIP-1 -/- mice (n = 14) and wild-type mice (n = 10). (biomedcentral.com)
By clustering posterior parameters we can identify markers genes that correspond with variable Ca 2+ responses. (biorxiv.org)

β2 subunit mRNA expression was significantly higher in PRIP-1 -/- mice than in wild-type mice in all areas of the spinal cord. (biomedcentral.com)
Therefore, in this study, we examined the phenotypes of pain behavior and GABAA receptor subunit mRNA expression in PRIP-1 -/- mice. (biomedcentral.com)

SHH signaling regulates dorsoventral patterning of the neural tube by repressing genes that are associated with dorsal and lateral fates and by activating genes associated with ventral fates (reviewed by Briscoe and Ericson, 2001 ). (silverchair.com)

In this study, we investigated the phenotypes of pain behaviors in PRIP type 1 knockout ( PRIP-1 -/- ) mice. (biomedcentral.com)
Take single-cell gene expression as an example: even if the overwhelming majority of the genes measured in a given experiment contain very little information about the phenotypes under investigation (say 90-95%, for sake of argument) that still leaves hundreds or thousands of genes that do contain relevant information. (biorxiv.org)

DNA methylation-induced ablation of miR-133a accelerates cancer aggressiveness in glioma through upregulating peroxisome proliferator-activated receptor γ. (nih.gov)
MiR-133a-5p inhibits androgen receptor (AR)-induced proliferation in prostate cancer cells via targeting FUsed in Sarcoma (FUS) and AR. (nih.gov)
Neuropathic pain is a critical disease that is induced by cancer, diabetes, infection or nerve damage [ 1 ]. (biomedcentral.com)

The third form of Griscelli syndrome, whose expression is restricted to the characteristic hypopigmentation, results from mutation in the gene that encodes melanophilin, MLPH , the ortholog of the gene mutated in leaden mice. (medscape.com)

Microglia and astrocytes may actively start, promote, or dampen neuroinflammation ( 5 - 8 ). (frontiersin.org)
It truly is identified that Ang II at low concentrations will not acutely impact neuronal excitability or smooth muscle cell reactivity but nevertheless impairs NVC,4 suggesting that astrocytes may perhaps play a central role within the acute Ang II nduced NVC impairment. (caspaseinhibitor.com)

While these second messengers are free to move, they can easily diffuse to other compartments of the cell, such as the nucleus, where they can influence gene expression and other processes. (axonmedchem.com)
Cell Death Discov 8(1): 459. (sdbonline.org)
Cell Div 17(1): 4. (sdbonline.org)
We investigated the effects of GSK-J4 treatment on cone cell survival in vivo and ex vivo and changes in cone-specific gene expression via single-cell RNA sequencing. (bvsalud.org)
Minigene splicing outcomes were similar in HEK293 cells and the human retinoblastoma cell line WERI-Rb1, the latter retaining a cone photoreceptor expression profile including endogenous OPN1LW and OPN1MW gene expression. (bvsalud.org)
In addition to inflammatory cell infiltration in the bronchial wall 1 , histological analysis of endobronchial biopsy specimens and new methods of blood flow measurements have revealed prominent alterations of the tracheobronchial (airway) vasculature in patients with asthma. (ersjournals.com)
There is growing evidence that resident progenitor cell populations exist in murine lung tissues and differentiate into a mesenchymal cell lineage [1, 2]. (keio.ac.jp)
Stem cell antigen-1 (Sca-1) is a cell surface glycoprotein, initially found in murine bone marrow-derived stem cell subtypes, such as hematopoietic stem cells. (keio.ac.jp)
While many studies of interactions between Pu and mammalian cells were done in the past, the cell and molecular biology aspects of these interactions remain unexplored. (grantome.com)
Here, making use of coupled data: single-cell gene expression and dynamic molecular measurements, we develop new methods for parameter inference. (biorxiv.org)
Though use of cell chains informed by single-cell gene expression does not improve sampling relative to random chain assignment, we show that the posteriors produced via gene expression-informed cell chains capture distinct properties of the dynamic Ca 2+ response. (biorxiv.org)
Even with only a few hundred genes retained, this is more than enough in theory to characterize any possible number of cell states or arbitrarily complex dynamical processes. (biorxiv.org)
In other cell types, Ca2+ and ROS jointly induce Ca2+ release mediated by ryanodine receptor (RyR) channels. (omicsdi.org)

Genomic actions involve the regulation of target genes, and suppress most of the vascular elements of inflammation and angiogenesis in the airway. (ersjournals.com)

Anatomy27

Organisms10

Chemicals and Drugs88

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Psychiatry and Psychology1

Phenomena and Processes24

Disciplines and Occupations2

Information Science2

Diacylglycerol5

Ryanodine receptors3

Phosphatidylinositol4

Glutamate8

Proteins11

Mechanisms9

Protein-coupled receptors1

Phospholipase3

Unsaturated fatt1

Induces4

Synaptic6

20191

Cellular6

20182

Molecules2

20202

Transcription5

Binds1

Calcium8

Pyramidal neurons1

Cyclic1

GPCR2

Activation6

Cytokine1

Kinase3

Endoplasmic reticulum1

Membrane4

Transmembrane2

20171

Antagonists2

TLRs1

Inhibitor2

GABA3

Pathways3

Kinases1

Localization2

Target of rapamycin complex1

Responses4

MRNA2

Dorsal1

Phenotypes2

Cancer3

Mutation in the gene1

Astrocytes2

Cell13

Genomic1