Molecular oxytocin. Medical search. Frequent questions

The role of oxytocin in maintaining health and wellness is huge, so this article takes you through various natural therapies for increasing the levels of oxytocin in your body. (naturaltherapypages.com.au)
By understanding the role of oxytocin in the mind-body connection, individuals can incorporate these natural therapy approaches into their lives to nurture emotional wellbeing and healing. (naturaltherapypages.com.au)
My ongoing interest in the field of neuroendocrinology led me to follow a traineeship post-laurea in the laboratory of Elena Choleris at the University of Guelph, which marked my desire to explore the role of oxytocin and its implications on adult emotional and social behaviour. (uni-regensburg.de)
The role of oxytocin on self-serving lying. (nih.gov)
These findings address two major points of the current debate on the etiology and pathogenesis of autism: the role of oxytocin, known to be involved in modeling human behavior, and the possible involvement of epigenetic mechanisms. (biomedcentral.com)

Finally, comparative analysis of the free- and agonist-bound forms of the wild-type oxytocin receptor and α 1B adrenergic receptor suggests that the highly conserved polar amino acids and the seven helices play similar mechanistic roles in the different G protein-coupled receptors. (aspetjournals.org)
Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system. (drugbank.com)
In this paper, the interactions responsible for binding of dDAVP to vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors has been examined. (drugbank.com)
Oxytocin receptors are thought to have evolved when ancestral women began nursing their children and stimulated oxytocin production in their bodies to ensure healthy breastfeeding after delivery. (naturaltherapypages.com.au)
Findings reveal parenting and bonding aren't purely dictated by oxytocin receptors. (neurosciencenews.com)
In the study, appearing Jan. 27, 2023 in Neuron , the team found that prairie voles bred without receptors for oxytocin and showed the same monogamous mating, attachment, and parenting behaviors as regular voles. (neurosciencenews.com)
In addition, females without oxytocin receptors gave birth and produced milk, though in smaller quantities, than ordinary female voles. (neurosciencenews.com)
The results indicate that the biology underlying pair bonding and parenting isn't purely dictated by the receptors for oxytocin, sometimes referred to as the "love hormone. (neurosciencenews.com)
They used CRISPR to generate prairie voles that lack functional oxytocin receptors. (neurosciencenews.com)
Female voles without receptors proved perfectly capable of giving birth, on the same timeframe and in the same way as the regular animals, even though labor has been thought to rely on oxytocin. (neurosciencenews.com)
They also measured the expression of the receptors for these hormones, as well as molecular activity in two signaling pathways linked to autism, PI3K and RAS/MAPK . (spectrumnews.org)
These axons (likely, but dendrites have not been ruled out) have collaterals that innervate neurons in the nucleus accumbens , a brain structure where oxytocin receptors are expressed. (wikidoc.org)

The neuropeptide oxytocin (OXT) has recently emerged as playing a key role in human social cognition and behaviour. (nature.com)
The neuropeptide oxytocin (OT) is associated with a plethora of social behaviors and is a key topic at the intersection of psychology and biology. (nature.com)
Further, they find that both the neuropeptide oxytocin and its neurons are capable of driving defensive swimming behavior, by activating a network of brainstem premotor targets. (harvard.edu)
The neuropeptide oxytocin (OT) is a well-described modulator of socio-emotional traits, such as anxiety, stress, social behavior, and pair-bonding, however, when dysregulated, it is associated with adverse psychiatric traits, like various aspects of autism spectrum disorder (ASD). (preprints.org)
In this study, we tested the effects of the neuropeptide oxytocin on ANS reactivity during couple conflict in a standardized laboratory paradigm. (edu.au)

However, oxytocin neurons make other peptides, including corticotropin-releasing hormone (CRH) and dynorphin, for example, that act locally. (wikipedia.org)
The magnocellular neurons that make oxytocin are adjacent to magnocellular neurons that make vasopressin, and are similar in many respects. (wikipedia.org)
These hypothalamic neurons express oxytocin, commonly portrayed as the 'love' hormone for its known role in social behaviors. (harvard.edu)
Researchers found that neurons activated by the "social hormone" oxytocin lessen anxiety in male mice, but not females. (nih.gov)
Her first original research article is in press titled "Effects of mutant huntingtin in oxytocin neurons on non-motor features of Huntington's disease" in Neuropathology and Applied Neurobiology. (lu.se)
Effects of mutant huntingtin in oxytocin neurons on non-motor features of Huntington's disease. (lu.se)

The paper appears today in Molecular Psychiatry . (stanford.edu)
Molecular Psychiatry. (salimetrics.com)
Molecular Psychiatry 97, pp. 907-917. (uni-regensburg.de)

Research studies surveying behavioral associations with SNPs in the Oxytocin Receptor Gene (OXTR) have found links to emotional regulation, behaviors, personality traits, and socially-related diagnoses (1). (salimetrics.com)
Oxytocin (OXT) and arginine-vasopressin (AVP) are two phylogenetically conserved neuropeptides that have been implicated in a wide range of social behaviors. (frontiersin.org)
Oxytocin (OT) is a crucial regulator of reproductive behaviors, including parturition in mammals. (frontiersin.org)
Taken together with its known functions in mammals, these results emphasize an important and conserved function for oxytocin in pain processing, particularly in the induction of pain-response behaviors. (harvard.edu)
A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors. (nih.gov)
It is well known that oxytocin is actively involved in early social, perceptual, and cognitive processes, and, that it influences complex social behaviors,' says Tobias Grossmann. (mpg.de)
Oxytocin (OXT) is a neuropeptide known to play a pivotal role in the regulation of social cognition as well as in emotional behaviors such as anxiety and depression. (lu.se)
Removing the oxytocin receptor in animal models still resulted in monogamous mating, attachment, and parental bonding behaviors, although females without the receptor produced milk in smaller quantities. (neurosciencenews.com)
Social isolation and oxytocin antagonism increase emotion-related behaviors and heart rate in female prairie voles. (neurotree.org)
Vasopressin and the related hormone oxytocin control a variety of social behaviors . (spectrumnews.org)

Oxytocin's molecular structure was determined in 1952. (wikipedia.org)

How the Transcription Factor MEF2 Might Explain the Manifold Behavioral Effects of Oxytocin. (uni-regensburg.de)
[27] The endocrine effects of hormonal oxytocin and the cognitive or behavioral effects of oxytocin neuropeptides are thought to be coordinated through its common release through these collaterals. (wikidoc.org)

It's well known that a new mother's oxytocin levels can influence her behavior and as a result, the bond she makes with her baby. (mpg.de)

Shah had been interested in the biology of oxytocin and social attachment in prairie voles since teaching about the oxytocin studies decades earlier. (neurosciencenews.com)

Turning a decades-old dogma on its head, new research from scientists at UC San Francisco and Stanford Medicine shows that the receptor for oxytocin, a hormone considered essential to forming social bonds, may not play the critical role that scientists have assigned to it for the past 30 years. (neurosciencenews.com)
published this month in BMC Medicine , reports on genomic and epigenetic alterations of OXTR , the gene encoding the receptor for oxytocin. (biomedcentral.com)

Parker's team is now conducting studies of possible therapeutic uses of oxytocin in children with autism. (stanford.edu)
instead, oxytocin levels in kids with autism fall across a broad range. (stanford.edu)
The findings hint at a future in which patients' oxytocin levels could be used to guide treatment for autism or other psychiatric or developmental disorders. (stanford.edu)
2008). Association between the oxytocin receptor (OXTR) gene and autism: relationship to Vineland Adaptive Behavior Scales and cognition. (salimetrics.com)
Anna Strunecka, Russell L. Blaylock, Mark A. Hyman, Ivo Paclt , " Cellular and Molecular Biology of Autism Spectrum Disorders ", Bentham Science Publishers (2010). (eurekaselect.com)
Manoli and Shah focused on understanding the neurobiology and molecular mechanisms of pair bonding because it is thought to hold the key to unlocking better treatments for psychiatric conditions, such as autism and schizophrenia, that interfere with a person's ability to form or maintain social bonds. (neurosciencenews.com)
Defective oxytocin function: a clue to understanding the cause of autism? (biomedcentral.com)
show that there is genomic and epigenetic evidence of a reduced function of the oxytocin receptor in autism. (biomedcentral.com)

Oxytocin (Oxt or OT) is a peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary. (wikipedia.org)
Amastatin, bestatin (ubenimex), leupeptin, and puromycin have been found to inhibit the enzymatic degradation of oxytocin, though they also inhibit the degradation of various other peptides, such as vasopressin, met-enkephalin, and dynorphin A. In the hypothalamus, oxytocin is made in magnocellular neurosecretory cells of the supraoptic and paraventricular nuclei, and is stored in Herring bodies at the axon terminals in the posterior pituitary. (wikipedia.org)
Produced by the hypothalamus and released by the pituitary gland, oxytocin is associated with social bonding, trust and emotional wellbeing. (naturaltherapypages.com.au)
Molecular genetics of neurotransmitters and neuropeptides involved in Internet use disorders including first insights on a potential role of hypothalamus' oxytocin hormone. (nih.gov)
The Brain-NA-adrenaline Axis Controls the Fight-or-flight Response in the Hypothalamus Signals for a Multi-hormonal Adaptive Response Shifting Levels of Oxytocin, Serotonin, etc. (novapublishers.com)
Oxytocin is normally produced by the paraventricular nucleus of the hypothalamus and released by the posterior pituitary . (wikidoc.org)
In the hypothalamus , oxytocin is made in magnocellular neurosecretory cells of the supraoptic and paraventricular nuclei, and is stored in Herring bodies at the axon terminals in the posterior pituitary. (wikidoc.org)

Mutation of the conserved arginine of the glutamate/aspartate-arginine-tyrosine motif located in the second intracellular domain gave rise to the first known constitutively active oxytocin receptor (R137A), whereas mutation of the aspartic acid located in the second transmembrane domain led to an inactive receptor (D85A). (aspetjournals.org)
The last hydrolysis that releases the active oxytocin nonapeptide is catalyzed by peptidylglycine alpha-amidating monooxygenase (PAM). (wikipedia.org)

Brain cells (shown in red) activated by the "social hormone" oxytocin prompt differences in how male and female mice behave. (nih.gov)
The oxytocin receptor is essential for the hormone oxytocin to exert its effects and the gene can determine how many are produced,' explains Kathleen Krol, a Hartwell postdoctoral fellow in Connelly's Lab at the University of Virginia who conducted the study together with Tobias Grossmann at MPI CBS in Leipzig. (mpg.de)
The "love hormone" oxytocin may not play as critical a role in bonding as previously believed. (neurosciencenews.com)

Production and secretion of oxytocin is controlled by a positive feedback mechanism, where its initial release stimulates production and release of further oxytocin. (wikipedia.org)
Molecular mechanism of the dDAVP binding has been suggested. (drugbank.com)
Overall, this molecular mechanism could be used to propose a model linking environmental stimulus resulting in cAMP and the rate of gene expression. (novapublishers.com)
Tonix Pharmaceuticals Holding Corp. today announced that David C. Yeomans, Ph.D. presented data relevant to the proposed mechanism of TNX-1900 (intranasal potentiated oxytocin) in treating chronic migraine in a poster and an oral presentation at the 2023 International Headache Congress (IHC), being held September 14-17, 2023, in Seoul, South Korea. (biospace.com)
The mechanism of ginger and its processed products in the treatment of estradiol valerate coupled with oxytocin-induced dysmenorrhea in mice via regulating the TRP ion channel-mediated ERK 1/2 /NF-κB signaling pathway. (bvsalud.org)
However, the molecular mechanism of the therapeutic effect of RZ and its processed products (RZPPs, including BG or GC) against PD has not been well characterized. (bvsalud.org)

Dr. Bice Chini, Consiglio Nazionale delle Richerche Cellular and Molecular Pharmacology Center, via Vanvitelli 32, 20129 Milan, Italy. (aspetjournals.org)
Our goal is to have a journal club that will enrich our knowledge and keep us current in the field of molecular and cellular neuroscience. (bcm.edu)
Is it relevant to molecular and cellular neuroscience? (bcm.edu)
Complex changes of cellular and molecular. (nova.edu)
My research aims to a) reveal how a traumatic social event affects astrocytes of various brain regions associated with socio-emotional behaviour on a molecular and cellular level and b) manipulate astrocytes cell type-specifically (using viral-vector based knockdown of targets involved in astrocytic oxytocin receptor signaling and astrocyte-specific DREADD) to examine their contribution to the acquisition, as well as extinction of social fear. (uni-regensburg.de)
The overall aim of the PhD project is to investigate the cellular and molecular mechanisms of limbic system pathology of Huntington's disease. (lu.se)
Cellular and molecular mechanisms of limbic system pathology in Huntington disease. (lu.se)
When I got into the neuroscience of complex behavior, I was working at the cellular/behavioral level, while the NIMH was shifting gears and moving into molecular biology. (medscape.com)

Plasma oxytocin and vasopressin levels in young and older men and women: Functional relationships with attachment and cognition. (neurotree.org)
The combination of oxytocin and vasopressin levels in cerebrospinal fluid, along with the activity of the PI3K pathway in blood, correctly classified 24 of the 27 monkeys. (spectrumnews.org)

The purpose of this journal club is to discuss high impact, insightful articles from all areas of Molecular Neuroscience. (bcm.edu)
The conceptual and methodological innovation of this project will allow the students to improve their neuroscience knowledge as well as learn numerous behavioral and molecular techniques. (kent.edu)
Frontiers in Molecular Neuroscience , 15 , 1-10. (lu.se)
If I had to guess ahead of time which one would be lower in the low-social guys, I would have picked oxytocin," says Larry Young , chief of behavioral neuroscience and psychiatric disorders at Emory University in Atlanta, who was not involved in the work. (spectrumnews.org)

Oxytocin (OT) is a highly conserved nonapeptide that was the first peptide hormone with determined molecular structure ( 1 ). (frontiersin.org)
Oxytocin ( Oxt ) is a peptide hormone and neuropeptide . (wikidoc.org)

For example, when oxytocin is released during a contraction of the uterus at the start of childbirth, this stimulates production and release of more oxytocin and an increase in the intensity and frequency of contractions. (wikipedia.org)
The oxytocin receptor is found in various tissues in the human body, including in a woman's breast and uterus, and in both male and female testicles. (naturaltherapypages.com.au)
LSD inhibited or abolished the oxytocic effect of serotonin but not that of oxytocin on the isolated rat uterus. (erowid.org)
[4] Oxytocin is released into the bloodstream as a hormone in response to stretching of the cervix and uterus during labor and with stimulation of the nipples from breastfeeding . (wikidoc.org)
In addition, differential metabolomics (DMs) was acquired between RZ- and RZPPs-treated estradiol valerate coupled with an oxytocin -induced PD mouse uterus using untargeted metabolomics (UM). (bvsalud.org)

Here using combined blood and cerebrospinal fluid (CSF) sampling in subjects receiving either 24 IU of oxytocin (n = 11) or placebo (n = 4) we have shown that oxytocin levels significantly increased in both plasma and CSF. (nature.com)
Nonperfused volume was statistically significantly larger in oxytocin group than in control group (p=0.0019). (hindawi.com)
Oxytocin significantly reduced sAA during couple conflict in women, whereas men showed increases in sAA levels (sex × group interaction: B = −49.36, t = −2.68, P = 0.009). (edu.au)
Analysis of the oxytocinergic system in the prenatally stressed male rats revealed significantly less oxytocin mRNA in the paraventricular nucleus and increased oxytocin receptor binding in the central amygdala. (elsevierpure.com)

In either form, oxytocin stimulates uterine contractions to speed up the process of childbirth. (wikipedia.org)
The results help to clear up some of the mystery surrounding the hormone's role in childbirth: Oxytocin is commonly used to induce labor but blocking its activity in mothers who experience premature labor isn't better than other approaches for halting contractions. (neurosciencenews.com)
[8] Oxytocin is also used as a medication to facilitate childbirth . (wikidoc.org)

A new epigenetic study by Kathleen Krol and Jessica Connelly from the University of Virginia and Tobias Grossmann from the Max Planck Institute for Human Cognitive and Brain Sciences now suggests that mothers' or fathers' behavior can also have a substantial impact on their children's developing oxytocin systems. (mpg.de)
Early social interaction with our caregivers, certainly including fathers, can influence our biological and psychological development through epigenetic changes to the oxytocin system. (mpg.de)
Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression. (neurotree.org)
Behavioral and epigenetic consequences of oxytocin treatment at birth. (neurotree.org)
A wealth of research has begun to identify the genetic, epigenetic, neural, and environmental underpinnings of resilience, and has indicated that resilience is mediated by adaptive changes encompassing several environmental factors, neural circuits, numerous neurotransmitters, and molecular pathways. (cdc.gov)
The first part of this review focuses on recent findings regarding the genetic, epigenetic, developmental, psychosocial , and neurochemical factors as well as neural circuits and molecular pathways that underlie the development of resilience. (cdc.gov)

By chance, sodium ascorbate by itself was found to stimulate the production of oxytocin from ovarian tissue over a range of concentrations in a dose-dependent manner. (wikipedia.org)
In the context of natural therapy, various practices have been found to stimulate oxytocin release. (naturaltherapypages.com.au)

Oxytocin is likely to have a role in both birth and lactation, but one that is more nuanced than previously thought, Manoli said. (neurosciencenews.com)
This overturns conventional wisdom about lactation and oxytocin that's existed for a much longer time than the pair bonding association," said Shah. (neurosciencenews.com)

Kenkel WM , Ortiz RJ , Yee JR , Perkeybile AM, Kulkarni P, Carter CS , Cushing BS , Ferris CF . Neuroanatomical and functional consequences of oxytocin treatment at birth in prairie voles. (neurotree.org)

They drew samples of blood and cerebrospinal fluid and measured levels of vasopressin and oxytocin. (spectrumnews.org)

In the 1920s, oxytocin and vasopressin were isolated from pituitary tissue and given their current names. (wikipedia.org)
Oxytocin and vasopressin are the only known hormones released by the human posterior pituitary gland to act at a distance. (wikipedia.org)

2009). Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. (salimetrics.com)
This study tells us that oxytocin is likely just one part of a much more complex genetic program. (neurosciencenews.com)
For this study, 15 years in the making, the two applied new genetic technologies to confirm if oxytocin binding to its receptor was indeed the factor behind pair bonding. (neurosciencenews.com)
Because of this complexity, decades of experimental work, even with the aid of sophisticated molecular genetic tools (such as high resolution total genome quantitative analysis, array expression analysis or high resolution single nucleotide polymorphism (SNP) array platforms) have failed to identify specific causes in any substantial proportion of cases [ 4 , 5 ]. (biomedcentral.com)
With the advent of molecular technique, it has become clear that carriage of the genetic defect is much more common than symptomatic AIP. (medscape.com)

This study helps scientifically validate the use of measuring oxytocin in the blood, and suggests that oxytocin may be a biomarker of anxiety. (stanford.edu)
Oxytocin receptor gene DNA methylation : A biomarker of treatment response in obsessive-compulsive disorder? (edu.au)

This precursor protein also includes the oxytocin carrier protein neurophysin I. The inactive precursor protein is progressively hydrolyzed into smaller fragments (one of which is neurophysin I) via a series of enzymes. (wikipedia.org)

There has been an unprecedented interest in the modulatory effects of intranasal oxytocin on human social cognition and behaviour, however as yet no study has actually demonstrated that this modality of administration increases concentrations of the peptide in the brain as well as blood in humans. (nature.com)
2014). Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills. (salimetrics.com)
In addition to reduced stress, other benefits associated with increased oxytocin production include lower blood pressure, higher empathy with others and better social behaviour. (naturaltherapypages.com.au)
Understanding the significance of oxytocin in natural therapy can help individuals harness its benefits to foster emotional wellbeing, social connection and overall healing. (naturaltherapypages.com.au)
Beyond its role in social bonding and emotional healing, oxytocin has been found to have analgesic properties, making it relevant in pain management through natural therapies. (naturaltherapypages.com.au)
Oxytocin is a hormone that plays a role in social behavior, but can also help regulate stress and anxiety. (nih.gov)
A team of researchers led by Dr. Nathaniel Heintz at Rockefeller University previously discovered a group of oxytocin-responsive brain cells-called oxytocin receptor interneurons-that regulate a social behavior in female mice. (nih.gov)
The scientists activated oxytocin receptor interneurons and then compared how anxious or social the mice were during different tasks. (nih.gov)
Stress, social situations, and sex-related differences can affect how much oxytocin and CRH is present in different brain areas. (nih.gov)
Oxytocin is an extremely important hormone, involved in social interaction and bonding in mammals, including humans. (mpg.de)
As oxytocin and its homologues have evolutionarily conserved roles in the modulation of behavior, this work has implications for understanding the neural underpinnings of social behavior across species and will be the first to delve into the prenatal organizational effects of oxytocin on aggressive behavior. (kent.edu)
Prof Stephen Bustin is Professor of Molecular Medicine in the School of Allied Health and Social Care . (aru.ac.uk)
Moreover, oxytocin, but not vasopressin, administration into the central amygdala reversed the social incompetence of the prenatally stressed rats without increasing behavior in non-stressed control animals. (elsevierpure.com)
El trastorno del espectro autista (TEA) se caracterizan por deficiencias de interacción social en el dominio del lenguaje verbal y pueden in- currir en comportamientos gestuales repetitivos, estereotipados y restringidos. (bvsalud.org)
El objetivo de nuestro estudio tuvo como objetivo revisar y correlacionar genes involucrados en TEA y aque- llos relacionados con la comunicación ultrasónica en estudios con modelos animales de comportamiento social basado en el lenguaje en la base de datos PubMed. (bvsalud.org)
It is amazing to reflect on how that research on oxytocin and social behavior still goes on today. (medscape.com)

We encourage candidates with a strong background and interests in microbiology, biochemistry and/or molecular biology and who are interested in working in a diverse research environment, to apply. (edu.au)

Thank you for sharing this Molecular Pharmacology article. (aspetjournals.org)
Message Body (Your Name) thought you would be interested in this article in Molecular Pharmacology. (aspetjournals.org)

Tango Therapeutics, Inc. today announced that five abstracts have been selected for poster presentations at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, taking place from October 11-15, 2023 in Boston, Massachusetts. (biospace.com)
Relay Therapeutics, Inc. (Nasdaq: RLAY) today announced that data for RLY-4008 (lirafugratinib) in patients with advanced FGFR2-altered solid tumors outside of cholangiocarcinoma will be presented at the upcoming AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, taking place October 11-15, 2023. (biospace.com)

In the early 1950s, American biochemist Vincent du Vigneaud found that oxytocin is made up of nine amino acids, and he identified its amino acid sequence, the first polypeptide hormone to be sequenced. (wikipedia.org)
The oxytocin peptide is composed of nine amino acids and has a molecular weight of 1007 daltons (Da). (naturaltherapypages.com.au)

2011). Oxytocin receptor gene (OXTR) is related to psychological resources. (salimetrics.com)
They identified a genomic deletion containing the gene encoding for the oxytocin receptor ( OXTR ) in an autistic male individual and in his mother, who probably experienced obsessive-compulsive disorder (OCD). (biomedcentral.com)

Together, these data provide crucial insights into the plasma and CSF kinetics of intranasally administered oxytocin. (nature.com)
In a double-blind, placebo-controlled design, 47 heterosexual couples (total n = 94) received oxytocin or placebo intranasally prior to instructed couple conflict. (edu.au)

Our work is at the stage of understanding the molecular mechanisms by which the aging of the regenerative potential of organ stem cells can be reversed by particular human embryonic factors that are capable of neutralizing the affects of aged niches on tissue regenerative capacity. (ca.gov)
Additionally, our data in progress suggest that muscle and brain age by similar molecular mechanisms and thus, therapeutic strategies for rejuvenating muscle repair might be applicable to the restoration of neurogenesis in aged brain. (ca.gov)
Emerging and exciting areas of research and novel methodological approaches, including genome-wide gene expression studies, immune, endocannabinoid, oxytocin, and glutamatergic systems, are explored to help delineate innovative mechanisms that may contribute to resilience. (cdc.gov)

When oxytocin is released into your bloodstream, stress levels are reduced because of the effects of oxytocin on the body. (naturaltherapypages.com.au)
We further demonstrated that these chronic oxytocin effects result from 1) maintenance of energy expenditure at preintervention levels despite ongoing weight loss, 2) a reduction in respiratory quotient, consistent with increased fat oxidation, and 3) an enhanced satiety response to cholecystokinin-8 and associated decrease of meal size. (nih.gov)
These weight-reducing effects persisted for approximately 10 days after termination of 3V oxytocin administration and occurred independently of whether sucrose was added to the HFD. (nih.gov)
Our results imply sex-specific effects of oxytocin on sympathetic activity, to negative couple interaction, with the neuropeptide reducing sAA responses and emotional arousal in women while increasing them in men. (edu.au)

The uterine-contracting properties of the principle that would later be named oxytocin were discovered by British pharmacologist Henry Hallett Dale in 1906, and its milk ejection property was described by Ott and Scott in 1910 and by Schafer and Mackenzie in 1911. (wikipedia.org)
The aim of the study was to evaluate the clinical efficacy of magnetic resonance-guided High-Intensity Focused Ultrasound (HIFU) in patients with symptomatic uterine fibroids (myomata) after application of oxytocin. (hindawi.com)

If mothers were particularly involved in the game with their children, there was a greater reduction in DNA methylation of the oxytocin receptor gene one year later. (mpg.de)
Decreased DNA methylation in this region has previously been associated with increased expression of the oxytocin receptor gene. (mpg.de)
The children with higher methylation levels at 18-months, and presumably lower levels of oxytocin receptor, were also more temperamental and less well balanced. (mpg.de)

Did you know that oxytocin reduces stress? (naturaltherapypages.com.au)
For instance, massage therapy, known for its relaxation benefits, has been shown to boost oxytocin levels, promoting a sense of calm and reducing stress. (naturaltherapypages.com.au)
Quite literally, the welcome touch of another person - a hug, a kiss, a massage - enacts beneficial changes in gene expression at the molecular level, changes that reduce stress, release oxytocin, and lower inflammation. (zenhabits.com)

The molecular structures of serotonin (hydroxytryptamine) and LSD are similar. (erowid.org)

This oxytocin receptor provides oxytocin's action within these tissues. (naturaltherapypages.com.au)

Not surprisingly, interfering with oxytocin neuron signaling attenuates pain responses. (harvard.edu)

Oxytocin is derived by enzymatic splitting from the peptide precursor encoded by the human OXT gene. (wikipedia.org)
The oxytocin peptide is synthesized as an inactive precursor protein from the OXT gene. (wikipedia.org)

Oxytocin , sometimes dubbed " the love hormone ," can be tricky to study in humans. (stanford.edu)
A new Stanford study simplifies the problem: It is the first research in children, and some of the first in any age group of humans, to indicate that blood and CSF oxytocin levels track together. (stanford.edu)
The research also found a correlation between low-oxytocin and high-anxiety levels in children, adding to findings from animal studies and adult humans that have documented this oxytocin-anxiety link. (stanford.edu)
Our first scientific effort is to develop effective preclinical tools to study higher-order cognitive abilities with high translational validity from/to humans, while taking advantage of the outstanding advanced molecular and mechanistic tools available for mice. (iit.it)

We found that chronic 3V oxytocin infusion between 21 and 26 days by osmotic minipumps both reduced weight gain associated with the progression of high-fat diet (HFD)-induced obesity and elicited a sustained reduction of fat mass with no decrease of lean mass in rats with established diet-induced obesity. (nih.gov)
We conclude that long-term 3V administration of oxytocin to rats can both prevent and treat diet-induced obesity. (nih.gov)
Exposure of pregnant female rats to a series of unpredictable stresses during the final week of pregnancy generates behavioral deficits and molecular changes in the offspring similar to those observed in schizophrenic individuals. (elsevierpure.com)

2020-2022 Master of Science in Molecular biology specializing in medical biology, Lund university, Lund, Sweden. (lu.se)

Advances in molecular biology, epigenetics in particular, have recently made it possible to investigate the interaction of nature and nurture, in this case infant care, in fine detail. (mpg.de)

Mechanistically, MBH Socs3-deficient mice display increased hindbrain sensitivity to endogenous, meal-related satiety signals, mediated by oxytocin signaling. (jneurosci.org)
Sex and hormonal status influence the anxiolytic-like effect of oxytocin in mice. (neurotree.org)
We just lucked into finding oxytocin and vasopressin and then some interesting animal models: voles, monogamous mice, and a bunch of animals that no one else in molecular biology was studying at that time. (medscape.com)

Thus, oxytocin signaling likely mediates the effect of hypothalamic leptin on satiety circuits of the caudal brainstem. (jneurosci.org)

We were interested in exploring whether the involvement of the mother, in the original play session, would have an influence on the oxytocin receptor gene of the child, a year later. (mpg.de)
Greater maternal involvement seems to have the potential to upregulate the oxytocin system in babys. (mpg.de)

Studies in the 1990s using drugs that prevent oxytocin from binding to its receptor found that voles were unable to pair bond, giving rise to the idea that the hormone is essential to forming such attachments. (neurosciencenews.com)

To conduct research on the connection between oxytocin and emotion, scientists want to assess the hormone's levels in the brain. (stanford.edu)

Interaction of oxytocin with Ca2+: II. (mcmaster.ca)

CUD is characterized by a loss of control over cocaine use and is associated with structural, functional, and molecular alterations in the human brain. (medscape.com)

Measuring blood oxytocin is much easier, but some researchers have questioned whether blood oxytocin levels truly reflect what's happening in the brain. (stanford.edu)
The volunteers agreed to have oxytocin levels measured in their blood and CSF, and the parents of 10 children in the study answered questions about their children's anxiety levels. (stanford.edu)
Mindfulness practices, such as meditation and yoga, encourage a state of present-moment awareness and can enhance oxytocin levels, thereby improving emotional wellbeing. (naturaltherapypages.com.au)
Animal-assisted therapy, involving interactions with therapy animals, has also been linked to increased oxytocin levels. (naturaltherapypages.com.au)
The authors suggest that the balance between oxytocin and CRH levels may be what determines the differences in behavior. (nih.gov)

Anatomy8

Organisms1

Diseases2

Chemicals and Drugs12

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Psychiatry and Psychology3

Phenomena and Processes9

Role of oxytocin5

Receptors12

Neuropeptide oxytocin5

Neurons6

Psychiatry3

Behaviors10

Structure was determined in 19521

Behavioral Effects of Oxytocin2

Mother's oxytocin levels1

Biology of oxytocin1

Receptor for oxytocin2

Autism8

Hypothalamus7

Active oxytocin2

Hormone oxytocin3

Mechanism6

Cellular8

Vasopressin levels2

Neuroscience4

Peptide hormone2

Uterus5

Significantly4

Childbirth3

Epigenetic6

Found to stimulate2

Lactation2

Prairie voles1

Cerebrospinal fluid1

Pituitary2

Genetic5

Biomarker2

Neurophysin1

Social16

Biochemistry1

Pharmacology2

20232

Nine amino acids2

OXTR2

Intranasally2

Mechanisms3

Effects4

Uterine2

Methylation3

Stress3

Serotonin1

Oxytocin's1

Responses1

Precursor2

Humans4

Rats3

20221

Epigenetics1

Mice3

Hypothalamic1

Involvement2

Voles1

Scientists1

Interaction1

Alterations1

Levels5