• Albeit the molecular mechanisms responsible for the therapeutic effects of CBD have yet to be fully elucidated, many efforts have been devoted in the last decades to shed light on its complex pharmacological profile. (nih.gov)
  • I am interested in the molecular mechanisms during development and morphogenesis. (uni-potsdam.de)
  • Research in Dr. Guo-li Ming's laboratory centers on understanding molecular mechanisms underlying neurodevelopment and how its dysregulation may contribute to developmental neurological disorders. (upenn.edu)
  • However, the underlying molecular mechanisms during these pathological processing remain unknown. (imperial.ac.uk)
  • Research in our lab uses the genetic tool kit of fruit flies (Drosophila melanogaster) to identify molecular mechanisms of synapse formation, animal behavior, and neurodegeneration. (truman.edu)
  • Sebastian Glatt summarizes ?our work provides a milestone in understanding the dual character of this system and provides deep molecular insights in the underlying mechanisms. (fnp.org.pl)
  • He received his Ph.D. at the Massachusetts Institute of Technology, studying the neural mechanisms of early motor control in the juvenile songbird model system. (nih.gov)
  • She studies the molecular mechanisms of various diseases, including cancer, diabetes, and neurological disorders. (cbs42.com)
  • Whenever available, the molecular mechanisms involved in these progesterone effects were examined. (bvsalud.org)
  • Also, in collaboration with Dr. Kelly Lohr (Washington & Jefferson College), research in my lab uses the fruit fly, Drosophila , as a powerful genetic model to study the effects of stress on human neurodegenerative diseases (i.e., tauopathies). (chatham.edu)
  • Handbook of Neurochemistry and Molecular Neurobiology describes recent developmeents in varuous pathological aspects of neurological disorders with special emphasis on neurodegenerative diseases, molecular mechanism of neuronal death in the various diseases and their models, prospects for neuroprotection, and development of disease-modifying drugs. (chipsbooks.com)
  • lysosomal storage diseases such as Niemann-Pick disease can lead to neurological deterioration. (wikipedia.org)
  • Mootha's lab has been studying hypoxia as a potential treatment for rare neurological diseases since 2016. (broadinstitute.org)
  • The major reasons that will escalate the adoption of molecular diagnostics are a high prevalence of infectious diseases and cancers, increasing awareness and acceptance of personalized medicine and companion diagnostics, growth in the biomarker identification market, and advancements in molecular techniques. (openpr.com)
  • Drosophila melanogaster is a genetic model organism that has contributed to the discovery of numerous genes whose human homologues are associated with diseases. (nih.gov)
  • The development of sophisticated genetic tools to manipulate its genome accelerates the discovery of the genetic basis of undiagnosed human diseases and the elucidation of molecular pathogenic events of known and novel diseases. (nih.gov)
  • Blood protein extravasation through a disrupted blood-brain barrier and innate immune activation are hallmarks of neurological diseases and emerging therapeutic targets. (nature.com)
  • I later joined a neuropathology research lab at Harvard Medical School as a postdoctoral fellow, where I used the fruit fly Drosophila to study how disruption of specific cellular pathways can lead to neurodegeneration, a phenomenon seen in neurological disorders such as Alzheimer's and Parkinson's diseases. (chatham.edu)
  • We carry out translational gene therapy studies targeting several neurological and metabolic diseases. (umassmed.edu)
  • In addition to targeting specific diseases, we develop therapeutic platforms based on molecular approaches such as genome editing and RNA-based methods. (umassmed.edu)
  • By creating the first song bird models for vocal degeneration, we have achieved what I believe is a turning point for all kinds of diseases that affect speech, like Alzheimer's, Parkinson's, and autism. (neurosciencenews.com)
  • Research at my Cellular and Molecular Neurobiology Lab focuses on studying chronic stress and its neurochemical effects on the brain. (chatham.edu)
  • The SH-SY5Y neuroblastoma cell line, a widely validated model in neurobiology, is employed as a cellular model of chronic stress in combination with stress hormones. (chatham.edu)
  • Students interested in joining the Cellular and Molecular Neurobiology Lab at Chatham University should contact Dr. Sierra. (chatham.edu)
  • Handbook of Neurochemistry and Molecular Neurobiology is intended to serve as a reference source for basic researchers and clinicians involved in the neurodegenerative field in particular and in the neuroscience field in general. (chipsbooks.com)
  • Based on neurobiology studies of the insect working memory we will explore how several different memory concepts can be implemented using III-V nanowires and molecular dyes. (lu.se)
  • There are many recognized neurological disorders, some relatively common, but many rare. (wikipedia.org)
  • Invited Chapter - Shyam Diwakar, Computational Modeling of Neuronal Dysfunction at Molecular Level Validates the Role of Single Neurons in Circuit Functions in Cerebellum Granule Layer, in "Validating Neuro-Computational Models of Neurological and Psychiatric Disorders", Springer, 2015, available at http://www.springer.com/in/book/9783319200361. (amrita.edu)
  • Early-life environmental stress is a powerful disposing factor for later neurological and psychiatric disorders. (mcknight.org)
  • It also plays a role in various neurological and psychiatric disorders. (pediastaff.com)
  • Neuronal cell apoptosis is associated with various neurological damaging factors, including radiation ( 1 ). (spandidos-publications.com)
  • Studies on the molecular mechanism of neuronal cell apoptosis following radiation have enriched the number of protective therapeutic strategies against radiation-induced neuronal cell death ( 2 ). (spandidos-publications.com)
  • As an undergraduate student, I had the opportunity to join a biochemistry research lab during my freshman year, where I used calcium-transporting enzymes as model systems to study the toxic effects of drugs and environmental pollutants. (chatham.edu)
  • said Vamsi Mootha , senior author of the study, an institute member at the Broad, professor of systems biology and medicine at Harvard Medical School, and professor of molecular biology at Massachusetts General Hospital. (broadinstitute.org)
  • Accordingly, the group is positioned to work at the interface of systems biology, RNA biology and molecular neuroscience. (ed.ac.uk)
  • Mechanistic follow-up of key events is then carried out within hiPSC models using established molecular biology, functional genomics and systems biology methods in order to determine both their cause and consequence. (ed.ac.uk)
  • Within the group, we develop and apply computational methods for multiscale molecular modeling and simulations, which are fully integrated with medicinal chemistry and structural/molecular biology. (iit.it)
  • It was not known how NCOR1/2 regulates memory or other cognitive functions, but there is evidence that NCOR1/2 plays a fundamental role in the activity of many hormones,' said the corresponding author of the report Dr. Zheng Sun, an assistant professor of medicine and of molecular and cellular biology at Baylor College of Medicine. (labroots.com)
  • What struck us the most was that the process by which NCOR1/2 regulates memory involves a new circuit that links two brain regions: the lateral hypothalamus, known as a feeding center of the brain, and the hippocampus, a place that stores memory,' said study collaborator Dr. Yong Xu, an associate professor of pediatrics, molecular and cellular biology at Baylor. (labroots.com)
  • He is a world-known expert in structural biology, molecular modeling, bioinformatics, and using AI for drug design and treatment. (cbs42.com)
  • Cannabidiol (CBD), the major nonpsychoactive Cannabis constituent, has been proposed for the treatment of a wide panel of neurological and neuropsychiatric disorders, including anxiety, schizophrenia, epilepsy and drug addiction due to the ability of its versatile scaffold to interact with diverse molecular targets that are not restricted to the endocannabinoid system. (nih.gov)
  • In this view, here we will try to provide a comprehensive and up-to-date overview of the molecular basis underlying the therapeutic effects of CBD involved in the treatment of neurological and neuropsychiatric disorders. (nih.gov)
  • Human brain organoids are used for understanding pathogenesis and investigating therapeutic options for neurodevelopmental, neuropsychiatric, neurodegenerative, and neurological disorders. (mdpi.com)
  • Imbalance of the oxytocin-vasopressin system contributes to the neuropsychiatric phenotype in the BACHD mouse model of Huntington disease. (lu.se)
  • The National Institute of Neurological Disorders and Stroke (NINDS) conducts research related to myotonia congenita and also supports additional research through grants to major research institutions across the country. (brainfacts.org)
  • NINDS Disorders is an index of neurological conditions provided by the National Institute of Neurological Disorders and Stroke. (brainfacts.org)
  • Note: The National Institute of Neurological Disorders and Stroke was inadvertently omitted and will be added next year. (bvsalud.org)
  • In particular, an ever-increasing number of molecular targets linked to those disorders have been identified for this phytocannabinoid, along with the modulatory effects of CBD on their cascade signaling. (nih.gov)
  • Molecular targets of NPD1 and RvD1 are defined by following dose-response and therapeutic window. (springer.com)
  • UBLs and the underlying degradation pathways have been the focus of many academic and industrial projects, aiming to exploit them as diagnostic markers, drug targets and molecular drugs themselves. (fnp.org.pl)
  • I later returned to UTEP for another postdoctoral appointment, where I used rodents as preclinical models to study how chronic stress can alter protein degradation pathways in the brain, how this is connected to the development of neurological disorders and devising potential therapeutic interventions. (chatham.edu)
  • Therapeutic effects of progesterone in animal models of neurological disorders. (bvsalud.org)
  • In this way, results obtained in animal models could provide the basis for novel therapeutic strategies and pre-clinical studies. (bvsalud.org)
  • Hence, we can observe and study cellular and molecular processes that are dysfunctional under disease condition. (uni-potsdam.de)
  • Recently, laboratory-based advancements in our understanding of central nervous system injuries at the cellular and molecular levels have ushered in new drug treatment strategies for neuroprotection and regeneration following SCI. (eurekaselect.com)
  • For this project, she has designed experiments that are designed to fill a considerable knowledge gap regarding the cellular and molecular programs that drive normal human cerebellar development and the pathogenesis of human cerebellar malformations. (nih.gov)
  • My research aims to determine how chronic stress can modify specific cellular and molecular pathways to predispose individuals to suffering from a neurological disorder later in life. (chatham.edu)
  • Molecular pathways involved in this disease have been described, however, the very onset or non-genetic triggers that cause CCM remain undetermined. (uni-potsdam.de)
  • Friedreich's ataxia is caused by loss of a mitochondrial protein called frataxin, which helps make molecular complexes called iron-sulfur clusters required for a number of cellular pathways, including those involved in energy metabolism. (broadinstitute.org)
  • Perturbation of these specific modification pathways results in protein homeostasis defects and has been linked to neurological disorders and cancer in humans. (fnp.org.pl)
  • Sec. Molecular Signalling and Pathways. (lu.se)
  • The study appeared recently in Human Molecular Genetics . (broadinstitute.org)
  • Dr. Kathleen Millen's research program seeks identify the events that regulate cerebellar development, using the power and strengths of both mouse and human genetics with embryological analysis in mice and other model vertebrates. (nih.gov)
  • Reporting in Nature Neuroscience , the team learned more about how neurons change when molecules called NCOR1 and NCOR2 (NCOR1/2) are lost, and the resulting impact on memory in a mouse model. (labroots.com)
  • Neuroscience focusing on human development and disease has long been hampered due to ethical rea¬sons, low tissue availability, and low translatability from animal models. (lu.se)
  • An international team of researchers from the Max Planck Research Group at the Malopolska Centre of Biotechnology (MCB) deciphered the molecular mechanism of a sulfur carrier system that stands at the root of all eukaryotic Ubiquitin-conjugation systems. (fnp.org.pl)
  • The Wallenberg Centre for Molecular and Translational Medicine. (lu.se)
  • Patients with CCM lesions suffer from neurological deficits such as headaches and hemorrhagic stroke. (uni-potsdam.de)
  • Other neurological deficits such as rigidity, bradykinesia or dystonia should prompt alternative diagnoses. (eurekaselect.com)
  • This study showing that severe acute respiratory syndrome coronavirus directly infects coronary artery plaques, producing inflammatory substances, really joins the dots and helps our understanding on why we're seeing so much heart disease in COVID patients," Peter Hotez, MD, professor of molecular virology and microbiology at Baylor College of Medicine in Houston, told Medscape. (medscape.com)
  • In addition, clinical neuropsychology uses neuropsychological assessment to precisely identify and track problems in mental functioning, usually after some sort of brain injury or neurological impairment. (wikipedia.org)
  • In patients who are untreated or diagnosed late, severe neurological impairment, wasting, and depression develop, subsequently leading to a high mortality rate. (medscape.com)
  • citation needed] The specific causes of neurological problems vary, but can include genetic disorders, congenital abnormalities or disorders, infections, lifestyle or environmental health problems including malnutrition, brain damage, spinal cord injury, nerve injury or gluten sensitivity (with or without intestinal damage or digestive symptoms). (wikipedia.org)
  • The National Institute for Health and Care Excellence recommends considering the evaluation of an underlying coeliac disease in people with unexplained neurological symptoms, particularly peripheral neuropathy or ataxia. (wikipedia.org)
  • In a substantial minority of cases of neurological symptoms, no neural cause can be identified using current testing procedures, and such "idiopathic" conditions can invite different theories about what is occurring. (wikipedia.org)
  • However, the molecular and neurological dysfunctions that cause these symptoms aren't well understood. (neurosciencenews.com)
  • Noninvasive treatments are limited for easing symptoms partially due to the complexity of the disorder and lack of knowledge of specific molecular malfunctions. (fau.edu)
  • Current research is exploring how, at the molecular level, the defective gene in myotonia congenita causes the specific symptoms of the disorder. (brainfacts.org)
  • This buildup of ammonia damages the brain and other tissues and causes neurological problems and other signs and symptoms of argininosuccinic aciduria. (medlineplus.gov)
  • A strong advantage of the zebrafish model is the availability of in vivo imaging techniques, because the embryo is completely transparent and can live for several days without a functional cardiovascular system. (uni-potsdam.de)
  • DTEM) has developed and coordinated a mixtures program that includes trend analysis to identify the mixtures most often found in environmental media, in vivo and in vitro toxicological testing of mixtures, quantitative modeling of joint action, and methodological development for assessment of joint toxicity. (cdc.gov)
  • Using an ex vivo model, the researchers also found that atherosclerotic tissue could be directly infected by the virus. (medscape.com)
  • We also use mutations to address how neurons die in fly models of neurological illness. (truman.edu)
  • The study, "Modulating Behavior in C.elegans Using Electroshock and Antiepileptic Drugs," just published in PLOS One ( http://dx.plos.org/10.1371/journal.pone.0163786 ), has led the researchers to build on the current animal models for inducing seizures via electroconvulsion in the genetically modifiable C.elegans that only has 302 brain cells called neurons. (fau.edu)
  • A neurological disorder is any disorder of the nervous system. (wikipedia.org)
  • citation needed] Alternatively, a condition might first be detected through the presence of abnormalities in mental functioning, and further assessment may indicate an underlying neurological disorder. (wikipedia.org)
  • The work may help researchers understand neurological problems including autism spectrum disorder, intellectual disability, and neurodegenerative disease. (labroots.com)
  • There hasn't been a good animal model for any kind of speech disorder," says study author Wan-chun Liu, a senior research associate in Fernando Nottebohn's Laboratory of Animal Behavior. (neurosciencenews.com)
  • Additional research is focused on developing animal models of the disorder to test potential treatments and therapies. (brainfacts.org)
  • The molecular diagnostics market is anticipated to gain the market worth of US$ 9.5 billion by 2025, expanding at a CAGR of 6.3% during the forecast period 2019-2025. (openpr.com)
  • The high prices of molecular diagnostics tests and unfavorable reimbursement policies will act as the major restraints in the growth of this market. (openpr.com)
  • This will lead to the rise in the entry of players and this domain and will affect the molecular diagnostics market. (openpr.com)
  • Thanks to the technological advances made in molecular diagnostics, above all in next-generation sequencing (NGS) and digital polymerase chain reaction (dPCR) platforms, clinical laboratories benefit from the rapid translation of established and emerging molecular tests. (openpr.com)
  • Advancing molecular diagnostics has been the prime agenda of biomedical scientists around the globe. (openpr.com)
  • Molecular diagnostics has made possible the diagnosis of the previously undetected viral nucleic acids and helped provide a deeper understanding of the cause of disease, treatment dose, and success of the treatment depending upon the case. (openpr.com)
  • Increasing R&D activities focused on developing advanced tools and techniques intended to enable rapid as well as accurate diagnosis of disease will propel molecular diagnostics' market growth. (openpr.com)
  • Based on product type the global molecular diagnostics market is bifurcated into Instruments, Reagents and services and others. (openpr.com)
  • Molecular diagnostics market, based on technique is segmented into Polymerase Chain Reaction (PCR), Transcription-Mediated Amplification (TMA), In Situ Hybridization, DNA Sequencing & Next-Generation Sequencing (NGS), Chips and Microarrays and others. (openpr.com)
  • In 2018, PCR dominated the global molecular diagnostics technology type market and is anticipated to generate a market size of US$ 3,508.8 million by 2025. (openpr.com)
  • Prediction of quality of life in schizophrenia using machine learning models on data from Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial. (cdc.gov)
  • Collectively, our data provide evidence that activated microglia and complement cascade c1q signaling in the hippocampus may account for synaptic loss and cognitive impairments in a mouse model of neuroinflammation induced by repeated LPS injections. (imperial.ac.uk)
  • A separate training laboratory where biochemical and molecular analyzes, metabolism analyzes, and structural and biochemical analyzes of microorganisms are carried out is located in the infrastructure of the faculty. (ciu.edu.tr)
  • Numerous examples have been described of neurological disorders that are associated with mutated DNA repair genes (for reviews see). (wikipedia.org)
  • The researchers used a mouse model for this work that carried mutations in the NCOR1/2 genes. (labroots.com)
  • The crystal structure of the Uba4-Urm1 complex provides molecular insights into substrate recognition and the enzymatic reaction cascade. (fnp.org.pl)
  • Our research includes the use of knockout mice and zebrafish as laboratory models. (ncl.ac.uk)
  • Dr. Goodman's laboratory studies the molecular events that give rise to the sensation of touch and temperature using C. elegans nematodes as a model system. (nih.gov)
  • The concept of clinical validity and utility underpins the use of molecular diagnostic tests in the clinical laboratory, and continuous sharing of expertise between clinical and laboratory partners will enhance the appropriateness of molecular testing and interpretation, thus improving personalized medicine. (openpr.com)
  • There is an advanced cadaver room as well as a comprehensive model laboratory designed for anatomy education. (ciu.edu.tr)
  • Additionally, a rise in occurrence rates of cardiovascular disorders, genetic disorders, neurological disorders is also expected to fuel market growth. (openpr.com)
  • Activated microglia and subsequent release of pro-inflammatory cytokines result in neuroinflammatory status which further damage neurological function including cognitive impairments in various neurological conditions. (imperial.ac.uk)
  • To discover the molecular programs controlling microglial and macrophage polarization by blood proteins, we developed an unbiased blood-innate immunity multiomic and genetic loss-of-function pipeline consisting of deep sequencing of blood-induced transcriptomes, functional single-cell and oxidative stress transcriptomics, global phosphoproteomics and integration with innate immune signatures from AD and MS models (Extended Data Fig. 1 ). (nature.com)
  • Mechanistically dissect key RNA metabolism changes causing neural cell dysfunction: Our priorities are to understand the cause and consequence of dysregulated splicing events, and to identify intrinsic master regulators driving transcriptome-wide signatures of neurological disease. (ed.ac.uk)
  • Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders. (mpg.de)
  • It is based on (i) neural circuit architectures found in insects (ii) replacing physical interconnects by light (iii) using novel nanoscale components and molecular dyes to control and interpret signals with extreme energy efficiency. (lu.se)
  • Understanding of the neuro-architecture of key areas in the insect brain and its attached sensory systems will be used to create III-V nanowire and molecular dye-based network systems that mimic neural computations underlying specific behaviours (in particular, navigation). (lu.se)
  • To use light for connectivity we apply a broadcasting concept sensitizing the neural nodes to specific light signals and by sub-wavelength light manipulation of emission patterns using III-V nanowire-based components as well as molecular dyes. (lu.se)
  • My lab integrates traditional and single-nuclei RNA sequencing to elucidate transcriptome-wide changes to RNA metabolism in clinically relevant post-mortem brain tissue and human induced pluripotent stem cell (hiPSC) models of neurological disease including ALS and autism. (ed.ac.uk)
  • Atta-ur- Rahman , " Frontiers in Clinical Drug Research - CNS and Neurological Disorders ", Bentham Science Publishers (2017). (eurekaselect.com)
  • The project's training goal is to produce a new generation of exposome researchers, trained in academia, applied research and industry, with transdisciplinary skills (environmental end exposure modelling, HBM, -omics technologies, high dimensional bioinformatics and environmental epidemiology,) and understanding of fundamental science and its direct application to environmental health challenges. (europa.eu)
  • These models are presenting new research questions that students are currently addressing. (truman.edu)
  • Like humans, songbirds such as zebra finches (above) can learn vocalizations, and this similarity suggests they could serve as models for research on Huntington's disease and other neurodegenerative disorders that affect speech and vocalization. (neurosciencenews.com)
  • Researchers from Florida Atlantic University, in collaboration with The Scripps Research Institute, have opened up the possibilities for rapid drug screens to treat seizures in the near future by developing the smallest whole-animal electroconvulsive seizure model using a microscopic nematode worm. (fau.edu)
  • The multiplicity of progesterone beneficial effects has opened new venues of research for neurological disorders . (bvsalud.org)
  • Moreover, environmental exposures could contribute to a dysregulated immune system that interacts at the molecular level with glial cells and astrocytes, creating a neuroinflammatory condition. (europa.eu)
  • Oxygen restriction is an exciting experimental modality, and it's now been shown to have pretty potent beneficial effects across multiple models of aging and disease," said Robert Rogers, first author on the PLOS study, postdoctoral fellow in Mootha's lab, and an instructor in the Division of Pulmonary and Critical Care Medicine at Massachusetts General Hospital. (broadinstitute.org)
  • Electroshock is one of the most common experimental models of acute and chronic seizure in mammals to study epilepsy. (fau.edu)
  • Footprint-free human fetal foreskin derived iPSCs: A tool for modeling hepatogenesis associated gene regulatory networks. (mpg.de)
  • To look for other possible regimens, Mootha's team, in their latest study, tested seven different hypoxia treatments in the same mouse model of Friedreich's ataxia and included animals in later stages of the disease. (broadinstitute.org)
  • Healthy male Sprague‑Dawley rats were used in the present study to examine the radioprotective effect of a type of pan-caspase inhibitor, z-VAD-fmk, following radiation, to investigate the effects of caspase blockade in a model of the nucleus of the abducens nerve. (spandidos-publications.com)
  • In the present study, a model of the nucleus of abducens nerve was established to examine this. (spandidos-publications.com)
  • The lead author, Marta Pabis, explains that ?UBL protein modifications in eukaryotes might have evolved from prokaryotic sulfurtransferase systems and our study provides further evidence that the Uba4-Urm1 system represents that missing ?molecular fossil? (fnp.org.pl)
  • In recent years, songbirds' similarities to human vocal learning have piqued researchers' interests in using them as a functional animal model to study the neurological basis for Huntington's disease. (neurosciencenews.com)
  • C.elegans has been used for decades as a model animal to study the genetic and molecular underpinnings of neurological disorders through a number of techniques including bio imaging, electrophysiology and behavior. (fau.edu)
  • To develop, evaluate and test an array of prediction models, we created stratified (on the outcome measure) random samples of our study population. (lu.se)
  • RUNX1-positive leukemia cells in preclinical models. (lu.se)
  • Biologists at the University of Bath in the UK, led by Dr Vasanta Subramanian, made this link in animal models by manipulating a gene (one of 34) known to cause JS in humans. (pediastaff.com)
  • Like humans, songbirds learn their vocalizations, suggesting they could be useful as models for certain disorders. (neurosciencenews.com)
  • A Non-Invasive Interpretable Diagnosis of Melanoma Skin Cancer Using Deep Learning and Ensemble Stacking of Machine Learning Models. (cdc.gov)
  • Improved Machine Learning-Based Predictive Models for Breast Cancer Diagnosis. (cdc.gov)
  • Many of the leukemia terms have undergone name changes as immunophenotypic and molecular biological techniques have made diagnosis more precise. (bvsalud.org)
  • The neurological problem may start in another body system that interacts with the nervous system. (wikipedia.org)
  • Now, researchers at the Broad Institute of MIT and Harvard have found that treatment with continuous hypoxia - low-oxygen conditions comparable to levels at a Mount Everest base camp - restores balance and coordination in a mouse model of Friedreich's ataxia. (broadinstitute.org)
  • We explore genetic disease at the molecular and cellular level and its treatment. (ncl.ac.uk)
  • This valuable tool offers detailed descriptions, facts on treatment and prognosis, and patient organization contact information for over 500 identified neurological disorders. (brainfacts.org)
  • Rats transgenic for Huntington's disease (tgHD51 CAG rats), surviving up to two years, represent an animal model of HD similar to the late-onset form of human disease. (hindawi.com)
  • To the best of our knowledge, our findings are the first to document that tgHD51 CAG rats can be used as a valid animal model for detailed histopathological studies related to HD in human. (hindawi.com)
  • We also develop platform technologies to facilitate AAV-based gene therapy, such as animal modeling and AAV vector production. (umassmed.edu)
  • We next described our results involving animal models of human neuropathologies to elucidate the protective roles of progesterone . (bvsalud.org)
  • In terms of modelling environmental exposure, assessment of BPA, PM and PAHs has been carried out, as well as a comprehensive assessment of Hg exposure through the food chain. (europa.eu)
  • Information from environmental exposure and personal sensors, as well as from Agent Based models data has been used to estimate personal exposure and validate it against HBM data. (europa.eu)
  • Currently, we are developing statistical models to describe the environmental variables that affect the number of ticks. (truman.edu)
  • They may be assessed by neurological examination, and studied and treated within the specialties of neurology and clinical neuropsychology. (wikipedia.org)
  • Background: A prediction model that estimates survival and neurological outcome in out-of-hospital cardiac arrest patients has the potential to improve clinical management in emergency rooms. (lu.se)
  • Last month, for instance, Mootha's team showed that a mouse model of an accelerated aging disease lived 50 percent longer and showed slower neurological decline in low-oxygen conditions. (broadinstitute.org)