AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation ScienceHealth Care
InterferonsInterferon Type IInterferon InducersReceptors, InterferonInterferon-alphaInterferon-gammaInterferon-betaInterferon Regulatory Factor-3Interferon Regulatory Factor-1Interferon Regulatory FactorsReceptor, Interferon alpha-betaInterferon Regulatory Factor-7Antiviral AgentsPoly I-CRecombinant ProteinsInterferon Regulatory Factor-2Newcastle disease virusRibavirinCell LineVesicular stomatitis Indiana virusSTAT1 Transcription Factor2',5'-Oligoadenylate SynthetaseL Cells (Cell Line)Hepatitis C, ChronicPolyethylene GlycolsCells, CulturedCytokinesVirus ReplicationEncephalomyocarditis virusSTAT2 Transcription FactorInterferon-Stimulated Gene Factor 3Mice, Inbred C57BLImmunity, InnateHepacivirusInterferon-Stimulated Gene Factor 3, gamma SubunitMyxovirus Resistance ProteinsRNA, MessengerMice, Inbred BALB CGene Expression RegulationMacrophagesSignal TransductionParainfluenza Virus 1, HumanRNA, Double-StrandedSpleenHepatitis CFibroblastsViral InterferenceT-LymphocytesDrug Therapy, CombinationMolecular Sequence DataTumor Necrosis Factor-alphaKiller Cells, NaturalRNA, ViralVirus DiseasesDNA-Binding ProteinsMice, KnockoutInterleukin-12Leukocytes, MononuclearSendai virusLeukocytesBase SequenceInterleukin-4Lymphocyte ActivationViral Nonstructural ProteinsDendritic CellsDEAD-box RNA HelicasesTranscription, GeneticLymphocytesTime FactorsCD4-Positive T-LymphocytesCytopathogenic Effect, ViralTiloroneViral ProteinseIF-2 KinaseInterleukinsInterleukin-2Chemokine CXCL10MengovirusDactinomycinTh1 CellsInterleukin-10Trans-ActivatorsCulture TechniquesVero CellsGene ExpressionVirusesCD8-Positive T-LymphocytesTranscription FactorsPromoter Regions, GeneticMonocytesTreatment OutcomeMacrophage ActivationImmunologic FactorsViral LoadLipopolysaccharidesToll-Like Receptor 3Immune EvasionTYK2 KinaseImmunity, CellularCercopithecus aethiops
SubtypesAntiviralHuman interferon-gamma reTreated with interferon alfaBiologyMechanismsInducesRegulatory factorVirologyAlpha-2aCytokineReceptorRibavirinGeneInduceGenesEvasionRecombinantPathwaysIFNsProteinInducibleTherapiesDifferent molecularIsoformsInhibits viralAntibodiesGammaVirusesCorticosteroidsInternational JournalImmunityTypeTumorsClinicalResponsePathogensMedicationEpidemiologyInteractionsPatients
Subtypes6
  • Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (nih.gov)
  • By reviewing biomarkers and breast cancer molecular subtypes, we propose that the divergent outcome observed from patients stratified by hormone status are driven by different cancer hallmarks. (jcancer.org)
  • In order to do this, firstly, we correlate molecular subtypes and BCG responses. (urotoday.com)
  • In muscle-invasive bladder cancer, molecular subtypes haven't been thoroughly studied. (urotoday.com)
  • Out of our six consensus molecular subtypes, [inaudible] belong to three luminal tumors. (urotoday.com)
  • And when we looked at the relationship between molecular subtypes and response, we couldn't see any correlations. (urotoday.com)
Antiviral8
  • They studied how a certain enzyme called PKR behaves in human cells, and showed that this enzyme is important for the antiviral effect of interferon against some viruses, but not others. (medicalxpress.com)
  • The overall objective of Samuel's laboratory is to elucidate, in molecular terms, the mechanisms by which interferons exert their antiviral and cell growth control actions in mammalian cells. (medicalxpress.com)
  • Using three separate viruses, the scientists found that PKR is important for the antiviral effect of interferon against some viruses but not others. (medicalxpress.com)
  • This volume summarizes current knowledge of the interferon-based natural antiviral protection system including 2',5'-oligoadenylate and double-stranded RNA. (powells.com)
  • Interferon beta-1a (Avonex) is a recombinant form of a physiologic human type I interferon important for antiviral, immunomodulatory and antiproliferative effects. (clinimmsoc.org)
  • We present a biophysical characterization of the oligomerization and aggregation processes by Interferon alpha-2a (IFNα-2a), a protein drug with antiviral and immunomodulatory properties. (lu.se)
  • Interferons are naturally produced proteins with antiviral, antitumor, and immunomodulatory actions. (medscape.com)
  • The direct antiviral activity of interferon alfa-2b activates viral ribonucleases and inhibits viral entry into cells and viral replication. (medscape.com)
Human interferon-gamma re1
Treated with interferon alfa2
  • Compare clinical response, in terms of 1-year progression-free survival and rate of molecular complete remission, in patients with Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML) in chronic phase who have achieved a complete cytogenetic remission to single-agent tyrosine kinase inhibitor treated with interferon alfa and sargramostim (GM-CSF) vs tyrosine kinase inhibitor and GM-K562 cell vaccine. (knowcancer.com)
  • Peginterferon alfa-2a is also FDA approved for treatment of chronic hepatitis C, alone or in combination with ribavirin, in patients not previously treated with interferon alfa, and with compensated liver disease. (medscape.com)
Biology4
  • The study was conducted in the laboratory of Charles Samuel, the Charles A. Storke II Professor of Molecular Biology at UCSB. (medicalxpress.com)
  • I joined the department of Molecular Biology as Scientist in 1989, and my lab helped establish a technology to fuse biologically important proteins to antibody molecules. (gene.com)
  • Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. (books-express.ro)
  • Practical and authoritative, Regulatory B Cells: Methods and Protocols serves as an ideal guide for immunologists as well as for cell and molecular biologists interested in the intricacies of B cell biology. (books-express.ro)
Mechanisms6
  • STING works as both a direct cytosolic DNA sensor (CDS) and an adaptor protein in Type I interferon signaling through different molecular mechanisms. (wikipedia.org)
  • The study highlights how combining multiple methods helps to systematically dissect the molecular mechanisms driving oligomer formation and to design ultimately efficient strategies for preventing detrimental protein aggregation. (lu.se)
  • We use molecular, biochemical, genetic and evolutionary approaches to characterize the mechanisms underlying these activities and how emerging viruses evade them. (uwo.ca)
  • Interferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-apoptotic and antitumor mechanisms. (nih.gov)
  • Use of new knowledge on molecular inflammation to approach inflammatory diseases with new hypotheses of underlying abnormal immune mechanisms, provides a more solid foundation for the search for new therapeutic approaches and biomarkers. (ntnu.edu)
  • To overcome BCG resistance, we need to understand the mechanisms of a BCG therapeutic effect and identify molecular correlates that can predict the BCG responses. (urotoday.com)
Induces3
  • STING induces type I interferon production when cells are infected with intracellular pathogens, such as viruses, mycobacteria and intracellular parasites. (wikipedia.org)
  • This study demonstrates that TMAO induces distinct time-dependent molecular signatures involving inflammation and remodelling pathways, while pathways such as oxidative stress are also modulated, but in a non-time-dependent manner. (nature.com)
  • As the second messenger, cGAMP activates STING and induces the following cascade to produce type I interferon (IFN-I) to protect against infections. (frontiersin.org)
Regulatory factor1
  • Produced peptides such as that for CUB and sushi domain-containing protein 1 and interferon regulatory factor 1 further originate from regulatory domains involved in inflammatory modulation, suggesting bioactive potential. (cdc.gov)
Virology1
  • Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, and Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai 200032, China. (bvsalud.org)
Alpha-2a1
  • The objectives of this work were twofold: 1) to evaluate the effectiveness and safety of treatment with classic dual interferon pegylated alpha-2a (IFN) and ribavirin therapy in Benin, and 2) to present problems related to financial accessibility to this treatment. (scirp.org)
Cytokine4
  • Further, we found that the cytokine interferon-β (IFN-β) can induce miR-1 expression in mammalian cells, reducing TBC1D15 levels, and safeguarding against proteotoxic challenges. (elifesciences.org)
  • Predicted to enable cytokine activity and type I interferon receptor binding activity. (nih.gov)
  • Furthermore, manipulating an inflammatory cytokine called interferon gamma had much stronger impact on microglia movements in males than in females. (uvic.ca)
  • Dr. Crow identified the type I interferon (IFN) pathway as central to the pathogenesis of SLE, and she continues to investigate the cellular and cytokine mediators of immune system activation and inflammation in those disorders. (hss.edu)
Receptor7
  • Type I interferon produced by infected cells can find and bind to Interferon-alpha/beta receptor of nearby cells to protect cells from local infection. (wikipedia.org)
  • Interferon gamma receptor 1 ( IFNGR1 ) also known as CD119 ( C luster of D ifferentiation 119 ), is a protein that in humans is encoded by the IFNGR1 gene . (wikidoc.org)
  • The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages . (wikidoc.org)
  • Interferon gamma receptor 1 has been shown to interact with Interferon-gamma . (wikidoc.org)
  • Binding of interferon beta-1a to its receptor leads to induction of many interferon inducible genes, including beta 2-microglobulin and neopterin, both of which can serve as biomarkers for interferon beta-1a administration. (clinimmsoc.org)
  • NMR structure of the interferon-binding ectodomain of the human interferon receptor. (wikidoc.org)
  • The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. (wikidoc.org)
Ribavirin3
  • Although treatment for viral hepatitis C (VHC) has been around for many years and is widely used in developed countries, the high cost of pharmaceuticals (pegylated interferon and ribavirin) and pre-, per-, and post-treatment assessment has long been a brake on its implementation in developing countries, including Benin. (scirp.org)
  • Two treatment regimens are available: traditional dual therapy (interferon + ribavirin) used since 2010 and direct-acting antivirals (DAAs) since the end of 2015. (scirp.org)
  • We investigated the response to standard combination therapy (pegylated interferon/ribavirin) of different genotypes of HCV in Kuwaiti patients and factors that could be associated with sustained virological response (SVR). (who.int)
Gene6
  • Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by the STING1 gene. (wikipedia.org)
  • Nucleotide sequence of a portion of human chromosome 9 containing a leukocyte interferon gene cluster. (nih.gov)
  • We provide evidence that such failure to resolve R-loops causes sustained activation of a systemic inflammatory response characterized by an interferon (IFN) gene expression signature. (uni-koeln.de)
  • Moreover, increased interferon gene expression signature in patients is associated with markedly poor prognosis. (uni-koeln.de)
  • [9] For example, type I IFNs induce interferon-stimulated gene ( ISG ) expression, classically resulting in a robust anti-viral immune response. (wikidoc.org)
  • By exploiting state-of-the-art genetic strategies, including novel gene knockdown platforms and exogenously- and microRNA-regulated vectors, I will identify and validate molecular pathways that may be targeted to selectively inhibit TEMs activity in tumors. (europa.eu)
Induce1
  • Upon infection, STING from infected cells can sense the presence of nucleic acids from intracellular pathogens, and then induce interferon β and more than 10 forms of interferon α production. (wikipedia.org)
Genes1
  • The cyclic GMP-AMP synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway is a critical defender to sense various pathogens and trigger innate immunity of mammalian cells. (frontiersin.org)
Evasion1
  • Garcia-Sastre A. Induction and evasion of type I interferon responses by influenza viruses. (smw.ch)
Recombinant1
  • Interferon alfa-2b is a protein product manufactured by recombinant DNA technology. (medscape.com)
Pathways4
  • After recognizing viral DNA, DNA sensors initiate the downstream signaling pathways by activating STING-mediated interferon response. (wikipedia.org)
  • This study aims to clarify the time-dependent molecular pathways by which TMAO mediates endothelial dysfunction through transcriptomics and metabolomics analyses in human microvascular endothelial cells (HMEC-1). (nature.com)
  • It's just a matter of identifying and understanding the molecular pathways and networks involved. (sciencedaily.com)
  • [7] [8] Upon binding of type I interferons, IFNAR activates the JAK-STAT signalling pathway , along with MAPK , PI3K , and Akt signaling pathways. (wikidoc.org)
IFNs1
  • This senses pathogen-associated molecular patterns (PAMPs), which triggers the synthesis of interferons (IFNs). (fsu.edu)
Protein2
  • Abstract Objective To investigate the effect and molecular mechanism of interferon-α (INF-α) on the apoptosis of the mouse podocyte cell line MPC5 induced by hepatitis B virus X (HBx) protein. (zgddek.com)
  • The immunomodulatory effects of interferon alfa-2b include enhancement of cytolytic T-cell activity, stimulation of natural killer cell activity, amplification of human leukocyte antigen (HLA) class I protein on infected cells, and suppression of tumor cell proliferation. (medscape.com)
Inducible1
  • Current work in Samuel's lab includes biochemical and molecular genetic studies of two interferon-inducible enzymes, PKR and ADAR. (medicalxpress.com)
Therapies2
  • Interferons are widely used platform therapies as disease-modifying treatment of patients with multiple sclerosis. (uni-wuerzburg.de)
  • These systemic Interferons are widely used platform therapies as disease-modifying treatment of patients with multiple sclerosis. (uni-wuerzburg.de)
Different molecular1
  • Consensus molecular classification was developed by compiling six different molecular classifiers. (urotoday.com)
Isoforms1
Inhibits viral1
  • But clearance of the HCV virus (via the drug sofosbuvir) partially restored cellular sensitivity to interferon-a, which inhibits viral replication. (sciencedaily.com)
Antibodies3
  • In this study, we isolated samples of the SARS-CoV-2 R.1 lineage, categorized as a variant under monitoring by the World Health Organization, and evaluated their sensitivity to neutralizing antibodies and type I interferons. (cdc.gov)
  • Our study demonstrates that the R.1 variant retained sensitivity to neutralizing antibodies but evolved resistance to type I interferons. (cdc.gov)
  • Studies on HCV genotypes in people of HCV-specific antibodies and the latter with haemophilia have identified types 1, was used for molecular analysis. (who.int)
Gamma2
  • A latent TB infection (LTBI) case was defined as an individual who had a positive interferon-gamma release assay (IGRA). (who.int)
  • At the school, new teachers and students are tested with tuberculin skin testing (TST), followed by interferon-gamma release assay (IGRA), if indicated, and annual chest X-ray (CXR) thereafter. (who.int)
Viruses5
  • Interferon is a naturally occurring substance that is also used as a drug to treat certain viruses such as Hepatitis C. (medicalxpress.com)
  • STING mediates the type I interferon production in response to intracellular DNA and a variety of intracellular pathogens, including viruses, intracellular bacteria and intracellular parasites. (wikipedia.org)
  • Although type I IFN is absolutely critical for resistance to viruses, there is growing literature about the negative role of type I interferon in host immunity mediated by STING. (wikipedia.org)
  • Our laboratory is in learning how the human interferon response, touted as the first line of defence against all viruses, responds to these pathogens. (uwo.ca)
  • Viruses infecting many organisms will be covered in the context of their global impact on disease and history, beneficial uses of viruses, and their role in advances of molecular theory. (uoguelph.ca)
Corticosteroids1
  • 8. Gerischer LM, Siebert E, Janke O, Jungehuelsing GJ, Ruprecht K. Favorable outcome of interferon-beta associated thrombotic microangiopathy following treatment with corticosteroids, plasma exchange and rituximab: A case report. (clinimmsoc.org)
International Journal1
  • International Journal of Molecular Sciences 2015, 16, 14951-14960. (uni-wuerzburg.de)
Immunity1
  • STING elicits powerful type I interferon immunity against viral infection. (wikipedia.org)
Type6
  • Type I interferon, mediated by STING, protects infected cells and nearby cells from local infection by binding to the same cell that secretes it (autocrine signaling) and nearby cells (paracrine signaling. (wikipedia.org)
  • STING deficiency in mice led to lethal susceptibility to HSV-1 infection due to the lack of a successful type I interferon response. (wikipedia.org)
  • AT-rich stem-loop DNA motif in the Plasmodium falciparum and Plasmodium berghei genome and extracellular DNA from Mycobacterium tuberculosis have been shown to activate type I interferon through STING. (wikipedia.org)
  • Of note, the R.1 variant was significantly more resistant to type I interferons (IFN-α/β) than was the ancestral isolate. (cdc.gov)
  • type II interferon. (nih.gov)
  • Interferon É (IFNÉ ) is a unique type I IFN that has been implicated in host defense against sexually transmitted infections . (bvsalud.org)
Tumors2
  • Prospective randomized controlled study of interferon-alpha in preventing hepatocellular carcinoma recurrence after medical ablation therapy for primary tumors[J]. Cancer, 2004, 100(2):376-382. (zgddek.com)
  • I recently showed that TEMs can be turned into efficient and therapeutically effective vehicles for the targeted delivery of interferon-alpha to tumors. (europa.eu)
Clinical2
  • Clinical and molecular phenotype of Aicardi-Goutieres syndrome. (medlineplus.gov)
  • Interferon : properties and clinical uses, proceedings of the International Symposium on Interferon, held at Wadley Institutes of Molecular Medicine, Dallas, Texas, October 18-20, 1979 / edited by Amanullah Khan, N. O. Hill, Gordon L. Dorn. (who.int)
Response3
  • In addition to inhibiting virus multiplication, interferons affect other processes in animal cells, including cell growth and differentiation and the immune response. (medicalxpress.com)
  • Twenty-two patients received 135 &mgr;g peglyated-interferon α-2a weekly for 48 wk (group A). The remaining patients were left untreated, eleven refused therapy, and three were not candidates for kidney transplantation and were allocated to the control group (group B). At the end of the treatment biochemical and virological response was evaluated, and 24 wk after completion of therapy sustained virological response (SVR) was assessed. (wjgnet.com)
  • Baseline viral load and alanine aminotransferase level in addition to early virological response to pegylated interferon-based therapy may serve as a decision tool for clinicians to identify patients who are unlikely to achieve SVR. (who.int)
Pathogens1
  • The interferon system is an important host defense against viral and microbial pathogens," said Samuel. (medicalxpress.com)
Medication1
  • In 2014, the FDA approved a new form of this medication Plegridy ("pegylated" form of interferon) for the approved treatment of relapsing
 MS. Plegridy can be administered subcutaneously every two weeks. (clinimmsoc.org)
Epidemiology1
  • Analysis of an echovirus 18 outbreak in Thuringia, Germany: insights into the molecular epidemiology and evolution of several enterovirus species B members. (cdc.gov)
Interactions1
  • We show that monomer attraction is driven mainly by molecular anisotropic dipole-dipole interactions that increase with increasing pH. (lu.se)
Patients3
  • SVR could be achieved in 64.7% of patients on hemodialysis with chronic hepatitis C by a treatment with peglyated-interferon α-2a. (wjgnet.com)
  • Arm I : Patients receive interferon alfa subcutaneously (SC) and GM-CSF SC once daily for 6 months. (knowcancer.com)
  • Cases of pulmonary arterial hypertension (PAH) have been reported in patients treated with interferon beta products, including BETASERON. (nih.gov)