• These applications include surgery, radiation therapy, chemotherapy, hormone therapy, immunotherapy and combined treatment modalities such as chemo-radiotherapy. (wikipedia.org)
  • The management of advanced HNSCC consists of multiple-modality therapy with surgery, radiation, and chemotherapy. (medscape.com)
  • The current conventional modalities (surgery, radiation, chemotherapy) are nonselective and can cause damage to normal tissue. (medscape.com)
  • Targeted molecular therapy, like therapy with monoclonal antibodies, gene therapy, and other therapies, has limited or nonexistent side effects on normal cells of the body, unlike present modalities such as surgery, chemotherapy, and radiotherapy. (medscape.com)
  • The therapeutic efficiency of combined chemotherapy and gene therapy on human hepatocellular carcinoma HepG2 cells was investigated using double-walled microspheres that consisted of a poly(d,. l-lactic-co-glycolic acid) (PLGA) core surrounded by a poly(l-lactic acid) (PLLA) shell layer and fabricated via the precision particle fabrication (PPF) technique. (uky.edu)
  • Overall, double-walled microspheres present a promising dual anticancer delivery system for combined chemotherapy and gene therapy. (uky.edu)
  • Although advances in chemotherapy and the development of specific antibody therapies, surgery as well as radiation therapy have been made, long-term outcome and disease-free survival rates still have not improved. (jcancer.org)
  • In 2005, the first-ever trial combining small molecular targeted agent known as bevacizumab, an anti-vascular endothelial growth factor (VEGF) monoclonal antibody, with doublet chemotherapy, had shown superiority of overall survival with this treatment modality in advanced non-squamous non-small cell lung cancer patients without brain metastasis [ 2 ]. (biomedcentral.com)
  • Usually, associated with such congresses are conferences of radiation oncology focusing on advances in molecular imaging and therapeutics, particle and other types of radiation therapy, and combined modality approaches with chemotherapy and radiotherapy. (ptbr.org.pl)
  • Radiation therapy plus surgery (for head and neck, laryngeal, or uterine cancer) or combined with chemotherapy and surgery (for sarcomas or breast, esophageal, lung, or rectal cancers) improves cure rates and allows for more limited surgery. (msdmanuals.com)
  • The role of FcγRIIIa receptor polymorphism in antibody-dependent cell-mediated cytotoxicity (ADCC), which may be a mechanism of anticancer activity of cetuximab will be discussed, as well as the resistance to radiotherapy and receptor blocking therapy mediated by the insulin-like growth factor receptor I (IGF-1R). (eurekaselect.com)
  • [ 3 ] In an attempt to improve outcomes in HNSCC, most research in the field is now focusing on the molecular biology of HNSCC in an attempt to target select pathways involved in carcinogenesis. (medscape.com)
  • As our understanding of the molecular biology of HNSCC continues to develop, we can target the specific components of cancer cells that are not found in normal cells. (medscape.com)
  • An insight into the biology of ischemic stroke indicates that a stream of molecular events initiates instantly after the onset of ischemic stroke, such as oxidative stress, increased level of intracellular calcium, excitotoxicity, and inflammation which results in apoptotic or necrotic neuronal cell death [ 12 - 14 ]. (hindawi.com)
  • Dr. Pryhuber trained as a post-doctoral Proctor Research Scholar and participant in the University of Cincinnati Program of Excellence in Molecular Biology of the Heart and Lung. (rochester.edu)
  • A better understanding the biology of the above-mentioned features will indeed lead to more effective cancer therapy options in prostate cancer. (uni-hamburg.de)
  • These sections span 60 smaller groups of diseases or disorders.The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients. (ox.ac.uk)
  • Omid Veiseh's laboratory utilizes advanced nano, micro, and macro fabrication techniques in combination with molecular engineering and cellular and molecular biology, to develop platforms of implantable devices tailored for in vivo chemical sensing and delivery of therapeutics. (rice.edu)
  • By combining the latest innovations in nanotechnology, chemical engineering, high-throughput synthesis and screening methods, molecular biology, and pediatric brain tumor oncology, his lab can develop a new modality for the treatment of pediatric brain tumors. (rice.edu)
  • The Veiseh Lab utilizes multi-scaled (nano, micro, and macro) fabrication techniques, combined with molecule engineering and cellular and molecular biology, to develop functional platforms of implantable devices tailored for applications in immunology, regenerative medicine, and disease monitoring. (rice.edu)
  • Written within the hugely winning equipment in Molecular Biology™ sequence layout, chapters contains introductions to their respective matters, lists of the required fabrics, step by step, effortlessly reproducible laboratory protocols, and tips about troubleshooting and fending off recognized pitfalls. (make-a-thon.org)
  • below the assistance of a uncommon group of foreign specialists, 6 volumes accumulated three hundred articles from the entire most sensible scientists laying out our present wisdom at the anatomy, body structure, and molecular biology of sensory organs. (make-a-thon.org)
  • The collaborations across disciplines (cancer biology, imaging probe development, imaging technologies, evaluation of modes of cancer detection and targeted therapies) are expected to enrich the multidisciplinary knowledge networks on campus and enhance various research infrastructures. (illinois.edu)
  • However especially metastatic diseases and relapses still require the development of new therapeutic modalities. (uni-muenchen.de)
  • Targeted molecular therapy against EGFR has shown promise as an adjuvant therapy in preliminary studies in several solid tumors, including head and neck cancer. (medscape.com)
  • Surface engineered nanoparticles (metallic and nonmetallic) have gained tremendous attention for precise imaging and therapeutics of cell/tumors at molecular and anatomic levels. (ntno.org)
  • Phenotypically and genetically heterogeneous tumors are more aggressive, have a higher relapse rate, and are more resilient to therapy. (uni-hamburg.de)
  • New research in Veiseh's laboratory, which is supported by a $2 million grant from the Cancer Prevention and Research Institute of Texas (CPRIT), utilizes a multidisciplinary approach to improve the diagnosis and therapy of pediatric brain tumors. (rice.edu)
  • Compared to traditional antibodies, nanobodies have smaller molecular weights and improved tissue penetration ability, which make them effective at infiltrating tumors and crossing blood-brain barriers. (businesswire.com)
  • We look forward to collaboratively exploring the potential of this approach to treat cold tumors and bring new drug therapies to patients who do not respond to existing immunotherapies. (astellas.com)
  • This strategic partnership will engage in the development of iADCs, a next generation modality with the potential for effective and efficient approaches for treatment of cold tumors so as to bring new drug therapies to patients who do not respond to existing therapies. (astellas.com)
  • TTFields have revolutionized the treatment modality of tumors, particularly glioblastomas (GBMs) and mesotheliomas. (conditionmed.org)
  • Investigating the associated dosimetry estimations help to decrease the risk of diagnostic and therapy techniques. (nih.gov)
  • His research goals focus on developing novel diagnostic and treatment modalities for localized and locally advanced prostate cancer. (cancer.gov)
  • Dr. Pinto's scientific mission is development of novel diagnostic and treatment modalities for localized and locally advanced prostate cancer. (cancer.gov)
  • Within LIMA, Philips seeks to determine how results from these different diagnostic modalities might fit together, as well as how results might be delivered to improve patient outcomes. (genomeweb.com)
  • It allows a cross-modality combination of diagnostic data from the same patient, of imaging and liquid biopsy data. (genomeweb.com)
  • CoMMiTMenT will ensure an effective therapy with diminished undesirable adverse effects, largely replacing splenectomy, and will thus contribute to the goal of the International Rare Diseases Research Consortium (IRDiRC) to deliver novel diagnostic modalities and 200 new therapies for rare diseases by 2020. (eurice.eu)
  • issues lined comprise the conception, psychophysics, and better order processing of sensory info, in addition to problems and new diagnostic and therapy equipment. (make-a-thon.org)
  • Together, they plan to develop selective theranostic (i.e., integrated therapeutic and diagnostic) agents for multi-target and multi-modal cancer imaging and therapy that span the scale from molecular to animal models. (illinois.edu)
  • Second-tier imaging with molecular methods, preferably with fluorodeoxyglucose positron emission tomography (FDG-PET) (or single-photon emission CT [SPECT] if PET is unavailable), can provide greater diagnostic specificity. (medscape.com)
  • Starting in the mid-1990s, the emphasis in clinical cancer research shifted towards therapies derived from biotechnology research, such as cancer immunotherapy and gene therapy. (wikipedia.org)
  • Combined with another type of immunotherapy, their vaccine had robust antitumor effects in multiple mouse models. (nih.gov)
  • and evaluation of immunotherapy, molecular targeted therapy or other pharmacotherapies in the management of localized or locally advanced prostate cancer. (cancer.gov)
  • Indeed, similar to targeted therapy, patients may eventually develop resistance to immunotherapy [ 32 , 33 ] and some may even suffer hyperprogression after immunotherapy [ 34 , 35 ]. (biomedcentral.com)
  • Biocytogen is actively seeking collaborations with global pharmaceutical and biotech companies to combine its large-scale nanobody development abilities with collaborators' expertise in nanobody-related therapeutics, such as cell therapies, bispecific and multi-specific antibodies, ADCs and RACs, to develop novel drugs with first-in-class and/or best-in-class potentials. (businesswire.com)
  • A phase I/II study in relapsing GBM of IA carboplatin chemoradiation therapy using imaging and in vitro data for planning and treatment response prediction. (usherbrooke.ca)
  • Overall, the combined Dox and chi-p53 treatment exhibited enhanced cytotoxicity as compared to either Dox or chi-p53 treatments alone. (uky.edu)
  • The remaining 41% elude this treatment modality. (ucdenver.edu)
  • Haemodiafiltration combines elements of diffusion and convection in a single treatment modality to provide solute removal over a wide range of molecular weights. (herts.ac.uk)
  • We also combined the immune features extracted from peripheral blood immune responses using flow cytometry and routine blood tests before and after treatment. (bvsalud.org)
  • The project aims to apply liquid biopsies, molecular tests, and magnetic resonance imaging (MRI) during the early stages of cancer treatment. (genomeweb.com)
  • Some of the mechansisms leading to resistance to the combined treatment are already understood. (eurekaselect.com)
  • Inside the cell, proteins expressed in radioresistant cells will be highlighted before turning the attention to the impact epithelial mesenchymal transition (EMT) may have on increased resistance to different treatment modalities. (eurekaselect.com)
  • This commitment to advancing cancer care has led to the development of innovative therapies, better patient outcomes, and an increased focus on personalized treatment plans. (artofhealingcancer.com)
  • Ongoing research in the Veiseh lab address challenges of pancreatic islet transplantation - an established experimental therapy for the treatment of Type-1 diabetes. (rice.edu)
  • Often, modalities are combined to create a treatment program that is appropriate for the patient, based on patient and tumor characteristics as well as patient preferences. (msdmanuals.com)
  • These modalities can be combined with the primary treatment at the same time or used before or after. (msdmanuals.com)
  • Repeat histologic evaluation and molecular testing in patients with EGFR-mutant non-small cell lung cancer who develop acquired resistance to osimertinib can deliver pertinent information that can help guide subsequent treatment decisions. (onclive.com)
  • First-line FDA-approved therapies for patients with common EGFR -sensitizing mutations like exon 19 deletions and L858R point mutations include osimertinib (Tagrisso) as the preferred frontline treatment, followed by erlotinib (Tarceva), gefitinib (Iressa), afatinib (Gilotrif), and dacomitinib (Vizimpro). (onclive.com)
  • Potential clinical applications include early identification and staging of malignancies, therapy planning and treatment. (dotmed.com)
  • The goal of therapy with unsealed radiopharmaceutical sources is to provide either cure or significant prolongation of disease-specific survival, and effective reduction and/or prevention of adverse disease-related symptoms or untoward events while minimizing treatment-associated side effects and complications. (nih.gov)
  • Hormonal treatment of advanced prostate cancer should be consideredfor patients who have stages C and D1 disease, a high risk of recurrenceafter local therapy, or prostate-specific antigen-measured recurrenceafter local treatment. (cancernetwork.com)
  • The resulting general platform will help to characterize the content of markers and receptors, monitor their dynamic responses to treatment protocols, and target appropriate therapies. (illinois.edu)
  • Objective Incorporating an enhancer such as nano-titanium dioxide into antimicrobial photodynamic therapy can improve treatment outcome. (thieme-connect.de)
  • We also suggest that individualized treatment modalities and preventive vaccination should be further explored. (cdc.gov)
  • This study confirms that insulin resistance affects treatment outcome, and thus HOMA-IR testing before initiation of therapy may be a cost-effective tool. (who.int)
  • In summary, dentistry begins to show an increasingly close relationship with pharmacogenomics, which may result in the development and improvement of treatment modalities more individualized and potentially more effective. (bvsalud.org)
  • For HIV/AIDS, new evidence that antiretroviral therapy prevents transmission of HIV sparked significant revision and consolidation of all related WHO policy advice, further simplifying treatment protocols and streamlining operational demands. (who.int)
  • [ 1 ] Early stage head and neck squamous cell carcinoma (HNSCC) is treated relatively well with single-modality therapy (either surgery or radiation alone). (medscape.com)
  • Artificial intelligence for detecting superficial esophageal squamous cell carcinoma under multiple endoscopic imaging modalities: a multicenter study. (cdc.gov)
  • Cancer research ranges from epidemiology, molecular bioscience to the performance of clinical trials to evaluate and compare applications of the various cancer treatments. (wikipedia.org)
  • However, despite having the promising outcome of preclinical studies, the clinical application of stem cell therapy remained elusive due to little or no progress in clinical trials. (hindawi.com)
  • The objective of this study was to provide a generalized critique for the role of mesenchymal stem cell therapy in ischemic stroke injury, its underlying mechanisms, and constraints on its preclinical and clinical applications. (hindawi.com)
  • Thus, we attempted to present an overview of previously published reports to evaluate the progress and provide molecular basis of mesenchymal stem cells (MSCs) therapy and its application in preclinical and clinical settings, which could aid in designing an effective regenerative therapeutic strategy in the future. (hindawi.com)
  • However, effective dose and appropriate time of MSCs delivery are the main challenges in the clinical translation of stem cell therapy. (hindawi.com)
  • We aim to provide the basis for establishing a future study to promote the clinical translation of stem cell therapy in ischemic brain diseases. (hindawi.com)
  • This may well lead to new, next-generation or combined tests," said Hofstraat, "but the first step will be to investigate in a clinical setting how to best combine these approaches. (genomeweb.com)
  • Epidermal growth factor receptor, a well-known biomarker for targeted therapy at present, was first brought up with potential clinical responsiveness to tyrosine kinase inhibitor gefitinib in 2004[ 6 ]. (biomedcentral.com)
  • With its unique optical absorption contrast mechanism, PAT is inherently sensitive to the functional and molecular information of biological tissues, and thus has been widely used in preclinical and clinical studies. (duke.edu)
  • To that end, molecular techniques mixed with scientific experience of the medical scientist Dr. Mansour complemented by clinical medical oncology expertise of Dr. Oing are gathered to promote the current bidirectional translational research project entitled DRAGOON. (uni-hamburg.de)
  • Recent discoveries on physical properties (geometry, surface porosity, mechanical stiffness) and chemical properties (molecular surface engineering, reducing protein fouling, and biomolecule displays) that can modulate host immune responses are now creating new opportunities to innovate novel, long-term functioning implantable systems for a broad spectrum of clinical applications, including cell transplantation, localized controlled drug release, continuous sensing and monitoring of physiological conditions, and tissue regeneration. (rice.edu)
  • Colon Cancer Genetics Group, University of Edinburgh, School of Molecular and Clinical Medicine and MRC Human Genetics Unit, Western General Hospital, Edinburgh, U.K. (health.am)
  • Groundbreaking system with a multitude of opportunities Asotnish TF Time-of-Flight technology combined with exceptional soft tissue imaging of Achieva 3.0 T MRI in a whole Body footprint Allows advanced clinical research via whole-body molecular imaging across a wide range of validated application. (dotmed.com)
  • Such therapy requires close cooperation and communication between the physicians who are responsible for the clinical management of the patient and those who administer radiopharmaceutical therapy and manage the attendant side effects. (nih.gov)
  • When combining the expected strong growth trajectories for these medicines with candidates that could emerge from Seagen's pipeline, subject to clinical trial and regulatory success, Pfizer believes Seagen could contribute more than $10 billion in risk-adjusted revenues in 2030, with potential significant growth beyond 2030. (businesswire.com)
  • Clinical development programs are ongoing for each of these medicines for potential new tumor types or expanded indications in earlier lines of therapy, with catalysts expected annually through 2027. (businesswire.com)
  • Although limited CF screening using IRT and molecular tests has been used among newborns since the mid-1980s, the clinical, social, and economic outcomes of population-based screening are still controversial. (cdc.gov)
  • Next, we will explore the possibility of combining clinical trials and registry data, by using registry infrastructure to conduct simplified randomized trials. (lu.se)
  • Additionally, we hope to host a yearly symposium that will combine the presentation of both methodological and clinical advances with hands-on sessions on neuroimaging analysis for students and early-career researchers. (lu.se)
  • Conventional cytotoxic drugs and new therapies target p53, a key regulator of apoptosis. (uni-muenchen.de)
  • Interestingly, the molecular mechanisms required to extend lifespan upon reduced food intake are being evaluated, and these mechanisms may offer new opportunities for therapeutic intervention. (nih.gov)
  • With the increased understanding of molecular mechanisms and basic pathways in the pathogenesis of squamous cell cancer of the head and neck , these pathways may be modified, and rational approaches in cancer therapy at the molecular level may be created. (medscape.com)
  • Herein, we presented an overview of a previously published work regarding the role of stem cell therapy in ischemic stroke and its underlying molecular mechanisms. (hindawi.com)
  • In this review, potential mechanisms of resistance to therapy will be addressed, starting from the outside of the cells looking at the potential role the ECM may play, then continuing with EGF receptor alterations, which may contribute to resistance to therapy with antibodies. (eurekaselect.com)
  • Our laboratory has been studying the molecular mechanisms governing the association of proteins to their membrane interfaces in order to understand the functional implications of this interplay. (epfl.ch)
  • We investigated the importance of p53 in the intrinsic and extrinsic apoptosis signaling, via a variety of molecular biological approaches (Wachter et al. (uni-muenchen.de)
  • Developing a successful one for the combined therapeutic approaches of cancer viz. (ntno.org)
  • Various techniques have been developed for targeting cancer cells: gene therapy, monoclonal antibodies (MAbs), antibody toxin conjugates, small-molecule inhibitors, antisense molecules, and tumor vaccines. (medscape.com)
  • The Project combines Biocytogen's proprietary fully human nanobody mouse, RenNano ® , with its high-throughput in vitro and in vivo antibody screening platforms to develop fully human nanobody drugs on a large-scale. (businesswire.com)
  • Due to their simpler structure, nanobodies are more stable and easier to produce and engineer, making them ideal building blocks for complex modalities such as cell therapy, bispecific antibody and engager, multi-specific antibody, antibody drug-conjugate (ADC), and radionuclide antibody-conjugate (RAC). (businesswire.com)
  • An iADC, which combines an antibody with a small molecule compound that induces immunogenic cell death *2 in addition to an immune activating molecule, has the potential to boost the anti-cancer action. (astellas.com)
  • Together, Pfizer and Seagen seek to accelerate the next generation of cancer breakthroughs and bring new solutions to patients by combining the power of Seagen's antibody-drug conjugate (ADC) technology with the scale and strength of Pfizer's capabilities and expertise. (businesswire.com)
  • Combined modality therapy for rectal cancer. (health.am)
  • Researchers are able to identify molecular features that can be translated into appropriate therapies in approximately 59% of lung cancer patients. (ucdenver.edu)
  • The goal of gene therapy is to introduce new genetic material into cancer cells that selectively kills them without causing toxicity to the surrounding cells. (medscape.com)
  • Process development and control of gene therapy products such as recombinant adeno-associated virus (rAAV) pose significant challenges due to their relatively high dose requirements and generally low-yield processes, says Ranga Godavarti, vice president, bioprocess R&D and drug substance supply at Pfizer. (biopharminternational.com)
  • The growing success of Positron Emission Tomography (PET) combined with X-ray computerised tomography (PET/CT) and magnetic resonance imaging (PET/MR) has led to the evolution of molecular imaging modalities that assist in improving diagnosis and staging of disease. (cam.ac.uk)
  • Rapidly emerging advanced systems for biomedical applications, namely multifunctional theranostics agents are designed to support multiple tasks in diagnosis and advanced therapy. (ntno.org)
  • The aim of CoMMiTMenT is the development of combined imaging technologies based on optofluidic microscopy (OMiCS) and scanning ion conductance microscopy (SCIM), the so-called µCOSMOS, a multi-modular device, which will allow the exploration, diagnosis and development of therapeutic interventions for several rare anaemias. (eurice.eu)
  • Molecular and cytogenetic studies in the diagnosis of patients with poorly differentiated carcinomas of unknown primary site. (medscape.com)
  • Artificial intelligence in cancer research, diagnosis and therapy. (cdc.gov)
  • contradictory] Furthermore, it is estimated that with further research cancer death rates could be reduced by 70% around the world even without the development of any new therapies. (wikipedia.org)
  • The goal of specific molecular targets in cancer therapy is to create a "magic bullet" that selectively kills cancer cells. (medscape.com)
  • Targeted molecular therapy can also act as a complement to other existing cancer therapies. (medscape.com)
  • Development of cancer therapies targeting Myc with cell penetrating b-HLH-LZ domains. (usherbrooke.ca)
  • Optimiser les soins des patients atteints du cancer de la prostate résistant à la castration en utilisant une stratégie de triple traceur en imagerie moléculaire et en radiothérapie ciblée. (usherbrooke.ca)
  • 2011). A single drug is not very effective in cancer therapy therefore malignant diseases are usually treated with a combination of cytostatic agents. (uni-muenchen.de)
  • In the US, lung cancer is responsible for 29% of cancer deaths, more than breast cancer, colon cancer and prostate cancer combined. (ucdenver.edu)
  • Novel multimode thermal therapy by freezing before radio-frequency heating has achieved a desirable therapeutic effect in liver cancer. (bvsalud.org)
  • We believe that imaging, part of the gold standard to diagnose cancer and monitor therapy response, will continue to play a key role in the future," said Hofstraat. (genomeweb.com)
  • Among many functional capabilities of PAT, measuring blood oxygenation is arguably one of the most important applications, and has been widely performed in photoacoustic studies of brain functions, tumor hypoxia, wound healing, and cancer therapy. (duke.edu)
  • Our research efforts emphasize the study of cancer genomics and transcriptomics, which enable us to better understand the genetic and molecular basis of breast cancer. (artofhealingcancer.com)
  • Today, cancer claims more lives globally than HIV/AIDS, malaria, and tuberculosis combined, and the death toll from cancer is only going to grow. (health.am)
  • Systematic therapy for colorectal cancer. (health.am)
  • Surgery is the oldest effective cancer therapy. (msdmanuals.com)
  • The primary purpose of adjuvant therapy, which is given after, and neoadjuvant therapy, which is given beforehand, is to prevent cancer recurrence and increase survival. (msdmanuals.com)
  • The collaboration leverages the unique cancer-fighting potential of iADCs as a novel modality, enabled by Sutro's ability to engineer complex conjugated antibodies, and Astellas' global oncology R&D expertise. (astellas.com)
  • Notably, exposure of cancer cells to TTFields has been shown to result in immunogenic cell death, which is reflected by damage-associated molecular patterns and the formation of micronuclei that further activate DNA sensor-related inflammatory pathways, indicating the immunomodulatory role for TTFields. (conditionmed.org)
  • ADCs are a transformative modality that is emerging as a powerful tool across a broad range of cancers designed to preferentially kill cancer cells and limit off-target toxicities. (businesswire.com)
  • Although hormonal therapy is an importanttreatment modality for advanced prostate cancer, long-termtreatment carries significant side effects that need to be considered. (cancernetwork.com)
  • A critical barrier to achieving successful cancer imaging and therapy is the lack of specificity for targeting only cancer cells and not normal cells. (illinois.edu)
  • While this project focuses on breast cancer, the methods used can be applied generally to other cell-specific cancer therapies. (illinois.edu)
  • Therefore, this bacterium can be a harmless candidate for esophageal cancer therapy. (hindawi.com)
  • Thus, targeting signal molecules can be helpful for cancer therapy [ 6 ]. (hindawi.com)
  • Lactic acid bacteria, especially lactobacilli with probiotic potential, are known as promising tools for cancer therapy. (hindawi.com)
  • Emerging PET imaging is used to drive patient therapy, therefore high resolution and reliable image quantification are important factors. (cam.ac.uk)
  • In this context, basic requirements of multifunctional theranostics design for targeted imaging and therapy have been highlighted and with several challenges. (ntno.org)
  • Hofstraat said that within Philips Research, the company's private research organization based in nearby Eindhoven, oncology is a "key area of focus" where Philips is keen to combine its expertise in imaging with molecular testing. (genomeweb.com)
  • and creating data-analysis tools for combining imaging and liquid biopsy results. (genomeweb.com)
  • He is the principal investigator of the Cardiovascular Molecular Imaging Laboratory, which aims to develop new imaging techniques to visualize, characterize, and quantify molecular and cellular processes involved in cardiovascular diseases. (yalemedicine.org)
  • Dr. Sadeghi is a recipient of the Hermann Blumgart Award from the Society of Nuclear Medicine and Molecular Imaging. (yalemedicine.org)
  • He is also a member of the American College of Cardiology, the Society of Nuclear Medicine and Molecular Imaging, and the American Society of Nuclear Cardiology. (yalemedicine.org)
  • Chinese Journal Of Nuclear Medicine And Molecular Imaging 2023, 43: 187-192. (yalemedicine.org)
  • Photoacoustic tomography (PAT) is a hybrid imaging modality that combines rich contrast of optical excitation and deep penetration of ultrasound detection. (duke.edu)
  • A variety of PAT methods have been developed to improve the accuracy of blood oxygenation measurement, using novel laser illumination schemes, oxygen-sensitive fluorescent dyes, comprehensive mathematic models, or prior information provided by complementary imaging modalities. (duke.edu)
  • His research under Miqin Zhang, the Kyocera Professor of Materials Science and Engineering, was focused on the development of magnetic nanotechnologies for multimodality molecular imaging, and targeted drug delivery of nucleic acid based therapies. (rice.edu)
  • Built with pioneering Turbo Time-of-Flight (TOF) technology, the GE SIGNA™ PET/MR combines an integrated PET with exceptional quantitative count rate accuracy with 3.0T simultaneous imaging. (dotmed.com)
  • For the first time, state-of-the-art 3T MRI and cutting-edge molecular imaging are fully integrated as one. (dotmed.com)
  • The only LabPET/MR system that combines two unique technologies: digital APD-based PET imaging with cryogen-free superconducting 3.0T MRI for one-step in-line PET/MR imaging of small animals. (dotmed.com)
  • The benefit of combining multiple in vivo imaging t. (dotmed.com)
  • At the same time, it has also become clear that imaging modalities with high sensitivities may have relatively poor resolution and specificity, while those with high resolution and specificity can be poor in sensitivity. (illinois.edu)
  • The researchers in this project will explore advantages that might result from combining highly selective and versatile aptamers that can recognize a number of receptors together with clinically proven liposomes that can encapsulate several imaging and therapeutic agents. (illinois.edu)
  • A variety of imaging modalities, including structural and functional magnetic resonance imaging (MRI) and positron emission tomography (PET) studies of cerebral metabolism, have shown characteristic changes in the brain of patients with Alzheimer disease in prodromal and even presymptomatic states. (medscape.com)
  • The recent decade has seen encouraging outcomes of mesenchymal stem cell therapy that holds promise to alleviate the burden of neurological disorders Moreover, initial study data of preclinical trials have also indicated the effectiveness, tolerance, and safety of MSC-based therapy [ 10 ]. (hindawi.com)
  • Multisystem Inflammatory Syndrome in Children - Initial Therapy and Outcomes. (childrensmercy.org)
  • Using tDCS for rehabilitation is a promising strategy, and numerous publications suggest that it can be used alone or combined to augment the outcomes of behavioral training and pharmacologi- cal interventions. (bvsalud.org)
  • Advancements in technology for manufacturing and online analytical monitoring have not caught up to the innovative drug candidates and emerging modalities present in the candidate pipeline today. (biopharminternational.com)
  • Lack of pre-determined process and analytical platforms for these modalities often translates to longer development times. (biopharminternational.com)
  • Distant healing (DH) includes a broad variety of complementary therapies. (researchgate.net)
  • We do this by combining multiple modalities, including MRI, PET, fluid-based markers and genetics, to clarify the biological processes leading to neurodegenerative conditions. (lu.se)
  • In particular, chemoradiotherapy is associated with systemic toxicities that often reduce compliance and prevent timely completion of therapy. (medscape.com)
  • New onset of symptoms or a rising CEA warrants investigation with chest and abdominal CT to look for recurrent or metastatic disease that may be amenable to therapy. (health.am)
  • Convincing data doexist for the use of adjuvant/neoadjuvant hormonal therapy with external-beam radiation therapy. (cancernetwork.com)
  • This approach is dependent on most prostatecancer cells being androgen-dependent, but androgen-independentcells may arise after several years of hormonal therapy. (cancernetwork.com)
  • This program supports the research and development of technologies and techniques that create images of internal structures, contrast agents, or molecular probes using x-rays transmitted through the body (CT, mammography) or x-ray stimulation of secondary emissions (x-ray fluorescence tomography). (nih.gov)
  • Increasing molecular diversity is creating a need for the reinvention of process development and control strategies. (biopharminternational.com)
  • Increasing molecular diversity leads to more challenges in process development and control. (biopharminternational.com)
  • Induced pluripotent stem cells (iPSCs) are another modality on the horizon with process challenges particularly associated with inducement, directed differentiation, and banking steps, comments Avi Nandi, VP and head of process development at the Center for Breakthrough Medicines. (biopharminternational.com)
  • New modalities are more difficult to fully characterize due to their complexity, and some highly complex tests take weeks to complete. (biopharminternational.com)
  • Dual-Modality PET and MR Imager for preclinical studies. (dotmed.com)
  • Recently, a growing number of studies are focusing on mesenchymal stem cell-based therapies for neurodegenerative disorders. (hindawi.com)
  • 2013). Cell cycle arrest was induced in tumor cell lines and patient samples in G0, G1 or G2 with cytostatic drugs, phase-specific inhibitors or RNA interference against cyclinB and E. Molecular or biochemical arrest at any point of the cell cycle augmented the rate of apoptosis by TRAIL. (uni-muenchen.de)
  • Recent recognitions for his research include being named one of MedTech Boston's 40 Under 40 Healthcare Innovators for 2017, and his encapsulated cell therapies have been listed in the Top 10 Emerging Technologies of 2018 by the World Economic Forum. (rice.edu)
  • you may still have a small cell component, so you want to leave the option for EGFR TKI therapy, as well. (onclive.com)
  • Single cell sequencing combined with deep learning enables him to analyse and model differences between cells. (lu.se)
  • Positive impact of short-term gait rehabilitation in Parkinson patients: a combined approach based on statistics and machine learning. (cdc.gov)
  • This study aimed to compare the anticandidal efficacy of photodynamic therapy by erythrosine with nano-titanium dioxide (nano-TiO 2 ) stimulated by a blue light emitting diode with three standard dental antifungal agents. (thieme-connect.de)
  • Molecular ablation of tumor blood vessels inhibits therapeutic effects of radiation and bevacizumab. (childrensmercy.org)
  • Materials and Methods Candida albicans biofilms on acrylic resin plates were treated for 15 minutes with either nystatin, fluconazole, Polident, 220µM erythrosine + 1% (w/w) nano-TiO 2 + 15 J/cm 2 blue light photodynamic therapy (Ery PDT), or distilled water. (thieme-connect.de)
  • Conclusion Photodynamic therapy with erythrosine + nano-TiO 2 + blue light at low light power density (15 J/cm 2 ) was as effective at inhibiting C. albicans biofilm on acrylic resin as fluconazole and Polident. (thieme-connect.de)
  • The Oates lab is exploring how spatio-temporal patterns emerge at the tissue level from noisy cellular and molecular interactions using a population of genetic oscillators in the zebrafish embryo termed the segmentation clock. (epfl.ch)
  • This multi-cellular clock governs the rhythmic, sequential, and precise formation of embryonic body segments, termed somites, and exhibits a rich set of spatial and temporal phenomena spanning from molecular to tissue scales. (epfl.ch)
  • Beginning with uncomplicated ideas, this reference and instruction manual discusses examples of the main complicated types of bacterial an infection with reference to their worth as paradigms to appreciate the molecular move talks among microbes and their host and tissue goals. (make-a-thon.org)
  • Despite significant improvements in these modalities, long-term survival rates in patients with advanced-stage HNSCC have not increased significantly in the past 30 years. (medscape.com)
  • Image reconstruction methods have a key role in converting the measurement to a meaningful and accurate representation of the molecular distribution. (cam.ac.uk)
  • and methods of visualizing or measuring therapy doses. (nih.gov)
  • Combining Resampling Strategies and Ensemble Machine Learning Methods to Enhance Prediction of Neonates with a Low Apgar Score After Induction of Labor in Northern Tanzania. (cdc.gov)