Modulate genes protein inhibitors of activated stat. Medical search. Frequent questions

They inactivate NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) and modulate mitogen-activated protein Kinase (MAPk) and arachidonic acids pathways. (scienceopen.com)
It is now known that many cytokines, hormones and growth factors utilize STAT signaling pathways to control a remarkable variety of biological responses, including development, differentiation, cell proliferation, and survival. (eurekaselect.com)
Moreover, STAT proteins can cross-talk with other central signaling pathways, such as the mitogen-activated protein kinase (MAPK) family of proteins and the nuclear receptor signaling pathways. (eurekaselect.com)
On the othe r hand, other proteins are known to interact with and modulate STAT signaling pathways, including histone acetyl-transferases and the protein inhibitor of activated STAT (PIAS) family of protein. (eurekaselect.com)
The present review will try to address some questions concerning the increasingly complex biological functions of STAT proteins, the many diverse mechanisms of STAT regulation and the expanding number of target genes that mediate the biological responses elicited by STAT signaling pathways. (eurekaselect.com)
TBC1D15 activated three novel oncogenic pathways to promote self-renewal, p53 loss, and Nanog transcription in TICs. (nature.com)
We postulate that specific immune response associated signalling, affecting gene transcription networks, may be associated with the activation of different oncogenic pathways in aggressive Non-Hodgkin lymphomas (NHL). (nih.gov)
We defined the extent to which different immune response associated pathways are responsible for differences in gene expression which distinguish individual DLBCL cases. (nih.gov)
Cytokines induce a variety of biological responses by binding to specific cell surface receptors and activating cytoplasmic signaling pathways (e.g., the JAK/STAT pathway). (creativebiomart.net)
Activation of various innate immune signaling pathways ( TLR3 , TLR4 , TLR7 , TLR8 , TLR9 , cGAS , RIG-I , MDA-5 ) leads to the rapid induction of type I IFNs due to their (mostly) intronless gene structure. (wikidoc.org)
[7] [8] Upon binding of type I interferons, IFNAR activates the JAK-STAT signalling pathway , along with MAPK , PI3K , and Akt signaling pathways. (wikidoc.org)
Examples include the identification of filovirus-encoded innate immune modulators that prevent production of type I interferons (IFN) via RIG-I-like receptor signaling pathways, that block IFN-induced Jak-STAT signaling and that activate cellular antioxidant response pathways. (mssm.edu)
The primary action of DAG is definitely to activate Protein Kinase C (PKC) which can then activate downstream signaling pathways ultimately leading to the nuclear translocation of important transcription factors AP-1 and NF-κB (examined in Isakov and Altman 2002 In the mean time IP3 engages the IP3 receptor (IP3R) liberating calcium from the endoplasmic reticulum (ER). (ecologicalsgardens.com)
Hypoxic cells activate a number of adaptive responses coordinated by various cellular pathways. (nutriforce.cn)
We review clinical data on the benefit of RASi in primary and metastatic tumors and propose that, by activating immunostimulatory pathways, these inhibitors can enhance immunotherapy of cancer. (nutriforce.cn)
Classification of the 37 genes by Panther System indicated that the dataset contains genes involved in biological processes that sustain HCV replication and/or in pathways potentially implicated in the control of antiviral response by HCV infection. (biomedcentral.com)
In vitro studies of monocytes/macrophages indicate that gamma interferon is an important regulator of 1α-hydroxylase but only when other key signaling pathways are also activated (eg, JAK-STAT and MAP-Kinase). (medscape.com)
Many genes involved in metabolic pathways have been found to contribute to lipid level variability [ 14 , 26 , 27 ]. (cdc.gov)

The PI3K/Akt signalling pathway is a crucial signalling cascade that regulates transcription, protein translation, cell growth, proliferation, cell survival, and metabolism. (bvsalud.org)
This pathway is hijacked for viral entry, regulation of endocytosis, suppression of premature apoptosis, viral protein expression, and replication. (bvsalud.org)
Moreover, the cell activates this pathway as an antiviral strategy for interferon and cytokine production, among other strategies. (bvsalud.org)
DSTN These results led us to consider the possibility that the defect in IFN-resistant Daudi cells may reflect an failure to activate a STAT3-dependent signaling pathway. (bibf1120.com)
Signaling through the Jak/STAT pathway is tightly controlled by several distinct mechanisms as dysregulation of Jak/STAT signaling is thought to underlie several disorders including rheumatologic and autoimmune disorders, transplant rejection, and several cancers. (creativebiomart.net)
Key negative regulators of this pathway include Suppressors of Cytokine Signaling (SOCS), Protein Inhibitors of Activated STATs (PIASs), and protein tyrosine phosphatases (PTPs). (creativebiomart.net)
The SOCS proteins are the primary regulators of the Jak/STAT pathway. (creativebiomart.net)
They also block STAT activation and target multiple components of the Jak/STAT pathway for Ubiquitin-mediated proteasomal degradation. (creativebiomart.net)
Jak/STAT signaling is also regulated by numerous constitutively expressed PTPs that dephosphorylate important tyrosine residues on multiple components of the pathway, thereby attenuating Jak/STAT signaling. (creativebiomart.net)
Fig.1 JAK-STAT pathway activation and its negative regulators. (creativebiomart.net)
Negative regulators employ diverse mechanisms to constrain the Jak/STAT pathway. (creativebiomart.net)
SOCS proteins are one of the major negative regulators of the Jak/STAT pathway. (creativebiomart.net)
Fig.2 Negative regulation of the JAK/STAT pathway. (creativebiomart.net)
Negative regulators of the Jak/STAT pathway play a critical role in modulating immune responses. (creativebiomart.net)
The Jak/STAT pathway is involved in cell differentiation and development. (creativebiomart.net)
Dysregulation of the Jak/STAT pathway is often associated with cancer development. (creativebiomart.net)
Negative regulators of the Jak/STAT pathway are essential for maintaining proper cellular homeostasis and preventing pathological conditions. (creativebiomart.net)
Understanding their mechanisms and functions provides valuable insights for therapeutic interventions aimed at modulating the Jak/STAT signaling pathway. (creativebiomart.net)
Creative BioMart offers a wide range of products and services related to Jak/STAT pathway research, including recombinant proteins, antibodies, and assay kits, to facilitate the study of these negative regulators and their potential applications in various fields. (creativebiomart.net)
The lab has extended its inquiries into RNA virus-nuclear import pathway interactions by defining novel IMPA interactions with the Nipah virus W and matrix (M) proteins that are defining the molecular basis for W and M interactions with IMPA proteins and the contribution of nuclear functions to virus propagation. (mssm.edu)
After STAT3 activation, nuclear factor (NF) -κB enter the nucleus, bind to the promoter of the target gene, and induce pro-inflammatory mediators such as InducibleNitric Oxide Synthase (iNOS) , Cyclooxygenase-2 (COX-2) , Tumor necrosis factor-α (TNF-α) and Interleukin-6 (IL-6) ,to reactivate the JAK/STAT3 pathway, thus forming a malignant pro-inflammatory cycle[6]. (researchsquare.com)
This cytokine utilizes the Jak (Janus kinase)/Stat (Sign transducer and activator of transcription) pathway in both paracrine and autocrine style to induce manifestation of genes necessary to travel clonal proliferation (Ihle et al. (ecologicalsgardens.com)
Although HCV activates the endogenous IFN-α/β pathway it conversely shows an impressive ability to induce persistent infections. (biomedcentral.com)
May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. (cusabio.com)

Protein inhibitor of activated STAT2 has been shown to interact with: Androgen receptor, DNMT3A, PARK7, and UBE2I. (wikipedia.org)
Polyphenolic compounds inhibit phosphatidylinositide 3-kinases/protein kinase B (PI3K/AkT), inhibitor of kappa kinase/c-Jun amino-terminal kinases (IKK/JNK), mammalian target of rapamycin complex 1 (mTORC1) which is a protein complex that controls protein synthesis, and JAK/STAT. They can suppress toll-like receptor (TLR) and pro-inflammatory genes' expression. (scienceopen.com)
The B cell receptor (BCR), CD40, B-cell activating factor (BAFF)-receptors and Interleukin (IL) 21 receptor and Toll like receptor 4 (TLR4) were stimulated in human transformed germinal centre B cells by treatment with anti IgM F(ab)2-fragments, CD40L, BAFF, IL21 and LPS respectively. (nih.gov)
While CD40L stimulation changed the expression of 1194 genes and IL21 stimulation affected 902 genes, only 283 and 129 genes were modulated by lipopolysaccharide or BAFF receptor stimulation, respectively. (nih.gov)
During entry, GP needs to be cleaved by host proteases to expose the receptor-binding site that binds to the endosomal receptor Niemann-Pick C1 (NPC1) protein. (bvsalud.org)
Our previous study identified a histamine receptor antagonist compound CP19 as an entry inhibitor against both EBOV and MARV. (bvsalud.org)
EPO activates the neuronal EPO receptor and, subsequently, JAK-2 and thereby PI3K. (jneurosci.org)
Monoclonal antibodies directed against the extracellular domain of EGFR and small molecule inhibitors of the tyrosine kinase domain of the receptor have been evaluated in the treatment of several solid tumours including CRC, NSCLC and HNSCC [ 3 ]. (biomedcentral.com)
In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. (thermofisher.com)
These long-lived na?ve T-cells circulate in the periphery and remain quiescent until activated by presentation of a T-cell receptor (TCR)-specific antigen. (ecologicalsgardens.com)
When GFLs bind with GFRα, they form complexes and associate with the RET receptor, subsequently activating downstream signaling. (medsci.org)
Small-molecule inhibitors, antagonistic monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), bispecific antibodies or biologics (bsAbs) and chimeric antigen receptor-modified T cells (CAR-Ts) targeting Notch signaling components have been developed as investigational anti-cancer drugs ( 10 - 12 ). (spandidos-publications.com)
Hereditary vitamin D-resistant rickets is a very rare autosomal recessive disorder in which mutations of vitamin D receptor (VDR) coding genes cause failure or abnormal binding of vitamin D to VDRs. (medscape.com)

The changes in gene expression following the activation of Jak/STAT, NF-кB, MAPK, Ca2+ and PI3K signalling triggered by these stimuli was assessed using microarray analysis. (nih.gov)

IFNs transduce indicators in the cell surface leading to selective gene activation (8-10) through the activation of JAK tyrosine kinases and indication transducers and activators of XMD8-92 transcription (STAT) elements (11 12 Upon their tyrosine phosphorylation IFN-activated STATs (STAT1 STAT2 and STAT3) dimerize and translocate towards the nucleus. (bibf1120.com)
PI-3 kinase is normally essential in the legislation of many mobile events involving proteins tyrosine kinases and can be an upstream aspect in a serine kinase transduction cascade (15 16 Serine and tyrosine phosphorylation of varied target protein (STATs IFNAR1 and IFNAR2 chains etc.) are fundamental early occasions in IFN signaling and actions (17-20). (bibf1120.com)
In NSCLC, approximately 85% of patients who responded favourably to gefitinib or erlotinib, two FDA-approved small-molecule EGFR-tyrosine-kinase inhibitors, were shown to have somatic mutations in the EGFR gene. (biomedcentral.com)
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. (cusabio.com)

Inactivation of AKT and GSK3β, proteins important in regulating apoptosis, was observed with a similar dose response to that of JAK2/STAT3 signaling. (medkoo.com)
We showed that overexpression of SOCS1 can induce apoptosis of leukemic cells constitutively expressing activated JAK2. (micrornaarray.com)
The dowstrean targets include cell cycle regulatory genes such as fos , cyclin D , c-Myc , pim1 and anti-apoptotic genes such as B-cell CLL/Lymphoma-2 ( Bcl-2 ), Bcl-xL , survivin and X-linked inhibitor of apoptosis protein ( XIAP ) (6). (abwizbio.com)
of transcription of genes that encode cytokines chemokines adhesion factors and inhibitors of apoptosis. (cancerrealitycheck.com)

Upon phosphorylation, STAT3 proteins dimerize and translocate to the nucleus where they bind to promoter elements of target genes and modulate their transcription (4). (abwizbio.com)
Prediction of target genes of 3 miRs, confirmed in all HCV clones, was performed by means of miRGator program. (biomedcentral.com)

selelck kinase inhibitor AZD1480 treatment induced regression of TPC one shSTAT3 tumors. (micrornaarray.com)
Canonical Notch signaling activates the transcription of BMI1 proto‑oncogene polycomb ring finger, cyclin D1, CD44, cyclin dependent kinase inhibitor 1A, hes family bHLH transcription factor 1, hes related family bHLH transcription factor with YRPW motif 1, MYC, NOTCH3, RE1 silencing transcription factor and transcription factor 7 in a cellular context‑dependent manner, while non‑canonical Notch signaling activates NF‑κB and Rac family small GTPase 1. (spandidos-publications.com)

Using chemical inhibitors for selected kinases we show that mitogen activated protein kinase- and phosphoinositide 3 kinase-signalling are dominantly involved in regulating genes included in the αIgM gene module. (nih.gov)
it may inhibit the activity of multiple kinases, such as c-Kit, EGFR, and Bcr-Abl, which as client proteins depend on functional HsP90 for maintenance. (medkoo.com)
JAK kinases are established Hsp90 client proteins and here we show that the novel small molecule Hsp90 inhibitor ganetespib (formerly STA-9090) exhibits potent in vitro activity in a range of solid and hematological tumor cells that are dependent on JAK2 activity for growth and survival. (medkoo.com)
In this review I explore the mechanisms by which constitutively activated kinases that GW788388 function upstream of the NF-κB cascade facilitate chemokine-mediated tumorigenesis. (cancerrealitycheck.com)

Furthermore, EPO-induced neuroprotection as well as phosphorylation of the proapoptotic Bcl family member Bad was reduced by the phosphoinositide-3 kinase (PI3K) inhibitor LY294002. (jneurosci.org)

SOCS proteins, including SOCS1, SOCS2, SOCS3, and CIS, bind to activated Jaks and cytokine receptors, leading to their degradation or blocking the recruitment of downstream signaling molecules. (creativebiomart.net)
109 Downregulation of SOCS gene expression by siRNA or through the expression of dominant adverse SOCS proteins to enhance cytokine signaling may be helpful for enhancing anti tumor immunity. (micrornaarray.com)
Upon cytokine and growth factor stimulation STAT3, a transcription factor, is activated. (abwizbio.com)
The antiapoptotic proteins are induced by this inflammatory cytokine in psoriatic skin 11, 12 . (ijpsr.com)
Modulating the cytokine network in thickening of the basement membrane underlying the respiratory diseases such as asthma, with expected airway epithelium. (cdc.gov)

Members of this relatively small family of proteins serve as both transducers of cytoplasmic signals and nuclear transcription factors, thereby directly converting a stimulus at the cell surface to an alteration in the genetic program. (eurekaselect.com)
15 The dynamic addition and removal of O-GlcNAc has been described for multiple cytoplasmic and nuclear proteins and it affects the function of various signaling molecules and transcription factors. (nature.com)
STAT3 belongs to the STAT family of cytoplasmic transcription factors that induces cell membrane-mediated nuclear signal transduction in various cellular activities (2). (abwizbio.com)

The signal transducer and activator of transcription (STAT) proteins and their mechanisms of signaling were originally discovered in the context of normal interferon signaling, where they have been shown to have specific roles in mediating host defenses. (eurekaselect.com)
Studies in the past decade have demonstrated the essential roles of several AJC protein, including underlying actinomyosin components, actin isoforms, and intracellular signal transducer and activator of transcription (STAT) transcription factors, and nuclear factor-κB (NF-κB) in the maintenance and remission of IBD progression ( 5 ). (frontiersin.org)
Signal transducer and activator of transcription 3 (STAT3) was initially showed to control acute-phase genes in response to interleukin-6 (IL-6) and epidermal growth factor (EGF) during inflammatory processes (1). (abwizbio.com)
We identified annexin A2 (ANXA2), N-myc downstream regulated gene 1 (NDRG1) and signal transducer and activator of transcription 1 (STAT1) as biomarkers of LACC patients' responsiveness to CRT. (biomedcentral.com)

Polyphenols regulate immunity by interfering with immune cell regulation, proinflammatory cytokines' synthesis, and gene expression. (scienceopen.com)
Interferons (IFNs) are cytokines that stop the viral an infection of cells inhibit cell proliferation and modulate cell differentiation. (bibf1120.com)
Following exposure to pathogens, the innate immune cells of gastrointestinal mucosa release pro-inflammatory cytokines and activate an adaptive immune response to aggravating inflammation in the intestine ( 3 ). (frontiersin.org)
Diazinon immunotoxicity in mice: Modulation of cytokines level and their gene expression. (cdc.gov)

PIAS proteins interact with activated STAT dimers and inhibit STAT-mediated transcription. (creativebiomart.net)
PIAS proteins are another class of negative regulators that exert their inhibitory effects by directly interacting with activated STATs. (creativebiomart.net)
Additionally, PIAS proteins can also recruit corepressors and histone deacetylases to inhibit STAT-mediated gene expression. (creativebiomart.net)

They act as pseudo-Jak substrates to inhibit Jak/STAT signaling. (creativebiomart.net)
They are induced by STAT activation and act as a negative feedback loop to inhibit further signaling. (creativebiomart.net)
Also, since BCL6 interacts with several co-repressor complexes to inhibit transcription, and its gene is frequently trans-located and hyper-mutated in diffuse large B cell lymphoma (DLBCL), miR-155 acts to enhance transcription and contribute to the pathogenesis of DLBCL. (biomedcentral.com)
They inhibit CELL DIFFERENTIATION and induce CELL PROLIFERATION by modulating different CELL CYCLE regulators. (bvsalud.org)

Such treatment was associated with upregulation of invasion- and inflammation-promoting soluble factors, such as matrix metalloproteinase 2 (MMP2), its activator MMP14, tissue inhibitors of matrix metalloproteinase 2 (TIMP2), chemokine ligand 2 (CCL2), and urokinase-type plasminogen activator (uPA), the latter two being linked to the recruitment of the monocytic cells. (biomedcentral.com)
These proteins restrict Ebola virus growth by binding and altering the phosphorylation status of the viral transcriptional activator VP30. (mssm.edu)

Collectively our data suggest that chromatin decondensation in peripheral T-cells is definitely controlled by modulating intracellular calcium levels. (ecologicalsgardens.com)
2000 In T-cells calcium mineral Ebastine signaling is necessary for activation proliferation and differentiation mainly through the experience of NFAT (Nuclear Element of Activated T-cells) a transcription element that becomes triggered because of improved intracellular calcium mineral ([Ca2+]we) (Macian 2005 It's been demonstrated that NFAT activation is essential for the manifestation of genes necessary for proper T-cell activation (evaluated in Hogan et al. (ecologicalsgardens.com)

Ganetespib, also known as STA-9090, is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. (medkoo.com)
Small‑molecule γ‑secretase inhibitors (AL101, MRK‑560, nirogacestat and others) and antibody‑based biologics targeting Notch ligands or receptors [ABT‑165, AMG 119, rovalpituzumab tesirine (Rova‑T) and others] have been developed as investigational drugs. (spandidos-publications.com)

35 Monoclonal antibodies against EGFR this kind of as cetuximab do appear to possess modest activity in superior NSCLC in blend with chemotherapy, but the lack Raf Inhibitor selleckchem of an apparent biomarker to identify individuals who could have increased advantage might possibly complicate its broad applicability. (pimsignaling.com)
The NCI-H1975 non-small cell lung cancer (NSCLC) cell line expresses the Hsp90 client EGFRL858R/T790M, a constitutively activated and erlotinib-resistant form of EGFR, and ganetespib treatment resulted in a dose-dependent decrease in EGFR expression in these cells (Fig. 2A). (medkoo.com)
The aim of this study was to analyse EGFR expression, EGFR gene copy number and EGFR and K-RAS mutations in two cohorts of squamous cell carcinomas, specifically anal canal and tonsil carcinomas. (biomedcentral.com)
EGFR protein expression and EGFR gene copy number were analysed by means of immunohistochemistry and fluorescence in situ hybridisation. (biomedcentral.com)
The somatic status of the EGFR gene was investigated by PCR using primers specific for exons 18 through 21. (biomedcentral.com)
EGFR mutations were absent from squamous cell carcinoma of the anus and tonsils, but EGFR protein expression was detected in the majority of the cases. (biomedcentral.com)

The oncogenic role of TLR4 activated by endotoxin has been confirmed by others in a different liver tumor model 10 . (nature.com)
Negative regulators, such as SOCS proteins, act as tumor suppressors by inhibiting aberrant Jak/STAT signaling. (creativebiomart.net)
To identify specific markers of CRT response, we compared pretreatment biopsies from LACC patients with pathological complete response (sensitive) with those from patients showing macroscopic residual tumor (resistant) after neoadjuvant CRT, using a proteomic approach integrated with gene expression profiling. (biomedcentral.com)
Mechanistic investigations demonstrated the key role of the identified genes in the balance between death and survival of tumor cells. (biomedcentral.com)
Decreased levels of 1,25(OH)2 D can result from chronic kidney disease, various heritable disorders, tumor-induced osteomalacia, the use of HIV protease inhibitors, or severe vitamin D deficiency. (medscape.com)

The Basler lab's interest in virus-IMPA interactions was initially spurred by the finding that the Ebola virus VP24 protein directly binds to a subset of IMPA family members, preventing IMPA interaction with the non-classical nuclear localization signal on activated STAT1. (mssm.edu)
The lab is also pursuing studies to understand how coronaviruses, including SARS-CoV-2 and MERS coronavirus, modulate host nuclear trafficking to counteract innate immune responses. (mssm.edu)

Materials and Methods Cell lines, plasmids, recombinant proteins All cells were maintained in DMEM (4.5?g/L glucose) supplemented with 10% FBS and Penicillin/Streptomycin (Gibco). (healthweblognews.info)

Of note, ganetespib treatment results in sustained depletion of JAK2, including the constitutively active JAK2(V617F) mutant, with subsequent loss of STAT activity and reduced STAT-target gene expression. (medkoo.com)
phosphorylation of STAT1: this peptide inhibited proliferation of prostate cancer cell lines, in which STAT3 is constitutively activated. (micrornaarray.com)

Tumour angiogenesis growth and metastasis are facilitated by the NF-κB-modulated transcription of chemokine genes. (cancerrealitycheck.com)

It may therefore be that the TBK1-dependent phosphorylation sites that match the motif are regulated by increases in TBK1 activity, whereas the others may be regulated BML-275 tyrosianse inhibitor by changes in TBK1 binding to Raptor. (healthweblognews.info)
The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. (cancerindex.org)
In addition ot Tyr705 phosphorylation, Ser727 is required for maximal activation although Tyr705 phopsohrylation plays a key activating role (7,8). (abwizbio.com)
Different responses, e.g. antiviral versus antiproliferative responses, to type I IFNs subtypes have been studied and proximal signaling, such as STAT phosphorylation, does not appear to correlate with the outcome. (wikidoc.org)

These regulatory proteins also modulate the DNA-binding properties of STATs by facilitating SUMOylation of the dimers. (creativebiomart.net)

For instance knockout from the STAT3 gene in mice network marketing leads to early embryonic lethality and STAT3-deficient cell lines cannot end up being isolated (13). (bibf1120.com)
Additionally, STATT can recruit protein phosphatases to dephosphorylate and inactivate STAT3, further attenuating its activity. (creativebiomart.net)
AZD1480 mediated development inhibition is independent of STAT3 JAKs would be the principal mediators of IL 6/gp130/STAT3 signaling and, in a number of cancer versions, JAK inhibitors anti tumorigenic results are mediated by STAT3. (micrornaarray.com)
So as to determine regardless of whether STAT3 was required for JAK inhibitor mediated growth arrest, we stably reduced STAT3 in TPC 1 cells utilizing a brief hairpin, as determined by western blot and immunohistochemistry. (micrornaarray.com)
Offered the major development suppressive actions on the JAK inhibitor on the oncogenic RET transformed TPC 1 xenograft independently of STAT3, we hypothesized that AZD1480 might possess a direct impact on RET mediated signaling. (micrornaarray.com)

[9] For example, type I IFNs induce interferon-stimulated gene ( ISG ) expression, classically resulting in a robust anti-viral immune response. (wikidoc.org)
The mouse counterpart of STAT5 alpha is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this protein in cells. (thermofisher.com)

[2] IFNAR agonism results in transcriptional changes, with the potential to increase or suppress the transcription of over 2000 different genes. (wikidoc.org)

Recently it was shown that JAK2 can modulate the activity of additional apoptotic regulators such as BAD and BCL-XL to promote cell survival. (medkoo.com)
Activation of STAT5 alpha in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. (thermofisher.com)

Cross-reactivity with other endogenous STAT isoforms has not been observed. (thermofisher.com)
In part the endogenous transcription of chemokine genes in melanoma cells is due to altered NF-κB activation. (cancerrealitycheck.com)

The innate immune response also includes complement proteins, defensins, and chemokines which attract inflammatory leukocytes, lipid mediator of inflammation, bioactive amines, and enzymes to enhance inflammation ( 2 ). (frontiersin.org)
The biological functions of chemokines are mediated through seven-transmembrane G-protein-coupled receptors. (cancerrealitycheck.com)
CXCL8 and CXCL6 bind to the chemokine receptors CXCR1 and CXCR2 whereas CXCL1 and other CXC-chemokines that have a Glu-Leu-Arg (ELR) motif at their amino terminus (CXCL2 -3 and-5) bind to and activate CXCR2 only2. (cancerrealitycheck.com)
This constitutive expression of chemokines occurs due to transcriptional activation of the encoding genes. (cancerrealitycheck.com)

The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. (cancerindex.org)

VPF In this review I discuss the factors that lie upstream of the NF-κB cascade that are activated during tumorigenesis and the role of the putative NF-κB enhanceosome in constitutive chemokine gene transcription during tumorigenesis. (cancerrealitycheck.com)
The transcription of chemokine genes is often inhibited by transforming growth factor-β (TGF-β) and glucocorticoids1. (cancerrealitycheck.com)

In this work, we have revealed that early viral protein UBCv1, the only known conjugating enzyme encoded by a virus, modulates innate immune and inflammatory signaling. (mdpi.com)
Innate immunity in gastrointestinal system includes epithelial cell layers that express tight cell-cell contact, secreted mucous layer which prevent entry of microbes, protective plasma protein, and circulating leukocytes, such as phagocytic macrophages, neutrophils, dendritic cells (DC), natural killer (NK) cells, NK T-cell, and innate lymphoid cells. (frontiersin.org)
Because viral innate immune evasion proteins typically carry out additional critical functions for the virus, the Basler lab has investigated virus-host interactions that modulate various aspects of viral replication. (mssm.edu)
The future use of miR inhibitors or mimics and/or siRNAs might be useful for the development of diagnostic and therapeutic strategies aimed at the recovering of protective innate responses in HCV infections. (biomedcentral.com)

In a recent example, the Basler lab identified multiple host proteins possessing PPxPxY motifs as modulators of Ebola virus mRNA synthesis. (mssm.edu)
HIV protease inhibitors have been reported to markedly suppress the activities of 25- and 1α-hydroxylase and thus affect 1,25(OH)2 D synthesis. (medscape.com)

The key function that STAT1 and STAT2 play in the transcriptional response to IFNα/β and in the induction of antiviral XMD8-92 activity continues to be showed in knockout mice and in mutant individual cell lines lacking in these proteins. (bibf1120.com)

DLBCLs with high module activation show strong expression of genes involved in cell-cell communication, immune responses or negative feedback loops. (nih.gov)
As BCL6 has been shown to modulate the STAT-dependent Interleukin 4 (IL-4) responses of B cells, miR-155 acts to increase B cell functioning. (biomedcentral.com)

Inhibitor of differentiation proteins are negative regulators of BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS. (bvsalud.org)

A peptide corresponding to the C-terminus of murine Stat5a coupled to a protein carrier. (thermofisher.com)

MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. (rndsystems.com)

[3] [4] The regulatory elements upstream of type I IFN genes differ, allowing differential transcription of type I IFNs in response to stimuli. (wikidoc.org)

MicroRNAs (miRNAs) are short (about 21 nucleotides long) strands of non-coding RNA that regulate the expression of multiple genes [ 1 ]. (biomedcentral.com)
African swine fever virus (ASFV) is an acute and persistent swine virus with a high economic burden that encodes multiple genes to evade host immune response. (mdpi.com)

Given the critical roles of STAT proteins in these fundamental cellular processes, which are often altered in cancer, there is accumulating evidence defining a critical role for STAT proteins in oncogenesis. (eurekaselect.com)

A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. (bvsalud.org)
In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus. (bvsalud.org)

NHL-patients were sorted according to their similarity in the expression of TOP100 affected genes to stimulated transformed germinal centre B cells The αIgM gene module discriminated individual DLBCL in a similar manner to CD40L or IL21 gene modules. (nih.gov)
MiR-155 is produced from the processing of the B-Cell Integration Cluster (BIC), which is a non-coding transcript expressed in activated B cells, T cells, monocytes and macrophages [ 11 , 12 ]. (biomedcentral.com)
18 Both enzymes, OGT and OGA as well as multiple O-GlcNAcylated proteins are enriched at sites of active transcription in human cells. (nature.com)
Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
Thus, we compared the expression profile of 24 selected miRs in IFN-β-treated Huh-7 cells and in three different clones of Huh-7 cells carrying a self-replicating HCV RNA which express all viral proteins (HCV replicon system). (biomedcentral.com)

In granulomatous disease such as lymphoproliferative disorders, sarcoidosis, tuberculosis, and inflammatory bowel disease, 1α-hydroxylase enzyme activity was found in macrophages as the extrarenal source of 1,25(OH)2 D. When 1α-hydroxylase is activated, it converts 25(OH)D to 1,25(OH)2 D, just as what occurs under physiologic conditions in the kidneys. (medscape.com)

Cultured neurons express EpoR, and the Janus kinase-2 (JAK-2) inhibitor AG490 abolished EPO-induced tolerance against OGD. (jneurosci.org)

Once these stores are depleted the ER-bound calcium sensor Stim1 (Stromal interaction molecule 1) couples the ER to the cytosolic Ca2+ channel protein Orai1 allowing extracellular calcium to enter the cell via store-operated calcium mineral admittance (SOCE) (evaluated in Feske 2007 Hogan et al. (ecologicalsgardens.com)

Interestingly, genes associated with a Burkitt-like phenotype, such as MYC, BCL6 or LEF1, were affected by αIgM. (nih.gov)

Targeting or activating the TIME components show a promising therapeutic avenue to combat cancer. (biomedcentral.com)

The presence of multiple host factors that can restrict virus replication by targeting a single interaction interface on a viral protein is highly unusual. (mssm.edu)

The mechanisms by which these modulate infection are currently being pursued. (mssm.edu)

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
Germline mutations in the NOTCH1 , NOTCH2 and NOTCH3 genes cause Adams-Oliver syndrome, Alagille syndrome and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, respectively ( 4 ), and DLL4-NOTCH3 signaling in human vascular organoids induces basement membrane thickening and drives vasculopathy in the diabetic microenvironment ( 5 ). (spandidos-publications.com)
Heritable disorders associated with low 1,25(OH)2 D levels include vitamin D-dependent rickets type 1 (inactivating mutation in the 1-hydroxylase gene),[5] autosomal-dominant hypophosphatemic rickets (mutation of the gene coding for FGF-23, which prevents its breakdown),[6] and X-linked hypophosphatemic rickets (mutations that elevate levels of FGF-23). (medscape.com)

with the mTOR inhibitors rapamycin or pp242 (each 100?nM). (healthweblognews.info)

Anatomy9

Organisms9

Diseases1

Chemicals and Drugs92

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes39

Disciplines and Occupations5

Technology, Industry, Agriculture2

Information Science21

Health Care2

Pathways18

Pathway24

Receptor13

MAPk1

Tyrosine4

Apoptosis4

Target genes2

Kinase inhibitor2

Kinases4

PI3K1

Cytokine5

Cytoplasmic3

Transducer and activator of transcription4

Cytokines4

PIAS3

Inhibit4

Activator2

Intracellular2

Small molecule2

EGFR6

Tumor5

Nuclear2

Recombinant proteins1

Constitutively2

Angiogenesis1

Phosphorylation4

Regulatory proteins1

STAT35

Induce2

20001

JAK22

Endogenous2

Chemokines4

Binds1

Chemokine2

Innate4

Synthesis2

Antiviral1

Responses2

Negative regulators1

Peptide1

Biological1

IFNs1

Multiple genes2

Cellular processes1

Bind2

Cells5

Inflammatory1

Janus1

Extracellular1

Interestingly1

Therapeutic1

Viral protein1

Mechanisms1

Cell-cycle1

Mutations3

Rapamycin1